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Protein

Homeotic protein ocelliless

Gene

oc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator involved in pattern formation and cell determination in the embryonic CNS and larval imaginal disks. Also later in development to coordinate the expression of regulatory and structural genes required for photoreceptor cell fate in the ocelli. Has a dual role in the terminal differentiation of subtypes of photoreceptors by regulating rhodopsin (rh) expression: essential for establishing the expression of rh genes in the pale subset of ommatidia as well as repressing Rh6 in outer photoreceptors.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi67 – 126HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase
  • sequence-specific DNA binding Source: InterPro
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • adult walking behavior Source: FlyBase
  • anterior head segmentation Source: FlyBase
  • anterior region determination Source: FlyBase
  • brain development Source: FlyBase
  • brain segmentation Source: FlyBase
  • central nervous system development Source: UniProtKB
  • compound eye morphogenesis Source: UniProtKB
  • compound eye photoreceptor development Source: FlyBase
  • embryonic development via the syncytial blastoderm Source: FlyBase
  • negative regulation of rhodopsin gene expression Source: FlyBase
  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • nervous system development Source: FlyBase
  • ocellus development Source: FlyBase
  • ocellus morphogenesis Source: FlyBase
  • ocellus photoreceptor cell development Source: FlyBase
  • pattern specification process Source: FlyBase
  • photoreceptor cell fate commitment Source: UniProtKB
  • positive regulation of compound eye photoreceptor development Source: FlyBase
  • positive regulation of gene expression Source: FlyBase
  • positive regulation of rhodopsin gene expression Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • rhabdomere development Source: UniProtKB
  • rhabdomere morphogenesis Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeotic protein ocelliless
Alternative name(s):
Protein orthodenticle
Gene namesi
Name:oc
Synonyms:Otd
ORF Names:CG12154
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0004102 oc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

In embryos, formation of an abnormal neuropil and the disappearance of the horizontal commissures associated with the midline of the CNS. In pupae, misshapen, duplicated, and shortened rhabdomeres within the eye. In adults, deletion of the ocelli.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490721 – 542Homeotic protein ocellilessAdd BLAST542

Proteomic databases

PaxDbiP22810
PRIDEiP22810

Expressioni

Tissue specificityi

Expressed in the anterior region of the embryo before cellularization and becomes localized to the procephalic head region following gastrulation. These cells correspond to the mesectoderm or midline neuroepithelium and will generate a mixed population of neurons and glia. Expressed in photoreceptors in pupae and adults.3 Publications

Developmental stagei

Expressed from early embryonic stages through to late pupation.1 Publication

Gene expression databases

BgeeiFBgn0004102
ExpressionAtlasiP22810 baseline and differential
GenevisibleiP22810 DM

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase
  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi58261, 14 interactors
IntActiP22810, 2 interactors
STRINGi7227.FBpp0304126

Structurei

3D structure databases

ProteinModelPortaliP22810
SMRiP22810
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 268Ser-richAdd BLAST137
Compositional biasi156 – 264Asn-richAdd BLAST109
Compositional biasi210 – 294Ala-richAdd BLAST85
Compositional biasi323 – 404Gly-richAdd BLAST82

Domaini

Contains multiple repeats consisting of single amino acids (e.g. Gly, Ser, His, and Asn) and pairs of amino acids (e.g. Gly-Val).

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG2251 Eukaryota
ENOG4111XIJ LUCA
GeneTreeiENSGT00900000140776
InParanoidiP22810
KOiK09326
OrthoDBiEOG091G0K9K
PhylomeDBiP22810

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGFLKSGD LGPHPHSYGG PHPHHSVPHG PLPPGMPMPS LGPFGLPHGL
60 70 80 90 100
EAVGFSQGMW GVNTRKQRRE RTTFTRAQLD VLEALFGKTR YPDIFMREEV
110 120 130 140 150
ALKINLPESR VQVWFKNRRA KCRQQLQQQQ QSNSLSSSKN ASGGGSGNSC
160 170 180 190 200
SSSSANSRSN SNNNGSSSNN NTQSSGGNNS NKSSQKQGNS QSSQQGGGSS
210 220 230 240 250
GGNNSNNNSA AAAASAAAAV AAAQSIKTHH SSFLSAAAAA ASGGTNQSAN
260 270 280 290 300
NNSNNNNQGN STPNSSSSGG GGGSQAGGHL SAAAAAAALN VTAAHQNSSP
310 320 330 340 350
LLPTPATSVS PVSIVCKKEH LSGGYGSSVG GGGGGGGASS GGLNLGVGVG
360 370 380 390 400
VGVGVGVGVS QDLLRSPYDQ LKDAGGDIGA GVHHHHSIYG SAAGSNPRLL
410 420 430 440 450
QPGGNITPMD SSSSITTPSP PITPMSPQSA AAAAHAAQSA QSAHHSAAHS
460 470 480 490 500
AAYMSNHDSY NFWHNQYQQY PNNYAQAPSY YSQMEYFSNQ NQVNYNMGHS
510 520 530 540
GYTASNFGLS PSPSFTGTVS AQAFSQNSLD YMSPQDKYAN MV
Length:542
Mass (Da):55,187
Last modified:April 14, 2009 - v2
Checksum:i73F6795CD8171EA0
GO

Sequence cautioni

The sequence CAA41732 differs from that shown. Reason: Frameshift at position 431.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61G → GDLCYPG in CAA41732 (PubMed:1979296).Curated1
Sequence conflicti240A → ASAQSIKTHHSSFLSAAAA in CAA41732 (PubMed:1979296).Curated1
Sequence conflicti272 – 273Missing in CAA41732 (PubMed:1979296).Curated2
Sequence conflicti337G → GGG in CAA41732 (PubMed:1979296).Curated1
Sequence conflicti434Missing in CAA41732 (PubMed:1979296).Curated1
Sequence conflicti530D → Y in AAR88546 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58983 mRNA Translation: CAA41732.1 Frameshift.
AE014298 Genomic DNA Translation: AAX52481.2
BT011185 mRNA Translation: AAR88546.1
PIRiA35912
RefSeqiNP_001014727.2, NM_001014727.3
NP_001259345.1, NM_001272416.1
NP_001259346.1, NM_001272417.1
UniGeneiDm.2933

Genome annotation databases

EnsemblMetazoaiFBtr0300106; FBpp0289383; FBgn0004102
FBtr0331305; FBpp0303737; FBgn0004102
FBtr0331306; FBpp0303738; FBgn0004102
FBtr0331738; FBpp0304127; FBgn0004102
GeneIDi31802
KEGGidme:Dmel_CG12154
UCSCiCG12154-RC d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiHMOC_DROME
AccessioniPrimary (citable) accession number: P22810
Secondary accession number(s): Q59E69, Q6NNU8, Q9W3D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: April 14, 2009
Last modified: May 23, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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