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Protein

Homeobox protein vnd

Gene

vnd

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable transcriptional regulator involved in the regulation of the proneural AS-C genes and the neurogenic genes of the enhancer of split complex. Could specifically activate proneural genes in the ventral-most neuroectoderm.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi545 – 604HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: InterPro
  • transcription factor binding Source: FlyBase

GO - Biological processi

  • brain development Source: FlyBase
  • central nervous system development Source: FlyBase
  • dorsal/ventral pattern formation Source: FlyBase
  • ectoderm development Source: FlyBase
  • glial cell development Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • neuroblast development Source: FlyBase
  • neuroblast fate determination Source: FlyBase
  • pattern specification process Source: FlyBase
  • positive regulation of transcription by RNA polymerase II Source: FlyBase
  • regulation of transcription by RNA polymerase II Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein vnd
Alternative name(s):
Homeobox protein NK-2
Protein ventral nervous system defective
Gene namesi
Name:vnd
Synonyms:NK2
ORF Names:CG6172
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0261930 vnd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi579A → T in vnd-29; disrupts neuroblast development. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490711 – 723Homeobox protein vndAdd BLAST723

Proteomic databases

PaxDbiP22808
PRIDEiP22808

Expressioni

Tissue specificityi

Expressed in the CNS and midgut.1 Publication

Gene expression databases

BgeeiFBgn0261930
ExpressionAtlasiP22808 baseline and differential
GenevisibleiP22808 DM

Interactioni

GO - Molecular functioni

  • transcription factor binding Source: FlyBase

Protein-protein interaction databases

BioGridi57572, 15 interactors
DIPiDIP-60882N
IntActiP22808, 3 interactors
STRINGi7227.FBpp0070105

Structurei

Secondary structure

1723
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi542 – 545Combined sources4
Helixi554 – 566Combined sources13
Helixi572 – 581Combined sources10
Helixi586 – 606Combined sources21
Beta strandi608 – 611Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NK2NMR-P538-613[»]
1NK3NMR-P538-613[»]
1QRYNMR-A538-613[»]
1VNDNMR-A538-613[»]
ProteinModelPortaliP22808
SMRiP22808
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22808

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 350His-richAdd BLAST126
Compositional biasi319 – 360Ala-richAdd BLAST42
Compositional biasi483 – 493Asn-richAdd BLAST11
Compositional biasi664 – 720Ala-richAdd BLAST57
Compositional biasi675 – 715His-richAdd BLAST41

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842 Eukaryota
ENOG410XR21 LUCA
GeneTreeiENSGT00910000144003
InParanoidiP22808
KOiK08029
OrthoDBiEOG091G0LZ2
PhylomeDBiP22808

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSASLERT PSKRDRDRER DNSSGLGSAG SLPASPQSAI TVSPSSPATP
60 70 80 90 100
KRPLRTSTPS LERKREREDR EDREDRKERQ ERHERDRDHE RFAAVFSTAS
110 120 130 140 150
TTVPTNTSSS SGLAPEQLRI PTGAAAFSGF PGLHSMSSLM LPSSAAVAAA
160 170 180 190 200
AAAPFLPWSP ILLPPWNHAL LPAAFYPAAL RNALPGLFDA KVPSSQRSGF
210 220 230 240 250
HISDILNLEG SELKNAAAAA AAAAHHGSDL SHHSASESTS GHRGQGSHTS
260 270 280 290 300
PSALSPTPAG VSADEHHNGS GTGGGAGEAD HHSTTEHHAP PSHPQQQHPH
310 320 330 340 350
HQQHHHPHLL LPQQHHQQAV APLPLAHHQS GEAQSHAHAN AAAAHLLASH
360 370 380 390 400
NAAAAAAVAA GQYLPNLPKN FPGSFGDEMS SYHHMAQTML QHSGRSAWIK
410 420 430 440 450
ENELYGTQQP ASPDSTSPVT SEVSYTYIGS NCQTSPALSG DYKSYSRSAD
460 470 480 490 500
SDALSVGDAL HTLHGSSGNG SAGGAPTAHA LHNNNNNTTN NNNHSLKAEG
510 520 530 540 550
INGAGSGHDD SLNEDGIEED IDDVDDADGS GGGDANGSDG LPNKKRKRRV
560 570 580 590 600
LFTKAQTYEL ERRFRQQRYL SAPEREHLAS LIRLTPTQVK IWFQNHRYKT
610 620 630 640 650
KRAQNEKGYE GHPGLLHGHA THPHHPSALP SPRRVAVPVL VRNGKPCLGD
660 670 680 690 700
SSKLGADCVS VSSATATAMQ NAAAHHLVAL NGAAAYQHAA AAAAGLHAHA
710 720
HAHAHAHGHG HPHAHAQRAA WWP
Length:723
Mass (Da):76,422
Last modified:May 10, 2004 - v3
Checksum:i811F20B03A93C95E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → A in AAB34960 (PubMed:7625694).Curated1
Sequence conflicti55R → P in AAB34960 (PubMed:7625694).Curated1
Sequence conflicti88D → E in CAA60619 (PubMed:7628450).Curated1
Sequence conflicti149A → R in CAA60619 (PubMed:7628450).Curated1
Sequence conflicti153Missing in CAA60619 (PubMed:7628450).Curated1
Sequence conflicti254L → V in AAB34960 (PubMed:7625694).Curated1
Sequence conflicti362Q → K in CAA60619 (PubMed:7628450).Curated1
Sequence conflicti399I → M in CAA60619 (PubMed:7628450).Curated1
Sequence conflicti405Y → H in CAA21410 (PubMed:10731137).Curated1
Sequence conflicti610E → D in CAA21410 (PubMed:10731137).Curated1
Sequence conflicti633 – 634RR → VG (PubMed:2573058).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87141 mRNA Translation: CAA60619.1
S78691 mRNA Translation: AAB34960.1
AE014298 Genomic DNA Translation: AAF45521.1
AL031883 Genomic DNA Translation: CAA21410.1
M27290 Genomic DNA Translation: AAA28617.1
PIRiS57246
RefSeqiNP_476786.2, NM_057438.4

Genome annotation databases

EnsemblMetazoaiFBtr0070110; FBpp0070105; FBgn0261930
GeneIDi31003
KEGGidme:Dmel_CG6172

Similar proteinsi

Entry informationi

Entry nameiVND_DROME
AccessioniPrimary (citable) accession number: P22808
Secondary accession number(s): Q24589
, Q26436, Q9UB43, Q9W5F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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