Reviewed, UniProtKB/Swiss-Prot P22807 (SLOU_DROME)

Names and origin

Protein names

Recommended name:
    Homeobox protein slou
Alternative name(s):
    S59/2
    Protein slouch
    Homeobox protein NK-1

Gene names

Name:	slou
Synonyms:	NK1, S59
ORF Names:	CG6534

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	659 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in specifying the identity of particular somatic muscles and neurons of the CNS.
Subcellular location	Nucleus Probable.
Tissue specificity	Mesodermal precursor cells of distinct muscles during embryogenesis, a subset of neuronal cells of the CNS and their precursors and also in cells of a small region of the midgut.
Developmental stage	Postgastrulation-stage.
Sequence similarities	Belongs to the NK-1 homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox Repeat
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mesodermal cell fate specification Non-traceable author statement. Source: FlyBase muscle cell fate determination Ref.1 Inferred from expression pattern. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular function	RNA polymerase II transcription factor activity Non-traceable author statement. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 659	659	Homeobox protein slou		PRO_0000049070
Regions
	Repeat	221 – 222	2	1
	Repeat	223 – 224	2	2
	Repeat	225 – 226	2	3
	Repeat	227 – 228	2	4
	Repeat	229 – 230	2	5
	Repeat	231 – 232	2	6
	Repeat	233 – 234	2	7
	DNA binding	545 – 604	60	Homeobox
	Region	221 – 234	14	7 X 2 AA tandem repeats of H-P
	Compositional bias	201 – 239	39	His-rich
	Compositional bias	364 – 372	9	Poly-Ala
	Compositional bias	477 – 522	46	Asp/Glu-rich (acidic)
	Compositional bias	536 – 542	7	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	P22807-1 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 5D401F55C4670280	FASTA	659	69,955
	10 20 30 40 50 60 MVMLQSPAQK ASDSASAQNT AVGGLMSPNS NPDSPKSNTS PDVASADSVV SGTGGGSTPP 70 80 90 100 110 120 AAKIPKFIIS ANGAAVAGKQ EQELRYSLER LKQMSSESGS LLSRLSPLQE DSQDKEKPNH 130 140 150 160 170 180 NNNNSLTNHN ANSNTRRSQS PPASVGSVSF SSPAQQRKLL ELNAVRHLAR PEPLQHPHAA 190 200 210 220 230 240 LLQQHPHLLQ NPQFLAAAQQ HMHHHQHQHH QHPAHPHSHQ HPHPHPHPHP HPHPSAVFHL 250 260 270 280 290 300 RAPSSSSTAP PSPATSPLSP PTSPAMHSDQ QMSPPIAPPQ NPPHSSQPPQ QQQVAAPSDM 310 320 330 340 350 360 DLERIKLVAA VAARTTQASS TSALASASNS VSNASISISN SSSGSPSGRD LSDYGFRIQL 370 380 390 400 410 420 GGLAAAAAAA AATSRQIAAA TYARSDTSEE LNVDGNDEDS NDGSHSTPSV CPVDLTRSVN 430 440 450 460 470 480 SSAAANPSSA STSASSDRDA ATKRLAFSVE NILDPNKFTG NKLPSGPFGH PRQWSYERDE 490 500 510 520 530 540 EMQERLDDDQ SEDMSAQDLN DMDQDDMCDD GSDIDDPSSE TDSKKGGSRN GDGKSGGGGG 550 560 570 580 590 600 GGSKPRRART AFTYEQLVSL ENKFKTTRYL SVCERLNLAL SLSLTETQVK IWFQNRRTKW 610 620 630 640 650 KKQNPGMDVN SPTIPPPGGG SFGPGAYASG LLYSHAVPYP PYGPYFHPLG AHHLSHSHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis." Dohrmann C., Azpiazu N., Frasch M. Genes Dev. 4:2098-2111(1990) [PubMed: 1980118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"Drosophila NK-homeobox genes." Kim Y., Nirenberg M. Proc. Natl. Acad. Sci. U.S.A. 86:7716-7720(1989) [PubMed: 2573058] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 497-625.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X55393 mRNA. Translation: CAA39067.1. AE014297 Genomic DNA. Translation: AAF55901.3. M27289 Genomic DNA. Translation: AAA28616.1.
PIR	A36664.
RefSeq	NP_476657.1.
UniGene	Dm.3456
3D structure databases
HSSP	HSSP built from PDB template 1IG7 based on UniProtKB P13297.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:17156N.
IntAct	P22807. 11 interactions.
Proteomic databases
PRIDE	P22807.
Genome annotation databases
Ensembl	FBgn0002941. Drosophila melanogaster. [Contig view]
GeneID	42547.
KEGG	dme:Dmel_CG6534.
NMPDR	fig|7227.3.peg.13935.
Organism-specific databases
FlyBase	FBgn0002941. slou.
Phylogenomic databases
HOGENOM	P22807.
OMA	P22807. ENILDPN.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-012689-MON.
Gene expression databases
ArrayExpress	P22807.
GermOnline	CG6534. Drosophila melanogaster.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	829362.

Entry information

Entry name

SLOU_DROME

Accession

Primary (citable) accession number: P22807
Secondary accession number(s): Q9VD96

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	June 16, 2009
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project