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P22807 (SLOU_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein slou
Alternative name(s):
Homeobox protein NK-1
Protein slouch
S59/2
Gene names
Name:slou
Synonyms:NK1, S59
ORF Names:CG6534
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length659 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in specifying the identity of particular somatic muscles and neurons of the CNS.

Subcellular location

Nucleus Probable.

Tissue specificity

Mesodermal precursor cells of distinct muscles during embryogenesis, a subset of neuronal cells of the CNS and their precursors and also in cells of a small region of the midgut.

Developmental stage

Postgastrulation-stage.

Sequence similarities

Belongs to the NK-1 homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 659659Homeobox protein slou
PRO_0000049070

Regions

Repeat221 – 22221
Repeat223 – 22422
Repeat225 – 22623
Repeat227 – 22824
Repeat229 – 23025
Repeat231 – 23226
Repeat233 – 23427
DNA binding545 – 60460Homeobox
Region221 – 234147 X 2 AA tandem repeats of H-P
Compositional bias201 – 23939His-rich
Compositional bias364 – 3729Poly-Ala
Compositional bias477 – 52246Asp/Glu-rich (acidic)
Compositional bias536 – 5427Poly-Gly

Sequences

Sequence LengthMass (Da)Tools
P22807 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 5D401F55C4670280

FASTA65969,955
        10         20         30         40         50         60 
MVMLQSPAQK ASDSASAQNT AVGGLMSPNS NPDSPKSNTS PDVASADSVV SGTGGGSTPP 

        70         80         90        100        110        120 
AAKIPKFIIS ANGAAVAGKQ EQELRYSLER LKQMSSESGS LLSRLSPLQE DSQDKEKPNH 

       130        140        150        160        170        180 
NNNNSLTNHN ANSNTRRSQS PPASVGSVSF SSPAQQRKLL ELNAVRHLAR PEPLQHPHAA 

       190        200        210        220        230        240 
LLQQHPHLLQ NPQFLAAAQQ HMHHHQHQHH QHPAHPHSHQ HPHPHPHPHP HPHPSAVFHL 

       250        260        270        280        290        300 
RAPSSSSTAP PSPATSPLSP PTSPAMHSDQ QMSPPIAPPQ NPPHSSQPPQ QQQVAAPSDM 

       310        320        330        340        350        360 
DLERIKLVAA VAARTTQASS TSALASASNS VSNASISISN SSSGSPSGRD LSDYGFRIQL 

       370        380        390        400        410        420 
GGLAAAAAAA AATSRQIAAA TYARSDTSEE LNVDGNDEDS NDGSHSTPSV CPVDLTRSVN 

       430        440        450        460        470        480 
SSAAANPSSA STSASSDRDA ATKRLAFSVE NILDPNKFTG NKLPSGPFGH PRQWSYERDE 

       490        500        510        520        530        540 
EMQERLDDDQ SEDMSAQDLN DMDQDDMCDD GSDIDDPSSE TDSKKGGSRN GDGKSGGGGG 

       550        560        570        580        590        600 
GGSKPRRART AFTYEQLVSL ENKFKTTRYL SVCERLNLAL SLSLTETQVK IWFQNRRTKW 

       610        620        630        640        650 
KKQNPGMDVN SPTIPPPGGG SFGPGAYASG LLYSHAVPYP PYGPYFHPLG AHHLSHSHS

« Hide

References

« Hide 'large scale' references
[1]"A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis."
Dohrmann C., Azpiazu N., Frasch M.
Genes Dev. 4:2098-2111(1990) [PubMed: 1980118] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"Drosophila NK-homeobox genes."
Kim Y., Nirenberg M.
Proc. Natl. Acad. Sci. U.S.A. 86:7716-7720(1989) [PubMed: 2573058] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 497-625.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X55393 mRNA. Translation: CAA39067.1.
AE014297 Genomic DNA. Translation: AAF55901.3.
M27289 Genomic DNA. Translation: AAA28616.1.
PIRA36664.
RefSeqNP_476657.1. NM_057309.2.
UniGeneDm.3456.

3D structure databases

ProteinModelPortalP22807.
SMRP22807. Positions 546-602.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-17156N.
MINTMINT-321547.
STRINGP22807.

Proteomic databases

PRIDEP22807.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0084123; FBpp0083521; FBgn0002941.
GeneID42547.
KEGGdme:Dmel_CG6534.
NMPDRfig|7227.3.peg.13935.

Organism-specific databases

CTD42547.
FlyBaseFBgn0002941. slou.

Phylogenomic databases

eggNOGinNOG05061.
GeneTreeEMGT00050000001569.
InParanoidP22807.
OMASEDMSAQ.
OrthoDBEOG40CG06.
PhylomeDBP22807.

Gene expression databases

BgeeP22807.
GermOnlineCG6534. Drosophila melanogaster.

Family and domain databases

InterProIPR001356. Homeobox.
IPR017970. Homeobox_CS.
IPR020479. Homeobox_eu.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KOK09309.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. Homeodomain_like. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio829362.

Entry information

Entry nameSLOU_DROME
AccessionPrimary (citable) accession number: P22807
Secondary accession number(s): Q9VD96
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: January 25, 2012
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents