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P22804

- BET1_YEAST

UniProt

P22804 - BET1_YEAST

Protein

Protein transport protein BET1

Gene

BET1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. SNAP receptor activity Source: SGD

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW
    3. retrograde vesicle-mediated transport, Golgi to ER Source: SGD
    4. vesicle fusion Source: SGD

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31283-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein BET1
    Alternative name(s):
    Suppressor of loss of YPT1 protein 12
    Short name:
    Protein SLY12
    Gene namesi
    Name:BET1
    Synonyms:SLY12
    Ordered Locus Names:YIL004C
    ORF Names:YIA4C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL004c.
    SGDiS000001266. BET1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. ER to Golgi transport vesicle Source: SGD
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: SGD
    5. SNARE complex Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 142142Protein transport protein BET1PRO_0000206892Add
    BLAST

    Proteomic databases

    MaxQBiP22804.
    PaxDbiP22804.

    Expressioni

    Gene expression databases

    GenevestigatoriP22804.

    Interactioni

    Subunit structurei

    Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with SEC24.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATG8P381822EBI-3550,EBI-2684

    Protein-protein interaction databases

    BioGridi34988. 44 interactions.
    DIPiDIP-2050N.
    IntActiP22804. 7 interactions.
    MINTiMINT-502359.
    STRINGi4932.YIL004C.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi52 – 565

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PCXX-ray2.50B51-58[»]
    ProteinModelPortaliP22804.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22804.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini142 – 1421VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 14124Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 11463t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BET1 family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308692.
    HOGENOMiHOG000209281.
    KOiK08504.
    OMAiDEIRGSN.
    OrthoDBiEOG7712MK.

    Family and domain databases

    InterProiIPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    PROSITEiPS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22804-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRFAGGNA YQRDTGRTQL FGPADGSNSL DDNVSSALGS TDKLDYSQST    50
    LASLESQSEE QMGAMGQRIK ALKSLSLKMG DEIRGSNQTI DQLGDTFHNT 100
    SVKLKRTFGN MMEMARRSGI SIKTWLIIFF MVGVLFFWVW IT 142
    Length:142
    Mass (Da):15,720
    Last modified:August 1, 1991 - v1
    Checksum:iDC1BD4FFE67E2217
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38113 Genomic DNA. Translation: CAA86247.1.
    X54237 Genomic DNA. Translation: CAA38143.1.
    X79743 Genomic DNA. Translation: CAB38096.1.
    BK006942 Genomic DNA. Translation: DAA08542.1.
    PIRiC39610.
    RefSeqiNP_012262.3. NM_001179354.3.

    Genome annotation databases

    EnsemblFungiiYIL004C; YIL004C; YIL004C.
    GeneIDi854813.
    KEGGisce:YIL004C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38113 Genomic DNA. Translation: CAA86247.1 .
    X54237 Genomic DNA. Translation: CAA38143.1 .
    X79743 Genomic DNA. Translation: CAB38096.1 .
    BK006942 Genomic DNA. Translation: DAA08542.1 .
    PIRi C39610.
    RefSeqi NP_012262.3. NM_001179354.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PCX X-ray 2.50 B 51-58 [» ]
    ProteinModelPortali P22804.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34988. 44 interactions.
    DIPi DIP-2050N.
    IntActi P22804. 7 interactions.
    MINTi MINT-502359.
    STRINGi 4932.YIL004C.

    Proteomic databases

    MaxQBi P22804.
    PaxDbi P22804.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL004C ; YIL004C ; YIL004C .
    GeneIDi 854813.
    KEGGi sce:YIL004C.

    Organism-specific databases

    CYGDi YIL004c.
    SGDi S000001266. BET1.

    Phylogenomic databases

    eggNOGi NOG308692.
    HOGENOMi HOG000209281.
    KOi K08504.
    OMAi DEIRGSN.
    OrthoDBi EOG7712MK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31283-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P22804.
    NextBioi 977645.

    Gene expression databases

    Genevestigatori P22804.

    Family and domain databases

    InterProi IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    PROSITEi PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily."
      Dascher C., Ossig R., Gallwitz D., Schmitt H.D.
      Mol. Cell. Biol. 11:872-885(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane."
      Newman A.P., Groesch M.E., Ferro-Novick S.
      EMBO J. 11:3609-3617(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    3. "Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX."
      Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W.
      Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. "Topological restriction of SNARE-dependent membrane fusion."
      Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E.
      Nature 407:194-198(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SED5; BOS1 AND SEC22.
    7. Cited for: INTERACTION WITH SEC24.

    Entry informationi

    Entry nameiBET1_YEAST
    AccessioniPrimary (citable) accession number: P22804
    Secondary accession number(s): D6VVS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3