Protein transport protein BET1 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P22804 (BET1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein transport protein BET1

Alternative name(s):
Suppressor of loss of YPT1 protein 12
Short name=Protein SLY12

Gene names

Name:	BET1
Synonyms:	SLY12
Ordered Locus Names:	YIL004C
ORF Names:	YIA4C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex. Ref.2 Ref.6
Subunit structure	Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with SEC24. Ref.6 Ref.7
Subcellular location	Golgi apparatus membrane; Single-pass type IV membrane protein Probable. Endoplasmic reticulum membrane; Single-pass type IV membrane protein Probable.
Sequence similarities	Belongs to the BET1 family. Contains 1 t-SNARE coiled-coil homology domain.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from mutant phenotype PubMed 3312234. Source: SGD protein transport Inferred from electronic annotation. Source: UniProtKB-KW retrograde vesicle-mediated transport, Golgi to ER Inferred from direct assay PubMed 9813082. Source: SGD vesicle fusion Inferred from direct assay PubMed 11001046. Source: SGD
Cellular_component	ER to Golgi transport vesicle Inferred from direct assay PubMed 11157978. Source: SGD Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell SNARE complex Inferred from direct assay Ref.6. Source: SGD endoplasmic reticulum membrane Inferred from direct assay Ref.2. Source: SGD integral to membrane Inferred from direct assay Ref.2. Source: SGD
Molecular_function	SNAP receptor activity Inferred from direct assay Ref.6. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATG8	P38182	2	EBI-3550,EBI-2684

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 142

142

Protein transport protein BET1

PRO_0000206892

Regions

Topological domain

1 – 117

117

Cytoplasmic Potential

Transmembrane

118 – 141

Helical; Anchor for type IV membrane protein; Potential

Topological domain

142

Vesicular Potential

Domain

52 – 114

t-SNARE coiled-coil homology

Secondary structure

142

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P22804 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: DC1BD4FFE67E2217
Show »

FASTA

142

15,720

        10         20         30         40         50         60 
MSSRFAGGNA YQRDTGRTQL FGPADGSNSL DDNVSSALGS TDKLDYSQST LASLESQSEE 

        70         80         90        100        110        120 
QMGAMGQRIK ALKSLSLKMG DEIRGSNQTI DQLGDTFHNT SVKLKRTFGN MMEMARRSGI 

       130        140 
SIKTWLIIFF MVGVLFFWVW IT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily." Dascher C., Ossig R., Gallwitz D., Schmitt H.D. Mol. Cell. Biol. 11:872-885(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane." Newman A.P., Groesch M.E., Ferro-Novick S. EMBO J. 11:3609-3617(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[3]	"Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX." Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W. Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX." Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. Barrell B.G. Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[5]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[6]	"Topological restriction of SNARE-dependent membrane fusion." Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E. Nature 407:194-198(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SED5; BOS1 AND SEC22.
[7]	"SNARE selectivity of the COPII coat." Mossessova E., Bickford L.C., Goldberg J. Cell 114:483-495(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SEC24.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z38113 Genomic DNA. Translation: CAA86247.1.
X54237 Genomic DNA. Translation: CAA38143.1.
X79743 Genomic DNA. Translation: CAB38096.1.
BK006942 Genomic DNA. Translation: DAA08542.1.

PIR

C39610.

RefSeq

NP_012262.3. NM_001179354.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PCX	X-ray	2.50	B	51-58	[»]

ProteinModelPortal

P22804.

SMR

P22804. Positions 59-111.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2050N.

IntAct

P22804. 5 interactions.

MINT

MINT-502359.

STRING

4932.YIL004C.

Proteomic databases

PaxDb

P22804.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YIL004C; YIL004C; YIL004C.

GeneID

854813.

KEGG

sce:YIL004C.

Organism-specific databases

CYGD

YIL004c.

SGD

S000001266. BET1.

Phylogenomic databases

eggNOG

NOG308692.

HOGENOM

HOG000209281.

K08504.

OMA

DEIRGSN.

OrthoDB

EOG4HB1VZ.

Enzyme and pathway databases

BioCyc

YEAST:G3O-31283-MONOMER.

Gene expression databases

Genevestigator

P22804.

GermOnline

YIL004C. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR000727. T_SNARE_dom.
[Graphical view]

Pfam

PF05739. SNARE. 1 hit.
[Graphical view]

SMART

SM00397. t_SNARE. 1 hit.
[Graphical view]

PROSITE

PS50192. T_SNARE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P22804.

NextBio

977645.

Entry information

Entry name

BET1_YEAST

Accession

Primary (citable) accession number: P22804
Secondary accession number(s): D6VVS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 29, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents