Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P22804

- BET1_YEAST

UniProt

P22804 - BET1_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein transport protein BET1

Gene

BET1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.2 Publications

GO - Molecular functioni

  1. SNAP receptor activity Source: SGD

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein transport Source: UniProtKB-KW
  3. retrograde vesicle-mediated transport, Golgi to ER Source: SGD
  4. vesicle fusion Source: SGD
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31283-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein BET1
Alternative name(s):
Suppressor of loss of YPT1 protein 12
Short name:
Protein SLY12
Gene namesi
Name:BET1
Synonyms:SLY12
Ordered Locus Names:YIL004C
ORF Names:YIA4C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL004c.
SGDiS000001266. BET1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. ER to Golgi transport vesicle Source: SGD
  3. Golgi apparatus Source: UniProtKB-KW
  4. integral component of membrane Source: SGD
  5. SNARE complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Protein transport protein BET1PRO_0000206892Add
BLAST

Proteomic databases

MaxQBiP22804.
PaxDbiP22804.

Expressioni

Gene expression databases

GenevestigatoriP22804.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with SEC24.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG8P381822EBI-3550,EBI-2684

Protein-protein interaction databases

BioGridi34988. 45 interactions.
DIPiDIP-2050N.
IntActiP22804. 7 interactions.
MINTiMINT-502359.
STRINGi4932.YIL004C.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 565

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PCXX-ray2.50B51-58[»]
ProteinModelPortaliP22804.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22804.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini142 – 1421VesicularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei118 – 14124Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 11463t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BET1 family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308692.
HOGENOMiHOG000209281.
InParanoidiP22804.
KOiK08504.
OMAiDEIRGSN.
OrthoDBiEOG7712MK.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22804-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSRFAGGNA YQRDTGRTQL FGPADGSNSL DDNVSSALGS TDKLDYSQST
60 70 80 90 100
LASLESQSEE QMGAMGQRIK ALKSLSLKMG DEIRGSNQTI DQLGDTFHNT
110 120 130 140
SVKLKRTFGN MMEMARRSGI SIKTWLIIFF MVGVLFFWVW IT
Length:142
Mass (Da):15,720
Last modified:August 1, 1991 - v1
Checksum:iDC1BD4FFE67E2217
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38113 Genomic DNA. Translation: CAA86247.1.
X54237 Genomic DNA. Translation: CAA38143.1.
X79743 Genomic DNA. Translation: CAB38096.1.
BK006942 Genomic DNA. Translation: DAA08542.1.
PIRiC39610.
RefSeqiNP_012262.3. NM_001179354.3.

Genome annotation databases

EnsemblFungiiYIL004C; YIL004C; YIL004C.
GeneIDi854813.
KEGGisce:YIL004C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38113 Genomic DNA. Translation: CAA86247.1 .
X54237 Genomic DNA. Translation: CAA38143.1 .
X79743 Genomic DNA. Translation: CAB38096.1 .
BK006942 Genomic DNA. Translation: DAA08542.1 .
PIRi C39610.
RefSeqi NP_012262.3. NM_001179354.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PCX X-ray 2.50 B 51-58 [» ]
ProteinModelPortali P22804.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34988. 45 interactions.
DIPi DIP-2050N.
IntActi P22804. 7 interactions.
MINTi MINT-502359.
STRINGi 4932.YIL004C.

Proteomic databases

MaxQBi P22804.
PaxDbi P22804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL004C ; YIL004C ; YIL004C .
GeneIDi 854813.
KEGGi sce:YIL004C.

Organism-specific databases

CYGDi YIL004c.
SGDi S000001266. BET1.

Phylogenomic databases

eggNOGi NOG308692.
HOGENOMi HOG000209281.
InParanoidi P22804.
KOi K08504.
OMAi DEIRGSN.
OrthoDBi EOG7712MK.

Enzyme and pathway databases

BioCyci YEAST:G3O-31283-MONOMER.

Miscellaneous databases

EvolutionaryTracei P22804.
NextBioi 977645.

Gene expression databases

Genevestigatori P22804.

Family and domain databases

InterProi IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
PROSITEi PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily."
    Dascher C., Ossig R., Gallwitz D., Schmitt H.D.
    Mol. Cell. Biol. 11:872-885(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane."
    Newman A.P., Groesch M.E., Ferro-Novick S.
    EMBO J. 11:3609-3617(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  3. "Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX."
    Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W.
    Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. "Topological restriction of SNARE-dependent membrane fusion."
    Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E.
    Nature 407:194-198(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SED5; BOS1 AND SEC22.
  7. Cited for: INTERACTION WITH SEC24.

Entry informationi

Entry nameiBET1_YEAST
AccessioniPrimary (citable) accession number: P22804
Secondary accession number(s): D6VVS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3