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P22804 (BET1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein transport protein BET1
Alternative name(s):
Suppressor of loss of YPT1 protein 12
Short name=Protein SLY12
Gene names
Name:BET1
Synonyms:SLY12
Ordered Locus Names:YIL004C
ORF Names:YIA4C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex. Ref.2 Ref.6

Subunit structure

Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with SEC24. Ref.6 Ref.7

Subcellular location

Golgi apparatus membrane; Single-pass type IV membrane protein Probable. Endoplasmic reticulum membrane; Single-pass type IV membrane protein Probable.

Sequence similarities

Belongs to the BET1 family.

Contains 1 t-SNARE coiled-coil homology domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ATG8P381822EBI-3550,EBI-2684

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 142142Protein transport protein BET1
PRO_0000206892

Regions

Topological domain1 – 117117Cytoplasmic Potential
Transmembrane118 – 14124Helical; Anchor for type IV membrane protein; Potential
Topological domain1421Vesicular Potential
Domain52 – 11463t-SNARE coiled-coil homology

Secondary structure

... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P22804 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: DC1BD4FFE67E2217

FASTA14215,720
        10         20         30         40         50         60 
MSSRFAGGNA YQRDTGRTQL FGPADGSNSL DDNVSSALGS TDKLDYSQST LASLESQSEE 

        70         80         90        100        110        120 
QMGAMGQRIK ALKSLSLKMG DEIRGSNQTI DQLGDTFHNT SVKLKRTFGN MMEMARRSGI 

       130        140 
SIKTWLIIFF MVGVLFFWVW IT 

« Hide

References

« Hide 'large scale' references
[1]"Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily."
Dascher C., Ossig R., Gallwitz D., Schmitt H.D.
Mol. Cell. Biol. 11:872-885(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane."
Newman A.P., Groesch M.E., Ferro-Novick S.
EMBO J. 11:3609-3617(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[3]"Nucleotide sequence and analysis of the centromeric region of yeast chromosome IX."
Voss H., Tamames J., Teodoru C., Valencia A., Sensen C., Wiemann S., Schwager C., Zimmermann J., Sander C., Ansorge W.
Yeast 11:61-78(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IX."
Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D., Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E., Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C. expand/collapse author list , Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:84-87(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[6]"Topological restriction of SNARE-dependent membrane fusion."
Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E.
Nature 407:194-198(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SED5; BOS1 AND SEC22.
[7]"SNARE selectivity of the COPII coat."
Mossessova E., Bickford L.C., Goldberg J.
Cell 114:483-495(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SEC24.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z38113 Genomic DNA. Translation: CAA86247.1.
X54237 Genomic DNA. Translation: CAA38143.1.
X79743 Genomic DNA. Translation: CAB38096.1.
BK006942 Genomic DNA. Translation: DAA08542.1.
PIRC39610.
RefSeqNP_012262.3. NM_001179354.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PCXX-ray2.50B51-58[»]
ProteinModelPortalP22804.
SMRP22804. Positions 59-111.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34988. 44 interactions.
DIPDIP-2050N.
IntActP22804. 7 interactions.
MINTMINT-502359.
STRING4932.YIL004C.

Proteomic databases

PaxDbP22804.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYIL004C; YIL004C; YIL004C.
GeneID854813.
KEGGsce:YIL004C.

Organism-specific databases

CYGDYIL004c.
SGDS000001266. BET1.

Phylogenomic databases

eggNOGNOG308692.
HOGENOMHOG000209281.
KOK08504.
OMADEIRGSN.
OrthoDBEOG7712MK.

Enzyme and pathway databases

BioCycYEAST:G3O-31283-MONOMER.

Gene expression databases

GenevestigatorP22804.

Family and domain databases

InterProIPR000727. T_SNARE_dom.
[Graphical view]
PfamPF05739. SNARE. 1 hit.
[Graphical view]
SMARTSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP22804.
NextBio977645.

Entry information

Entry nameBET1_YEAST
AccessionPrimary (citable) accession number: P22804
Secondary accession number(s): D6VVS6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: February 19, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IX

Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references