P22794 (EVI2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein EVI2A

Alternative name(s):
Ecotropic viral integration site 2A protein homolog
Short name=EVI-2A

Gene names

Name:	EVI2A
Synonyms:	EVDA, EVI2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the EVI2A family.
Caution	It is uncertain whether Met-1 or Met-5 is the initiator.
Sequence caution	The sequence AAA52413.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG35269.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Disease	Proto-oncogene
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transmembrane signaling receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P22794-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P22794-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLLRSWFGNKDFQALPILARLPSM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 236	206	Protein EVI2A		PRO_0000021211
Regions
	Topological domain	31 – 133	103	Extracellular Potential
	Transmembrane	134 – 154	21	Helical; Potential
	Topological domain	155 – 236	82	Cytoplasmic Potential
Amino acid modifications
	Modified residue	211	1	Phosphoserine By similarity
	Glycosylation	31	1	N-linked (GlcNAc...) Potential
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Glycosylation	49	1	N-linked (GlcNAc...) Potential
	Glycosylation	73	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1	1	M → MLLRSWFGNKDFQALPILAR LPSM in isoform 2.		VSP_038859

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 23, 2010. Version 2. Checksum: 5C62B05746BD975D	FASTA	236	26,213
	10 20 30 40 50 60 MPTDMEHTGH YLHLAFLMTT VFSLSPGTKA NYTRLWANST SSWDSVIQNK TGRNQNENIN 70 80 90 100 110 120 TNPITPEVDY KGNSTNMPET SHIVALTSKS EQELYIPSVV SNSPSTVQSI ENTSKSHGEI 130 140 150 160 170 180 FKKDVCAENN NNMAMLICLI IIAVLFLICT FLFLSTVVLA NKVSSLRRSK QVGKRQPRSN 190 200 210 220 230 GDFLASGLWP AESDTWKRTK QLTGPNLVMQ STGVLTATRE RKDEEGTEKL TNKQIG
	Isoform 2 [UniParc]. Checksum: FD2A815054984C62	FASTA	259	28,869
	10 20 30 40 50 60 MLLRSWFGNK DFQALPILAR LPSMPTDMEH TGHYLHLAFL MTTVFSLSPG TKANYTRLWA 70 80 90 100 110 120 NSTSSWDSVI QNKTGRNQNE NINTNPITPE VDYKGNSTNM PETSHIVALT SKSEQELYIP 130 140 150 160 170 180 SVVSNSPSTV QSIENTSKSH GEIFKKDVCA ENNNNMAMLI CLIIIAVLFL ICTFLFLSTV 190 200 210 220 230 240 VLANKVSSLR RSKQVGKRQP RSNGDFLASG LWPAESDTWK RTKQLTGPNL VMQSTGVLTA 250 TRERKDEEGT EKLTNKQIG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts." Cawthon R.M., O'Connell P., Buchberg A.M., Viskochil D., Weiss R.B., Culver M., Stevens J., Jenkins N.A., Copeland N.G., White R. Genomics 7:555-565(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Caudate nucleus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M55266 Genomic DNA. No translation available. M55267 Genomic DNA. Translation: AAA52413.1. Different initiation. AK295311 mRNA. Translation: BAG58290.1. AK312348 mRNA. Translation: BAG35269.1. Different initiation. BC035572 mRNA. Translation: AAH35572.2.
IPI	IPI00027506. IPI00456226.
PIR	A35329.
RefSeq	NP_001003927.1. NM_001003927.2. NP_055025.2. NM_014210.3.
UniGene	Hs.591198.
3D structure databases
ProteinModelPortal	P22794.
ModBase	Search...
Protein-protein interaction databases
IntAct	P22794. 3 interactions.
STRING	9606.ENSP00000247270.
PTM databases
PhosphoSite	P22794.
Polymorphism databases
DMDM	292495009.
Proteomic databases
PaxDb	P22794.
PRIDE	P22794.
Protocols and materials databases
DNASU	2123.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247270; ENSP00000247270; ENSG00000126860. ENST00000394755; ENSP00000378237; ENSG00000126860. ENST00000461237; ENSP00000418064; ENSG00000126860. ENST00000462804; ENSP00000420557; ENSG00000126860.
GeneID	2123.
KEGG	hsa:2123.
UCSC	uc002hgl.3. human. uc002hgm.3. human.
Organism-specific databases
CTD	2123.
GeneCards	GC17M029644.
HGNC	HGNC:3499. EVI2A.
HPA	HPA045033.
MIM	158380. gene.
neXtProt	NX_P22794.
PharmGKB	PA27913.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43871.
HOGENOM	HOG000069955.
HOVERGEN	HBG051513.
InParanoid	P22794.
OMA	LHLAFLM.
OrthoDB	EOG4J3WHZ.
Gene expression databases
Bgee	P22794.
CleanEx	HS_EVI2A.
Genevestigator	P22794.
GermOnline	ENSG00000126860. Homo sapiens.
Family and domain databases
InterPro	IPR008608. Ectropic_vir_integratn_site_2A. [Graphical view]
PANTHER	PTHR15568. PTHR15568. 1 hit.
Pfam	PF05399. EVI2A. 1 hit. [Graphical view]
PIRSF	PIRSF019625. EVI_S2A. 1 hit.
ProDom	PD037847. EVI_S2A. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
GenomeRNAi	2123.
NextBio	8587.
SOURCE	Search...

Entry information

Entry name

EVI2A_HUMAN

Accession

Primary (citable) accession number: P22794
Secondary accession number(s): B2R5X2, B4DHX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	March 23, 2010
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.