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Protein

Protein EVI2A

Gene

EVI2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • signal transduction Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EVI2A
Alternative name(s):
Ecotropic viral integration site 2A protein homolog
Short name:
EVI-2A
Gene namesi
Name:EVI2A
Synonyms:EVDA, EVI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:3499. EVI2A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 133103ExtracellularSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 23682CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA27913.

Polymorphism and mutation databases

BioMutaiEVI2A.
DMDMi292495009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 236206Protein EVI2APRO_0000021211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Modified residuei211 – 2111PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP22794.
PRIDEiP22794.

PTM databases

iPTMnetiP22794.
PhosphoSiteiP22794.

Expressioni

Gene expression databases

BgeeiP22794.
CleanExiHS_EVI2A.
GenevisibleiP22794. HS.

Organism-specific databases

HPAiHPA045033.

Interactioni

Protein-protein interaction databases

BioGridi108424. 9 interactions.
IntActiP22794. 3 interactions.
STRINGi9606.ENSP00000247270.

Structurei

3D structure databases

ProteinModelPortaliP22794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EVI2A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKC1. Eukaryota.
ENOG410XXMV. LUCA.
GeneTreeiENSGT00390000003004.
HOGENOMiHOG000069955.
HOVERGENiHBG051513.
InParanoidiP22794.
OMAiLHLAFLM.
OrthoDBiEOG78SQK0.
PhylomeDBiP22794.
TreeFamiTF336075.

Family and domain databases

InterProiIPR008608. Ectropic_vir_integratn_site_2A.
[Graphical view]
PANTHERiPTHR15568. PTHR15568. 1 hit.
PfamiPF05399. EVI2A. 1 hit.
[Graphical view]
PIRSFiPIRSF019625. EVI_S2A. 1 hit.
ProDomiPD037847. EVI_S2A. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P22794-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTDMEHTGH YLHLAFLMTT VFSLSPGTKA NYTRLWANST SSWDSVIQNK
60 70 80 90 100
TGRNQNENIN TNPITPEVDY KGNSTNMPET SHIVALTSKS EQELYIPSVV
110 120 130 140 150
SNSPSTVQSI ENTSKSHGEI FKKDVCAENN NNMAMLICLI IIAVLFLICT
160 170 180 190 200
FLFLSTVVLA NKVSSLRRSK QVGKRQPRSN GDFLASGLWP AESDTWKRTK
210 220 230
QLTGPNLVMQ STGVLTATRE RKDEEGTEKL TNKQIG
Length:236
Mass (Da):26,213
Last modified:March 23, 2010 - v2
Checksum:i5C62B05746BD975D
GO
Isoform 2 (identifier: P22794-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLLRSWFGNKDFQALPILARLPSM

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):28,869
Checksum:iFD2A815054984C62
GO

Sequence cautioni

The sequence AAA52413.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAG35269.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MLLRSWFGNKDFQALPILAR LPSM in isoform 2. 1 PublicationVSP_038859

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55266 Genomic DNA. No translation available.
M55267 Genomic DNA. Translation: AAA52413.1. Different initiation.
AK295311 mRNA. Translation: BAG58290.1.
AK312348 mRNA. Translation: BAG35269.1. Different initiation.
BC035572 mRNA. Translation: AAH35572.2.
CCDSiCCDS32608.1. [P22794-2]
CCDS42293.1. [P22794-1]
PIRiA35329.
RefSeqiNP_001003927.1. NM_001003927.2. [P22794-2]
NP_055025.2. NM_014210.3. [P22794-1]
UniGeneiHs.591198.

Genome annotation databases

EnsembliENST00000247270; ENSP00000247270; ENSG00000126860. [P22794-2]
ENST00000461237; ENSP00000418064; ENSG00000126860. [P22794-1]
ENST00000462804; ENSP00000420557; ENSG00000126860. [P22794-1]
GeneIDi2123.
KEGGihsa:2123.
UCSCiuc002hgl.4. human. [P22794-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55266 Genomic DNA. No translation available.
M55267 Genomic DNA. Translation: AAA52413.1. Different initiation.
AK295311 mRNA. Translation: BAG58290.1.
AK312348 mRNA. Translation: BAG35269.1. Different initiation.
BC035572 mRNA. Translation: AAH35572.2.
CCDSiCCDS32608.1. [P22794-2]
CCDS42293.1. [P22794-1]
PIRiA35329.
RefSeqiNP_001003927.1. NM_001003927.2. [P22794-2]
NP_055025.2. NM_014210.3. [P22794-1]
UniGeneiHs.591198.

3D structure databases

ProteinModelPortaliP22794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108424. 9 interactions.
IntActiP22794. 3 interactions.
STRINGi9606.ENSP00000247270.

PTM databases

iPTMnetiP22794.
PhosphoSiteiP22794.

Polymorphism and mutation databases

BioMutaiEVI2A.
DMDMi292495009.

Proteomic databases

PaxDbiP22794.
PRIDEiP22794.

Protocols and materials databases

DNASUi2123.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247270; ENSP00000247270; ENSG00000126860. [P22794-2]
ENST00000461237; ENSP00000418064; ENSG00000126860. [P22794-1]
ENST00000462804; ENSP00000420557; ENSG00000126860. [P22794-1]
GeneIDi2123.
KEGGihsa:2123.
UCSCiuc002hgl.4. human. [P22794-1]

Organism-specific databases

CTDi2123.
GeneCardsiEVI2A.
HGNCiHGNC:3499. EVI2A.
HPAiHPA045033.
MIMi158380. gene.
neXtProtiNX_P22794.
PharmGKBiPA27913.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKC1. Eukaryota.
ENOG410XXMV. LUCA.
GeneTreeiENSGT00390000003004.
HOGENOMiHOG000069955.
HOVERGENiHBG051513.
InParanoidiP22794.
OMAiLHLAFLM.
OrthoDBiEOG78SQK0.
PhylomeDBiP22794.
TreeFamiTF336075.

Miscellaneous databases

GenomeRNAii2123.
NextBioi8587.
PROiP22794.
SOURCEiSearch...

Gene expression databases

BgeeiP22794.
CleanExiHS_EVI2A.
GenevisibleiP22794. HS.

Family and domain databases

InterProiIPR008608. Ectropic_vir_integratn_site_2A.
[Graphical view]
PANTHERiPTHR15568. PTHR15568. 1 hit.
PfamiPF05399. EVI2A. 1 hit.
[Graphical view]
PIRSFiPIRSF019625. EVI_S2A. 1 hit.
ProDomiPD037847. EVI_S2A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts."
    Cawthon R.M., O'Connell P., Buchberg A.M., Viskochil D., Weiss R.B., Culver M., Stevens J., Jenkins N.A., Copeland N.G., White R.
    Genomics 7:555-565(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Caudate nucleus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.

Entry informationi

Entry nameiEVI2A_HUMAN
AccessioniPrimary (citable) accession number: P22794
Secondary accession number(s): B2R5X2, B4DHX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 23, 2010
Last modified: March 16, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.