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Protein

Carboxypeptidase N subunit 2

Gene

CPN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.

GO - Molecular functioni

  • enzyme regulator activity Source: UniProtKB

GO - Biological processi

  • protein stabilization Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase N subunit 2
Alternative name(s):
Carboxypeptidase N 83 kDa chain
Carboxypeptidase N large subunit
Carboxypeptidase N polypeptide 2
Carboxypeptidase N regulatory subunit
Gene namesi
Name:CPN2
Synonyms:ACBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2313. CPN2.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26830.

Polymorphism and mutation databases

BioMutaiCPN2.
DMDMi334302917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 545524Carboxypeptidase N subunit 2PRO_0000020989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)1 Publication
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis
Glycosylationi348 – 3481N-linked (GlcNAc...)1 Publication
Glycosylationi359 – 3591N-linked (GlcNAc...)1 Publication
Glycosylationi518 – 5181N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22792.
PeptideAtlasiP22792.
PRIDEiP22792.

PTM databases

iPTMnetiP22792.
PhosphoSiteiP22792.

Expressioni

Gene expression databases

BgeeiENSG00000178772.
CleanExiHS_CPN2.
GenevisibleiP22792. HS.

Organism-specific databases

HPAiHPA004732.

Interactioni

Subunit structurei

Tetramer of two catalytic chains and two glycosylated inactive chains.

Protein-protein interaction databases

BioGridi107762. 2 interactions.
STRINGi9606.ENSP00000319464.

Structurei

3D structure databases

ProteinModelPortaliP22792.
SMRiP22792. Positions 19-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 4928LRRNTAdd
BLAST
Repeati98 – 11922LRR 1Add
BLAST
Repeati122 – 14322LRR 2Add
BLAST
Repeati146 – 16722LRR 3Add
BLAST
Repeati170 – 19122LRR 4Add
BLAST
Repeati194 – 21522LRR 5Add
BLAST
Repeati218 – 23922LRR 6Add
BLAST
Repeati242 – 26322LRR 7Add
BLAST
Repeati266 – 28722LRR 8Add
BLAST
Repeati290 – 31122LRR 9Add
BLAST
Repeati314 – 33522LRR 10Add
BLAST
Repeati338 – 35922LRR 11Add
BLAST
Repeati362 – 38322LRR 12Add
BLAST
Domaini395 – 44753LRRCTAdd
BLAST

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000294123.
HOVERGENiHBG050814.
InParanoidiP22792.
KOiK13023.
OMAiWQCDCHL.
OrthoDBiEOG091G057B.
PhylomeDBiP22792.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGAWLLWT SLLLLARPAQ PCPMGCDCFV QEVFCSDEEL ATVPLDIPPY
60 70 80 90 100
TKNIIFVETS FTTLETRAFG SNPNLTKVVF LNTQLCQFRP DAFGGLPRLE
110 120 130 140 150
DLEVTGSSFL NLSTNIFSNL TSLGKLTLNF NMLEALPEGL FQHLAALESL
160 170 180 190 200
HLQGNQLQAL PRRLFQPLTH LKTLNLAQNL LAQLPEELFH PLTSLQTLKL
210 220 230 240 250
SNNALSGLPQ GVFGKLGSLQ ELFLDSNNIS ELPPQVFSQL FCLERLWLQR
260 270 280 290 300
NAITHLPLSI FASLGNLTFL SLQWNMLRVL PAGLFAHTPC LVGLSLTHNQ
310 320 330 340 350
LETVAEGTFA HLSNLRSLML SYNAITHLPA GIFRDLEELV KLYLGSNNLT
360 370 380 390 400
ALHPALFQNL SKLELLSLSK NQLTTLPEGI FDTNYNLFNL ALHGNPWQCD
410 420 430 440 450
CHLAYLFNWL QQYTDRLLNI QTYCAGPAYL KGQVVPALNE KQLVCPVTRD
460 470 480 490 500
HLGFQVTWPD ESKAGGSWDL AVQERAARSQ CTYSNPEGTV VLACDQAQCR
510 520 530 540
WLNVQLSPQQ GSLGLQYNAS QEWDLRSSCG SLRLTVSIEA RAAGP
Length:545
Mass (Da):60,557
Last modified:May 31, 2011 - v3
Checksum:i221AAF04413665AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561Q → R in AAH42334 (PubMed:15489334).Curated
Sequence conflicti509 – 5091Q → W in AAH31569 (PubMed:15489334).Curated
Sequence conflicti509 – 5091Q → W in AAH42334 (PubMed:15489334).Curated
Sequence conflicti509 – 5091Q → W in AAI37399 (PubMed:15489334).Curated
Sequence conflicti509 – 5091Q → W in AAI37404 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti305 – 3051A → T.
Corresponds to variant rs3732477 [ dbSNP | Ensembl ].
VAR_019722
Natural varianti509 – 5091Q → R.1 Publication
Corresponds to variant rs4974538 [ dbSNP | Ensembl ].
VAR_065186
Natural varianti536 – 5361V → M.1 Publication
Corresponds to variant rs11711157 [ dbSNP | Ensembl ].
VAR_019721

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05158 mRNA. Translation: AAA51921.2.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
BC031569 mRNA. Translation: AAH31569.2.
BC042334 mRNA. Translation: AAH42334.2.
BC137398 mRNA. Translation: AAI37399.1.
BC137403 mRNA. Translation: AAI37404.1.
CCDSiCCDS33920.1.
PIRiA34901.
RefSeqiNP_001073982.3. NM_001080513.3.
NP_001278917.1. NM_001291988.1.
XP_005269337.1. XM_005269280.4.
UniGeneiHs.528368.

Genome annotation databases

EnsembliENST00000323830; ENSP00000319464; ENSG00000178772.
ENST00000429275; ENSP00000402232; ENSG00000178772.
GeneIDi1370.
KEGGihsa:1370.
UCSCiuc003fts.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05158 mRNA. Translation: AAA51921.2.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
BC031569 mRNA. Translation: AAH31569.2.
BC042334 mRNA. Translation: AAH42334.2.
BC137398 mRNA. Translation: AAI37399.1.
BC137403 mRNA. Translation: AAI37404.1.
CCDSiCCDS33920.1.
PIRiA34901.
RefSeqiNP_001073982.3. NM_001080513.3.
NP_001278917.1. NM_001291988.1.
XP_005269337.1. XM_005269280.4.
UniGeneiHs.528368.

3D structure databases

ProteinModelPortaliP22792.
SMRiP22792. Positions 19-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107762. 2 interactions.
STRINGi9606.ENSP00000319464.

PTM databases

iPTMnetiP22792.
PhosphoSiteiP22792.

Polymorphism and mutation databases

BioMutaiCPN2.
DMDMi334302917.

Proteomic databases

PaxDbiP22792.
PeptideAtlasiP22792.
PRIDEiP22792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323830; ENSP00000319464; ENSG00000178772.
ENST00000429275; ENSP00000402232; ENSG00000178772.
GeneIDi1370.
KEGGihsa:1370.
UCSCiuc003fts.3. human.

Organism-specific databases

CTDi1370.
GeneCardsiCPN2.
H-InvDBHIX0030813.
HGNCiHGNC:2313. CPN2.
HPAiHPA004732.
MIMi603104. gene.
neXtProtiNX_P22792.
PharmGKBiPA26830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000294123.
HOVERGENiHBG050814.
InParanoidiP22792.
KOiK13023.
OMAiWQCDCHL.
OrthoDBiEOG091G057B.
PhylomeDBiP22792.
TreeFamiTF351124.

Miscellaneous databases

GeneWikiiCPN2.
GenomeRNAii1370.
PROiP22792.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178772.
CleanExiHS_CPN2.
GenevisibleiP22792. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPN2_HUMAN
AccessioniPrimary (citable) accession number: P22792
Secondary accession number(s): B2RPE7, Q86SU4, Q8N5V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 31, 2011
Last modified: September 7, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.