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Protein

Carboxypeptidase N subunit 2

Gene

CPN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.

GO - Molecular functioni

  • enzyme regulator activity Source: UniProtKB

GO - Biological processi

  • protein stabilization Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase N subunit 2
Alternative name(s):
Carboxypeptidase N 83 kDa chain
Carboxypeptidase N large subunit
Carboxypeptidase N polypeptide 2
Carboxypeptidase N regulatory subunit
Gene namesi
Name:CPN2
Synonyms:ACBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2313. CPN2.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1370.
OpenTargetsiENSG00000178772.
PharmGKBiPA26830.

Polymorphism and mutation databases

BioMutaiCPN2.
DMDMi334302917.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002098922 – 545Carboxypeptidase N subunit 2Add BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi359N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi518N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Whether or not any Cys residues participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the 50 kDa catalytic subunit.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP22792.
PeptideAtlasiP22792.
PRIDEiP22792.

PTM databases

iPTMnetiP22792.
PhosphoSitePlusiP22792.

Expressioni

Gene expression databases

BgeeiENSG00000178772.
CleanExiHS_CPN2.
GenevisibleiP22792. HS.

Organism-specific databases

HPAiHPA004732.

Interactioni

Subunit structurei

Tetramer of two catalytic chains and two glycosylated inactive chains.

Protein-protein interaction databases

BioGridi107762. 3 interactors.
STRINGi9606.ENSP00000319464.

Structurei

3D structure databases

ProteinModelPortaliP22792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 49LRRNTAdd BLAST28
Repeati98 – 119LRR 1Add BLAST22
Repeati122 – 143LRR 2Add BLAST22
Repeati146 – 167LRR 3Add BLAST22
Repeati170 – 191LRR 4Add BLAST22
Repeati194 – 215LRR 5Add BLAST22
Repeati218 – 239LRR 6Add BLAST22
Repeati242 – 263LRR 7Add BLAST22
Repeati266 – 287LRR 8Add BLAST22
Repeati290 – 311LRR 9Add BLAST22
Repeati314 – 335LRR 10Add BLAST22
Repeati338 – 359LRR 11Add BLAST22
Repeati362 – 383LRR 12Add BLAST22
Domaini395 – 447LRRCTAdd BLAST53

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000294123.
HOVERGENiHBG050814.
InParanoidiP22792.
KOiK13023.
OMAiWQCDCHL.
OrthoDBiEOG091G057B.
PhylomeDBiP22792.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF13855. LRR_8. 3 hits.
SMARTiView protein in SMART
SM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPGAWLLWT SLLLLARPAQ PCPMGCDCFV QEVFCSDEEL ATVPLDIPPY
60 70 80 90 100
TKNIIFVETS FTTLETRAFG SNPNLTKVVF LNTQLCQFRP DAFGGLPRLE
110 120 130 140 150
DLEVTGSSFL NLSTNIFSNL TSLGKLTLNF NMLEALPEGL FQHLAALESL
160 170 180 190 200
HLQGNQLQAL PRRLFQPLTH LKTLNLAQNL LAQLPEELFH PLTSLQTLKL
210 220 230 240 250
SNNALSGLPQ GVFGKLGSLQ ELFLDSNNIS ELPPQVFSQL FCLERLWLQR
260 270 280 290 300
NAITHLPLSI FASLGNLTFL SLQWNMLRVL PAGLFAHTPC LVGLSLTHNQ
310 320 330 340 350
LETVAEGTFA HLSNLRSLML SYNAITHLPA GIFRDLEELV KLYLGSNNLT
360 370 380 390 400
ALHPALFQNL SKLELLSLSK NQLTTLPEGI FDTNYNLFNL ALHGNPWQCD
410 420 430 440 450
CHLAYLFNWL QQYTDRLLNI QTYCAGPAYL KGQVVPALNE KQLVCPVTRD
460 470 480 490 500
HLGFQVTWPD ESKAGGSWDL AVQERAARSQ CTYSNPEGTV VLACDQAQCR
510 520 530 540
WLNVQLSPQQ GSLGLQYNAS QEWDLRSSCG SLRLTVSIEA RAAGP
Length:545
Mass (Da):60,557
Last modified:May 31, 2011 - v3
Checksum:i221AAF04413665AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156Q → R in AAH42334 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAH31569 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAH42334 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAI37399 (PubMed:15489334).Curated1
Sequence conflicti509Q → W in AAI37404 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019722305A → T. Corresponds to variant dbSNP:rs3732477Ensembl.1
Natural variantiVAR_065186509Q → R1 PublicationCorresponds to variant dbSNP:rs4974538Ensembl.1
Natural variantiVAR_019721536V → M1 PublicationCorresponds to variant dbSNP:rs11711157Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05158 mRNA. Translation: AAA51921.2.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
BC031569 mRNA. Translation: AAH31569.2.
BC042334 mRNA. Translation: AAH42334.2.
BC137398 mRNA. Translation: AAI37399.1.
BC137403 mRNA. Translation: AAI37404.1.
CCDSiCCDS33920.1.
PIRiA34901.
RefSeqiNP_001073982.3. NM_001080513.3.
NP_001278917.1. NM_001291988.1.
XP_005269337.1. XM_005269280.4.
UniGeneiHs.528368.

Genome annotation databases

EnsembliENST00000323830; ENSP00000319464; ENSG00000178772.
ENST00000429275; ENSP00000402232; ENSG00000178772.
GeneIDi1370.
KEGGihsa:1370.
UCSCiuc003fts.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05158 mRNA. Translation: AAA51921.2.
AC125362 Genomic DNA. No translation available.
AC174158 Genomic DNA. No translation available.
BC031569 mRNA. Translation: AAH31569.2.
BC042334 mRNA. Translation: AAH42334.2.
BC137398 mRNA. Translation: AAI37399.1.
BC137403 mRNA. Translation: AAI37404.1.
CCDSiCCDS33920.1.
PIRiA34901.
RefSeqiNP_001073982.3. NM_001080513.3.
NP_001278917.1. NM_001291988.1.
XP_005269337.1. XM_005269280.4.
UniGeneiHs.528368.

3D structure databases

ProteinModelPortaliP22792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107762. 3 interactors.
STRINGi9606.ENSP00000319464.

PTM databases

iPTMnetiP22792.
PhosphoSitePlusiP22792.

Polymorphism and mutation databases

BioMutaiCPN2.
DMDMi334302917.

Proteomic databases

PaxDbiP22792.
PeptideAtlasiP22792.
PRIDEiP22792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323830; ENSP00000319464; ENSG00000178772.
ENST00000429275; ENSP00000402232; ENSG00000178772.
GeneIDi1370.
KEGGihsa:1370.
UCSCiuc003fts.3. human.

Organism-specific databases

CTDi1370.
DisGeNETi1370.
GeneCardsiCPN2.
H-InvDBiHIX0030813.
HGNCiHGNC:2313. CPN2.
HPAiHPA004732.
MIMi603104. gene.
neXtProtiNX_P22792.
OpenTargetsiENSG00000178772.
PharmGKBiPA26830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000294123.
HOVERGENiHBG050814.
InParanoidiP22792.
KOiK13023.
OMAiWQCDCHL.
OrthoDBiEOG091G057B.
PhylomeDBiP22792.
TreeFamiTF351124.

Enzyme and pathway databases

ReactomeiR-HSA-977606. Regulation of Complement cascade.

Miscellaneous databases

GeneWikiiCPN2.
GenomeRNAii1370.
PROiPR:P22792.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178772.
CleanExiHS_CPN2.
GenevisibleiP22792. HS.

Family and domain databases

Gene3Di3.80.10.10. 4 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF13855. LRR_8. 3 hits.
SMARTiView protein in SMART
SM00369. LRR_TYP. 12 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 11 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCPN2_HUMAN
AccessioniPrimary (citable) accession number: P22792
Secondary accession number(s): B2RPE7, Q86SU4, Q8N5V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 31, 2011
Last modified: June 7, 2017
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.