##gff-version 3 P22791 UniProtKB Transit peptide 1 37 . . . Note=Mitochondrion;Ontology_term=ECO:0000305;evidence=ECO:0000305 P22791 UniProtKB Chain 38 508 . . . ID=PRO_0000013486;Note=Hydroxymethylglutaryl-CoA synthase%2C mitochondrial P22791 UniProtKB Active site 132 132 . . . Note=Proton donor/acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10116 P22791 UniProtKB Active site 166 166 . . . Note=Acyl-thioester intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10116 P22791 UniProtKB Active site 301 301 . . . Note=Proton donor/acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU10116 P22791 UniProtKB Binding site 80 80 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54868 P22791 UniProtKB Binding site 204 204 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54868 P22791 UniProtKB Binding site 258 258 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54868 P22791 UniProtKB Binding site 380 380 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54868 P22791 UniProtKB Modified residue 52 52 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 83 83 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 83 83 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 118 118 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 118 118 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 221 221 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 243 243 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 256 256 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 256 256 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 306 306 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 310 310 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 310 310 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2KIE6 P22791 UniProtKB Modified residue 327 327 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 327 327 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 333 333 . . . Note=N6-succinyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 342 342 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 342 342 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 350 350 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 350 350 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 354 354 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 354 354 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 358 358 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 358 358 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 427 427 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 433 433 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54868 P22791 UniProtKB Modified residue 437 437 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 440 440 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P22791 UniProtKB Modified residue 447 447 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 447 447 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 456 456 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 473 473 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 473 473 . . . Note=N6-succinyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P54869 P22791 UniProtKB Modified residue 477 477 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 P22791 UniProtKB Sequence conflict 205 205 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305