P22779 (CP2AX_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Cytochrome P450 2A EC=1.14.14.1 Alternative name(s): Cytochrome OLF2 Olfactive cytochrome P450 P52
Organism	Bos taurus (Bovine) [Reference proteome]
Taxonomic identifier	9913 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	18 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›18	›18	Cytochrome P450 2A		PRO_0000051677
Natural variations
	Natural variant	6	1	G → D.
	Natural variant	11	1	A → E.
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	18	1

Sequences

	Sequence		Length	Mass (Da)
	P22779 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: F80746F76CCD77FF	FASTA	18	2,060
	10 MXYLPGPQQQ AFKELQGL

References

[1]	"Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase." Lazard D., Tal N., Rubinstein M., Khen M., Lancet D., Zupko K. Biochemistry 29:7433-7440(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
IPI	IPI00714077.
PIR	A35704.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
PROSITE	PS00086. CYTOCHROME_P450. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP2AX_BOVIN

Accession

Primary (citable) accession number: P22779

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program