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P22779 - CP2AX_BOVIN


Cytochrome P450 2A

Bos taurus (Bovine)
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.


    Heme group.By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. response to stimulus Source: UniProtKB-KW
    2. sensory perception of smell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2A (EC:
    Alternative name(s):
    Cytochrome OLF2
    Olfactive cytochrome P450
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›18›18Cytochrome P450 2APRO_0000051677Add

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated


    Sequence statusi: Fragment.

    P22779-1 [UniParc]FASTAAdd to Basket

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    MXYLPGPQQQ AFKELQGL                                      18
    Mass (Da):2,060
    Last modified:August 1, 1991 - v1

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei18 – 181

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61G → D.
    Natural varianti11 – 111A → E.

    Sequence databases



    Sequence databases

    PIRi A35704.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...


    1. "Identification and biochemical analysis of novel olfactory-specific cytochrome P-450IIA and UDP-glucuronosyl transferase."
      Lazard D., Tal N., Rubinstein M., Khen M., Lancet D., Zupko K.
      Biochemistry 29:7433-7440(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiCP2AX_BOVIN
    AccessioniPrimary (citable) accession number: P22779
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program


    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome


    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3