Plasminogen activator inhibitor 1 precursor

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P22777 (PAI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Plasminogen activator inhibitor 1
Short name=PAI
Short name=PAI-1

Alternative name(s):
Endothelial plasminogen activator inhibitor
Serpin E1

Gene names

Name:	Serpine1
Synonyms:	Mr1, Pai1, Planh1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis By similarity.
Subunit structure	Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	defense response to Gram-negative bacterium Inferred from mutant phenotype PubMed 17032919. Source: BHF-UCL negative regulation of plasminogen activation Inferred from mutant phenotype PubMed 19855083. Source: BHF-UCL negative regulation of vascular wound healing Inferred from mutant phenotype PubMed 9386191. Source: BHF-UCL positive regulation of angiogenesis Inferred from mutant phenotype PubMed 18835034. Source: BHF-UCL regulation of cell proliferation Inferred from genetic interaction PubMed 18258607. Source: MGI
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from direct assay PubMed 15328353. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Tmprss11e	Q5S248	2	EBI-490898,EBI-490889

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 22

Probable

Chain

23 – 402

380

Plasminogen activator inhibitor 1

PRO_0000032500

Sites

Site

369 – 370

Reactive bond

Amino acid modifications

Glycosylation

232

N-linked (GlcNAc...) Potential

Glycosylation

288

N-linked (GlcNAc...) Potential

Glycosylation

352

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

T → M AA sequence Ref.2

Secondary structure

402

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P22777 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 765FF1659C70F68C
Show »

FASTA

402

45,170

        10         20         30         40         50         60 
MQMSSALACL ILGLVLVSGK GFTLPLRESH TAHQATDFGV KVFQQVVQAS KDRNVVFSPY 

        70         80         90        100        110        120 
GVSSVLAMLQ MTTAGKTRRQ IQDAMGFKVN EKGTAHALRQ LSKELMGPWN KNEISTADAI 

       130        140        150        160        170        180 
FVQRDLELVQ GFMPHFFKLF QTMVKQVDFS EVERARFIIN DWVERHTKGM INDLLAKGAV 

       190        200        210        220        230        240 
DELTRLVLVN ALYFSGQWKT PFLEASTHQR LFHKSDGSTV SVPMMAQSNK FNYTEFTTPD 

       250        260        270        280        290        300 
GLEYDVVELP YQRDTLSMFI AAPFEKDVHL SALTNILDAE LIRQWKGNMT RLPRLLILPK 

       310        320        330        340        350        360 
FSLETEVDLR GPLEKLGMPD MFSATLADFT SLSDQEQLSV AQALQKVRIE VNESGTVASS 

       370        380        390        400 
STAFVISARM APTEMVIDRS FLFVVRHNPT ETILFMGQVM EP

« Hide

References

[1]	"The c-myc-regulated gene mr1 encodes plasminogen activator inhibitor 1." Prendergast G.C., Diamond L.E., Dahl D., Cole M.D. Mol. Cell. Biol. 10:1265-1269(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of the murine plasma fibrinolytic system." Lijnen H.R., van Hoef B., Beelen V., Collen D. Eur. J. Biochem. 224:863-871(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-29.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M33960 mRNA. Translation: AAA39887.1.

IPI

IPI00131547.

PIR

A34761.

UniGene

Mm.250422.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3LW2	X-ray	1.93	A	24-402	[»]

ProteinModelPortal

P22777.

SMR

P22777. Positions 30-402.

ModBase

Search...

Protein-protein interaction databases

IntAct

P22777. 1 interaction.

Protein family/group databases

MEROPS

I04.020.

PTM databases

PhosphoSite

P22777.

Proteomic databases

PaxDb

P22777.

PRIDE

P22777.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

MGI

MGI:97608. Serpine1.

Phylogenomic databases

eggNOG

COG4826.

HOGENOM

HOG000238519.

HOVERGEN

HBG106493.

InParanoid

P22777.

OrthoDB

EOG4X3H1K.

Gene expression databases

CleanEx

MM_MR1.

Genevestigator

P22777.

GermOnline

ENSMUSG00000037411. Mus musculus.

Family and domain databases

InterPro

IPR023795. Protease_inhib_I4_serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]

PANTHER

PTHR11461. PTHR11461. 1 hit.

Pfam

PF00079. Serpin. 1 hit.
[Graphical view]

SMART

SM00093. SERPIN. 1 hit.
[Graphical view]

SUPFAM

SSF56574. Prot_inh_serpin. 1 hit.

PROSITE

PS00284. SERPIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P22777.

SOURCE

Search...

Entry information

Entry name

PAI1_MOUSE

Accession

Primary (citable) accession number: P22777

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	April 3, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents