ID   HEMT_SIPCU              Reviewed;         113 AA.
AC   P22766;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   13-SEP-2023, entry version 84.
DE   RecName: Full=Hemerythrin;
OS   Siphonosoma cumanense (Sipunculan worm) (Lumbricus edulis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Sipuncula;
OC   Sipunculidea; Golfingiida; Sipunculidae; Siphonosoma.
OX   NCBI_TaxID=6444;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2362933;
RA   Uchida T., Yano H., Satake K., Kubota I., Tsugita A.;
RT   "The amino acid sequence of hemerythrin from Siphonosoma cumanense.";
RL   Protein Seq. Data Anal. 3:141-147(1990).
CC   -!- FUNCTION: Hemerythrin is a respiratory protein in blood cells of
CC       certain marine worms. The oxygen-binding site in each chain contains
CC       two iron atoms.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SIMILARITY: Belongs to the hemerythrin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; JT0556; HRIN.
DR   AlphaFoldDB; P22766; -.
DR   SMR; P22766; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd12107; Hemerythrin; 1.
DR   Gene3D; 1.20.120.50; Hemerythrin-like; 1.
DR   InterPro; IPR002063; Haemerythrin.
DR   InterPro; IPR016131; Haemerythrin_Fe_BS.
DR   InterPro; IPR035938; Hemerythrin-like_sf.
DR   InterPro; IPR012827; Hemerythrin_metal-bd.
DR   NCBIfam; TIGR00058; Hemerythrin; 1.
DR   PANTHER; PTHR37164; BACTERIOHEMERYTHRIN; 1.
DR   PANTHER; PTHR37164:SF1; BACTERIOHEMERYTHRIN; 1.
DR   PIRSF; PIRSF002033; Hemerythrin; 1.
DR   PRINTS; PR00186; HEMERYTHRIN.
DR   SUPFAM; SSF47188; Hemerythrin-like; 1.
DR   PROSITE; PS00550; HEMERYTHRINS; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..113
FT                   /note="Hemerythrin"
FT                   /id="PRO_0000191838"
FT   BINDING         25
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         54
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         58
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         58
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         73
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         77
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         101
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         106
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   BINDING         106
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P02244"
FT   VARIANT         3
FT                   /note="P -> E"
FT   VARIANT         10
FT                   /note="W -> D"
FT   VARIANT         60
FT                   /note="A -> G"
FT   VARIANT         66
FT                   /note="K -> N"
FT   VARIANT         83
FT                   /note="K -> Q"
SQ   SEQUENCE   113 AA;  12437 MW;  653C278D78F9E953 CRC64;
     GFPVPDPFIW DASFKTFYDD LDNQHKQLFQ AILTQGNVGG ATAGDNAYAC LVAHFLFEEA
     AMQVAKYGGY GAHKAAHEEF LGKVKGGSAD AAYCKDWLTQ HIKTIDFKYK GKL
//