P22766 (HEMT_SIPCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Hemerythrin
Organism	Siphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
Taxonomic identifier	6444 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Annelida › Polychaeta › Sipuncula › Sipunculidea › Golfingiida › Sipunculidae › Siphonosoma

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.
Subunit structure	Homotrimer.
Sequence similarities	Belongs to the hemerythrin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	iron ion binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 113	113	Hemerythrin		PRO_0000191838
Sites
	Metal binding	25	1	Iron 1 By similarity
	Metal binding	54	1	Iron 1 By similarity
	Metal binding	58	1	Iron 1 By similarity
	Metal binding	58	1	Iron 2 By similarity
	Metal binding	73	1	Iron 2 By similarity
	Metal binding	77	1	Iron 2 By similarity
	Metal binding	101	1	Iron 2 By similarity
	Metal binding	106	1	Iron 1 By similarity
	Metal binding	106	1	Iron 2 By similarity
Natural variations
	Natural variant	3	1	P → E.
	Natural variant	10	1	W → D.
	Natural variant	60	1	A → G.
	Natural variant	66	1	K → N.
	Natural variant	83	1	K → Q.

Sequences

	Sequence		Length	Mass (Da)
	P22766 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 653C278D78F9E953	FASTA	113	12,437
	10 20 30 40 50 60 GFPVPDPFIW DASFKTFYDD LDNQHKQLFQ AILTQGNVGG ATAGDNAYAC LVAHFLFEEA 70 80 90 100 110 AMQVAKYGGY GAHKAAHEEF LGKVKGGSAD AAYCKDWLTQ HIKTIDFKYK GKL

References

[1]	"The amino acid sequence of hemerythrin from Siphonosoma cumanense." Uchida T., Yano H., Satake K., Kubota I., Tsugita A. Protein Seq. Data Anal. 3:141-147(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	HRIN. JT0556.
3D structure databases
ProteinModelPortal	P22766.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.120.50. 1 hit.
InterPro	IPR002063. Haemerythrin. IPR012827. Haemerythrin-like_metal-bd. IPR016131. Haemerythrin_Fe_BS. [Graphical view]
PIRSF	PIRSF002033. Hemerythrin. 1 hit.
PRINTS	PR00186. HEMERYTHRIN.
SUPFAM	SSF47188. Hemryth_metal_bd. 1 hit.
TIGRFAMs	TIGR00058. Hemerythrin. 1 hit.
PROSITE	PS00550. HEMERYTHRINS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMT_SIPCU

Accession

Primary (citable) accession number: P22766

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)