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P22766

- HEMT_SIPCU

UniProt

P22766 - HEMT_SIPCU

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Protein

Hemerythrin

Gene
N/A
Organism
Siphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251Iron 1By similarity
Metal bindingi54 – 541Iron 1By similarity
Metal bindingi58 – 581Iron 1By similarity
Metal bindingi58 – 581Iron 2By similarity
Metal bindingi73 – 731Iron 2By similarity
Metal bindingi77 – 771Iron 2By similarity
Metal bindingi101 – 1011Iron 2By similarity
Metal bindingi106 – 1061Iron 1By similarity
Metal bindingi106 – 1061Iron 2By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemerythrin
OrganismiSiphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
Taxonomic identifieri6444 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaSipunculaSipunculideaGolfingiidaSipunculidaeSiphonosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113HemerythrinPRO_0000191838Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Structurei

3D structure databases

ProteinModelPortaliP22766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hemerythrin family.Curated

Family and domain databases

Gene3Di1.20.120.50. 1 hit.
InterProiIPR002063. Haemerythrin.
IPR012827. Haemerythrin-like_metal-bd.
IPR016131. Haemerythrin_Fe_BS.
[Graphical view]
PIRSFiPIRSF002033. Hemerythrin. 1 hit.
PRINTSiPR00186. HEMERYTHRIN.
SUPFAMiSSF47188. SSF47188. 1 hit.
TIGRFAMsiTIGR00058. Hemerythrin. 1 hit.
PROSITEiPS00550. HEMERYTHRINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22766 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GFPVPDPFIW DASFKTFYDD LDNQHKQLFQ AILTQGNVGG ATAGDNAYAC
60 70 80 90 100
LVAHFLFEEA AMQVAKYGGY GAHKAAHEEF LGKVKGGSAD AAYCKDWLTQ
110
HIKTIDFKYK GKL
Length:113
Mass (Da):12,437
Last modified:August 1, 1991 - v1
Checksum:i653C278D78F9E953
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31P → E.
Natural varianti10 – 101W → D.
Natural varianti60 – 601A → G.
Natural varianti66 – 661K → N.
Natural varianti83 – 831K → Q.

Sequence databases

PIRiJT0556. HRIN.

Cross-referencesi

Sequence databases

PIRi JT0556. HRIN.

3D structure databases

ProteinModelPortali P22766.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.120.50. 1 hit.
InterProi IPR002063. Haemerythrin.
IPR012827. Haemerythrin-like_metal-bd.
IPR016131. Haemerythrin_Fe_BS.
[Graphical view ]
PIRSFi PIRSF002033. Hemerythrin. 1 hit.
PRINTSi PR00186. HEMERYTHRIN.
SUPFAMi SSF47188. SSF47188. 1 hit.
TIGRFAMsi TIGR00058. Hemerythrin. 1 hit.
PROSITEi PS00550. HEMERYTHRINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The amino acid sequence of hemerythrin from Siphonosoma cumanense."
    Uchida T., Yano H., Satake K., Kubota I., Tsugita A.
    Protein Seq. Data Anal. 3:141-147(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiHEMT_SIPCU
AccessioniPrimary (citable) accession number: P22766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3