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Protein

Hemerythrin

Gene
N/A
Organism
Siphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi25Iron 1By similarity1
Metal bindingi54Iron 1By similarity1
Metal bindingi58Iron 1By similarity1
Metal bindingi58Iron 2By similarity1
Metal bindingi73Iron 2By similarity1
Metal bindingi77Iron 2By similarity1
Metal bindingi101Iron 2By similarity1
Metal bindingi106Iron 1By similarity1
Metal bindingi106Iron 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemerythrin
OrganismiSiphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
Taxonomic identifieri6444 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaSipunculaSipunculideaGolfingiidaSipunculidaeSiphonosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001918381 – 113HemerythrinAdd BLAST113

Interactioni

Subunit structurei

Homotrimer.

Structurei

3D structure databases

ProteinModelPortaliP22766.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hemerythrin family.Curated

Family and domain databases

Gene3Di1.20.120.50. 1 hit.
InterProiIPR002063. Haemerythrin.
IPR016131. Haemerythrin_Fe_BS.
IPR012827. Haemerythrin_metal-bd.
[Graphical view]
PIRSFiPIRSF002033. Hemerythrin. 1 hit.
PRINTSiPR00186. HEMERYTHRIN.
SUPFAMiSSF47188. SSF47188. 1 hit.
TIGRFAMsiTIGR00058. Hemerythrin. 1 hit.
PROSITEiPS00550. HEMERYTHRINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GFPVPDPFIW DASFKTFYDD LDNQHKQLFQ AILTQGNVGG ATAGDNAYAC
60 70 80 90 100
LVAHFLFEEA AMQVAKYGGY GAHKAAHEEF LGKVKGGSAD AAYCKDWLTQ
110
HIKTIDFKYK GKL
Length:113
Mass (Da):12,437
Last modified:August 1, 1991 - v1
Checksum:i653C278D78F9E953
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti3P → E.1
Natural varianti10W → D.1
Natural varianti60A → G.1
Natural varianti66K → N.1
Natural varianti83K → Q.1

Sequence databases

PIRiJT0556. HRIN.

Cross-referencesi

Sequence databases

PIRiJT0556. HRIN.

3D structure databases

ProteinModelPortaliP22766.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.120.50. 1 hit.
InterProiIPR002063. Haemerythrin.
IPR016131. Haemerythrin_Fe_BS.
IPR012827. Haemerythrin_metal-bd.
[Graphical view]
PIRSFiPIRSF002033. Hemerythrin. 1 hit.
PRINTSiPR00186. HEMERYTHRIN.
SUPFAMiSSF47188. SSF47188. 1 hit.
TIGRFAMsiTIGR00058. Hemerythrin. 1 hit.
PROSITEiPS00550. HEMERYTHRINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMT_SIPCU
AccessioniPrimary (citable) accession number: P22766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: January 20, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.