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P22766

- HEMT_SIPCU

UniProt

P22766 - HEMT_SIPCU

Protein

Hemerythrin

Gene
N/A
Organism
Siphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi25 – 251Iron 1By similarity
    Metal bindingi54 – 541Iron 1By similarity
    Metal bindingi58 – 581Iron 1By similarity
    Metal bindingi58 – 581Iron 2By similarity
    Metal bindingi73 – 731Iron 2By similarity
    Metal bindingi77 – 771Iron 2By similarity
    Metal bindingi101 – 1011Iron 2By similarity
    Metal bindingi106 – 1061Iron 1By similarity
    Metal bindingi106 – 1061Iron 2By similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemerythrin
    OrganismiSiphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
    Taxonomic identifieri6444 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaSipunculaSipunculideaGolfingiidaSipunculidaeSiphonosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 113113HemerythrinPRO_0000191838Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP22766.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hemerythrin family.Curated

    Family and domain databases

    Gene3Di1.20.120.50. 1 hit.
    InterProiIPR002063. Haemerythrin.
    IPR012827. Haemerythrin-like_metal-bd.
    IPR016131. Haemerythrin_Fe_BS.
    [Graphical view]
    PIRSFiPIRSF002033. Hemerythrin. 1 hit.
    PRINTSiPR00186. HEMERYTHRIN.
    SUPFAMiSSF47188. SSF47188. 1 hit.
    TIGRFAMsiTIGR00058. Hemerythrin. 1 hit.
    PROSITEiPS00550. HEMERYTHRINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22766-1 [UniParc]FASTAAdd to Basket

    « Hide

    GFPVPDPFIW DASFKTFYDD LDNQHKQLFQ AILTQGNVGG ATAGDNAYAC    50
    LVAHFLFEEA AMQVAKYGGY GAHKAAHEEF LGKVKGGSAD AAYCKDWLTQ 100
    HIKTIDFKYK GKL 113
    Length:113
    Mass (Da):12,437
    Last modified:August 1, 1991 - v1
    Checksum:i653C278D78F9E953
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31P → E.
    Natural varianti10 – 101W → D.
    Natural varianti60 – 601A → G.
    Natural varianti66 – 661K → N.
    Natural varianti83 – 831K → Q.

    Sequence databases

    PIRiJT0556. HRIN.

    Cross-referencesi

    Sequence databases

    PIRi JT0556. HRIN.

    3D structure databases

    ProteinModelPortali P22766.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.120.50. 1 hit.
    InterProi IPR002063. Haemerythrin.
    IPR012827. Haemerythrin-like_metal-bd.
    IPR016131. Haemerythrin_Fe_BS.
    [Graphical view ]
    PIRSFi PIRSF002033. Hemerythrin. 1 hit.
    PRINTSi PR00186. HEMERYTHRIN.
    SUPFAMi SSF47188. SSF47188. 1 hit.
    TIGRFAMsi TIGR00058. Hemerythrin. 1 hit.
    PROSITEi PS00550. HEMERYTHRINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The amino acid sequence of hemerythrin from Siphonosoma cumanense."
      Uchida T., Yano H., Satake K., Kubota I., Tsugita A.
      Protein Seq. Data Anal. 3:141-147(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiHEMT_SIPCU
    AccessioniPrimary (citable) accession number: P22766
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3