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P22766 (HEMT_SIPCU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemerythrin
OrganismSiphonosoma cumanense (Sipunculan worm) (Lumbricus edulis)
Taxonomic identifier6444 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaSipunculaSipunculideaGolfingiidaSipunculidaeSiphonosoma

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.

Subunit structure

Homotrimer.

Sequence similarities

Belongs to the hemerythrin family.

Ontologies

Keywords
   Biological processOxygen transport
Transport
   LigandIron
Metal-binding
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

oxygen transporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 113113Hemerythrin
PRO_0000191838

Sites

Metal binding251Iron 1 By similarity
Metal binding541Iron 1 By similarity
Metal binding581Iron 1 By similarity
Metal binding581Iron 2 By similarity
Metal binding731Iron 2 By similarity
Metal binding771Iron 2 By similarity
Metal binding1011Iron 2 By similarity
Metal binding1061Iron 1 By similarity
Metal binding1061Iron 2 By similarity

Natural variations

Natural variant31P → E.
Natural variant101W → D.
Natural variant601A → G.
Natural variant661K → N.
Natural variant831K → Q.

Sequences

Sequence LengthMass (Da)Tools
P22766 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 653C278D78F9E953

FASTA11312,437
        10         20         30         40         50         60 
GFPVPDPFIW DASFKTFYDD LDNQHKQLFQ AILTQGNVGG ATAGDNAYAC LVAHFLFEEA 

        70         80         90        100        110 
AMQVAKYGGY GAHKAAHEEF LGKVKGGSAD AAYCKDWLTQ HIKTIDFKYK GKL 

« Hide

References

[1]"The amino acid sequence of hemerythrin from Siphonosoma cumanense."
Uchida T., Yano H., Satake K., Kubota I., Tsugita A.
Protein Seq. Data Anal. 3:141-147(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRHRIN. JT0556.

3D structure databases

ProteinModelPortalP22766.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.120.50. 1 hit.
InterProIPR002063. Haemerythrin.
IPR012827. Haemerythrin-like_metal-bd.
IPR016131. Haemerythrin_Fe_BS.
[Graphical view]
PIRSFPIRSF002033. Hemerythrin. 1 hit.
PRINTSPR00186. HEMERYTHRIN.
SUPFAMSSF47188. SSF47188. 1 hit.
TIGRFAMsTIGR00058. Hemerythrin. 1 hit.
PROSITEPS00550. HEMERYTHRINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMT_SIPCU
AccessionPrimary (citable) accession number: P22766
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families