P22764 (HEMTA_LINUN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Hemerythrin subunit alpha
Organism	Lingula unguis
Taxonomic identifier	7574 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Brachiopoda › Linguliformea › Lingulata › Lingulida › Linguloidea › Lingulidae › Lingula

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.
Subunit structure	Octamer composed of two types of chains: alpha and beta.
Sequence similarities	Belongs to the hemerythrin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	iron ion binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Hemerythrin subunit alpha		PRO_0000191830
Sites
	Metal binding	24	1	Iron 1 By similarity
	Metal binding	53	1	Iron 1 By similarity
	Metal binding	57	1	Iron 1 By similarity
	Metal binding	57	1	Iron 2 By similarity
	Metal binding	72	1	Iron 2 By similarity
	Metal binding	76	1	Iron 2 By similarity
	Metal binding	105	1	Iron 2 By similarity
	Metal binding	110	1	Iron 1 By similarity
	Metal binding	110	1	Iron 2 By similarity
Experimental info
	Sequence conflict	112	1	K → H AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P22764 [UniParc]. Last modified May 1, 1992. Version 3. Checksum: 5EB2F77B2D4BABCB	FASTA	117	13,905
	10 20 30 40 50 60 VKVPEPFAWN ESFATSYKNI DLEHRTLFNG LFALSEFNTR DQLLACKEVF VMHFRDEQGQ 70 80 90 100 110 MEKANYEHFE EHRGIHEGFL EKMGHWKAPV AQKDIKFGME WLVNHIPTED FKYKGKL

References

[1]	"Amino acid sequence of the hemerythrin alpha subunit from Lingula unguis." Yano H., Satake K., Ueno Y., Kondo K., Tsugita A. J. Biochem. 110:376-380(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Hemerythrin from Lingula unguis consists of two different subunits, alpha and beta." Satake K., Yugi M., Kamo M., Kihara H., Tsugita A. Protein Seq. Data Anal. 3:1-5(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-41 AND 110-117.

Cross-references

Sequence databases
PIR	JX0184.
3D structure databases
ProteinModelPortal	P22764.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.120.50. 1 hit.
InterPro	IPR002063. Haemerythrin. IPR012827. Haemerythrin-like_metal-bd. IPR012312. Haemerythrin/HHE_cat-bd_motif. IPR016131. Haemerythrin_Fe_BS. [Graphical view]
Pfam	PF01814. Hemerythrin. 1 hit. [Graphical view]
PIRSF	PIRSF002033. Hemerythrin. 1 hit.
PRINTS	PR00186. HEMERYTHRIN.
SUPFAM	SSF47188. Hemryth_metal_bd. 1 hit.
TIGRFAMs	TIGR02481. hemeryth_dom. 1 hit. TIGR00058. Hemerythrin. 1 hit.
PROSITE	PS00550. HEMERYTHRINS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMTA_LINUN

Accession

Primary (citable) accession number: P22764

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	May 1, 1992
Last modified:	April 3, 2013
This is version 65 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)