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P22762 (GLHA_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycoprotein hormones alpha chain
Alternative name(s):
Anterior pituitary glycoprotein hormones common subunit alpha
Choriogonadotropin alpha chain
Chorionic gonadotrophin subunit alpha
Short name=CG-alpha
Follicle-stimulating hormone alpha chain
Short name=FSH-alpha
Follitropin alpha chain
Luteinizing hormone alpha chain
Short name=LSH-alpha
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Short name=TSH-alpha
Thyrotropin alpha chain
Gene names
Name:CGA
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Subunit structure

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glycoprotein hormones subunit alpha family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 By similarity
Chain25 – 12096Glycoprotein hormones alpha chain
PRO_0000011642

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) By similarity
Glycosylation1061N-linked (GlcNAc...) By similarity
Disulfide bond35 ↔ 59 By similarity
Disulfide bond38 ↔ 88 By similarity
Disulfide bond56 ↔ 110 By similarity
Disulfide bond60 ↔ 112 By similarity
Disulfide bond87 ↔ 115 By similarity

Sequences

Sequence LengthMass (Da)Tools
P22762 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 92E92D716093F406

FASTA12013,785
        10         20         30         40         50         60 
MDYYRKYAAV ILVTLSVFLH ILHSFPDGEF TMQDCPECKP RENKFFSKPG APIYQCMGCC 

        70         80         90        100        110        120 
FSRAYPTPVR SKKTMLVQKN VTSESTCCVA KSLTRVMVMG SVRVENHTEC HCSTCYYHKF

« Hide

References

[1]"Molecular cloning of the rhesus glycoprotein hormone alpha-subunit gene."
Golos T.G., Durning M., Fisher J.M.
DNA Cell Biol. 10:367-380(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

PIRA39555.

3D structure databases

ProteinModelPortalP22762.
SMRP22762. Positions 32-119.
ModBaseSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000000313.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG44826.
HOGENOMHOG000232008.
HOVERGENHBG000452.
InParanoidP22762.
OrthoDBEOG4G7C11.

Family and domain databases

InterProIPR000476. Glyco_hormone.
[Graphical view]
PANTHERPTHR11509. PTHR11509. 1 hit.
PfamPF00236. Hormone_6. 1 hit.
[Graphical view]
PRINTSPR00274. GLYCOHORMONE.
SMARTSM00067. GHA. 1 hit.
[Graphical view]
PROSITEPS00779. GLYCO_HORMONE_ALPHA_1. 1 hit.
PS00780. GLYCO_HORMONE_ALPHA_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLHA_MACMU
AccessionPrimary (citable) accession number: P22762
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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