P22761 (HEMTM_HEDDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Myohemerythrin Short name=MHr
Organism	Hediste diversicolor (Sandworm) (Nereis diversicolor)
Taxonomic identifier	126592 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Annelida › Polychaeta › Palpata › Aciculata › Phyllodocida › Nereididae › Hediste › Hediste diversicolor species group

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Myohemerythrin is an oxygen-binding protein found in the retractor muscles of certain worms. The oxygen-binding site contains two iron atoms By similarity.
Subunit structure	Monomer By similarity.
Tissue specificity	Muscle. Ref.1
Sequence similarities	Belongs to the hemerythrin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Iron Metal-binding
Molecular function	Muscle protein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	iron ion binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Myohemerythrin		PRO_0000191833
Sites
	Metal binding	25	1	Iron 1 By similarity
	Metal binding	54	1	Iron 1 By similarity
	Metal binding	58	1	Iron 1 By similarity
	Metal binding	58	1	Iron 2 By similarity
	Metal binding	75	1	Iron 2 By similarity
	Metal binding	79	1	Iron 2 By similarity
	Metal binding	108	1	Iron 2 By similarity
	Metal binding	113	1	Iron 1 By similarity
	Metal binding	113	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P22761 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: A793589D582E8B97	FASTA	120	13,641
	10 20 30 40 50 60 GFEVPEPFKW DESFQVFYDK LDEEHKQIFN AIFALGGGNN ADNLKKMIDV TANHFADEEA 70 80 90 100 110 120 MMLASAAYKS EHPGHKKKHE DFLAVIRGLS APVPNDKLLY AKDWLVNHIK GTDFTYKGKL

References

[1]	"Primary structure of myohemerythrin from the annelid Nereis diversicolor." Takagi T., Cox J.A. FEBS Lett. 285:25-27(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, TISSUE SPECIFICITY. Tissue: Muscle.

Cross-references

Sequence databases
PIR	S16190.
3D structure databases
ProteinModelPortal	P22761.
SMR	P22761. Positions 1-120.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.120.50. 1 hit.
InterPro	IPR002063. Haemerythrin. IPR012827. Haemerythrin-like_metal-bd. IPR012312. Haemerythrin/HHE_cat-bd_motif. IPR016131. Haemerythrin_Fe_BS. [Graphical view]
Pfam	PF01814. Hemerythrin. 1 hit. [Graphical view]
PIRSF	PIRSF002033. Hemerythrin. 1 hit.
PRINTS	PR00186. HEMERYTHRIN.
SUPFAM	SSF47188. Hemryth_metal_bd. 1 hit.
TIGRFAMs	TIGR02481. hemeryth_dom. 1 hit. TIGR00058. Hemerythrin. 1 hit.
PROSITE	PS00550. HEMERYTHRINS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMTM_HEDDI

Accession

Primary (citable) accession number: P22761

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)