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P22758

- TGM1_RABIT

UniProt

P22758 - TGM1_RABIT

Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

TGM1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Enzyme regulationi

    Inhibited by retinoic acid, but phorbol ester treatment activates it.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei397 – 3971PROSITE-ProRule annotation
    Active sitei456 – 4561PROSITE-ProRule annotation
    Active sitei479 – 4791PROSITE-ProRule annotation
    Metal bindingi519 – 5191CalciumBy similarity
    Metal bindingi521 – 5211CalciumBy similarity
    Metal bindingi568 – 5681CalciumBy similarity
    Metal bindingi573 – 5731CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. keratinization Source: UniProtKB-KW
    2. peptide cross-linking Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Keratinization

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
    Alternative name(s):
    Epidermal TGase
    Transglutaminase K
    Short name:
    TG(K)
    Short name:
    TGK
    Short name:
    TGase K
    Transglutaminase-1
    Short name:
    TGase-1
    Gene namesi
    Name:TGM1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 836836Protein-glutamine gamma-glutamyltransferase KPRO_0000213703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 481PhosphoserineBy similarity
    Modified residuei112 – 1121PhosphoserineBy similarity
    Modified residuei824 – 8241PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000002542.

    Structurei

    3D structure databases

    ProteinModelPortaliP22758.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22758-1 [UniParc]FASTAAdd to Basket

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    MDGPRSDMGR SDVSRSDMSR SDMGRSDMGR SDVGRCGGGP LQPSATPSPE    50
    PEPEPEPEPD RGSRSRGGRG RSFWARCCGC CSCRNAADDD WGREPSDSRD 100
    RGSSSRGGRP DSRGGGVNAA GDGTIREGML VVTGVDLLSS RSDQNRREHH 150
    TDEFEYEELI VRRGQPFHLV LFLSRPYESS DRIALELQIG NNPEVGKGTH 200
    VIIPVGKGNS GGWKAQVTKA SGQTLNLRVH SPASAIIGKF QFTVRTRTEA 250
    GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQDYVLN ESGRIYYGTE 300
    AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVS VSRVISAMVN 350
    SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGY SVPYGQCWVF 400
    AGVTTTVLRC LGLATRTVTN FNSAHDTDTS LTMDIYFDEN MKPLEHLNRD 450
    SVWNFHVWND CWMKRPDLPS GFDGWQVVDA TPQETSSGIF CCGPCSVESV 500
    KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD GSFKIVYVEE KAIGTLIVTK 550
    AVRSHMREDI THIYKHPEGS DAERKAVETA AAHGSKPNVY DSRDSAEDVA 600
    MQVEAQDAVM GQDLTVSVVL TNRSSSRRTV KLHLYLSVTF YTGVTGSIFK 650
    ESKKEVVLAA GSSDSVVMPV AYKEYRPHLV DQGAMLLNVS GHVKESGQVL 700
    AKQHTFRVRT PDLSLTLLGA AVVGQECEVQ IVFRNPLPIT LTNVVFRLEG 750
    SGLQRPKILN VGDIGGNETV TLRQTFVPVR PGPRQLIASL DSPQLSQVHG 800
    VIQVDVAPAS GGRGFLHAGG DSYSGETIPM TSRGEA 836
    Length:836
    Mass (Da):91,935
    Last modified:October 1, 1996 - v2
    Checksum:iB3D281F7BECB9C00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10714 mRNA. No translation available.
    M30468 mRNA. Translation: AAA31475.1.
    PIRiA33477.
    A54269.
    UniGeneiOcu.1972.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10714 mRNA. No translation available.
    M30468 mRNA. Translation: AAA31475.1 .
    PIRi A33477.
    A54269.
    UniGenei Ocu.1972.

    3D structure databases

    ProteinModelPortali P22758.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000002542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of transglutaminase type I expression in squamous differentiating rabbit tracheal epithelial cells and human epidermal keratinocytes: effects of retinoic acid and phorbol esters."
      Saunders N.A., Bernacki S.H., Vollberg T.M., Jetten A.M.
      Mol. Endocrinol. 7:387-398(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: New Zealand white.
      Tissue: Tracheobronchial epithelium.
    2. "Regulation of type I (epidermal) transglutaminase mRNA levels during squamous differentiation: down regulation by retinoids."
      Floyd E.E., Jetten A.M.
      Mol. Cell. Biol. 9:4846-4851(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-749.
    3. "The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones."
      Kim H.C., Idler W.W., Kim I.-G., Han J.H., Chung S.-I., Steinert P.M.
      J. Biol. Chem. 266:536-539(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiTGM1_RABIT
    AccessioniPrimary (citable) accession number: P22758
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3