SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P22758

- TGM1_RABIT

UniProt

P22758 - TGM1_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein-glutamine gamma-glutamyltransferase K
Gene
TGM1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Enzyme regulationi

Inhibited by retinoic acid, but phorbol ester treatment activates it.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei397 – 3971 By similarity
Active sitei456 – 4561 By similarity
Active sitei479 – 4791 By similarity
Metal bindingi519 – 5191Calcium By similarity
Metal bindingi521 – 5211Calcium By similarity
Metal bindingi568 – 5681Calcium By similarity
Metal bindingi573 – 5731Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. keratinization Source: UniProtKB-KW
  2. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:TGM1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Protein-glutamine gamma-glutamyltransferase K
PRO_0000213703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Phosphoserine By similarity
Modified residuei112 – 1121Phosphoserine By similarity
Modified residuei824 – 8241Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002542.

Structurei

3D structure databases

ProteinModelPortaliP22758.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22758-1 [UniParc]FASTAAdd to Basket

« Hide

MDGPRSDMGR SDVSRSDMSR SDMGRSDMGR SDVGRCGGGP LQPSATPSPE    50
PEPEPEPEPD RGSRSRGGRG RSFWARCCGC CSCRNAADDD WGREPSDSRD 100
RGSSSRGGRP DSRGGGVNAA GDGTIREGML VVTGVDLLSS RSDQNRREHH 150
TDEFEYEELI VRRGQPFHLV LFLSRPYESS DRIALELQIG NNPEVGKGTH 200
VIIPVGKGNS GGWKAQVTKA SGQTLNLRVH SPASAIIGKF QFTVRTRTEA 250
GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQDYVLN ESGRIYYGTE 300
AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVS VSRVISAMVN 350
SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGY SVPYGQCWVF 400
AGVTTTVLRC LGLATRTVTN FNSAHDTDTS LTMDIYFDEN MKPLEHLNRD 450
SVWNFHVWND CWMKRPDLPS GFDGWQVVDA TPQETSSGIF CCGPCSVESV 500
KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD GSFKIVYVEE KAIGTLIVTK 550
AVRSHMREDI THIYKHPEGS DAERKAVETA AAHGSKPNVY DSRDSAEDVA 600
MQVEAQDAVM GQDLTVSVVL TNRSSSRRTV KLHLYLSVTF YTGVTGSIFK 650
ESKKEVVLAA GSSDSVVMPV AYKEYRPHLV DQGAMLLNVS GHVKESGQVL 700
AKQHTFRVRT PDLSLTLLGA AVVGQECEVQ IVFRNPLPIT LTNVVFRLEG 750
SGLQRPKILN VGDIGGNETV TLRQTFVPVR PGPRQLIASL DSPQLSQVHG 800
VIQVDVAPAS GGRGFLHAGG DSYSGETIPM TSRGEA 836
Length:836
Mass (Da):91,935
Last modified:October 1, 1996 - v2
Checksum:iB3D281F7BECB9C00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10714 mRNA. No translation available.
M30468 mRNA. Translation: AAA31475.1.
PIRiA33477.
A54269.
UniGeneiOcu.1972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10714 mRNA. No translation available.
M30468 mRNA. Translation: AAA31475.1 .
PIRi A33477.
A54269.
UniGenei Ocu.1972.

3D structure databases

ProteinModelPortali P22758.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000002542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of transglutaminase type I expression in squamous differentiating rabbit tracheal epithelial cells and human epidermal keratinocytes: effects of retinoic acid and phorbol esters."
    Saunders N.A., Bernacki S.H., Vollberg T.M., Jetten A.M.
    Mol. Endocrinol. 7:387-398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Tracheobronchial epithelium.
  2. "Regulation of type I (epidermal) transglutaminase mRNA levels during squamous differentiation: down regulation by retinoids."
    Floyd E.E., Jetten A.M.
    Mol. Cell. Biol. 9:4846-4851(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-749.
  3. "The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones."
    Kim H.C., Idler W.W., Kim I.-G., Han J.H., Chung S.-I., Steinert P.M.
    J. Biol. Chem. 266:536-539(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiTGM1_RABIT
AccessioniPrimary (citable) accession number: P22758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1996
Last modified: November 13, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi