Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P22758

- TGM1_RABIT

UniProt

P22758 - TGM1_RABIT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein-glutamine gamma-glutamyltransferase K

Gene

TGM1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.By similarity

Enzyme regulationi

Inhibited by retinoic acid, but phorbol ester treatment activates it.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei397 – 3971PROSITE-ProRule annotation
Active sitei456 – 4561PROSITE-ProRule annotation
Active sitei479 – 4791PROSITE-ProRule annotation
Metal bindingi519 – 5191CalciumBy similarity
Metal bindingi521 – 5211CalciumBy similarity
Metal bindingi568 – 5681CalciumBy similarity
Metal bindingi573 – 5731CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. keratinization Source: UniProtKB-KW
  2. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Keratinization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase K (EC:2.3.2.13)
Alternative name(s):
Epidermal TGase
Transglutaminase K
Short name:
TG(K)
Short name:
TGK
Short name:
TGase K
Transglutaminase-1
Short name:
TGase-1
Gene namesi
Name:TGM1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 836836Protein-glutamine gamma-glutamyltransferase KPRO_0000213703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei112 – 1121PhosphoserineBy similarity
Modified residuei824 – 8241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002542.

Structurei

3D structure databases

ProteinModelPortaliP22758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiP22758.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22758-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGPRSDMGR SDVSRSDMSR SDMGRSDMGR SDVGRCGGGP LQPSATPSPE
60 70 80 90 100
PEPEPEPEPD RGSRSRGGRG RSFWARCCGC CSCRNAADDD WGREPSDSRD
110 120 130 140 150
RGSSSRGGRP DSRGGGVNAA GDGTIREGML VVTGVDLLSS RSDQNRREHH
160 170 180 190 200
TDEFEYEELI VRRGQPFHLV LFLSRPYESS DRIALELQIG NNPEVGKGTH
210 220 230 240 250
VIIPVGKGNS GGWKAQVTKA SGQTLNLRVH SPASAIIGKF QFTVRTRTEA
260 270 280 290 300
GEFQLPFDPR NEIYILFNPW CPEDIVYVDH EDWRQDYVLN ESGRIYYGTE
310 320 330 340 350
AQIGERTWNY GQFDHGVLDA CLYILDRRGM PYGGRGDPVS VSRVISAMVN
360 370 380 390 400
SLDDNGVLIG NWSGDYSRGT NPSAWVGSVE ILLSYLRTGY SVPYGQCWVF
410 420 430 440 450
AGVTTTVLRC LGLATRTVTN FNSAHDTDTS LTMDIYFDEN MKPLEHLNRD
460 470 480 490 500
SVWNFHVWND CWMKRPDLPS GFDGWQVVDA TPQETSSGIF CCGPCSVESV
510 520 530 540 550
KNGLVYMKYD TPFIFAEVNS DKVYWQRQDD GSFKIVYVEE KAIGTLIVTK
560 570 580 590 600
AVRSHMREDI THIYKHPEGS DAERKAVETA AAHGSKPNVY DSRDSAEDVA
610 620 630 640 650
MQVEAQDAVM GQDLTVSVVL TNRSSSRRTV KLHLYLSVTF YTGVTGSIFK
660 670 680 690 700
ESKKEVVLAA GSSDSVVMPV AYKEYRPHLV DQGAMLLNVS GHVKESGQVL
710 720 730 740 750
AKQHTFRVRT PDLSLTLLGA AVVGQECEVQ IVFRNPLPIT LTNVVFRLEG
760 770 780 790 800
SGLQRPKILN VGDIGGNETV TLRQTFVPVR PGPRQLIASL DSPQLSQVHG
810 820 830
VIQVDVAPAS GGRGFLHAGG DSYSGETIPM TSRGEA
Length:836
Mass (Da):91,935
Last modified:October 1, 1996 - v2
Checksum:iB3D281F7BECB9C00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10714 mRNA. No translation available.
M30468 mRNA. Translation: AAA31475.1.
PIRiA33477.
A54269.
UniGeneiOcu.1972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10714 mRNA. No translation available.
M30468 mRNA. Translation: AAA31475.1 .
PIRi A33477.
A54269.
UniGenei Ocu.1972.

3D structure databases

ProteinModelPortali P22758.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000002542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi P22758.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of transglutaminase type I expression in squamous differentiating rabbit tracheal epithelial cells and human epidermal keratinocytes: effects of retinoic acid and phorbol esters."
    Saunders N.A., Bernacki S.H., Vollberg T.M., Jetten A.M.
    Mol. Endocrinol. 7:387-398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Tracheobronchial epithelium.
  2. "Regulation of type I (epidermal) transglutaminase mRNA levels during squamous differentiation: down regulation by retinoids."
    Floyd E.E., Jetten A.M.
    Mol. Cell. Biol. 9:4846-4851(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 368-749.
  3. "The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones."
    Kim H.C., Idler W.W., Kim I.-G., Han J.H., Chung S.-I., Steinert P.M.
    J. Biol. Chem. 266:536-539(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiTGM1_RABIT
AccessioniPrimary (citable) accession number: P22758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3