P22736 (NR4A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear receptor subfamily 4 group A member 1

Alternative name(s):
Early response protein NAK1
Nuclear hormone receptor NUR/77
Short name=Nur77
Orphan nuclear receptor HMR
Orphan nuclear receptor TR3
ST-59
Testicular receptor 3

Gene names

Name:	NR4A1
Synonyms:	GFRP1, HMR, NAK1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	598 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' By similarity. May inhibit NF-kappa-B transactivation of IL2. Ref.8
Subunit structure	Binds DNA as a monomer By similarity. Interacts with GADD45GIP1. Ref.9
Subcellular location	Nucleus.
Tissue specificity	Fetal muscle and adult liver, brain and thyroid.
Induction	By growth-stimulating agents.
Post-translational modification	Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. Ref.10
Sequence similarities	Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration involved in sprouting angiogenesis Inferred from direct assay PubMed 18059339. Source: BHF-UCL cellular response to vascular endothelial growth factor stimulus Inferred from mutant phenotype PubMed 18059339. Source: BHF-UCL endothelial cell chemotaxis Inferred from mutant phenotype PubMed 18059339. Source: BHF-UCL epidermal growth factor receptor signaling pathway Traceable author statement. Source: Reactome fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome induction of apoptosis Inferred from electronic annotation. Source: Compara negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome phosphatidylinositol-mediated signaling Traceable author statement. Source: Reactome positive regulation of endothelial cell proliferation Inferred from mutant phenotype PubMed 18059339. Source: BHF-UCL transcription initiation from RNA polymerase II promoter Traceable author statement. Source: Reactome
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: BHF-UCL RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Traceable author statement Ref.2. Source: ProtInc sequence-specific DNA binding Inferred from electronic annotation. Source: Compara steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ANKIB1	Q9P2G1	2	EBI-721550,EBI-2687890
BCL2	P10415	7	EBI-721550,EBI-77694
CUTA	O60888	2	EBI-721550,EBI-1051556
GK	P32189	3	EBI-721550,EBI-3926629
MATR3	P43243	2	EBI-721550,EBI-352602
STAT3	P40763	3	EBI-721550,EBI-518675
TUBB4A	P04350	2	EBI-721550,EBI-355007
VASP	P50552	2	EBI-721550,EBI-748201

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P22736-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P22736-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWLAKACWSIQSEM

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 598

598

Nuclear receptor subfamily 4 group A member 1

PRO_0000053715

Regions

DNA binding

264 – 339

76

Nuclear receptor

Zinc finger

267 – 287

21

NR C4-type

Zinc finger

303 – 327

25

NR C4-type

Region

409 – 459

51

Ligand-binding Potential

Compositional bias

82 – 92

11

Poly-Ser

Compositional bias

583 – 586

4

Poly-Pro

Amino acid modifications

Modified residue

341

1

Phosphoserine; by PKA By similarity

Modified residue

351

1

Phosphoserine Ref.10 Ref.12

Natural variations

Alternative sequence

1

1

M → MWLAKACWSIQSEM in isoform 2.

VSP_043086

Natural variant

26

1

L → V.
Corresponds to variant rs1882118 [ dbSNP | Ensembl ].

VAR_061534

Experimental info

Sequence conflict

253

1

T → I Ref.7

Sequence conflict

262

1

G → P in AAA36763. Ref.2

Sequence conflict

370

1

R → L in AAA36763. Ref.2

Secondary structure

1

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598

Helix Strand Turn

Details...

Helix

363 – 374

12

Helix

379 – 381

3

Helix

400 – 412

13

Helix

414 – 422

9

Helix

427 – 429

3

Helix

432 – 454

23

Helix

457 – 459

3

Beta strand

461 – 463

3

Beta strand

467 – 471

5

Helix

472 – 479

8

Helix

482 – 495

14

Helix

500 – 511

12

Helix

521 – 543

23

Helix

550 – 556

7

Helix

558 – 579

22

Helix

586 – 595

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 41DAAEA7C25FDA22	FASTA	598	64,463
	10 20 30 40 50 60 MPCIQAQYGT PAPSPGPRDH LASDPLTPEF IKPTMDLASP EAAPAAPTAL PSFSTFMDGY 70 80 90 100 110 120 TGEFDTFLYQ LPGTVQPCSS ASSSASSTSS SSATSPASAS FKFEDFQVYG CYPGPLSGPV 130 140 150 160 170 180 DEALSSSGSD YYGSPCSAPS PSTPSFQPPQ LSPWDGSFGH FSPSQTYEGL RAWTEQLPKA 190 200 210 220 230 240 SGPPQPPAFF SFSPPTGPSP SLAQSPLKLF PSQATHQLGE GESYSMPTAF PGLAPTSPHL 250 260 270 280 290 300 EGSGILDTPV TSTKARSGAP GGSEGRCAVC GDNASCQHYG VRTCEGCKGF FKRTVQKNAK 310 320 330 340 350 360 YICLANKDCP VDKRRRNRCQ FCRFQKCLAV GMVKEVVRTD SLKGRRGRLP SKPKQPPDAS 370 380 390 400 410 420 PANLLTSLVR AHLDSGPSTA KLDYSKFQEL VLPHFGKEDA GDVQQFYDLL SGSLEVIRKW 430 440 450 460 470 480 AEKIPGFAEL SPADQDLLLE SAFLELFILR LAYRSKPGEG KLIFCSGLVL HRLQCARGFG 490 500 510 520 530 540 DWIDSILAFS RSLHSLLVDV PAFACLSALV LITDRHGLQE PRRVEELQNR IASCLKEHVA 550 560 570 580 590 AVAGEPQPAS CLSRLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPPIIDK IFMDTLPF
	Isoform 2 [UniParc]. Checksum: 21F3BC282AE6BE8D	FASTA	611	65,998
	10 20 30 40 50 60 MWLAKACWSI QSEMPCIQAQ YGTPAPSPGP RDHLASDPLT PEFIKPTMDL ASPEAAPAAP 70 80 90 100 110 120 TALPSFSTFM DGYTGEFDTF LYQLPGTVQP CSSASSSASS TSSSSATSPA SASFKFEDFQ 130 140 150 160 170 180 VYGCYPGPLS GPVDEALSSS GSDYYGSPCS APSPSTPSFQ PPQLSPWDGS FGHFSPSQTY 190 200 210 220 230 240 EGLRAWTEQL PKASGPPQPP AFFSFSPPTG PSPSLAQSPL KLFPSQATHQ LGEGESYSMP 250 260 270 280 290 300 TAFPGLAPTS PHLEGSGILD TPVTSTKARS GAPGGSEGRC AVCGDNASCQ HYGVRTCEGC 310 320 330 340 350 360 KGFFKRTVQK NAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV RTDSLKGRRG 370 380 390 400 410 420 RLPSKPKQPP DASPANLLTS LVRAHLDSGP STAKLDYSKF QELVLPHFGK EDAGDVQQFY 430 440 450 460 470 480 DLLSGSLEVI RKWAEKIPGF AELSPADQDL LLESAFLELF ILRLAYRSKP GEGKLIFCSG 490 500 510 520 530 540 LVLHRLQCAR GFGDWIDSIL AFSRSLHSLL VDVPAFACLS ALVLITDRHG LQEPRRVEEL 550 560 570 580 590 600 QNRIASCLKE HVAAVAGEPQ PASCLSRLLG KLPELRTLCT QGLQRIFYLK LEDLVPPPPI 610 IDKIFMDTLP F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily." Nakai A., Kartha S., Sakurai A., Toback F.G., Degroot L.J. Mol. Endocrinol. 4:1438-1443(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal skeletal muscle.
[2]	"Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily." Chang C., Kokontis J., Liao S., Chang Y. J. Steroid Biochem. 34:391-395(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[7]	"Phorbol ester, forskolin, and serum induction of a human colon nuclear hormone receptor gene related to the NUR 77/NGFI-B genes." Bondy G.P. Cell Growth Differ. 2:203-208(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-398 (ISOFORM 1). Tissue: Colon adenocarcinoma.
[8]	"Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB." Harant H., Lindley I.J. Nucleic Acids Res. 32:5280-5290(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation." Park K.C., Song K.-H., Chung H.K., Kim H., Kim D.W., Song J.H., Hwang E.S., Jung H.S., Park S.-H., Bae I., Lee I.K., Choi H.-S., Shong M. Mol. Endocrinol. 19:12-24(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GADD45GIP1.
[10]	"RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation." Roux P.P., Shahbazian D., Vu H., Holz M.K., Cohen M.S., Taunton J., Sonenberg N., Blenis J. J. Biol. Chem. 282:14056-14064(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-351.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D49728 mRNA. Translation: BAA08565.1.
L13740 mRNA. Translation: AAA36763.1.
AK297526 mRNA. Translation: BAG59929.1.
AC025259 Genomic DNA. No translation available.
CH471111 Genomic DNA. Translation: EAW58222.1.
BC016147 mRNA. Translation: AAH16147.1.

IPI

IPI00743108.
IPI01011914.

PIR

A37251.

RefSeq

NP_001189162.1. NM_001202233.1.
NP_002126.2. NM_002135.4.
NP_775180.1. NM_173157.2.

UniGene

Hs.524430.
Hs.670088.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2QW4	X-ray	2.80	A/B/C/D	347-598	[»]
3V3E	X-ray	2.06	A/B	351-598	[»]
3V3Q	X-ray	2.22	A/B	351-598	[»]

ProteinModelPortal

P22736.

ModBase

Search...

Protein-protein interaction databases

IntAct

P22736. 58 interactions.

MINT

MINT-2859679.

STRING

9606.ENSP00000243050.

PTM databases

PhosphoSite

P22736.

Polymorphism databases

DMDM

127819.

Proteomic databases

PaxDb

P22736.

PRIDE

P22736.

Protocols and materials databases

DNASU

3164.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000243050; ENSP00000243050; ENSG00000123358.
ENST00000360284; ENSP00000353427; ENSG00000123358.
ENST00000394824; ENSP00000378301; ENSG00000123358.
ENST00000394825; ENSP00000378302; ENSG00000123358.
ENST00000550082; ENSP00000449539; ENSG00000123358.

GeneID

3164.

KEGG

hsa:3164.

UCSC

uc001rzs.3. human.

Organism-specific databases

CTD

3164.

GeneCards

GC12P052416.

H-InvDB

HIX0171621.

HGNC

HGNC:7980. NR4A1.

MIM

139139. gene.

neXtProt

NX_P22736.

PharmGKB

PA31761.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG245120.

HOGENOM

HOG000230925.

HOVERGEN

HBG052663.

InParanoid

P22736.

KO

K04465.

OrthoDB

EOG4VMFF7.

PhylomeDB

P22736.

Enzyme and pathway databases

Pathway_Interaction_DB

nfat_3pathway. Role of Calcineurin-dependent NFAT signaling in lymphocytes.
rxr_vdr_pathway. RXR and RAR hetrodimerization with other nuclear receptor.

Reactome

REACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

P22736.

Bgee

P22736.

CleanEx

HS_NR4A1.

Genevestigator

P22736.

GermOnline

ENSG00000123358. Homo sapiens.

Family and domain databases

Gene3D

1.10.565.10. 1 hit.
3.30.50.10. 1 hit.

InterPro

IPR003071. Nuc_orp_HMR_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]

Pfam

PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]

PRINTS

PR01285. HMRNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.

SMART

SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]

SUPFAM

SSF48508. Str_ncl_receptor. 1 hit.

PROSITE

PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P22736.

ChEMBL

CHEMBL1293229.

ChiTaRS

NR4A1. human.

EvolutionaryTrace

P22736.

GenomeRNAi

3164.

NextBio

12546.

SOURCE

Search...

Entry information

Entry name

NR4A1_HUMAN

Accession

Primary (citable) accession number: P22736
Secondary accession number(s): B4DML7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	May 1, 2013
This is version 148 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.