Reviewed,
UniProtKB/Swiss-Prot P22732 (GTR5_HUMAN)
Last modified
June 16, 2009.
Version 97.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Solute carrier family 2, facilitated glucose transporter member 5 Alternative name(s): Glucose transporter type 5, small intestine Short name=GLUT-5 Fructose transporter | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 501 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter. |
| Subcellular location | |
| Tissue specificity | Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue. |
| Induction | By forskolin (in Caco-2 cells). Ref.2 |
| Sequence similarities | Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification] |
| Mass spectrometry | Molecular mass is 54973.98 Da from positions 1 - 501. Determined by MALDI. Ref.7 |
| Sequence caution | The sequence AAB60641.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sugar transport Transport |
| Cellular component | Membrane |
| Domain | Transmembrane |
| PTM | Glycoprotein |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Traceable author statement. Source: ProtInc fructose transportTraceable author statement. Source: ProtInc glucose transport Ref.1Traceable author statement. Source: ProtInc transmembrane transportInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneTraceable author statement. Source: ProtInc |
| Molecular function | fructose transmembrane transporter activity Traceable author statement. Source: ProtInc glucose transmembrane transporter activity Ref.1Traceable author statement. Source: ProtInc sugar:hydrogen symporter activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 501 | 501 | Solute carrier family 2, facilitated glucose transporter member 5 | PRO_0000050369 | |||||
Regions | |||||||||
| Topological domain | 1 – 12 | 12 | Cytoplasmic Potential | ||||||
| Transmembrane | 13 – 33 | 21 | 1 Potential | ||||||
| Topological domain | 34 – 68 | 35 | Extracellular Potential | ||||||
| Transmembrane | 69 – 89 | 21 | 2 Potential | ||||||
| Topological domain | 90 – 98 | 9 | Cytoplasmic Potential | ||||||
| Transmembrane | 99 – 119 | 21 | 3 Potential | ||||||
| Topological domain | 120 | 1 | Extracellular Potential | ||||||
| Transmembrane | 121 – 141 | 21 | 4 Potential | ||||||
| Topological domain | 142 – 161 | 20 | Cytoplasmic Potential | ||||||
| Transmembrane | 162 – 182 | 21 | 5 Potential | ||||||
| Topological domain | 183 – 192 | 10 | Extracellular Potential | ||||||
| Transmembrane | 193 – 213 | 21 | 6 Potential | ||||||
| Topological domain | 214 – 277 | 64 | Cytoplasmic Potential | ||||||
| Transmembrane | 278 – 298 | 21 | 7 Potential | ||||||
| Topological domain | 299 – 318 | 20 | Extracellular Potential | ||||||
| Transmembrane | 319 – 339 | 21 | 8 Potential | ||||||
| Topological domain | 340 – 342 | 3 | Cytoplasmic Potential | ||||||
| Transmembrane | 343 – 363 | 21 | 9 Potential | ||||||
| Topological domain | 364 – 368 | 5 | Extracellular Potential | ||||||
| Transmembrane | 369 – 389 | 21 | 10 Potential | ||||||
| Topological domain | 390 – 412 | 23 | Cytoplasmic Potential | ||||||
| Transmembrane | 413 – 433 | 21 | 11 Potential | ||||||
| Topological domain | 434 – 439 | 6 | Extracellular Potential | ||||||
| Transmembrane | 440 – 460 | 21 | 12 Potential | ||||||
| Topological domain | 461 – 501 | 41 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 51 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 202 | 1 | P → G in AAB60641. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6)." Kayano T., Burant C.F., Fukumoto H., Gould G.W., Fan Y.-S., Eddy R.L., Byers M.G., Shows T.B., Seino S., Bell G.I. J. Biol. Chem. 265:13276-13282(1990) [PubMed: 1695905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Jejunum. |
| [2] | "Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP." Mahraoui L., Takeda J., Mesonero J., Chantret I., Dussaulx E., Bell G.I., Brot-Laroche E. Biochem. J. 301:169-175(1994) [PubMed: 8037665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION. Tissue: Fetal liver. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood. |
| [4] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph. |
| [7] | "Cluster analysis of an extensive human breast cancer cell line protein expression map database." Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J. Proteomics 2:212-223(2002) [PubMed: 11840567] [Abstract] Cited for: MASS SPECTROMETRY. Tissue: Mammary cancer. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M55531 mRNA. Translation: AAA52570.1. U11843 U11842 Genomic DNA. Translation: AAB60641.1. Sequence problems.AK290398 mRNA. Translation: BAF83087.1. AL158048 Genomic DNA. Translation: CAI23458.1. CH471130 Genomic DNA. Translation: EAW71610.1. BC001692 mRNA. Translation: AAH01692.1. BC001820 mRNA. Translation: AAH01820.1. | |||||||||||||
| IPI | IPI00027452. | ||||||||||||
| PIR | A36629. G02864. | ||||||||||||
| RefSeq | NP_003030.1. | ||||||||||||
| UniGene | Hs.530003 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P22732. | ||||||||||||
| PRIDE | P22732. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000142583. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 6518. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC01M009031. | ||||||||||||
| H-InvDB | HIX0000102. | ||||||||||||
| HGNC | HGNC:11010. SLC2A5. | ||||||||||||
| HPA | HPA005449. | ||||||||||||
| MIM | 138230. gene. | ||||||||||||
| PharmGKB | PA35880. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P22732. | ||||||||||||
| HOVERGEN | P22732. | ||||||||||||
| OMA | P22732. LMGGQQL. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P22732. | ||||||||||||
| Bgee | P22732. | ||||||||||||
| CleanEx | HS_SLC2A5. | ||||||||||||
| GermOnline | ENSG00000142583. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002442. Fru_transpt_5. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view] | ||||||||||||
| PANTHER | PTHR11600:SF105. Fruc_transpt5. 1 hit. | ||||||||||||
| Pfam | PF00083. Sugar_tr. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR01194. GLUCTRSPORT5. PR00171. SUGRTRNSPORT. | ||||||||||||
| TIGRFAMs | TIGR00879. SP. 1 hit. | ||||||||||||
| PROSITE | PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 25345. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | GTR5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P22732 Secondary accession number(s): Q14770, Q5T977 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


