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Reviewed, UniProtKB/Swiss-Prot P22732 (GTR5_HUMAN)

Last modified June 16, 2009. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Solute carrier family 2, facilitated glucose transporter member 5
Alternative name(s):
    Glucose transporter type 5, small intestine
      Short name=GLUT-5
    Fructose transporter
Gene names
Name: SLC2A5
Synonyms: GLUT5
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Induction

By forskolin (in Caco-2 cells). Ref.2

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]

Mass spectrometry

Molecular mass is 54973.98 Da from positions 1 - 501. Determined by MALDI. Ref.7

Sequence caution

The sequence AAB60641.1 differs from that shown. Reason: Erroneous gene model prediction.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Solute carrier family 2, facilitated glucose transporter member 5
PRO_0000050369

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 33211 Potential
Topological domain34 – 6835Extracellular Potential
Transmembrane69 – 89212 Potential
Topological domain90 – 989Cytoplasmic Potential
Transmembrane99 – 119213 Potential
Topological domain1201Extracellular Potential
Transmembrane121 – 141214 Potential
Topological domain142 – 16120Cytoplasmic Potential
Transmembrane162 – 182215 Potential
Topological domain183 – 19210Extracellular Potential
Transmembrane193 – 213216 Potential
Topological domain214 – 27764Cytoplasmic Potential
Transmembrane278 – 298217 Potential
Topological domain299 – 31820Extracellular Potential
Transmembrane319 – 339218 Potential
Topological domain340 – 3423Cytoplasmic Potential
Transmembrane343 – 363219 Potential
Topological domain364 – 3685Extracellular Potential
Transmembrane369 – 3892110 Potential
Topological domain390 – 41223Cytoplasmic Potential
Transmembrane413 – 4332111 Potential
Topological domain434 – 4396Extracellular Potential
Transmembrane440 – 4602112 Potential
Topological domain461 – 50141Cytoplasmic Potential

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2021P → G in AAB60641. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P22732-1 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 090B12F529C7B857

FASTA50154,974
        10         20         30         40         50         60 
MEQQDQSMKE GRLTLVLALA TLIAAFGSSF QYGYNVAAVN SPALLMQQFY NETYYGRTGE 

        70         80         90        100        110        120 
FMEDFPLTLL WSVTVSMFPF GGFIGSLLVG PLVNKFGRKG ALLFNNIFSI VPAILMGCSR 

       130        140        150        160        170        180 
VATSFELIII SRLLVGICAG VSSNVVPMYL GELAPKNLRG ALGVVPQLFI TVGILVAQIF 

       190        200        210        220        230        240 
GLRNLLANVD GWPILLGLTG VPAALQLLLL PFFPESPRYL LIQKKDEAAA KKALQTLRGW 

       250        260        270        280        290        300 
DSVDREVAEI RQEDEAEKAA GFISVLKLFR MRSLRWQLLS IIVLMGGQQL SGVNAIYYYA 

       310        320        330        340        350        360 
DQIYLSAGVP EEHVQYVTAG TGAVNVVMTF CAVFVVELLG RRLLLLLGFS ICLIACCVLT 

       370        380        390        400        410        420 
AALALQDTVS WMPYISIVCV ISYVIGHALG PSPIPALLIT EIFLQSSRPS AFMVGGSVHW 

       430        440        450        460        470        480 
LSNFTVGLIF PFIQEGLGPY SFIVFAVICL LTTIYIFLIV PETKAKTFIE INQIFTKMNK 

       490        500 
VSEVYPEKEE LKELPPVTSE Q

« Hide

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References

« Hide 'large scale' references
[1]"Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6)."
Kayano T., Burant C.F., Fukumoto H., Gould G.W., Fan Y.-S., Eddy R.L., Byers M.G., Shows T.B., Seino S., Bell G.I.
J. Biol. Chem. 265:13276-13282(1990) [PubMed: 1695905] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Jejunum.
[2]"Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP."
Mahraoui L., Takeda J., Mesonero J., Chantret I., Dussaulx E., Bell G.I., Brot-Laroche E.
Biochem. J. 301:169-175(1994) [PubMed: 8037665] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
Tissue: Fetal liver.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
[7]"Cluster analysis of an extensive human breast cancer cell line protein expression map database."
Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J.
Proteomics 2:212-223(2002) [PubMed: 11840567] [Abstract]
Cited for: MASS SPECTROMETRY.
Tissue: Mammary cancer.
+Additional computationally mapped references.

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Cross-references

Sequence databases

M55531 mRNA. Translation: AAA52570.1.
U11843 expand/collapse EMBL AC list , U05344, U11839, U11840, U11841, U11842 Genomic DNA. Translation: AAB60641.1. Sequence problems.
AK290398 mRNA. Translation: BAF83087.1.
AL158048 Genomic DNA. Translation: CAI23458.1.
CH471130 Genomic DNA. Translation: EAW71610.1.
BC001692 mRNA. Translation: AAH01692.1.
BC001820 mRNA. Translation: AAH01820.1.
IPIIPI00027452.
PIRA36629.
G02864.
RefSeqNP_003030.1.
UniGeneHs.530003

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1YG1model-A1-501[»]
ModBaseSearch...

Proteomic databases

PeptideAtlasP22732.
PRIDEP22732.

Genome annotation databases

EnsemblENSG00000142583. Homo sapiens. [Contig view]
GeneID6518.

Organism-specific databases

GeneCardsGC01M009031.
H-InvDBHIX0000102.
HGNCHGNC:11010. SLC2A5.
HPAHPA005449.
MIM138230. gene.
PharmGKBPA35880.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP22732.
HOVERGENP22732.
OMAP22732. LMGGQQL.

Gene expression databases

ArrayExpressP22732.
BgeeP22732.
CleanExHS_SLC2A5.
GermOnlineENSG00000142583. Homo sapiens.

Family and domain databases

InterProIPR002442. Fru_transpt_5.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PANTHERPTHR11600:SF105. Fruc_transpt5. 1 hit.
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR01194. GLUCTRSPORT5.
PR00171. SUGRTRNSPORT.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio25345.
SOURCESearch...

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Entry information

Entry nameGTR5_HUMAN
AccessionPrimary (citable) accession number: P22732
Secondary accession number(s): Q14770, Q5T977
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: June 16, 2009
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents