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Protein

High-affinity branched-chain amino acid transport ATP-binding protein LivF

Gene

livF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the leucine-specific transport system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: EcoCyc
  • branched-chain amino acid transmembrane transporter activity Source: EcoCyc
  • L-isoleucine transmembrane transporter activity Source: EcoCyc
  • L-valine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • branched-chain amino acid transport Source: EcoCyc
  • isoleucine transmembrane transport Source: EcoCyc
  • L-valine transmembrane transport Source: EcoCyc
  • phenylalanine transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:LIVF-MONOMER
MetaCyc:LIVF-MONOMER

Protein family/group databases

TCDBi3.A.1.4.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity branched-chain amino acid transport ATP-binding protein LivF
Alternative name(s):
LIV-I protein F
Gene namesi
Name:livF
Ordered Locus Names:b3454, JW3419
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10536 livF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924011 – 237High-affinity branched-chain amino acid transport ATP-binding protein LivFAdd BLAST237

Proteomic databases

PaxDbiP22731
PRIDEiP22731

Interactioni

Protein-protein interaction databases

BioGridi4261110, 17 interactors
IntActiP22731, 13 interactors
STRINGi316385.ECDH10B_3628

Structurei

3D structure databases

ProteinModelPortaliP22731
SMRiP22731
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 237ABC transporterPROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4108IV0 Bacteria
COG0410 LUCA
InParanoidiP22731
KOiK01996
OMAiMGAYILD
PhylomeDBiP22731

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR030660 ABC_branched_ATPase_LivF/BraG
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PIRSFiPIRSF039137 ABC_branched_ATPase, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P22731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVMLSFDK VSAHYGKIQA LHEVSLHINQ GEIVTLIGAN GAGKTTLLGT
60 70 80 90 100
LCGDPRATSG RIVFDDKDIT DWQTAKIMRE AVAIVPEGRR VFSRMTVEEN
110 120 130 140 150
LAMGGFFAER DQFQERIKWV YELFPRLHER RIQRAGTMSG GEQQMLAIGR
160 170 180 190 200
ALMSNPRLLL LDEPSLGLAP IIIQQIFDTI EQLREQGMTI FLVEQNANQA
210 220 230
LKLADRGYVL ENGHVVLSDT GDALLANEAV RSAYLGG
Length:237
Mass (Da):26,310
Last modified:October 1, 1994 - v2
Checksum:i7E4129E54ED1BD02
GO

Sequence cautioni

The sequence AAB18429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56R → G in AAA83887 (PubMed:2195019).Curated1
Sequence conflicti120V → A in AAA83887 (PubMed:2195019).Curated1
Sequence conflicti200A → G in AAA83887 (PubMed:2195019).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA Translation: AAA83887.1
U00039 Genomic DNA Translation: AAB18429.1 Different initiation.
U00096 Genomic DNA Translation: AAC76479.2
AP009048 Genomic DNA Translation: BAE77839.1
PIRiS47673
RefSeqiNP_417911.4, NC_000913.3
WP_000416891.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76479; AAC76479; b3454
BAE77839; BAE77839; BAE77839
GeneIDi947961
KEGGiecj:JW3419
eco:b3454
PATRICifig|511145.12.peg.3552

Similar proteinsi

Entry informationi

Entry nameiLIVF_ECOLI
AccessioniPrimary (citable) accession number: P22731
Secondary accession number(s): P76697, Q2M7B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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