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Protein

High-affinity branched-chain amino acid transport ATP-binding protein LivF

Gene

livF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the leucine-specific transport system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 45ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • branched-chain amino acid transmembrane transporter activity Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:LIVF-MONOMER.
ECOL316407:JW3419-MONOMER.
MetaCyc:LIVF-MONOMER.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity branched-chain amino acid transport ATP-binding protein LivF
Alternative name(s):
LIV-I protein F
Gene namesi
Name:livF
Ordered Locus Names:b3454, JW3419
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10536. livF.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924011 – 237High-affinity branched-chain amino acid transport ATP-binding protein LivFAdd BLAST237

Proteomic databases

PaxDbiP22731.
PRIDEiP22731.

Interactioni

Protein-protein interaction databases

BioGridi4261110. 10 interactors.
IntActiP22731. 13 interactors.
STRINGi511145.b3454.

Structurei

3D structure databases

ProteinModelPortaliP22731.
SMRiP22731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 237ABC transporterPROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108IV0. Bacteria.
COG0410. LUCA.
InParanoidiP22731.
KOiK01996.
OMAiMGAFLKT.
PhylomeDBiP22731.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030660. ABC_branched_ATPase_LivF/BraG.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039137. ABC_branched_ATPase. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVMLSFDK VSAHYGKIQA LHEVSLHINQ GEIVTLIGAN GAGKTTLLGT
60 70 80 90 100
LCGDPRATSG RIVFDDKDIT DWQTAKIMRE AVAIVPEGRR VFSRMTVEEN
110 120 130 140 150
LAMGGFFAER DQFQERIKWV YELFPRLHER RIQRAGTMSG GEQQMLAIGR
160 170 180 190 200
ALMSNPRLLL LDEPSLGLAP IIIQQIFDTI EQLREQGMTI FLVEQNANQA
210 220 230
LKLADRGYVL ENGHVVLSDT GDALLANEAV RSAYLGG
Length:237
Mass (Da):26,310
Last modified:October 1, 1994 - v2
Checksum:i7E4129E54ED1BD02
GO

Sequence cautioni

The sequence AAB18429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56R → G in AAA83887 (PubMed:2195019).Curated1
Sequence conflicti120V → A in AAA83887 (PubMed:2195019).Curated1
Sequence conflicti200A → G in AAA83887 (PubMed:2195019).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83887.1.
U00039 Genomic DNA. Translation: AAB18429.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76479.2.
AP009048 Genomic DNA. Translation: BAE77839.1.
PIRiS47673.
RefSeqiNP_417911.4. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76479; AAC76479; b3454.
BAE77839; BAE77839; BAE77839.
GeneIDi947961.
KEGGiecj:JW3419.
eco:b3454.
PATRICi32122350. VBIEscCol129921_3552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83887.1.
U00039 Genomic DNA. Translation: AAB18429.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76479.2.
AP009048 Genomic DNA. Translation: BAE77839.1.
PIRiS47673.
RefSeqiNP_417911.4. NC_000913.3.

3D structure databases

ProteinModelPortaliP22731.
SMRiP22731.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261110. 10 interactors.
IntActiP22731. 13 interactors.
STRINGi511145.b3454.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP22731.
PRIDEiP22731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76479; AAC76479; b3454.
BAE77839; BAE77839; BAE77839.
GeneIDi947961.
KEGGiecj:JW3419.
eco:b3454.
PATRICi32122350. VBIEscCol129921_3552.

Organism-specific databases

EchoBASEiEB0531.
EcoGeneiEG10536. livF.

Phylogenomic databases

eggNOGiENOG4108IV0. Bacteria.
COG0410. LUCA.
InParanoidiP22731.
KOiK01996.
OMAiMGAFLKT.
PhylomeDBiP22731.

Enzyme and pathway databases

BioCyciEcoCyc:LIVF-MONOMER.
ECOL316407:JW3419-MONOMER.
MetaCyc:LIVF-MONOMER.

Miscellaneous databases

PROiP22731.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR030660. ABC_branched_ATPase_LivF/BraG.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF039137. ABC_branched_ATPase. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIVF_ECOLI
AccessioniPrimary (citable) accession number: P22731
Secondary accession number(s): P76697, Q2M7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1994
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.