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Protein

High-affinity branched-chain amino acid transport system permease protein LivM

Gene

livM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

GO - Molecular functioni

  • branched-chain amino acid transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • branched-chain amino acid transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:LIVM-MONOMER.
ECOL316407:JW3421-MONOMER.
MetaCyc:LIVM-MONOMER.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity branched-chain amino acid transport system permease protein LivM
Alternative name(s):
LIV-I protein M
Gene namesi
Name:livM
Ordered Locus Names:b3456, JW3421
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10541. livM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Transmembranei145 – 16521HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Transmembranei353 – 37321HelicalSequence analysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425High-affinity branched-chain amino acid transport system permease protein LivMPRO_0000060062Add
BLAST

Proteomic databases

PaxDbiP22729.

Interactioni

Protein-protein interaction databases

BioGridi4262489. 17 interactions.
STRINGi511145.b3456.

Structurei

3D structure databases

ProteinModelPortaliP22729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CF8. Bacteria.
COG4177. LUCA.
HOGENOMiHOG000202415.
InParanoidiP22729.
KOiK01998.
OMAiSINKVIF.
PhylomeDBiP22729.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
IPR021807. LivHM_N.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
PF11862. DUF3382. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPMHIAMAL LSAAMFFVLA GVFMGVQLEL DGTKLVVDTA SDVRWQWVFI
60 70 80 90 100
GTAVVFFFQL LRPAFQKGLK SVSGPKFILP AIDGSTVKQK LFLVALLVLA
110 120 130 140 150
VAWPFMVSRG TVDIATLTMI YIILGLGLNV VVGLSGLLVL GYGGFYAIGA
160 170 180 190 200
YTFALLNHYY GLGFWTCLPI AGLMAAAAGF LLGFPVLRLR GDYLAIVTLG
210 220 230 240 250
FGEIVRILLL NNTEITGGPN GISQIPKPTL FGLEFSRTAR EGGWDTFSNF
260 270 280 290 300
FGLKYDPSDR VIFLYLVALL LVVLSLFVIN RLLRMPLGRA WEALREDEIA
310 320 330 340 350
CRSLGLSPRR IKLTAFTISA AFAGFAGTLF AARQGFVSPE SFTFAESAFV
360 370 380 390 400
LAIVVLGGMG SQFAVILAAI LLVVSRELMR DFNEYSMLML GGLMVLMMIW
410 420
RPQGLLPMTR PQLKLKNGAA KGEQA
Length:425
Mass (Da):46,269
Last modified:October 1, 1994 - v2
Checksum:iF9658D0E5FCE987F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 17829AYTFA…MAAAA → LHFCAAQSLLRLGLLDLPAD CWINGSGG in AAA83885 (PubMed:2195019).CuratedAdd
BLAST
Sequence conflicti295 – 2951R → G in AAA83885 (PubMed:2195019).Curated
Sequence conflicti411 – 4111P → R in AAA83885 (PubMed:2195019).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83885.1.
U00039 Genomic DNA. Translation: AAB18431.1.
U00096 Genomic DNA. Translation: AAC76481.1.
AP009048 Genomic DNA. Translation: BAE77837.1.
PIRiS47675.
RefSeqiNP_417913.1. NC_000913.3.
WP_000803813.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76481; AAC76481; b3456.
BAE77837; BAE77837; BAE77837.
GeneIDi947966.
KEGGiecj:JW3421.
eco:b3456.
PATRICi32122354. VBIEscCol129921_3554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA. Translation: AAA83885.1.
U00039 Genomic DNA. Translation: AAB18431.1.
U00096 Genomic DNA. Translation: AAC76481.1.
AP009048 Genomic DNA. Translation: BAE77837.1.
PIRiS47675.
RefSeqiNP_417913.1. NC_000913.3.
WP_000803813.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP22729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262489. 17 interactions.
STRINGi511145.b3456.

Protein family/group databases

TCDBi3.A.1.4.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP22729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76481; AAC76481; b3456.
BAE77837; BAE77837; BAE77837.
GeneIDi947966.
KEGGiecj:JW3421.
eco:b3456.
PATRICi32122354. VBIEscCol129921_3554.

Organism-specific databases

EchoBASEiEB0536.
EcoGeneiEG10541. livM.

Phylogenomic databases

eggNOGiENOG4105CF8. Bacteria.
COG4177. LUCA.
HOGENOMiHOG000202415.
InParanoidiP22729.
KOiK01998.
OMAiSINKVIF.
PhylomeDBiP22729.

Enzyme and pathway databases

BioCyciEcoCyc:LIVM-MONOMER.
ECOL316407:JW3421-MONOMER.
MetaCyc:LIVM-MONOMER.

Miscellaneous databases

PROiP22729.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
IPR021807. LivHM_N.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
PF11862. DUF3382. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIVM_ECOLI
AccessioniPrimary (citable) accession number: P22729
Secondary accession number(s): Q2M7B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.