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Protein

High-affinity branched-chain amino acid transport system permease protein LivM

Gene

livM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane.

GO - Molecular functioni

  • branched-chain amino acid transmembrane transporter activity Source: EcoCyc
  • L-isoleucine transmembrane transporter activity Source: EcoCyc
  • L-phenylalanine transmembrane transporter activity Source: EcoCyc
  • L-valine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • branched-chain amino acid transport Source: EcoCyc
  • isoleucine transmembrane transport Source: EcoCyc
  • L-valine transmembrane transport Source: EcoCyc
  • phenylalanine transport Source: EcoCyc

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:LIVM-MONOMER
MetaCyc:LIVM-MONOMER

Protein family/group databases

TCDBi3.A.1.4.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity branched-chain amino acid transport system permease protein LivM
Alternative name(s):
LIV-I protein M
Gene namesi
Name:livM
Ordered Locus Names:b3456, JW3421
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10541 livM

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600621 – 425High-affinity branched-chain amino acid transport system permease protein LivMAdd BLAST425

Proteomic databases

PaxDbiP22729
PRIDEiP22729

Interactioni

Protein-protein interaction databases

BioGridi4262489, 17 interactors
STRINGi316385.ECDH10B_3630

Structurei

3D structure databases

ProteinModelPortaliP22729
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CF8 Bacteria
COG4177 LUCA
HOGENOMiHOG000202415
InParanoidiP22729
KOiK01998
OMAiKMQALVL
PhylomeDBiP22729

Family and domain databases

InterProiView protein in InterPro
IPR001851 ABC_transp_permease
IPR021807 LivHM_N
PfamiView protein in Pfam
PF02653 BPD_transp_2, 1 hit
PF11862 DUF3382, 1 hit

Sequencei

Sequence statusi: Complete.

P22729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPMHIAMAL LSAAMFFVLA GVFMGVQLEL DGTKLVVDTA SDVRWQWVFI
60 70 80 90 100
GTAVVFFFQL LRPAFQKGLK SVSGPKFILP AIDGSTVKQK LFLVALLVLA
110 120 130 140 150
VAWPFMVSRG TVDIATLTMI YIILGLGLNV VVGLSGLLVL GYGGFYAIGA
160 170 180 190 200
YTFALLNHYY GLGFWTCLPI AGLMAAAAGF LLGFPVLRLR GDYLAIVTLG
210 220 230 240 250
FGEIVRILLL NNTEITGGPN GISQIPKPTL FGLEFSRTAR EGGWDTFSNF
260 270 280 290 300
FGLKYDPSDR VIFLYLVALL LVVLSLFVIN RLLRMPLGRA WEALREDEIA
310 320 330 340 350
CRSLGLSPRR IKLTAFTISA AFAGFAGTLF AARQGFVSPE SFTFAESAFV
360 370 380 390 400
LAIVVLGGMG SQFAVILAAI LLVVSRELMR DFNEYSMLML GGLMVLMMIW
410 420
RPQGLLPMTR PQLKLKNGAA KGEQA
Length:425
Mass (Da):46,269
Last modified:October 1, 1994 - v2
Checksum:iF9658D0E5FCE987F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150 – 178AYTFA…MAAAA → LHFCAAQSLLRLGLLDLPAD CWINGSGG in AAA83885 (PubMed:2195019).CuratedAdd BLAST29
Sequence conflicti295R → G in AAA83885 (PubMed:2195019).Curated1
Sequence conflicti411P → R in AAA83885 (PubMed:2195019).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05516 Genomic DNA Translation: AAA83885.1
U00039 Genomic DNA Translation: AAB18431.1
U00096 Genomic DNA Translation: AAC76481.1
AP009048 Genomic DNA Translation: BAE77837.1
PIRiS47675
RefSeqiNP_417913.1, NC_000913.3
WP_000803813.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76481; AAC76481; b3456
BAE77837; BAE77837; BAE77837
GeneIDi947966
KEGGiecj:JW3421
eco:b3456
PATRICifig|1411691.4.peg.3270

Similar proteinsi

Entry informationi

Entry nameiLIVM_ECOLI
AccessioniPrimary (citable) accession number: P22729
Secondary accession number(s): Q2M7B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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