Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P22727

- WNT6_MOUSE

UniProt

P22727 - WNT6_MOUSE

Protein

Protein Wnt-6

Gene

Wnt6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor binding Source: MGI

    GO - Biological processi

    1. axis specification Source: MGI
    2. branching involved in ureteric bud morphogenesis Source: MGI
    3. cell-cell signaling Source: MGI
    4. cell fate commitment Source: RefGenome
    5. epithelial-mesenchymal cell signaling Source: MGI
    6. nephron tubule development Source: MGI
    7. nephron tubule formation Source: MGI
    8. neuron differentiation Source: RefGenome
    9. odontogenesis of dentin-containing tooth Source: Ensembl
    10. organ morphogenesis Source: MGI
    11. positive regulation of gene expression Source: MGI
    12. positive regulation of tooth mineralization Source: Ensembl
    13. positive regulation of transcription, DNA-templated Source: MGI
    14. signal transduction Source: MGI
    15. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-6
    Gene namesi
    Name:Wnt6
    Synonyms:Wnt-6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98960. Wnt6.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular matrix Source: MGI
    4. extracellular space Source: RefGenome
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 364341Protein Wnt-6PRO_0000041441Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 86By similarity
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 131By similarity
    Disulfide bondi133 ↔ 171By similarity
    Disulfide bondi221 ↔ 235By similarity
    Disulfide bondi223 ↔ 230By similarity
    Lipidationi227 – 2271O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi309 ↔ 324By similarity
    Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi339 ↔ 354By similarity
    Disulfide bondi341 ↔ 351By similarity
    Disulfide bondi346 ↔ 347By similarity

    Post-translational modificationi

    Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP22727.

    Expressioni

    Tissue specificityi

    Detected in ileum, colon and stomach (at protein level).1 Publication

    Gene expression databases

    BgeeiP22727.
    CleanExiMM_WNT6.
    GenevestigatoriP22727.

    Interactioni

    Subunit structurei

    Interacts with PORCN.1 Publication

    Protein-protein interaction databases

    BioGridi204579. 1 interaction.
    STRINGi10090.ENSMUSP00000006716.

    Structurei

    3D structure databases

    ProteinModelPortaliP22727.
    SMRiP22727. Positions 62-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG246444.
    GeneTreeiENSGT00730000110244.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    InParanoidiQ80ZM9.
    KOiK00445.
    OMAiRTLKPPG.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009143. Wnt6.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01845. WNT6PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22727-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ    50
    AELCQAEPEV VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD 100
    IRETAFVFAI TAAGASHAVT QACSMGELLQ CGCQAPRGRA PPRPSGLLGT 150
    PGPPGPTGSP DASAAWEWGG CGDDVDFGDE KSRLFMDAQH KRGRGDIRAL 200
    VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP PFREVGARLL 250
    ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG 300
    SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ 350
    CHRCRVRKEL SLCL 364
    Length:364
    Mass (Da):39,656
    Last modified:June 28, 2011 - v2
    Checksum:i6F28CE191F98A0AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti233 – 2331R → S in AAA40569. (PubMed:2279700)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89800 mRNA. Translation: AAA40569.1.
    AK133954 mRNA. Translation: BAE21949.1.
    CH466548 Genomic DNA. Translation: EDL00351.1.
    BC048700 mRNA. Translation: AAH48700.1.
    CCDSiCCDS15056.1.
    PIRiF36470.
    RefSeqiNP_033552.2. NM_009526.3.
    XP_006495950.1. XM_006495887.1.
    XP_006495951.1. XM_006495888.1.
    UniGeneiMm.268282.

    Genome annotation databases

    EnsembliENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227.
    GeneIDi22420.
    KEGGimmu:22420.
    UCSCiuc007bne.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89800 mRNA. Translation: AAA40569.1 .
    AK133954 mRNA. Translation: BAE21949.1 .
    CH466548 Genomic DNA. Translation: EDL00351.1 .
    BC048700 mRNA. Translation: AAH48700.1 .
    CCDSi CCDS15056.1.
    PIRi F36470.
    RefSeqi NP_033552.2. NM_009526.3.
    XP_006495950.1. XM_006495887.1.
    XP_006495951.1. XM_006495888.1.
    UniGenei Mm.268282.

    3D structure databases

    ProteinModelPortali P22727.
    SMRi P22727. Positions 62-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204579. 1 interaction.
    STRINGi 10090.ENSMUSP00000006716.

    Proteomic databases

    PRIDEi P22727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006716 ; ENSMUSP00000006716 ; ENSMUSG00000033227 .
    GeneIDi 22420.
    KEGGi mmu:22420.
    UCSCi uc007bne.1. mouse.

    Organism-specific databases

    CTDi 7475.
    MGIi MGI:98960. Wnt6.

    Phylogenomic databases

    eggNOGi NOG246444.
    GeneTreei ENSGT00730000110244.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    InParanoidi Q80ZM9.
    KOi K00445.
    OMAi RTLKPPG.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302849.
    PROi P22727.
    SOURCEi Search...

    Gene expression databases

    Bgeei P22727.
    CleanExi MM_WNT6.
    Genevestigatori P22727.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009143. Wnt6.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01845. WNT6PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
      Gavin B.J., McMahon J.A., McMahon A.P.
      Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.
    5. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
      Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
      Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PORCN.
    6. "WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells."
      Yuan G., Regel I., Lian F., Friedrich T., Hitkova I., Hofheinz R.D., Stroebel P., Langer R., Keller G., Roecken C., Zimmermann W., Schmid R.M., Ebert M.P.A., Burgermeister E.
      Oncogene 32:375-387(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiWNT6_MOUSE
    AccessioniPrimary (citable) accession number: P22727
    Secondary accession number(s): Q80ZM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3