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Protein

Protein Wnt-6

Gene

Wnt6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  1. frizzled binding Source: GO_Central
  2. receptor binding Source: MGI

GO - Biological processi

  1. axis specification Source: MGI
  2. branching involved in ureteric bud morphogenesis Source: MGI
  3. cell-cell signaling Source: MGI
  4. cell fate commitment Source: GO_Central
  5. epithelial-mesenchymal cell signaling Source: MGI
  6. nephron tubule development Source: MGI
  7. nephron tubule formation Source: MGI
  8. neuron differentiation Source: GO_Central
  9. odontogenesis of dentin-containing tooth Source: MGI
  10. organ morphogenesis Source: MGI
  11. positive regulation of gene expression Source: MGI
  12. positive regulation of tooth mineralization Source: MGI
  13. positive regulation of transcription, DNA-templated Source: MGI
  14. signal transduction Source: MGI
  15. Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-6
Gene namesi
Name:Wnt6
Synonyms:Wnt-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98960. Wnt6.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular space Source: GO_Central
  4. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 364341Protein Wnt-6PRO_0000041441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 86By similarity
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi123 ↔ 131By similarity
Disulfide bondi133 ↔ 171By similarity
Disulfide bondi221 ↔ 235By similarity
Disulfide bondi223 ↔ 230By similarity
Lipidationi227 – 2271O-palmitoyl serine; by PORCNBy similarity
Disulfide bondi309 ↔ 324By similarity
Glycosylationi310 – 3101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP22727.

Expressioni

Tissue specificityi

Detected in ileum, colon and stomach (at protein level).1 Publication

Gene expression databases

BgeeiP22727.
CleanExiMM_WNT6.
GenevestigatoriP22727.

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

Protein-protein interaction databases

BioGridi204579. 1 interaction.
STRINGi10090.ENSMUSP00000006716.

Structurei

3D structure databases

ProteinModelPortaliP22727.
SMRiP22727. Positions 62-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG246444.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP22727.
KOiK00445.
OMAiCGCEATR.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ
60 70 80 90 100
AELCQAEPEV VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD
110 120 130 140 150
IRETAFVFAI TAAGASHAVT QACSMGELLQ CGCQAPRGRA PPRPSGLLGT
160 170 180 190 200
PGPPGPTGSP DASAAWEWGG CGDDVDFGDE KSRLFMDAQH KRGRGDIRAL
210 220 230 240 250
VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP PFREVGARLL
260 270 280 290 300
ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG
310 320 330 340 350
SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ
360
CHRCRVRKEL SLCL
Length:364
Mass (Da):39,656
Last modified:June 28, 2011 - v2
Checksum:i6F28CE191F98A0AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2331R → S in AAA40569 (PubMed:2279700).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89800 mRNA. Translation: AAA40569.1.
AK133954 mRNA. Translation: BAE21949.1.
CH466548 Genomic DNA. Translation: EDL00351.1.
BC048700 mRNA. Translation: AAH48700.1.
CCDSiCCDS15056.1.
PIRiF36470.
RefSeqiNP_033552.2. NM_009526.3.
XP_006495950.1. XM_006495887.1.
XP_006495951.1. XM_006495888.1.
UniGeneiMm.268282.

Genome annotation databases

EnsembliENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227.
GeneIDi22420.
KEGGimmu:22420.
UCSCiuc007bne.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89800 mRNA. Translation: AAA40569.1.
AK133954 mRNA. Translation: BAE21949.1.
CH466548 Genomic DNA. Translation: EDL00351.1.
BC048700 mRNA. Translation: AAH48700.1.
CCDSiCCDS15056.1.
PIRiF36470.
RefSeqiNP_033552.2. NM_009526.3.
XP_006495950.1. XM_006495887.1.
XP_006495951.1. XM_006495888.1.
UniGeneiMm.268282.

3D structure databases

ProteinModelPortaliP22727.
SMRiP22727. Positions 62-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204579. 1 interaction.
STRINGi10090.ENSMUSP00000006716.

Proteomic databases

PRIDEiP22727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227.
GeneIDi22420.
KEGGimmu:22420.
UCSCiuc007bne.1. mouse.

Organism-specific databases

CTDi7475.
MGIiMGI:98960. Wnt6.

Phylogenomic databases

eggNOGiNOG246444.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP22727.
KOiK00445.
OMAiCGCEATR.
OrthoDBiEOG7C8GJ8.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

Miscellaneous databases

NextBioi302849.
PROiP22727.
SOURCEiSearch...

Gene expression databases

BgeeiP22727.
CleanExiMM_WNT6.
GenevestigatoriP22727.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
    Gavin B.J., McMahon J.A., McMahon A.P.
    Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  5. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
    Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
    Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PORCN.
  6. "WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells."
    Yuan G., Regel I., Lian F., Friedrich T., Hitkova I., Hofheinz R.D., Stroebel P., Langer R., Keller G., Roecken C., Zimmermann W., Schmid R.M., Ebert M.P.A., Burgermeister E.
    Oncogene 32:375-387(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiWNT6_MOUSE
AccessioniPrimary (citable) accession number: P22727
Secondary accession number(s): Q80ZM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 28, 2011
Last modified: March 4, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.