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P22727 (WNT6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-6
Gene names
Name:Wnt6
Synonyms:Wnt-6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subunit structure

Interacts with PORCN. Ref.5

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Detected in ileum, colon and stomach (at protein level). Ref.6

Post-translational modification

Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-75. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from direct assay PubMed 11948913PubMed 11973284. Source: MGI

axis specification

Inferred from direct assay PubMed 11948913. Source: MGI

branching involved in ureteric bud morphogenesis

Inferred from genetic interaction PubMed 11948913. Source: MGI

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell-cell signaling

Traceable author statement PubMed 9889131. Source: MGI

epithelial-mesenchymal cell signaling

Inferred from direct assay PubMed 11948913. Source: MGI

nephron tubule development

Inferred from direct assay PubMed 11948913. Source: MGI

nephron tubule formation

Inferred from direct assay PubMed 11948913. Source: MGI

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Traceable author statement PubMed 9889131. Source: MGI

positive regulation of gene expression

Inferred from direct assay PubMed 11948913PubMed 11973284. Source: MGI

positive regulation of tooth mineralization

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 9356179. Source: MGI

signal transduction

Traceable author statement PubMed 9889131. Source: MGI

   Cellular_componentcell surface

Inferred from direct assay PubMed 8167409. Source: BHF-UCL

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular matrix

Inferred from direct assay PubMed 8167409. Source: MGI

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

receptor binding

Traceable author statement PubMed 9889131. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 364341Protein Wnt-6
PRO_0000041441

Amino acid modifications

Lipidation751S-palmitoyl cysteine By similarity
Lipidation2271O-palmitoyl serine; by PORCN By similarity
Glycosylation851N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2331R → S in AAA40569. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P22727 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 6F28CE191F98A0AC

FASTA36439,656
        10         20         30         40         50         60 
MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ AELCQAEPEV 

        70         80         90        100        110        120 
VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD IRETAFVFAI TAAGASHAVT 

       130        140        150        160        170        180 
QACSMGELLQ CGCQAPRGRA PPRPSGLLGT PGPPGPTGSP DASAAWEWGG CGDDVDFGDE 

       190        200        210        220        230        240 
KSRLFMDAQH KRGRGDIRAL VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP 

       250        260        270        280        290        300 
PFREVGARLL ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG 

       310        320        330        340        350        360 
SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ CHRCRVRKEL 


SLCL 

« Hide

References

« Hide 'large scale' references
[1]"Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
Gavin B.J., McMahon J.A., McMahon A.P.
Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Limb.
[5]"The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PORCN.
[6]"WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells."
Yuan G., Regel I., Lian F., Friedrich T., Hitkova I., Hofheinz R.D., Stroebel P., Langer R., Keller G., Roecken C., Zimmermann W., Schmid R.M., Ebert M.P.A., Burgermeister E.
Oncogene 32:375-387(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M89800 mRNA. Translation: AAA40569.1.
AK133954 mRNA. Translation: BAE21949.1.
CH466548 Genomic DNA. Translation: EDL00351.1.
BC048700 mRNA. Translation: AAH48700.1.
CCDSCCDS15056.1.
PIRF36470.
RefSeqNP_033552.2. NM_009526.3.
XP_006495950.1. XM_006495887.1.
XP_006495951.1. XM_006495888.1.
UniGeneMm.268282.

3D structure databases

ProteinModelPortalP22727.
SMRP22727. Positions 62-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204579. 1 interaction.
STRING10090.ENSMUSP00000006716.

Proteomic databases

PRIDEP22727.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227.
GeneID22420.
KEGGmmu:22420.
UCSCuc007bne.1. mouse.

Organism-specific databases

CTD7475.
MGIMGI:98960. Wnt6.

Phylogenomic databases

eggNOGNOG246444.
GeneTreeENSGT00730000110244.
HOGENOMHOG000039528.
HOVERGENHBG001595.
InParanoidQ80ZM9.
KOK00445.
OMARTLKPPG.
OrthoDBEOG7C8GJ8.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeP22727.
CleanExMM_WNT6.
GenevestigatorP22727.

Family and domain databases

InterProIPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio302849.
PROP22727.
SOURCESearch...

Entry information

Entry nameWNT6_MOUSE
AccessionPrimary (citable) accession number: P22727
Secondary accession number(s): Q80ZM9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot