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Protein

Protein Wnt-6

Gene

Wnt6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • axis specification Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cell-cell signaling Source: MGI
  • cell fate commitment Source: GO_Central
  • epithelial-mesenchymal cell signaling Source: MGI
  • nephron tubule development Source: MGI
  • nephron tubule formation Source: MGI
  • neuron differentiation Source: GO_Central
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of tooth mineralization Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • signal transduction Source: MGI
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-6
Gene namesi
Name:Wnt6
Synonyms:Wnt-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98960. Wnt6.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular space Source: GO_Central
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004144124 – 364Protein Wnt-6Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 86By similarity
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi123 ↔ 131By similarity
Disulfide bondi133 ↔ 171By similarity
Disulfide bondi221 ↔ 235By similarity
Disulfide bondi223 ↔ 230By similarity
Lipidationi227O-palmitoleyl serine; by PORCNBy similarity1
Disulfide bondi309 ↔ 324By similarity
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP22727.
PRIDEiP22727.

PTM databases

PhosphoSitePlusiP22727.

Expressioni

Tissue specificityi

Detected in ileum, colon and stomach (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000033227.
CleanExiMM_WNT6.
GenevisibleiP22727. MM.

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor binding Source: MGI

Protein-protein interaction databases

BioGridi204579. 1 interactor.
STRINGi10090.ENSMUSP00000006716.

Structurei

3D structure databases

ProteinModelPortaliP22727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP22727.
KOiK00445.
OMAiRGKSDIR.
OrthoDBiEOG091G0OFF.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPVPSRLG LLLLLLCPAH VDGLWWAVGS PLVMDPTSIC RKARRLAGRQ
60 70 80 90 100
AELCQAEPEV VAELARGARL GVRECQFQFR FRRWNCSSHS KAFGRVLQQD
110 120 130 140 150
IRETAFVFAI TAAGASHAVT QACSMGELLQ CGCQAPRGRA PPRPSGLLGT
160 170 180 190 200
PGPPGPTGSP DASAAWEWGG CGDDVDFGDE KSRLFMDAQH KRGRGDIRAL
210 220 230 240 250
VQLHNNEAGR LAVRSHTRTE CKCHGLSGSC ALRTCWQKLP PFREVGARLL
260 270 280 290 300
ERFHGASRVM GTNDGKALLP AVRTLKPPGR ADLLYAADSP DFCAPNRRTG
310 320 330 340 350
SPGTRGRACN SSAPDLSGCD LLCCGRGHRQ ESVQLEENCL CRFHWCCVVQ
360
CHRCRVRKEL SLCL
Length:364
Mass (Da):39,656
Last modified:June 28, 2011 - v2
Checksum:i6F28CE191F98A0AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233R → S in AAA40569 (PubMed:2279700).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89800 mRNA. Translation: AAA40569.1.
AK133954 mRNA. Translation: BAE21949.1.
CH466548 Genomic DNA. Translation: EDL00351.1.
BC048700 mRNA. Translation: AAH48700.1.
CCDSiCCDS15056.1.
PIRiF36470.
RefSeqiNP_033552.2. NM_009526.3.
XP_006495950.1. XM_006495887.3.
XP_006495951.1. XM_006495888.3.
UniGeneiMm.268282.

Genome annotation databases

EnsembliENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227.
GeneIDi22420.
KEGGimmu:22420.
UCSCiuc007bne.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89800 mRNA. Translation: AAA40569.1.
AK133954 mRNA. Translation: BAE21949.1.
CH466548 Genomic DNA. Translation: EDL00351.1.
BC048700 mRNA. Translation: AAH48700.1.
CCDSiCCDS15056.1.
PIRiF36470.
RefSeqiNP_033552.2. NM_009526.3.
XP_006495950.1. XM_006495887.3.
XP_006495951.1. XM_006495888.3.
UniGeneiMm.268282.

3D structure databases

ProteinModelPortaliP22727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204579. 1 interactor.
STRINGi10090.ENSMUSP00000006716.

PTM databases

PhosphoSitePlusiP22727.

Proteomic databases

PaxDbiP22727.
PRIDEiP22727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006716; ENSMUSP00000006716; ENSMUSG00000033227.
GeneIDi22420.
KEGGimmu:22420.
UCSCiuc007bne.1. mouse.

Organism-specific databases

CTDi7475.
MGIiMGI:98960. Wnt6.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiP22727.
KOiK00445.
OMAiRGKSDIR.
OrthoDBiEOG091G0OFF.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.

Miscellaneous databases

PROiP22727.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033227.
CleanExiMM_WNT6.
GenevisibleiP22727. MM.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWNT6_MOUSE
AccessioniPrimary (citable) accession number: P22727
Secondary accession number(s): Q80ZM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.