Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P22726

- WNT5B_MOUSE

UniProt

P22726 - WNT5B_MOUSE

Protein

Protein Wnt-5b

Gene

Wnt5b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor binding Source: MGI

    GO - Biological processi

    1. cell-cell signaling Source: MGI
    2. cell fate commitment Source: RefGenome
    3. chondrocyte differentiation Source: Ensembl
    4. negative regulation of canonical Wnt signaling pathway Source: MGI
    5. neuron differentiation Source: RefGenome
    6. organ morphogenesis Source: MGI
    7. positive regulation of cell migration Source: Ensembl
    8. positive regulation of fat cell differentiation Source: MGI
    9. signal transduction Source: MGI
    10. Wnt signaling pathway Source: UniProtKB-KW
    11. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5b
    Gene namesi
    Name:Wnt5b
    Synonyms:Wnt-5b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:98959. Wnt5b.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular matrix Source: MGI
    4. extracellular space Source: RefGenome
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 359342Protein Wnt-5bPRO_0000041435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 94By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 141By similarity
    Disulfide bondi143 ↔ 161By similarity
    Disulfide bondi217 ↔ 231By similarity
    Disulfide bondi219 ↔ 226By similarity
    Lipidationi223 – 2231O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 319By similarity
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi334 ↔ 349By similarity
    Disulfide bondi336 ↔ 346By similarity
    Disulfide bondi341 ↔ 342By similarity

    Post-translational modificationi

    Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP22726.

    PTM databases

    PhosphoSiteiP22726.

    Expressioni

    Gene expression databases

    ArrayExpressiP22726.
    BgeeiP22726.
    CleanExiMM_WNT5B.
    GenevestigatoriP22726.

    Interactioni

    Subunit structurei

    Interacts with PORCN.1 Publication

    Protein-protein interaction databases

    BioGridi204578. 1 interaction.
    STRINGi10090.ENSMUSP00000032273.

    Structurei

    3D structure databases

    ProteinModelPortaliP22726.
    SMRiP22726. Positions 73-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115016.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiP22726.
    KOiK00444.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP22726.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22726-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSLLLVVVA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ    50
    LPGLSPGQRK LCQLYQEHMS YIGEGAKTGI RECQHQFRQR RWNCSTVDNT 100
    SVFGRVMQIG SRETAFTYAV SAAGVVNAIS RACREGELST CGCSRAARPK 150
    DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRALMNLQ 200
    NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD 250
    SAAAMRITRQ GKLELANSRF NQPTPEDLVY VDPSPDYCLR NETTGSLGTQ 300
    GRLCNKTSEG MDGCELMCCG RGYDRFKSVQ VERCHCRFHW CCFVRCKKCT 350
    EVVDQYVCK 359
    Length:359
    Mass (Da):40,343
    Last modified:June 20, 2001 - v2
    Checksum:i308ED393D3020DEB
    GO

    Sequence cautioni

    The sequence AAA40568.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH10775.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89799 mRNA. Translation: AAA40568.1. Different initiation.
    BC010775 mRNA. Translation: AAH10775.1. Different initiation.
    BC051406 mRNA. Translation: AAH51406.1.
    CCDSiCCDS20474.2.
    PIRiE36470.
    RefSeqiNP_001258686.1. NM_001271757.1.
    NP_001258687.1. NM_001271758.1.
    NP_033551.2. NM_009525.3.
    XP_006505987.1. XM_006505924.1.
    XP_006505988.1. XM_006505925.1.
    UniGeneiMm.321818.

    Genome annotation databases

    EnsembliENSMUST00000117171; ENSMUSP00000113188; ENSMUSG00000030170.
    ENSMUST00000119369; ENSMUSP00000112448; ENSMUSG00000030170.
    ENSMUST00000178696; ENSMUSP00000137065; ENSMUSG00000030170.
    GeneIDi22419.
    KEGGimmu:22419.
    UCSCiuc009dmg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89799 mRNA. Translation: AAA40568.1 . Different initiation.
    BC010775 mRNA. Translation: AAH10775.1 . Different initiation.
    BC051406 mRNA. Translation: AAH51406.1 .
    CCDSi CCDS20474.2.
    PIRi E36470.
    RefSeqi NP_001258686.1. NM_001271757.1.
    NP_001258687.1. NM_001271758.1.
    NP_033551.2. NM_009525.3.
    XP_006505987.1. XM_006505924.1.
    XP_006505988.1. XM_006505925.1.
    UniGenei Mm.321818.

    3D structure databases

    ProteinModelPortali P22726.
    SMRi P22726. Positions 73-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204578. 1 interaction.
    STRINGi 10090.ENSMUSP00000032273.

    PTM databases

    PhosphoSitei P22726.

    Proteomic databases

    PRIDEi P22726.

    Protocols and materials databases

    DNASUi 22419.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000117171 ; ENSMUSP00000113188 ; ENSMUSG00000030170 .
    ENSMUST00000119369 ; ENSMUSP00000112448 ; ENSMUSG00000030170 .
    ENSMUST00000178696 ; ENSMUSP00000137065 ; ENSMUSG00000030170 .
    GeneIDi 22419.
    KEGGi mmu:22419.
    UCSCi uc009dmg.2. mouse.

    Organism-specific databases

    CTDi 81029.
    MGIi MGI:98959. Wnt5b.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115016.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi P22726.
    KOi K00444.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P22726.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302845.
    PROi P22726.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P22726.
    Bgeei P22726.
    CleanExi MM_WNT5B.
    Genevestigatori P22726.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
      Gavin B.J., McMahon J.A., McMahon A.P.
      Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Liver and Mammary gland.
    3. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
      Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
      Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PORCN.

    Entry informationi

    Entry nameiWNT5B_MOUSE
    AccessioniPrimary (citable) accession number: P22726
    Secondary accession number(s): Q91XF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3