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Protein

Protein Wnt-5b

Gene

Wnt5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • cell-cell signaling Source: MGI
  • cell fate commitment Source: GO_Central
  • chondrocyte differentiation Source: Ensembl
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • neuron differentiation Source: GO_Central
  • positive regulation of cell migration Source: MGI
  • positive regulation of fat cell differentiation Source: MGI
  • signal transduction Source: MGI
  • Wnt signaling pathway Source: MGI
  • wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:Wnt5b
Synonyms:Wnt-5b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98959. Wnt5b.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular exosome Source: MGI
  • extracellular space Source: GO_Central
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000004143518 – 359Protein Wnt-5bAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 94By similarity
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi133 ↔ 141By similarity
Disulfide bondi143 ↔ 161By similarity
Disulfide bondi217 ↔ 231By similarity
Disulfide bondi219 ↔ 226By similarity
Lipidationi223O-palmitoleyl serine; by PORCNBy similarity1
Glycosylationi291N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi304 ↔ 319By similarity
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi334 ↔ 349By similarity
Disulfide bondi336 ↔ 346By similarity
Disulfide bondi341 ↔ 342By similarity

Post-translational modificationi

Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP22726.
PRIDEiP22726.

PTM databases

PhosphoSitePlusiP22726.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030170.
CleanExiMM_WNT5B.
ExpressionAtlasiP22726. baseline and differential.
GenevisibleiP22726. MM.

Interactioni

Subunit structurei

Interacts with PORCN.1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi204578. 1 interactor.
STRINGi10090.ENSMUSP00000113188.

Structurei

3D structure databases

ProteinModelPortaliP22726.
SMRiP22726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP22726.
KOiK00444.
PhylomeDBiP22726.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLLLVVVA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ
60 70 80 90 100
LPGLSPGQRK LCQLYQEHMS YIGEGAKTGI RECQHQFRQR RWNCSTVDNT
110 120 130 140 150
SVFGRVMQIG SRETAFTYAV SAAGVVNAIS RACREGELST CGCSRAARPK
160 170 180 190 200
DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRALMNLQ
210 220 230 240 250
NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD
260 270 280 290 300
SAAAMRITRQ GKLELANSRF NQPTPEDLVY VDPSPDYCLR NETTGSLGTQ
310 320 330 340 350
GRLCNKTSEG MDGCELMCCG RGYDRFKSVQ VERCHCRFHW CCFVRCKKCT

EVVDQYVCK
Length:359
Mass (Da):40,343
Last modified:June 20, 2001 - v2
Checksum:i308ED393D3020DEB
GO

Sequence cautioni

The sequence AAA40568 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH10775 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89799 mRNA. Translation: AAA40568.1. Different initiation.
BC010775 mRNA. Translation: AAH10775.1. Different initiation.
BC051406 mRNA. Translation: AAH51406.1.
CCDSiCCDS20474.2.
PIRiE36470.
RefSeqiNP_001258686.1. NM_001271757.1.
NP_001258687.1. NM_001271758.1.
NP_033551.2. NM_009525.3.
XP_006505987.1. XM_006505924.1.
UniGeneiMm.321818.

Genome annotation databases

EnsembliENSMUST00000117171; ENSMUSP00000113188; ENSMUSG00000030170.
ENSMUST00000178696; ENSMUSP00000137065; ENSMUSG00000030170.
GeneIDi22419.
KEGGimmu:22419.
UCSCiuc009dmg.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89799 mRNA. Translation: AAA40568.1. Different initiation.
BC010775 mRNA. Translation: AAH10775.1. Different initiation.
BC051406 mRNA. Translation: AAH51406.1.
CCDSiCCDS20474.2.
PIRiE36470.
RefSeqiNP_001258686.1. NM_001271757.1.
NP_001258687.1. NM_001271758.1.
NP_033551.2. NM_009525.3.
XP_006505987.1. XM_006505924.1.
UniGeneiMm.321818.

3D structure databases

ProteinModelPortaliP22726.
SMRiP22726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204578. 1 interactor.
STRINGi10090.ENSMUSP00000113188.

PTM databases

PhosphoSitePlusiP22726.

Proteomic databases

PaxDbiP22726.
PRIDEiP22726.

Protocols and materials databases

DNASUi22419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117171; ENSMUSP00000113188; ENSMUSG00000030170.
ENSMUST00000178696; ENSMUSP00000137065; ENSMUSG00000030170.
GeneIDi22419.
KEGGimmu:22419.
UCSCiuc009dmg.3. mouse.

Organism-specific databases

CTDi81029.
MGIiMGI:98959. Wnt5b.

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP22726.
KOiK00444.
PhylomeDBiP22726.
TreeFamiTF105310.

Enzyme and pathway databases

ReactomeiR-MMU-3238698. WNT ligand biogenesis and trafficking.

Miscellaneous databases

PROiP22726.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030170.
CleanExiMM_WNT5B.
ExpressionAtlasiP22726. baseline and differential.
GenevisibleiP22726. MM.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWNT5B_MOUSE
AccessioniPrimary (citable) accession number: P22726
Secondary accession number(s): Q91XF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 20, 2001
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.