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P22725

- WNT5A_MOUSE

UniProt

P22725 - WNT5A_MOUSE

Protein

Protein Wnt-5a

Gene

Wnt5a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.4 Publications

    GO - Molecular functioni

    1. cytokine activity Source: BHF-UCL
    2. frizzled-2 binding Source: MGI
    3. frizzled binding Source: BHF-UCL
    4. protein binding Source: UniProtKB
    5. protein domain specific binding Source: UniProtKB
    6. receptor binding Source: MGI
    7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    8. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. activation of JUN kinase activity Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. ameboidal cell migration Source: MGI
    4. anterior/posterior axis specification, embryo Source: BHF-UCL
    5. anterior/posterior pattern specification Source: MGI
    6. axis elongation Source: MGI
    7. axon guidance Source: UniProtKB
    8. canonical Wnt signaling pathway Source: BHF-UCL
    9. cartilage development Source: UniProtKB-KW
    10. cell-cell signaling Source: MGI
    11. cell fate commitment Source: RefGenome
    12. cell migration Source: MGI
    13. cellular protein localization Source: MGI
    14. cellular response to calcium ion Source: Ensembl
    15. cellular response to interferon-gamma Source: Ensembl
    16. cellular response to lipopolysaccharide Source: Ensembl
    17. cellular response to molecule of bacterial origin Source: BHF-UCL
    18. cellular response to transforming growth factor beta stimulus Source: Ensembl
    19. cervix development Source: MGI
    20. cochlea morphogenesis Source: MGI
    21. convergent extension Source: MGI
    22. convergent extension involved in organogenesis Source: MGI
    23. determination of left/right symmetry Source: MGI
    24. development of primary male sexual characteristics Source: MGI
    25. digestive tract morphogenesis Source: MGI
    26. dopaminergic neuron differentiation Source: MGI
    27. embryonic digit morphogenesis Source: MGI
    28. embryonic limb morphogenesis Source: MGI
    29. embryonic skeletal system development Source: Ensembl
    30. epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
    31. epithelial to mesenchymal transition Source: Ensembl
    32. establishment of planar polarity Source: MGI
    33. face development Source: Ensembl
    34. heart looping Source: MGI
    35. hematopoietic stem cell proliferation Source: MGI
    36. hindgut morphogenesis Source: MGI
    37. hypophysis morphogenesis Source: MGI
    38. inner ear morphogenesis Source: MGI
    39. JNK cascade Source: MGI
    40. keratinocyte differentiation Source: Ensembl
    41. lateral sprouting involved in mammary gland duct morphogenesis Source: MGI
    42. limb morphogenesis Source: MGI
    43. lung development Source: MGI
    44. male gonad development Source: MGI
    45. mammary gland branching involved in thelarche Source: MGI
    46. mesenchymal-epithelial cell signaling Source: MGI
    47. midgut development Source: MGI
    48. morphogenesis of an epithelium Source: MGI
    49. negative chemotaxis Source: MGI
    50. negative regulation of apoptotic process Source: Ensembl
    51. negative regulation of axon extension involved in axon guidance Source: MGI
    52. negative regulation of BMP signaling pathway Source: MGI
    53. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    54. negative regulation of epithelial cell proliferation Source: MGI
    55. negative regulation of fat cell differentiation Source: Ensembl
    56. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
    57. negative regulation of mesenchymal cell proliferation Source: Ensembl
    58. negative regulation of prostatic bud formation Source: MGI
    59. negative regulation of synapse assembly Source: BHF-UCL
    60. negative regulation of transcription, DNA-templated Source: Ensembl
    61. neural tube closure Source: MGI
    62. neural tube development Source: MGI
    63. neuron projection morphogenesis Source: UniProtKB
    64. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
    65. olfactory bulb interneuron development Source: UniProtKB
    66. organ morphogenesis Source: MGI
    67. palate development Source: Ensembl
    68. pericardium morphogenesis Source: MGI
    69. planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: MGI
    70. planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: MGI
    71. planar cell polarity pathway involved in neural tube closure Source: MGI
    72. planar cell polarity pathway involved in outflow tract morphogenesis Source: MGI
    73. planar cell polarity pathway involved in pericardium morphogenesis Source: MGI
    74. planar cell polarity pathway involved in ventricular septum morphogenesis Source: MGI
    75. positive regulation of angiogenesis Source: Ensembl
    76. positive regulation of cartilage development Source: MGI
    77. positive regulation of cell-cell adhesion mediated by cadherin Source: MGI
    78. positive regulation of cell proliferation Source: MGI
    79. positive regulation of cGMP metabolic process Source: Ensembl
    80. positive regulation of chemokine biosynthetic process Source: Ensembl
    81. positive regulation of cytokine secretion involved in immune response Source: Ensembl
    82. positive regulation of endothelial cell migration Source: Ensembl
    83. positive regulation of endothelial cell proliferation Source: Ensembl
    84. positive regulation of epithelial cell proliferation Source: MGI
    85. positive regulation of fibroblast proliferation Source: Ensembl
    86. positive regulation of inflammatory response Source: Ensembl
    87. positive regulation of interferon-gamma production Source: BHF-UCL
    88. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
    89. positive regulation of interleukin-6 production Source: BHF-UCL
    90. positive regulation of interleukin-8 secretion Source: BHF-UCL
    91. positive regulation of JNK cascade Source: BHF-UCL
    92. positive regulation of JUN kinase activity Source: MGI
    93. positive regulation of macrophage activation Source: Ensembl
    94. positive regulation of macrophage cytokine production Source: Ensembl
    95. positive regulation of meiosis Source: MGI
    96. positive regulation of mesenchymal cell proliferation Source: MGI
    97. positive regulation of neuron projection development Source: UniProtKB
    98. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    99. positive regulation of ossification Source: Ensembl
    100. positive regulation of peptidyl-serine phosphorylation Source: MGI
    101. positive regulation of peptidyl-threonine phosphorylation Source: MGI
    102. positive regulation of protein catabolic process Source: Ensembl
    103. positive regulation of protein kinase C signaling Source: Ensembl
    104. positive regulation of protein phosphorylation Source: MGI
    105. positive regulation of T cell chemotaxis Source: Ensembl
    106. positive regulation of thymocyte apoptotic process Source: MGI
    107. positive regulation of transcription, DNA-templated Source: BHF-UCL
    108. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    109. positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
    110. post-anal tail morphogenesis Source: MGI
    111. primitive streak formation Source: MGI
    112. protein phosphorylation Source: MGI
    113. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
    114. signal transduction Source: MGI
    115. somitogenesis Source: MGI
    116. tube closure Source: MGI
    117. type B pancreatic cell development Source: MGI
    118. urinary bladder development Source: MGI
    119. uterus development Source: MGI
    120. vagina development Source: MGI
    121. Wnt signaling pathway Source: MGI
    122. Wnt signaling pathway, calcium modulating pathway Source: BHF-UCL
    123. Wnt signaling pathway, planar cell polarity pathway Source: MGI
    124. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
    REACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_214043. PCP/CE pathway.
    REACT_221970. Ca2+ pathway.
    REACT_222404. WNT5A-dependent internalization of FZD4.
    REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5a
    Gene namesi
    Name:Wnt5a
    Synonyms:Wnt-5a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:98958. Wnt5a.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular matrix Source: MGI
    4. extracellular region Source: Reactome
    5. extracellular space Source: RefGenome
    6. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice display perinatal lethality and display gross morphological defects in outgrowing tissues. They are truncated caudally, displaying loss of the tail and a significant shortening of the anterior-posterior axis. The shape of the head is abnormal with truncated snout, mandible and tongue and reduced outgrowth of the external ear. Fore- and hindlimbs lack digits, the genital tubercle is missing and chondrocyte differentiation is inhibited.2 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi104 – 1041C → A: Abolishes palmitoylation. No effect on secretion. 1 Publication
    Mutagenesisi114 – 1141N → Q: Abolishes glycosylation; when associated with Q-120, Q-312 and Q-326. 1 Publication
    Mutagenesisi120 – 1201N → Q: Abolishes glycosylation; when associated with Q-114, Q-312 and Q-326. 1 Publication
    Mutagenesisi312 – 3121N → Q: Abolishes glycosylation; when associated with Q-114, Q-120 and Q-326. 1 Publication
    Mutagenesisi326 – 3261N → Q: Abolishes glycosylation; when associated with Q-114, Q-120 and Q-312. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3737Sequence AnalysisAdd
    BLAST
    Propeptidei38 – 61241 PublicationPRO_0000352797Add
    BLAST
    Chaini62 – 380319Protein Wnt-5aPRO_0000041428Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi104 ↔ 115By similarity
    Glycosylationi114 – 1141N-linked (GlcNAc...)1 Publication
    Glycosylationi120 – 1201N-linked (GlcNAc...)1 Publication
    Disulfide bondi154 ↔ 162By similarity
    Disulfide bondi164 ↔ 182By similarity
    Disulfide bondi238 ↔ 252By similarity
    Disulfide bondi240 ↔ 247By similarity
    Lipidationi244 – 2441O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi312 – 3121N-linked (GlcNAc...)1 Publication
    Disulfide bondi325 ↔ 340By similarity
    Glycosylationi326 – 3261N-linked (GlcNAc...)1 Publication
    Disulfide bondi355 ↔ 370By similarity
    Disulfide bondi357 ↔ 367By similarity
    Disulfide bondi362 ↔ 363By similarity

    Post-translational modificationi

    Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding.
    Glycosylation is necessary for secretion but not for activity.1 Publication
    Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface, A palmitoylation site was proposed at Cys-104, but it was later shown that this cysteine is engaged in a disulfide bond By similarity.By similarity
    Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiP22725.

    Expressioni

    Tissue specificityi

    Expressed in a gradient at the caudal end of the embryo during gastrulation and later in the distal-most aspect of several structures that extend from the body such as the limbs and genital tubercle.1 Publication

    Gene expression databases

    BgeeiP22725.
    CleanExiMM_WNT5A.
    GenevestigatoriP22725.

    Interactioni

    Subunit structurei

    Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KlO350822EBI-1570983,EBI-1570828
    WIF1Q9Y5W57EBI-1570983,EBI-3922719From a different organism.

    Protein-protein interaction databases

    BioGridi204577. 7 interactions.
    DIPiDIP-39893N.
    IntActiP22725. 4 interactions.
    MINTiMINT-6476731.

    Structurei

    3D structure databases

    ProteinModelPortaliP22725.
    SMRiP22725. Positions 94-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115016.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiP22725.
    KOiK00444.
    OMAiIVERCHC.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiP22725.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026538. Wnt5a.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P22725-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKKPIGILSP GVALGTAGGA MSSKFFLMAL ATFFSFAQVV IEANSWWSLG    50
    MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG 100
    IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM 150
    SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR 200
    ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK 250
    TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 300
    YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV 350
    QTERCHCKFH WCCYVKCKKC TEIVDQFVCK 380
    Length:380
    Mass (Da):42,309
    Last modified:November 4, 2008 - v2
    Checksum:i64CA36C516D22D8A
    GO
    Isoform 2 (identifier: P22725-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:360
    Mass (Da):40,489
    Checksum:i626372A278164C18
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti168 – 1681Missing in AAA40567. (PubMed:2279700)Curated
    Sequence conflicti190 – 1912YR → HP in AAA40567. (PubMed:2279700)Curated
    Sequence conflicti377 – 3771F → L in BAC27430. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020Missing in isoform 2. 1 PublicationVSP_035595Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89798 mRNA. Translation: AAA40567.1.
    AK031512 mRNA. Translation: BAC27430.1.
    AK031597 mRNA. Translation: BAC27468.1.
    AK036824 mRNA. Translation: BAC29593.1.
    CT025649 Genomic DNA. Translation: CAM27826.1.
    CT025649 Genomic DNA. Translation: CAM27827.1.
    BC018425 mRNA. Translation: AAH18425.1.
    CCDSiCCDS26888.1. [P22725-1]
    CCDS56946.1. [P22725-2]
    PIRiD36470.
    RefSeqiNP_001243153.1. NM_001256224.1. [P22725-2]
    NP_033550.2. NM_009524.3. [P22725-1]
    XP_006518987.1. XM_006518924.1. [P22725-2]
    XP_006518988.1. XM_006518925.1. [P22725-2]
    UniGeneiMm.287544.

    Genome annotation databases

    EnsembliENSMUST00000063465; ENSMUSP00000064878; ENSMUSG00000021994. [P22725-1]
    ENSMUST00000112272; ENSMUSP00000107891; ENSMUSG00000021994. [P22725-2]
    GeneIDi22418.
    KEGGimmu:22418.
    UCSCiuc007sug.2. mouse. [P22725-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M89798 mRNA. Translation: AAA40567.1 .
    AK031512 mRNA. Translation: BAC27430.1 .
    AK031597 mRNA. Translation: BAC27468.1 .
    AK036824 mRNA. Translation: BAC29593.1 .
    CT025649 Genomic DNA. Translation: CAM27826.1 .
    CT025649 Genomic DNA. Translation: CAM27827.1 .
    BC018425 mRNA. Translation: AAH18425.1 .
    CCDSi CCDS26888.1. [P22725-1 ]
    CCDS56946.1. [P22725-2 ]
    PIRi D36470.
    RefSeqi NP_001243153.1. NM_001256224.1. [P22725-2 ]
    NP_033550.2. NM_009524.3. [P22725-1 ]
    XP_006518987.1. XM_006518924.1. [P22725-2 ]
    XP_006518988.1. XM_006518925.1. [P22725-2 ]
    UniGenei Mm.287544.

    3D structure databases

    ProteinModelPortali P22725.
    SMRi P22725. Positions 94-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204577. 7 interactions.
    DIPi DIP-39893N.
    IntActi P22725. 4 interactions.
    MINTi MINT-6476731.

    Proteomic databases

    PRIDEi P22725.

    Protocols and materials databases

    DNASUi 22418.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063465 ; ENSMUSP00000064878 ; ENSMUSG00000021994 . [P22725-1 ]
    ENSMUST00000112272 ; ENSMUSP00000107891 ; ENSMUSG00000021994 . [P22725-2 ]
    GeneIDi 22418.
    KEGGi mmu:22418.
    UCSCi uc007sug.2. mouse. [P22725-1 ]

    Organism-specific databases

    CTDi 7474.
    MGIi MGI:98958. Wnt5a.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115016.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi P22725.
    KOi K00444.
    OMAi IVERCHC.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi P22725.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_207044. TCF dependent signaling in response to WNT.
    REACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
    REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_214043. PCP/CE pathway.
    REACT_221970. Ca2+ pathway.
    REACT_222404. WNT5A-dependent internalization of FZD4.
    REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

    Miscellaneous databases

    NextBioi 302841.
    PROi P22725.
    SOURCEi Search...

    Gene expression databases

    Bgeei P22725.
    CleanExi MM_WNT5A.
    Genevestigatori P22725.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026538. Wnt5a.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF33. PTHR12027:SF33. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
      Gavin B.J., McMahon J.A., McMahon A.P.
      Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Embryo.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Testis and Vagina.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary tumor.
    5. "Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context."
      Mikels A.J., Nusse R.
      PLoS Biol. 4:E115-E115(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 62-82, FUNCTION.
    6. "A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo."
      Yamaguchi T.P., Bradley A., McMahon A.P., Jones S.
      Development 126:1211-1223(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    7. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
      Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
      Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PORCN.
    8. "Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation."
      Topol L., Jiang X., Choi H., Garrett-Beal L., Carolan P.J., Yang Y.
      J. Cell Biol. 162:899-908(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    9. "Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling."
      Kurayoshi M., Yamamoto H., Izumi S., Kikuchi A.
      Biochem. J. 402:515-523(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PRELIMINARY CYSTEINE PALMITOYLATION, GLYCOSYLATION AT ASN-114; ASN-120; ASN-312 AND ASN-326, MUTAGENESIS OF CYS-104; ASN-114; ASN-120; ASN-312 AND ASN-326.
    10. "Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation."
      Fu J., Jiang M., Mirando A.J., Yu H.-M., Hsu W.
      Proc. Natl. Acad. Sci. U.S.A. 106:18598-18603(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WLS.
    11. "Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation."
      Zhang X., Abreu J.G., Yokota C., Macdonald B.T., Singh S., Coburn K.L., Cheong S.M., Zhang M.M., Ye Q.Z., Hang H.C., Steen H., He X.
      Cell 149:1565-1577(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING BY TIKI1 AND TIKI2, DISULFIDE BONDS, SUBUNIT.

    Entry informationi

    Entry nameiWNT5A_MOUSE
    AccessioniPrimary (citable) accession number: P22725
    Secondary accession number(s): Q8BM17, Q8BMF9, Q8VCV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3