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P22725

- WNT5A_MOUSE

UniProt

P22725 - WNT5A_MOUSE

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Protein
Protein Wnt-5a
Gene
Wnt5a, Wnt-5a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.4 Publications

GO - Molecular functioni

  1. cytokine activity Source: BHF-UCL
  2. frizzled binding Source: BHF-UCL
  3. frizzled-2 binding Source: MGI
  4. protein binding Source: UniProtKB
  5. protein domain specific binding Source: UniProtKB
  6. receptor binding Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription regulatory region DNA binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. JNK cascade Source: MGI
  2. Wnt signaling pathway Source: MGI
  3. Wnt signaling pathway, calcium modulating pathway Source: BHF-UCL
  4. Wnt signaling pathway, planar cell polarity pathway Source: MGI
  5. activation of JUN kinase activity Source: Ensembl
  6. activation of protein kinase B activity Source: Ensembl
  7. ameboidal cell migration Source: MGI
  8. anterior/posterior axis specification, embryo Source: BHF-UCL
  9. anterior/posterior pattern specification Source: MGI
  10. axis elongation Source: MGI
  11. axon guidance Source: UniProtKB
  12. canonical Wnt signaling pathway Source: BHF-UCL
  13. cartilage development Source: UniProtKB-KW
  14. cell fate commitment Source: RefGenome
  15. cell migration Source: MGI
  16. cell-cell signaling Source: MGI
  17. cellular protein localization Source: MGI
  18. cellular response to calcium ion Source: Ensembl
  19. cellular response to interferon-gamma Source: Ensembl
  20. cellular response to lipopolysaccharide Source: Ensembl
  21. cellular response to molecule of bacterial origin Source: BHF-UCL
  22. cellular response to transforming growth factor beta stimulus Source: Ensembl
  23. cervix development Source: MGI
  24. cochlea morphogenesis Source: MGI
  25. convergent extension Source: MGI
  26. convergent extension involved in organogenesis Source: MGI
  27. determination of left/right symmetry Source: MGI
  28. development of primary male sexual characteristics Source: MGI
  29. digestive tract morphogenesis Source: MGI
  30. dopaminergic neuron differentiation Source: MGI
  31. embryonic digit morphogenesis Source: MGI
  32. embryonic limb morphogenesis Source: MGI
  33. embryonic skeletal system development Source: Ensembl
  34. epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
  35. epithelial to mesenchymal transition Source: Ensembl
  36. establishment of planar polarity Source: MGI
  37. face development Source: Ensembl
  38. heart looping Source: MGI
  39. hematopoietic stem cell proliferation Source: MGI
  40. hindgut morphogenesis Source: MGI
  41. hypophysis morphogenesis Source: MGI
  42. inner ear morphogenesis Source: MGI
  43. keratinocyte differentiation Source: Ensembl
  44. lateral sprouting involved in mammary gland duct morphogenesis Source: MGI
  45. limb morphogenesis Source: MGI
  46. lung development Source: MGI
  47. male gonad development Source: MGI
  48. mammary gland branching involved in thelarche Source: MGI
  49. mesenchymal-epithelial cell signaling Source: MGI
  50. midgut development Source: MGI
  51. morphogenesis of an epithelium Source: MGI
  52. negative chemotaxis Source: MGI
  53. negative regulation of BMP signaling pathway Source: MGI
  54. negative regulation of apoptotic process Source: Ensembl
  55. negative regulation of axon extension involved in axon guidance Source: MGI
  56. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  57. negative regulation of epithelial cell proliferation Source: MGI
  58. negative regulation of fat cell differentiation Source: Ensembl
  59. negative regulation of fibroblast growth factor receptor signaling pathway Source: MGI
  60. negative regulation of mesenchymal cell proliferation Source: Ensembl
  61. negative regulation of prostatic bud formation Source: MGI
  62. negative regulation of synapse assembly Source: BHF-UCL
  63. negative regulation of transcription, DNA-templated Source: Ensembl
  64. neural tube closure Source: MGI
  65. neural tube development Source: MGI
  66. neuron projection morphogenesis Source: UniProtKB
  67. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
  68. olfactory bulb interneuron development Source: UniProtKB
  69. organ morphogenesis Source: MGI
  70. palate development Source: Ensembl
  71. pericardium morphogenesis Source: MGI
  72. planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source: MGI
  73. planar cell polarity pathway involved in cardiac right atrium morphogenesis Source: MGI
  74. planar cell polarity pathway involved in neural tube closure Source: MGI
  75. planar cell polarity pathway involved in outflow tract morphogenesis Source: MGI
  76. planar cell polarity pathway involved in pericardium morphogenesis Source: MGI
  77. planar cell polarity pathway involved in ventricular septum morphogenesis Source: MGI
  78. positive regulation of JNK cascade Source: BHF-UCL
  79. positive regulation of JUN kinase activity Source: MGI
  80. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  81. positive regulation of T cell chemotaxis Source: Ensembl
  82. positive regulation of angiogenesis Source: Ensembl
  83. positive regulation of cGMP metabolic process Source: Ensembl
  84. positive regulation of cartilage development Source: MGI
  85. positive regulation of cell proliferation Source: MGI
  86. positive regulation of cell-cell adhesion mediated by cadherin Source: MGI
  87. positive regulation of chemokine biosynthetic process Source: Ensembl
  88. positive regulation of cytokine secretion involved in immune response Source: Ensembl
  89. positive regulation of endothelial cell migration Source: Ensembl
  90. positive regulation of endothelial cell proliferation Source: Ensembl
  91. positive regulation of epithelial cell proliferation Source: MGI
  92. positive regulation of fibroblast proliferation Source: Ensembl
  93. positive regulation of inflammatory response Source: Ensembl
  94. positive regulation of interferon-gamma production Source: BHF-UCL
  95. positive regulation of interleukin-1 beta secretion Source: BHF-UCL
  96. positive regulation of interleukin-6 production Source: BHF-UCL
  97. positive regulation of interleukin-8 secretion Source: BHF-UCL
  98. positive regulation of macrophage activation Source: Ensembl
  99. positive regulation of macrophage cytokine production Source: Ensembl
  100. positive regulation of meiosis Source: MGI
  101. positive regulation of mesenchymal cell proliferation Source: MGI
  102. positive regulation of neuron projection development Source: UniProtKB
  103. positive regulation of ossification Source: Ensembl
  104. positive regulation of peptidyl-serine phosphorylation Source: MGI
  105. positive regulation of peptidyl-threonine phosphorylation Source: MGI
  106. positive regulation of protein catabolic process Source: Ensembl
  107. positive regulation of protein kinase C signaling Source: Ensembl
  108. positive regulation of protein phosphorylation Source: MGI
  109. positive regulation of thymocyte apoptotic process Source: MGI
  110. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  111. positive regulation of transcription, DNA-templated Source: BHF-UCL
  112. positive regulation of type I interferon-mediated signaling pathway Source: Ensembl
  113. post-anal tail morphogenesis Source: MGI
  114. primitive streak formation Source: MGI
  115. protein phosphorylation Source: MGI
  116. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
  117. signal transduction Source: MGI
  118. somitogenesis Source: MGI
  119. tube closure Source: MGI
  120. type B pancreatic cell development Source: MGI
  121. urinary bladder development Source: MGI
  122. uterus development Source: MGI
  123. vagina development Source: MGI
  124. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
REACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_213918. WNT ligand biogenesis and trafficking.
REACT_214043. PCP/CE pathway.
REACT_221970. Ca2+ pathway.
REACT_222404. WNT5A-dependent internalization of FZD4.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5a
Gene namesi
Name:Wnt5a
Synonyms:Wnt-5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:98958. Wnt5a.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: BHF-UCL
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular matrix Source: MGI
  4. extracellular region Source: Reactome
  5. extracellular space Source: RefGenome
  6. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice display perinatal lethality and display gross morphological defects in outgrowing tissues. They are truncated caudally, displaying loss of the tail and a significant shortening of the anterior-posterior axis. The shape of the head is abnormal with truncated snout, mandible and tongue and reduced outgrowth of the external ear. Fore- and hindlimbs lack digits, the genital tubercle is missing and chondrocyte differentiation is inhibited.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi104 – 1041C → A: Abolishes palmitoylation. No effect on secretion. 1 Publication
Mutagenesisi114 – 1141N → Q: Abolishes glycosylation; when associated with Q-120, Q-312 and Q-326. 1 Publication
Mutagenesisi120 – 1201N → Q: Abolishes glycosylation; when associated with Q-114, Q-312 and Q-326. 1 Publication
Mutagenesisi312 – 3121N → Q: Abolishes glycosylation; when associated with Q-114, Q-120 and Q-326. 1 Publication
Mutagenesisi326 – 3261N → Q: Abolishes glycosylation; when associated with Q-114, Q-120 and Q-312. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 Reviewed prediction
Add
BLAST
Propeptidei38 – 6124
PRO_0000352797Add
BLAST
Chaini62 – 380319Protein Wnt-5a
PRO_0000041428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 115 By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...)1 Publication
Glycosylationi120 – 1201N-linked (GlcNAc...)1 Publication
Disulfide bondi154 ↔ 162 By similarity
Disulfide bondi164 ↔ 182 By similarity
Disulfide bondi238 ↔ 252 By similarity
Disulfide bondi240 ↔ 247 By similarity
Lipidationi244 – 2441O-palmitoyl serine; by PORCN By similarity
Glycosylationi312 – 3121N-linked (GlcNAc...)1 Publication
Disulfide bondi325 ↔ 340 By similarity
Glycosylationi326 – 3261N-linked (GlcNAc...)1 Publication
Disulfide bondi355 ↔ 370 By similarity
Disulfide bondi357 ↔ 367 By similarity
Disulfide bondi362 ↔ 363 By similarity

Post-translational modificationi

Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor binding.1 Publication
Glycosylation is necessary for secretion but not for activity.
Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface, A palmitoylation site was proposed at Cys-104, but it was later shown that this cysteine is engaged in a disulfide bond By similarity.1 Publication
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP22725.

Expressioni

Tissue specificityi

Expressed in a gradient at the caudal end of the embryo during gastrulation and later in the distal-most aspect of several structures that extend from the body such as the limbs and genital tubercle.1 Publication

Gene expression databases

BgeeiP22725.
CleanExiMM_WNT5A.
GenevestigatoriP22725.

Interactioni

Subunit structurei

Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KlO350822EBI-1570983,EBI-1570828
WIF1Q9Y5W57EBI-1570983,EBI-3922719From a different organism.

Protein-protein interaction databases

BioGridi204577. 7 interactions.
DIPiDIP-39893N.
IntActiP22725. 4 interactions.
MINTiMINT-6476731.

Structurei

3D structure databases

ProteinModelPortaliP22725.
SMRiP22725. Positions 94-309.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG284879.
GeneTreeiENSGT00740000115016.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiP22725.
KOiK00444.
OMAiIVERCHC.
OrthoDBiEOG7C8GJ8.
PhylomeDBiP22725.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P22725-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKKPIGILSP GVALGTAGGA MSSKFFLMAL ATFFSFAQVV IEANSWWSLG    50
MNNPVQMSEV YIIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG 100
IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM 150
SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR 200
ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK 250
TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV 300
YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV 350
QTERCHCKFH WCCYVKCKKC TEIVDQFVCK 380
Length:380
Mass (Da):42,309
Last modified:November 4, 2008 - v2
Checksum:i64CA36C516D22D8A
GO
Isoform 2 (identifier: P22725-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.

Show »
Length:360
Mass (Da):40,489
Checksum:i626372A278164C18
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 2.
VSP_035595Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681Missing in AAA40567. 1 Publication
Sequence conflicti190 – 1912YR → HP in AAA40567. 1 Publication
Sequence conflicti377 – 3771F → L in BAC27430. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M89798 mRNA. Translation: AAA40567.1.
AK031512 mRNA. Translation: BAC27430.1.
AK031597 mRNA. Translation: BAC27468.1.
AK036824 mRNA. Translation: BAC29593.1.
CT025649 Genomic DNA. Translation: CAM27826.1.
CT025649 Genomic DNA. Translation: CAM27827.1.
BC018425 mRNA. Translation: AAH18425.1.
CCDSiCCDS26888.1. [P22725-1]
CCDS56946.1. [P22725-2]
PIRiD36470.
RefSeqiNP_001243153.1. NM_001256224.1. [P22725-2]
NP_033550.2. NM_009524.3. [P22725-1]
XP_006518987.1. XM_006518924.1. [P22725-2]
XP_006518988.1. XM_006518925.1. [P22725-2]
UniGeneiMm.287544.

Genome annotation databases

EnsembliENSMUST00000063465; ENSMUSP00000064878; ENSMUSG00000021994. [P22725-1]
ENSMUST00000112272; ENSMUSP00000107891; ENSMUSG00000021994. [P22725-2]
GeneIDi22418.
KEGGimmu:22418.
UCSCiuc007sug.2. mouse. [P22725-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M89798 mRNA. Translation: AAA40567.1 .
AK031512 mRNA. Translation: BAC27430.1 .
AK031597 mRNA. Translation: BAC27468.1 .
AK036824 mRNA. Translation: BAC29593.1 .
CT025649 Genomic DNA. Translation: CAM27826.1 .
CT025649 Genomic DNA. Translation: CAM27827.1 .
BC018425 mRNA. Translation: AAH18425.1 .
CCDSi CCDS26888.1. [P22725-1 ]
CCDS56946.1. [P22725-2 ]
PIRi D36470.
RefSeqi NP_001243153.1. NM_001256224.1. [P22725-2 ]
NP_033550.2. NM_009524.3. [P22725-1 ]
XP_006518987.1. XM_006518924.1. [P22725-2 ]
XP_006518988.1. XM_006518925.1. [P22725-2 ]
UniGenei Mm.287544.

3D structure databases

ProteinModelPortali P22725.
SMRi P22725. Positions 94-309.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204577. 7 interactions.
DIPi DIP-39893N.
IntActi P22725. 4 interactions.
MINTi MINT-6476731.

Proteomic databases

PRIDEi P22725.

Protocols and materials databases

DNASUi 22418.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063465 ; ENSMUSP00000064878 ; ENSMUSG00000021994 . [P22725-1 ]
ENSMUST00000112272 ; ENSMUSP00000107891 ; ENSMUSG00000021994 . [P22725-2 ]
GeneIDi 22418.
KEGGi mmu:22418.
UCSCi uc007sug.2. mouse. [P22725-1 ]

Organism-specific databases

CTDi 7474.
MGIi MGI:98958. Wnt5a.

Phylogenomic databases

eggNOGi NOG284879.
GeneTreei ENSGT00740000115016.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi P22725.
KOi K00444.
OMAi IVERCHC.
OrthoDBi EOG7C8GJ8.
PhylomeDBi P22725.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_207044. TCF dependent signaling in response to WNT.
REACT_210612. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
REACT_213918. WNT ligand biogenesis and trafficking.
REACT_214043. PCP/CE pathway.
REACT_221970. Ca2+ pathway.
REACT_222404. WNT5A-dependent internalization of FZD4.
REACT_222715. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Miscellaneous databases

NextBioi 302841.
PROi P22725.
SOURCEi Search...

Gene expression databases

Bgeei P22725.
CleanExi MM_WNT5A.
Genevestigatori P22725.

Family and domain databases

InterProi IPR005817. Wnt.
IPR026538. Wnt5a.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF33. PTHR12027:SF33. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
    Gavin B.J., McMahon J.A., McMahon A.P.
    Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Testis and Vagina.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary tumor.
  5. "Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context."
    Mikels A.J., Nusse R.
    PLoS Biol. 4:E115-E115(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 62-82, FUNCTION.
  6. "A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo."
    Yamaguchi T.P., Bradley A., McMahon A.P., Jones S.
    Development 126:1211-1223(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  7. "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
    Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
    Eur. J. Biochem. 267:4300-4311(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PORCN.
  8. "Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation."
    Topol L., Jiang X., Choi H., Garrett-Beal L., Carolan P.J., Yang Y.
    J. Cell Biol. 162:899-908(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  9. "Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling."
    Kurayoshi M., Yamamoto H., Izumi S., Kikuchi A.
    Biochem. J. 402:515-523(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PRELIMINARY CYSTEINE PALMITOYLATION, GLYCOSYLATION AT ASN-114; ASN-120; ASN-312 AND ASN-326, MUTAGENESIS OF CYS-104; ASN-114; ASN-120; ASN-312 AND ASN-326.
  10. "Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation."
    Fu J., Jiang M., Mirando A.J., Yu H.-M., Hsu W.
    Proc. Natl. Acad. Sci. U.S.A. 106:18598-18603(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WLS.
  11. "Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation."
    Zhang X., Abreu J.G., Yokota C., Macdonald B.T., Singh S., Coburn K.L., Cheong S.M., Zhang M.M., Ye Q.Z., Hang H.C., Steen H., He X.
    Cell 149:1565-1577(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING BY TIKI1 AND TIKI2, DISULFIDE BONDS, SUBUNIT.

Entry informationi

Entry nameiWNT5A_MOUSE
AccessioniPrimary (citable) accession number: P22725
Secondary accession number(s): Q8BM17, Q8BMF9, Q8VCV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 4, 2008
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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