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Reviewed, UniProtKB/Swiss-Prot P22724 (WNT4_MOUSE)

Last modified June 16, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein Wnt-4
Gene names
Name: Wnt4
Synonyms: Wnt-4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May be an intracellular signaling molecule involved in segmentation of the forebrain. Is likely to signal over only few cell diameters By similarity. Seems to be involved in kidney development.

Subunit structure

Interacts with PORCN. Ref.2

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

In adults in lung and brain.

Sequence similarities

Belongs to the Wnt family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KlO350821EBI-1570945,EBI-1570828

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 351329Protein Wnt-4
PRO_0000041422

Amino acid modifications

Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P22724-1 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 7E1C5C739BE939D9

FASTA35139,050
        10         20         30         40         50         60 
MSPRSCLRSL RLLVFAVFSA AASNWLYLAK LSSVGSISEE ETCEKLKGLI QRQVQMCKRN 

        70         80         90        100        110        120 
LEVMDSVRRG AQLAIEECQY QFRNRRWNCS TLDSLPVFGK VVTQGTREAA FVYAISSAGV 

       130        140        150        160        170        180 
AFAVTRACSS GELEKCGCDR TVHGVSPQGF QWSGCSDNIA YGVAFSQSFV DVRERSKGAS 

       190        200        210        220        230        240 
SSRALMNLHN NEAGRKAILT HMRVECKCHG VSGSCEVKTC WRAVPPFRQV GHALKEKFDG 

       250        260        270        280        290        300 
ATEVEPRRVG SSRALVPRNA QFKPHTDEDL VYLEPSPDFC EQDIRSGVLG TRGRTCNKTS 

       310        320        330        340        350 
KAIDGCELLC CGRGFHTAQV ELAERCGCRF HWCCFVKCRQ CQRLVEMHTC R 

« Hide

References

[1]"Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
Gavin B.J., McMahon J.A., McMahon A.P.
Genes Dev. 4:2319-2332(1990) [PubMed: 2279700] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."
Tanaka K., Okabayashi H., Asashima M., Perrimon N., Kadowaki T.
Eur. J. Biochem. 267:4300-4311(2000) [PubMed: 10866835] [Abstract]
Cited for: INTERACTION WITH PORCN.
+Additional computationally mapped references.

Cross-references

Sequence databases

M89797 mRNA. Translation: AAA40566.1.
IPIIPI00131373.
PIRC36470.
RefSeqNP_033549.1.
UniGeneMm.20355

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP22724. 1 interaction.

Genome annotation databases

EnsemblENSMUSG00000036856. Mus musculus. [Contig view]
GeneID22417.
KEGGmmu:22417.

Organism-specific databases

MGIMGI:98957. Wnt4.

Phylogenomic databases

HOGENOMP22724.
HOVERGENP22724.
OMAP22724. SHMRVEC.

Gene expression databases

ArrayExpressP22724.
BgeeP22724.
CleanExMM_WNT4.
GermOnlineENSMUSG00000036856. Mus musculus.

Family and domain databases

InterProIPR009142. Wnt4.
IPR005816. Wnt_grthfactor.
IPR018161. Wnt_grthfactor_CS.
IPR005817. Wnt_SF.
[Graphical view]
PANTHERPTHR12027. Wnt. 1 hit.
PTHR12027:SF19. Wnt4. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01844. WNT4PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio302837.
SOURCESearch...

Entry information

Entry nameWNT4_MOUSE
AccessionPrimary (citable) accession number: P22724
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents