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Protein

Gamma-aminobutyric acid receptor subunit gamma-2

Gene

Gabrg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.1 Publication

Miscellaneous

This subunit carries the benzodiazepine binding site.

GO - Molecular functioni

  • chloride channel activity Source: UniProtKB
  • extracellular ligand-gated ion channel activity Source: InterPro
  • GABA-A receptor activity Source: MGI

GO - Biological processi

  • adult behavior Source: MGI
  • cellular response to histamine Source: UniProtKB
  • chemical synaptic transmission Source: MGI
  • chloride transmembrane transport Source: UniProtKB
  • gamma-aminobutyric acid signaling pathway Source: MGI
  • post-embryonic development Source: MGI

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-MMU-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-2
Alternative name(s):
GABA(A) receptor subunit gamma-2
Gene namesi
Name:Gabrg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95623 Gabrg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 272ExtracellularCuratedAdd BLAST234
Transmembranei273 – 295HelicalCuratedAdd BLAST23
Transmembranei299 – 321HelicalCuratedAdd BLAST23
Transmembranei333 – 355HelicalCuratedAdd BLAST23
Topological domaini356 – 450CytoplasmicCuratedAdd BLAST95
Transmembranei451 – 474HelicalCuratedAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2094133

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000000047839 – 474Gamma-aminobutyric acid receptor subunit gamma-2Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi189 ↔ 203By similarity
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei381Phosphoserine; by PKCCurated1

Post-translational modificationi

Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP22723
PaxDbiP22723
PeptideAtlasiP22723
PRIDEiP22723

PTM databases

iPTMnetiP22723
PhosphoSitePlusiP22723
SwissPalmiP22723

Expressioni

Tissue specificityi

Expressed in brain neurons (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000020436
ExpressionAtlasiP22723 baseline and differential
GenevisibleiP22723 MM

Interactioni

Subunit structurei

Interacts with GABARAP (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:18281286). Interacts with KIF21B (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi199808, 3 interactors
DIPiDIP-48995N
IntActiP22723, 1 interactor
STRINGi10090.ENSMUSP00000063812

Structurei

3D structure databases

ProteinModelPortaliP22723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiP22723
KOiK05186
OMAiYPGFTSQ
OrthoDBiEOG091G0805
PhylomeDBiP22723
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR005439 GABBAg2_rcpt
IPR005437 GABBAg_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01620 GABAARGAMMA
PR01622 GABAARGAMMA2
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2L (identifier: P22723-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPNTWSIG SSVYSPVFSQ KMTLWILLLL SLYPGFTSQK SDDDYEDYAS
60 70 80 90 100
NKTWVLTPKV PEGDVTVILN NLLEGYDNKL RPDIGVKPTL IHTDMYVNSI
110 120 130 140 150
GPVNAINMEY TIDIFFAQTW YDRRLKFNST IKVLRLNSNM VGKIWIPDTF
160 170 180 190 200
FRNSKKADAH WITTPNRMLR IWNDGRVLYT LRLTIDAECQ LQLHNFPMDE
210 220 230 240 250
HSCPLEFSSY GYPREEIVYQ WKRSSVEVGD TRSWRLYQFS FVGLRNTTEV
260 270 280 290 300
VKTTSGDYVV MSVYFDLSRR MGYFTIQTYI PCTLIVVLSW VSFWINKDAV
310 320 330 340 350
PARTSLGITT VLTMTTLSTI ARKSLPKVSY VTAMDLFVSV CFIFVFSALV
360 370 380 390 400
EYGTLHYFVS NRKPSKDKDK KKKNPLLRMF SFKAPTIDIR PRSATIQMNN
410 420 430 440 450
ATHLQERDEE YGYECLDGKD CASFFCCFED CRTGAWRHGR IHIRIAKMDS
460 470
YARIFFPTAF CLFNLVYWVS YLYL
Length:474
Mass (Da):55,099
Last modified:March 27, 2002 - v3
Checksum:i45BD61649C296EA9
GO
Isoform 2S (identifier: P22723-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-383: Missing.

Show »
Length:466
Mass (Da):54,075
Checksum:i670A0E228975A4AE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti49A → T in strain: DBA/2J. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000091376 – 383Missing in isoform 2S. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86572 mRNA Translation: AAB59635.1
M62374 mRNA Translation: AAA37653.1
AF233775 mRNA Translation: AAK71573.1
AF233776 mRNA Translation: AAK71574.1
AF233777 mRNA Translation: AAK71575.1
AF233778 mRNA Translation: AAK71576.1
AF233779 mRNA Translation: AAK71577.1
AF233780 mRNA Translation: AAK71578.1
AF233781 mRNA Translation: AAK71579.1
AF233782 mRNA Translation: AAK71580.1
AF233783 mRNA Translation: AAK71581.1
AF233784 mRNA Translation: AAK71582.1
AF233785 mRNA Translation: AAK71583.1
AF233786 mRNA Translation: AAK71584.1
AF233787 mRNA Translation: AAK71585.1
AF233788 mRNA Translation: AAK71586.1
AF233789 mRNA Translation: AAK71587.1
AF233790 mRNA Translation: AAK71588.1
AF233791 mRNA Translation: AAK71589.1
AF233792 mRNA Translation: AAK71590.1
AF233793 mRNA Translation: AAK71591.1
AF233794 mRNA Translation: AAK71592.1
AF233795 mRNA Translation: AAK71593.1
AF233796 mRNA Translation: AAK71594.1
AF233797 mRNA Translation: AAK71595.1
AF233798 mRNA Translation: AAK71596.1
AF233799 mRNA Translation: AAK71597.1
AF233800 mRNA Translation: AAK71598.1
AF233801 mRNA Translation: AAK71599.1
AF233802 mRNA Translation: AAK71600.1
BC031762 mRNA Translation: AAH31762.1
CCDSiCCDS24551.1 [P22723-1]
CCDS24552.2 [P22723-2]
PIRiJH0316
JH0317
RefSeqiNP_032099.1, NM_008073.3 [P22723-1]
NP_803127.3, NM_177408.6 [P22723-2]
UniGeneiMm.5309

Genome annotation databases

EnsembliENSMUST00000070725; ENSMUSP00000064739; ENSMUSG00000020436 [P22723-2]
ENSMUST00000070735; ENSMUSP00000063812; ENSMUSG00000020436 [P22723-1]
GeneIDi14406
KEGGimmu:14406
UCSCiuc007imb.2 mouse [P22723-1]
uc007imc.3 mouse [P22723-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGBRG2_MOUSE
AccessioniPrimary (citable) accession number: P22723
Secondary accession number(s): Q91V50, Q91VA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 27, 2002
Last modified: March 28, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health