Reviewed, UniProtKB/Swiss-Prot P22714 (GAL7_SALTY)

Names and origin

Protein names

Recommended name:
    Galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	STM0775

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Galactose-1-phosphate uridylyltransferase		PRO_0000169896
Sites
	Active site	166	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	52	1	Zinc By similarity
	Metal binding	55	1	Zinc By similarity
	Metal binding	115	1	Zinc By similarity
	Metal binding	164	1	Zinc By similarity
	Metal binding	182	1	Iron By similarity
	Metal binding	281	1	Iron By similarity
	Metal binding	296	1	Iron By similarity
	Metal binding	298	1	Iron By similarity
Experimental info
	Sequence conflict	31	1	Missing in AAA27112. Ref.1
	Sequence conflict	180	1	E → AE Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P22714-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 2D2CA786668A178E	FASTA	348	39,675
	10 20 30 40 50 60 MTPFNPIDHP HRRYNPLTGQ WVLVSPHRAK RPWQGAQETP SQQMLPAHDP DCFLCAGNTR 70 80 90 100 110 120 VTGDKNPDYK GTYVFTNDFA ALMADTPDAP DSHDPLMRCQ SARGTSRVIC FSPDHSKTLP 130 140 150 160 170 180 ELSLPALTEI VRTWQTQTAE LGKTYPWVQV FENKGAAMGC SNPHPHGQVW ANSFLPNEAE 190 200 210 220 230 240 REDRLQKAYF AEQRSPMLVD YVQRELADGS RTVVETEHWL AVVPYWAAWP FETLLLPKTH 250 260 270 280 290 300 VLRITDLSDE QRDSLALALK KLTSRYDNLF QCSFPYSMGW HGAPFNGEEN AHWQLHAHFY 310 320 330 340 PPLLRSATVR KFMVGYEMLA ETQRDLTAEQ AAERLRAVSD IHFRESGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and physical and functional characterization of the Salmonella typhimurium and Salmonella typhi galactose utilization operons." Houng H.S.H., Kopecko D.J., Baron L.S. J. Bacteriol. 172:4392-4398(1990) [PubMed: 2198256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M33681 Genomic DNA. Translation: AAA27112.1. AE008731 Genomic DNA. Translation: AAL19713.1.
PIR	B37760.
RefSeq	NP_459754.1.
3D structure databases
HSSP	HSSP built from PDB template 1HXP based on UniProtKB P09148.
SMR	P22714. Positions 2-348.
ModBase	Search...
Genome annotation databases
GeneID	1252295.
GenomeReviews	Gene locus STM0775 in contig AE006468_GR.
KEGG	stm:STM0775.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P22714.
OMA	P22714. DHWQLHA.
Enzyme and pathway databases
BioCyc	STYP99287:STM0775-MON.
BRENDA	2.7.7.12. 2.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
ProDom	PD005051. GalP_Utransf. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00209. galT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_SALTY

Accession

Primary (citable) accession number: P22714

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	January 23, 2002
Last modified:	June 16, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)