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P22714 (GAL7_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12
Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase
Gene names
Name:galT
Ordered Locus Names:STM0775
OrganismSalmonella typhimurium
Taxonomic identifier90371 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Pathway

Carbohydrate metabolism; galactose metabolism.

Sequence similarities

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Galactose-1-phosphate uridylyltransferase
PRO_0000169896

Sites

Active site1661Tele-UMP-histidine intermediate By similarity
Metal binding521Zinc By similarity
Metal binding551Zinc By similarity
Metal binding1151Zinc By similarity
Metal binding1641Zinc By similarity
Metal binding1821Iron By similarity
Metal binding2811Iron By similarity
Metal binding2961Iron By similarity
Metal binding2981Iron By similarity

Experimental info

Sequence conflict311Missing in AAA27112. Ref.1
Sequence conflict1801E → AE Ref.1

Sequences

Sequence LengthMass (Da)Tools
P22714 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: 2D2CA786668A178E

FASTA34839,675
        10         20         30         40         50         60 
MTPFNPIDHP HRRYNPLTGQ WVLVSPHRAK RPWQGAQETP SQQMLPAHDP DCFLCAGNTR 

        70         80         90        100        110        120 
VTGDKNPDYK GTYVFTNDFA ALMADTPDAP DSHDPLMRCQ SARGTSRVIC FSPDHSKTLP 

       130        140        150        160        170        180 
ELSLPALTEI VRTWQTQTAE LGKTYPWVQV FENKGAAMGC SNPHPHGQVW ANSFLPNEAE 

       190        200        210        220        230        240 
REDRLQKAYF AEQRSPMLVD YVQRELADGS RTVVETEHWL AVVPYWAAWP FETLLLPKTH 

       250        260        270        280        290        300 
VLRITDLSDE QRDSLALALK KLTSRYDNLF QCSFPYSMGW HGAPFNGEEN AHWQLHAHFY 

       310        320        330        340 
PPLLRSATVR KFMVGYEMLA ETQRDLTAEQ AAERLRAVSD IHFRESGV

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and physical and functional characterization of the Salmonella typhimurium and Salmonella typhi galactose utilization operons."
Houng H.S.H., Kopecko D.J., Baron L.S.
J. Bacteriol. 172:4392-4398(1990) [PubMed: 2198256] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed: 11677609] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M33681 Genomic DNA. Translation: AAA27112.1.
AE006468 Genomic DNA. Translation: AAL19713.1.
PIRB37760.
RefSeqNP_459754.1. NC_003197.1.

3D structure databases

ProteinModelPortalP22714.
SMRP22714. Positions 2-348.
ModBaseSearch...

Proteomic databases

PRIDEP22714.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1252295.
GenomeReviewsGene locus STM0775 in contig AE006468_GR.
KEGGstm:STM0775.
PATRIC32379920. VBISalEnt20916_0808.

Phylogenomic databases

HOGENOMHBG600409.
OMAGIHQAPL.
ProtClustDBPRK11720.

Enzyme and pathway databases

BioCycSTYP99287:STM0775-MONOMER.

Family and domain databases

InterProIPR001937. GalP_UDPtransf1.
IPR019779. GalP_UDPtransf1_His-AS.
IPR005850. GalP_Utransf_C.
IPR005849. GalP_Utransf_N.
IPR011146. His_triad-like_motif.
IPR011151. His_triad_motif.
[Graphical view]
Gene3DG3DSA:3.30.428.10. His_triad_motif. 2 hits.
KOK00965.
PANTHERPTHR11943. GalP_UDPtransf1. 1 hit.
PfamPF02744. GalP_UDP_tr_C. 1 hit.
PF01087. GalP_UDP_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000808. GalT. 1 hit.
SUPFAMSSF54197. His_triad-like_motif. 2 hits.
TIGRFAMsTIGR00209. GalT_1. 1 hit.
PROSITEPS00117. GAL_P_UDP_TRANSF_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGAL7_SALTY
AccessionPrimary (citable) accession number: P22714
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2002
Last modified: January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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