Reviewed, UniProtKB/Swiss-Prot P22713 (GAL1_SALTY)

Names and origin

Protein names

Recommended name:
    Galactokinase
    EC=2.7.1.6
Alternative name(s):
    Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	STM0774

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate phosphorylation Inferred from electronic annotation. Source: InterPro galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP galactokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Galactokinase HAMAP MF_00246		PRO_0000184622
Regions
	Nucleotide binding	122 – 132	11	ATP Potential
Experimental info
	Sequence conflict	6 – 9	4	KTRA → NASR in AAA27113. Ref.1
	Sequence conflict	105	1	Q → L in AAA27113. Ref.1
	Sequence conflict	119	1	Missing in AAA27113. Ref.1
	Sequence conflict	151	1	Missing in AAA27113. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P22713-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 754143671EAF2E8F	FASTA	382	41,302
	10 20 30 40 50 60 MNLKEKTRAL FAEIFGYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY QTVISCAPRD 70 80 90 100 110 120 DRTVRVIAAD YDNQVDEFSL DAPIVTHDSQ QWSNYVRGVV KHLQQRNNAF GGVDMVISGN 130 140 150 160 170 180 VPQGAGLSSS ASLEVAVGTV FQQLYHLPLD GAQIALNGQE AENQFVGCNC GIMDQLISAL 190 200 210 220 230 240 GKKDHALLID CRTLGAKAVS MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP 250 260 270 280 290 300 ALRDVSLEAF NAVASELDPV VAKRVRHVLS ENARTVEAAS ALEKGDLQRM GQLMAESHAS 310 320 330 340 350 360 MRDDFEITVP QIDTLVDIVK ATIGDRGGVR MTGGGFGGCV VALIPEDLVP AVRQAVAQQY 370 380 EAKTGIKETF YVCKPSQGAG QC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and physical and functional characterization of the Salmonella typhimurium and Salmonella typhi galactose utilization operons." Houng H.S.H., Kopecko D.J., Baron L.S. J. Bacteriol. 172:4392-4398(1990) [PubMed: 2198256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M33681 Genomic DNA. Translation: AAA27113.1. AE008731 Genomic DNA. Translation: AAL19712.1.
PIR	C37760.
RefSeq	NP_459753.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1252294.
GenomeReviews	Gene locus STM0774 in contig AE006468_GR.
KEGG	stm:STM0774.
NMPDR	fig|99287.1.peg.741.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P22713.
OMA	P22713. YNDGFVM.
Enzyme and pathway databases
BioCyc	STYP99287:STM0774-MON.
BRENDA	2.7.1.6. 2.
Family and domain databases
HAMAP	MF_00246. [Tree]
InterPro	IPR000705. Galactokinase. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal_bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00131. gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_SALTY

Accession

Primary (citable) accession number: P22713

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	January 23, 2002
Last modified:	June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)