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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:alr1594
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11311131DNA-directed RNA polymerase subunit betaPRO_0000047854Add
BLAST

Proteomic databases

PRIDEiP22703.

Interactioni

Subunit structurei

In cyanobacteria the RNAP catalytic core is composed of 2 alpha, 1 beta, 1 beta', 1 gamma and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi103690.alr1594.

Structurei

3D structure databases

ProteinModelPortaliP22703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKKFNQVD KGRGMISENY IEPAFLLPDL IEIQRSSFRW FLEEGLIEEL
60 70 80 90 100
NSFSPITDYT GKLELHFLGH NYKLKEPKYS VEEAKRRDST YAVQMYVPTR
110 120 130 140 150
LLNKETGDIK EQEVFIGDLP LMTDRGTFII NGAERVIVNQ IVRSPGVYYK
160 170 180 190 200
SEIDKNGRRT YSASLIPNRG AWLKFETDRN DLVWVRIDKT RKLSAQVLLK
210 220 230 240 250
ALGLSDNEIF DALRHPEYFQ KTIEKEGQFS EEEALMELYR KLRPGEPPTV
260 270 280 290 300
LGGQQLLDSR FFDPKRYDLG RVGRYKLNKK LRLSVPDTVR VLTSGDILAA
310 320 330 340 350
VDYLINLEYD IGSIDDIDHL GNRRVRSVGE LLQNQVRVGL NRLERIIRER
360 370 380 390 400
MTVSDAEVLT PASLVNPKPL VAAIKEFFGS SQLSQFMDQT NPLAELTHKR
410 420 430 440 450
RLSALGPGGL TRERAGFAVR DIHPSHYGRI CPIETPEGPN AGLIGSLATH
460 470 480 490 500
ARVNQYGFLE TPFRPVENGR VRFDQPAAYM TADEEDDLRV APGDIPVDEN
510 520 530 540 550
GYIIGPQVPV RYRQEFSTTT PEQVDYVAVS PVQIVSVATS MIPFLEHDDA
560 570 580 590 600
NRALMGSNMQ RQAVPLLKPE RPLVGTGLEA QGARDSGMVI VSRTDGDVVY
610 620 630 640 650
VDATEIRVRV SGQLPTASGK STDNGQLTSQ KGQEIRYTVS KYQRSNQDTC
660 670 680 690 700
LNQKPLVRIG ERVVAGQVLA DGSSTEGGEL ALGQNIVVAY MPWEGYNYED
710 720 730 740 750
AILISERLVQ DDIYTSIHIE KYEIEARQTK LGPEEITREI PNVGEDALRQ
760 770 780 790 800
LDEQGIIRIG AWVEAGDILV GKVTPKGESD QPPEEKLLRA IFGEKARDVR
810 820 830 840 850
DNSLRVPNGE KGRVVDVRLF TREQGDELPP GANMVVRVYV AQKRKIQVGD
860 870 880 890 900
KMAGRHGNKG IISRILPIED MPYLPDGSPV DIVLNPLGVP SRMNVGQVFE
910 920 930 940 950
CLLGWAGHTL GVRFKITPFD EMYGEESSRR IVHGKLQEAR DETGKDWVYN
960 970 980 990 1000
PDDPGKIMVY DGRTGEAFDR PVTIGVAYML KLVHLVDDKI HARSTGPYSL
1010 1020 1030 1040 1050
VTQQPLGGKA QQGGQRFGEM EVWALEAFGA AYTLQELLTV KSDDMQGRNE
1060 1070 1080 1090 1100
ALNAIVKGKA IPRPGTPESF KVLMRELQSL GLDIAVHKVE TQADGSSLDV
1110 1120 1130
EVDLMADQLA RRTPPRPTYE SLSRESLDDD E
Length:1,131
Mass (Da):126,525
Last modified:January 23, 2002 - v2
Checksum:i7AB6E1D28199FFD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB77960.1.
M60831 Genomic DNA. Translation: AAA22032.1.
PIRiA42361.
AD2005.

Genome annotation databases

EnsemblBacteriaiBAB77960; BAB77960; BAB77960.
KEGGiana:alr1594.
PATRICi22773218. VBINosSp37423_2089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000019 Genomic DNA. Translation: BAB77960.1.
M60831 Genomic DNA. Translation: AAA22032.1.
PIRiA42361.
AD2005.

3D structure databases

ProteinModelPortaliP22703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr1594.

Proteomic databases

PRIDEiP22703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB77960; BAB77960; BAB77960.
KEGGiana:alr1594.
PATRICi22773218. VBINosSp37423_2089.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiPOG091H01MI.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 1 hit.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 2 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_NOSS1
AccessioniPrimary (citable) accession number: P22703
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: January 23, 2002
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.