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Protein

Endoglucanase

Gene

celA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May digest the spore cell wall during germination, to release the enclosed amoeba.1 Publication

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei390By similarity1
Active sitei428By similarity1
Active sitei437By similarity1

GO - Molecular functioni

  • cellulase activity Source: dictyBase
  • cellulose binding Source: dictyBase

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation, Sporulation

Protein family/group databases

CAZyiCBM8 Carbohydrate-Binding Module Family 8
GH9 Glycoside Hydrolase Family 9

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Spore germination protein 270-6
Gene namesi
Name:celA
ORF Names:DDB_G0271134
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0271134 celA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000795324 – 705EndoglucanaseAdd BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP22699

Expressioni

Developmental stagei

Found predominantly during early stages of spore germination.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0215351

Structurei

3D structure databases

ProteinModelPortaliP22699
SMRiP22699
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni463 – 552Pro/Thr repeats ("hinge") (Pro/Thr box)Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXW Eukaryota
ENOG410XPC9 LUCA
InParanoidiP22699
KOiK01179
OMAiSNSGYND
PhylomeDBiP22699

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001701 Glyco_hydro_9
IPR033126 Glyco_hydro_9_Asp/Glu_AS
IPR018221 Glyco_hydro_9_His_AS
PfamiView protein in Pfam
PF00759 Glyco_hydro_9, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00592 GLYCOSYL_HYDROL_F9_1, 1 hit
PS00698 GLYCOSYL_HYDROL_F9_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22699-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILKNCILL IIFGLLSTQL INADTDYCSL LENALMFYKM NRAGRLPDND
60 70 80 90 100
IPWRGNSALN DASPNSAKDA NGDGNLSGGY FDAGDGVKFG LPMAYSMTML
110 120 130 140 150
GWSFIEYESN IAQCGLTSLY LDTIKYGTDW LIAAHTADNE FAGQVGDGNV
160 170 180 190 200
DHSWWGPPED MTMARPTYML TTEAPGTEIA MEAASALAAA SIAFKSSNPT
210 220 230 240 250
YAATCLAHAK TLHNFGYTYR GVYSDSITNA QAFYNSWSGY KDDLVWGSIW
260 270 280 290 300
LYKATQDSDY LTKAVADYAS GGVGGMAQGN SHDWDNKAPG CCLLLSKLVP
310 320 330 340 350
TTSTYKTDFE GWLNYWLPGG GVTYTPGGLA WIRQWGPARY AATAAFLGSL
360 370 380 390 400
AGTEKGTDFT QKQVDYLIGN NPNQQSFVVG MGPNYPINPH HRAAHHSTTN
410 420 430 440 450
DINNPVNNLY LLKGALVGGP GSNDEYTDDR TDYISNEVAT DYNAGFVGAL
460 470 480 490 500
ASLVNPSSTS VPTTTPTVTE TPTETPTETP TETPTETPTE TPTETPTETP
510 520 530 540 550
TETPTETPTE TPTETPTETP TETPTETPTE TPTETPTETV TPTPTVTPTE
560 570 580 590 600
TPSSGESLSI YKSGLKNDFQ DWSWGEHSLT DTTNVESGET NSISFTPKAY
610 620 630 640 650
GAVFLGCFEC IDTDTYNNIE FDINGGSSGA QLLRITVVKN SKSVGSKLIT
660 670 680 690 700
DLNGGTPIEA NSWTKIKASF IDDFKVSGKV DGIWIQDIKG DTQSTVYISN

IIATA
Length:705
Mass (Da):75,911
Last modified:August 1, 1991 - v1
Checksum:iF0457BDC07576A15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33861 Genomic DNA Translation: AAA52077.1
AAFI02000006 Genomic DNA Translation: EAL71697.1
PIRiA35621
RefSeqiXP_645627.1, XM_640535.1

Genome annotation databases

EnsemblProtistsiEAL71697; EAL71697; DDB_G0271134
GeneIDi8617819
KEGGiddi:DDB_G0271134

Similar proteinsi

Entry informationi

Entry nameiGUN6_DICDI
AccessioniPrimary (citable) accession number: P22699
Secondary accession number(s): Q55BI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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