ID   CALB2_HUMAN             Reviewed;         271 AA.
AC   P22676; A8K4Y1; Q53HD2; Q96BK4;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   25-JAN-2012, entry version 104.
DE   RecName: Full=Calretinin;
DE            Short=CR;
DE   AltName: Full=29 kDa calbindin;
GN   Name=CALB2; Synonyms=CAB29;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90144185; PubMed=2618861;
RA   Parmentier M.;
RT   "The human calbindins: cDNA and gene cloning.";
RL   Adv. Exp. Med. Biol. 255:233-240(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   MEDLINE=91160569; PubMed=2001709;
RX   DOI=10.1111/j.1432-1033.1991.tb15788.x;
RA   Parmentier M., Lefort A.;
RT   "Structure of the human brain calcium-binding protein calretinin and
RT   its expression in bacteria.";
RL   Eur. J. Biochem. 196:79-85(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Adipose tissue, and Cerebellum;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Calretinin is a calcium-binding protein which is
CC       abundant in auditory neurons.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the calbindin family.
CC   -!- SIMILARITY: Contains 6 EF-hand domains.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Calbindin entry;
CC       URL="http://en.wikipedia.org/wiki/Calbindin";
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DR   EMBL; X56667; CAA39991.1; -; mRNA.
DR   EMBL; X56668; CAA39992.1; -; Genomic_DNA.
DR   EMBL; AK291096; BAF83785.1; -; mRNA.
DR   EMBL; AK222495; BAD96215.1; -; mRNA.
DR   EMBL; AK222648; BAD96368.1; -; mRNA.
DR   EMBL; BC015484; AAH15484.1; -; mRNA.
DR   IPI; IPI00027264; -.
DR   PIR; S14109; A60253.
DR   RefSeq; NP_001731.2; NM_001740.4.
DR   RefSeq; NP_009019.1; NM_007088.3.
DR   UniGene; Hs.106857; -.
DR   ProteinModelPortal; P22676; -.
DR   SMR; P22676; 10-269.
DR   STRING; P22676; -.
DR   PhosphoSite; P22676; -.
DR   DMDM; 109940061; -.
DR   REPRODUCTION-2DPAGE; IPI00027264; -.
DR   PRIDE; P22676; -.
DR   Ensembl; ENST00000302628; ENSP00000307508; ENSG00000172137.
DR   GeneID; 794; -.
DR   KEGG; hsa:794; -.
DR   NMPDR; fig|9606.3.peg.12526; -.
DR   UCSC; uc002faa.2; human.
DR   CTD; 794; -.
DR   GeneCards; GC16P071392; -.
DR   H-InvDB; HIX0013209; -.
DR   HGNC; HGNC:1435; CALB2.
DR   HPA; CAB000106; -.
DR   HPA; HPA007305; -.
DR   HPA; HPA007306; -.
DR   MIM; 114051; gene.
DR   neXtProt; NX_P22676; -.
DR   eggNOG; prNOG18489; -.
DR   GeneTree; ENSGT00390000013118; -.
DR   HOGENOM; HBG444505; -.
DR   HOVERGEN; HBG000855; -.
DR   InParanoid; P22676; -.
DR   OMA; SSTEFME; -.
DR   OrthoDB; EOG48SGTQ; -.
DR   PhylomeDB; P22676; -.
DR   NextBio; 3222; -.
DR   ArrayExpress; P22676; -.
DR   Bgee; P22676; -.
DR   CleanEx; HS_CALB2; -.
DR   Genevestigator; P22676; -.
DR   GermOnline; ENSG00000172137; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR018248; EF-hand.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR002048; EF_hand_Ca-bd.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 2.
DR   Pfam; PF00036; efhand; 1.
DR   SMART; SM00054; EFh; 5.
DR   PROSITE; PS00018; EF_HAND_1; 5.
DR   PROSITE; PS50222; EF_HAND_2; 5.
PE   1: Evidence at protein level;
KW   Calcium; Complete proteome; Reference proteome; Repeat.
FT   CHAIN         1    271       Calretinin.
FT                                /FTId=PRO_0000073479.
FT   DOMAIN       16     51       EF-hand 1.
FT   DOMAIN       63     98       EF-hand 2.
FT   DOMAIN      107    142       EF-hand 3.
FT   DOMAIN      151    186       EF-hand 4.
FT   DOMAIN      195    230       EF-hand 5.
FT   DOMAIN      235    270       EF-hand 6.
FT   CA_BIND      29     40       1 (Probable).
FT   CA_BIND      76     87       2; possibly ancestral (Probable).
FT   CA_BIND     120    131       3 (Probable).
FT   CA_BIND     164    175       4 (Probable).
FT   CA_BIND     208    219       5 (Probable).
FT   CA_BIND     251    262       6; possibly ancestral (Probable).
FT   CONFLICT    110    110       A -> T (in Ref. 5; AAH15484).
FT   CONFLICT    235    235       M -> I (in Ref. 2; CAA39991).
SQ   SEQUENCE   271 AA;  31540 MW;  98116AD706079DB9 CRC64;
     MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK
     SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD
     TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL
     PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL
     TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M
//