P22676 (CALB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calretinin
Short name=CR

Alternative name(s):
29 kDa calbindin

Gene names

Name:	CALB2
Synonyms:	CAB29

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calretinin is a calcium-binding protein which is abundant in auditory neurons.
Tissue specificity	Brain.
Sequence similarities	Belongs to the calbindin family. Contains 6 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA gap junction Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Calretinin		PRO_0000073479
Regions
	Domain	16 – 51	36	EF-hand 1
	Domain	63 – 98	36	EF-hand 2
	Domain	107 – 142	36	EF-hand 3
	Domain	151 – 186	36	EF-hand 4
	Domain	195 – 230	36	EF-hand 5
	Domain	235 – 270	36	EF-hand 6
	Calcium binding	29 – 40	12	1 Probable
	Calcium binding	76 – 87	12	2; possibly ancestral Probable
	Calcium binding	120 – 131	12	3 Probable
	Calcium binding	164 – 175	12	4 Probable
	Calcium binding	208 – 219	12	5 Probable
	Calcium binding	251 – 262	12	6; possibly ancestral Probable
Experimental info
	Sequence conflict	110	1	A → T in AAH15484. Ref.5
	Sequence conflict	235	1	M → I in CAA39991. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P22676 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 98116AD706079DB9	FASTA	271	31,540
	10 20 30 40 50 60 MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 70 80 90 100 110 120 SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 130 140 150 160 170 180 TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL 190 200 210 220 230 240 PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL 250 260 270 TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human calbindins: cDNA and gene cloning." Parmentier M. Adv. Exp. Med. Biol. 255:233-240(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of the human brain calcium-binding protein calretinin and its expression in bacteria." Parmentier M., Lefort A. Eur. J. Biochem. 196:79-85(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adipose tissue and Cerebellum.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.

Web resources

Wikipedia

Calbindin entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56667 mRNA. Translation: CAA39991.1. X56668 Genomic DNA. Translation: CAA39992.1. AK291096 mRNA. Translation: BAF83785.1. AK222495 mRNA. Translation: BAD96215.1. AK222648 mRNA. Translation: BAD96368.1. BC015484 mRNA. Translation: AAH15484.1.
IPI	IPI00027264.
PIR	A60253. S14109.
RefSeq	NP_001731.2. NM_001740.4. NP_009019.1. NM_007088.3.
UniGene	Hs.106857.
3D structure databases
ProteinModelPortal	P22676.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000307508.
PTM databases
PhosphoSite	P22676.
Polymorphism databases
DMDM	109940061.
2D gel databases
REPRODUCTION-2DPAGE	IPI00027264.
Proteomic databases
PaxDb	P22676.
PRIDE	P22676.
Protocols and materials databases
DNASU	794.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302628; ENSP00000307508; ENSG00000172137.
GeneID	794.
KEGG	hsa:794.
UCSC	uc002faa.4. human.
Organism-specific databases
CTD	794.
GeneCards	GC16P071392.
HGNC	HGNC:1435. CALB2.
HPA	CAB000106. HPA007305. HPA007306.
MIM	114051. gene.
neXtProt	NX_P22676.
PharmGKB	PA26027.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG299305.
HOGENOM	HOG000231866.
HOVERGEN	HBG000855.
InParanoid	P22676.
OMA	SSTEFME.
OrthoDB	EOG48SGTQ.
PhylomeDB	P22676.
Gene expression databases
ArrayExpress	P22676.
Bgee	P22676.
CleanEx	HS_CALB2.
Genevestigator	P22676.
GermOnline	ENSG00000172137. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. [Graphical view]
Pfam	PF13405. EF_hand_4. 1 hit. PF13499. EF_hand_5. 2 hits. [Graphical view]
SMART	SM00054. EFh. 5 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 5 hits. PS50222. EF_HAND_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	794.
NextBio	3222.
SOURCE	Search...

Entry information

Entry name

CALB2_HUMAN

Accession

Primary (citable) accession number: P22676
Secondary accession number(s): A8K4Y1, Q53HD2, Q96BK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.