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P22676 (CALB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calretinin

Short name=CR
Alternative name(s):
29 kDa calbindin
Gene names
Name:CALB2
Synonyms:CAB29
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Tissue specificity

Brain.

Sequence similarities

Belongs to the calbindin family.

Contains 6 EF-hand domains.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Metal-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcytosolic calcium ion homeostasis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay. Source: HPA

gap junction

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Calretinin
PRO_0000073479

Regions

Domain16 – 5136EF-hand 1
Domain63 – 9836EF-hand 2
Domain107 – 14236EF-hand 3
Domain151 – 18636EF-hand 4
Domain195 – 23036EF-hand 5
Domain235 – 27036EF-hand 6
Calcium binding29 – 40121 Probable
Calcium binding76 – 87122; possibly ancestral Probable
Calcium binding120 – 131123 Probable
Calcium binding164 – 175124 Probable
Calcium binding208 – 219125 Probable
Calcium binding251 – 262126; possibly ancestral Probable

Experimental info

Sequence conflict1101A → T in AAH15484. Ref.5
Sequence conflict2351M → I in CAA39991. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P22676 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: 98116AD706079DB9

FASTA27131,540
        10         20         30         40         50         60 
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 

        70         80         90        100        110        120 
SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 

       130        140        150        160        170        180 
TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL 

       190        200        210        220        230        240 
PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL 

       250        260        270 
TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M 

« Hide

References

« Hide 'large scale' references
[1]"The human calbindins: cDNA and gene cloning."
Parmentier M.
Adv. Exp. Med. Biol. 255:233-240(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the human brain calcium-binding protein calretinin and its expression in bacteria."
Parmentier M., Lefort A.
Eur. J. Biochem. 196:79-85(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adipose tissue and Cerebellum.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.

Web resources

Wikipedia

Calbindin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56667 mRNA. Translation: CAA39991.1.
X56668 Genomic DNA. Translation: CAA39992.1.
AK291096 mRNA. Translation: BAF83785.1.
AK222495 mRNA. Translation: BAD96215.1.
AK222648 mRNA. Translation: BAD96368.1.
BC015484 mRNA. Translation: AAH15484.1.
CCDSCCDS10899.1.
PIRA60253. S14109.
RefSeqNP_001731.2. NM_001740.4.
NP_009019.1. NM_007088.3.
UniGeneHs.106857.

3D structure databases

ProteinModelPortalP22676.
SMRP22676. Positions 10-267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107245. 1 interaction.
STRING9606.ENSP00000307508.

PTM databases

PhosphoSiteP22676.

Polymorphism databases

DMDM109940061.

2D gel databases

REPRODUCTION-2DPAGEIPI00027264.

Proteomic databases

MaxQBP22676.
PaxDbP22676.
PRIDEP22676.

Protocols and materials databases

DNASU794.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302628; ENSP00000307508; ENSG00000172137.
GeneID794.
KEGGhsa:794.
UCSCuc002faa.4. human.

Organism-specific databases

CTD794.
GeneCardsGC16P071392.
HGNCHGNC:1435. CALB2.
HPACAB000106.
HPA007305.
HPA007306.
MIM114051. gene.
neXtProtNX_P22676.
PharmGKBPA26027.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG299305.
HOGENOMHOG000231866.
HOVERGENHBG000855.
InParanoidP22676.
OMASSTEFME.
OrthoDBEOG71G9VB.
PhylomeDBP22676.
TreeFamTF325083.

Gene expression databases

ArrayExpressP22676.
BgeeP22676.
CleanExHS_CALB2.
GenevestigatorP22676.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 5 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCalretinin.
GenomeRNAi794.
NextBio3222.
PROP22676.
SOURCESearch...

Entry information

Entry nameCALB2_HUMAN
AccessionPrimary (citable) accession number: P22676
Secondary accession number(s): A8K4Y1, Q53HD2, Q96BK4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM