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P22676

- CALB2_HUMAN

UniProt

P22676 - CALB2_HUMAN

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Protein

Calretinin

Gene

CALB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi29 – 40121CuratedAdd
BLAST
Calcium bindingi76 – 87122; possibly ancestralCuratedAdd
BLAST
Calcium bindingi120 – 131123CuratedAdd
BLAST
Calcium bindingi164 – 175124CuratedAdd
BLAST
Calcium bindingi208 – 219125CuratedAdd
BLAST
Calcium bindingi251 – 262126; possibly ancestralCuratedAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl

GO - Biological processi

  1. cytosolic calcium ion homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calretinin
Short name:
CR
Alternative name(s):
29 kDa calbindin
Gene namesi
Name:CALB2
Synonyms:CAB29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1435. CALB2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. gap junction Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271CalretininPRO_0000073479Add
BLAST

Proteomic databases

MaxQBiP22676.
PaxDbiP22676.
PRIDEiP22676.

2D gel databases

REPRODUCTION-2DPAGEIPI00027264.

PTM databases

PhosphoSiteiP22676.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP22676.
CleanExiHS_CALB2.
ExpressionAtlasiP22676. baseline and differential.
GenevestigatoriP22676.

Organism-specific databases

HPAiCAB000106.
HPA007305.
HPA007306.

Interactioni

Protein-protein interaction databases

BioGridi107245. 5 interactions.
STRINGi9606.ENSP00000307508.

Structurei

3D structure databases

ProteinModelPortaliP22676.
SMRiP22676. Positions 10-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 9836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini107 – 14236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 18636EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 23036EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini235 – 27036EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calbindin family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299305.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP22676.
OMAiSSTEFME.
OrthoDBiEOG71G9VB.
PhylomeDBiP22676.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22676-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK
60 70 80 90 100
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL
110 120 130 140 150
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP
160 170 180 190 200
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF
210 220 230 240 250
NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL
260 270
AEAGKLYRKD LEIVLCSEPP M
Length:271
Mass (Da):31,540
Last modified:June 27, 2006 - v2
Checksum:i98116AD706079DB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101A → T in AAH15484. (PubMed:15489334)Curated
Sequence conflicti235 – 2351M → I in CAA39991. (PubMed:2001709)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56667 mRNA. Translation: CAA39991.1.
X56668 Genomic DNA. Translation: CAA39992.1.
AK291096 mRNA. Translation: BAF83785.1.
AK222495 mRNA. Translation: BAD96215.1.
AK222648 mRNA. Translation: BAD96368.1.
BC015484 mRNA. Translation: AAH15484.1.
CCDSiCCDS10899.1.
PIRiS14109. A60253.
RefSeqiNP_001731.2. NM_001740.4.
NP_009019.1. NM_007088.3.
UniGeneiHs.106857.

Genome annotation databases

EnsembliENST00000302628; ENSP00000307508; ENSG00000172137.
GeneIDi794.
KEGGihsa:794.
UCSCiuc002faa.4. human.

Polymorphism databases

DMDMi109940061.

Cross-referencesi

Web resourcesi

Wikipedia

Calbindin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56667 mRNA. Translation: CAA39991.1 .
X56668 Genomic DNA. Translation: CAA39992.1 .
AK291096 mRNA. Translation: BAF83785.1 .
AK222495 mRNA. Translation: BAD96215.1 .
AK222648 mRNA. Translation: BAD96368.1 .
BC015484 mRNA. Translation: AAH15484.1 .
CCDSi CCDS10899.1.
PIRi S14109. A60253.
RefSeqi NP_001731.2. NM_001740.4.
NP_009019.1. NM_007088.3.
UniGenei Hs.106857.

3D structure databases

ProteinModelPortali P22676.
SMRi P22676. Positions 10-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107245. 5 interactions.
STRINGi 9606.ENSP00000307508.

PTM databases

PhosphoSitei P22676.

Polymorphism databases

DMDMi 109940061.

2D gel databases

REPRODUCTION-2DPAGE IPI00027264.

Proteomic databases

MaxQBi P22676.
PaxDbi P22676.
PRIDEi P22676.

Protocols and materials databases

DNASUi 794.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302628 ; ENSP00000307508 ; ENSG00000172137 .
GeneIDi 794.
KEGGi hsa:794.
UCSCi uc002faa.4. human.

Organism-specific databases

CTDi 794.
GeneCardsi GC16P071392.
HGNCi HGNC:1435. CALB2.
HPAi CAB000106.
HPA007305.
HPA007306.
MIMi 114051. gene.
neXtProti NX_P22676.
PharmGKBi PA26027.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299305.
GeneTreei ENSGT00390000013118.
HOGENOMi HOG000231866.
HOVERGENi HBG000855.
InParanoidi P22676.
OMAi SSTEFME.
OrthoDBi EOG71G9VB.
PhylomeDBi P22676.
TreeFami TF325083.

Miscellaneous databases

GeneWikii Calretinin.
GenomeRNAii 794.
NextBioi 3222.
PROi P22676.
SOURCEi Search...

Gene expression databases

Bgeei P22676.
CleanExi HS_CALB2.
ExpressionAtlasi P22676. baseline and differential.
Genevestigatori P22676.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
PANTHERi PTHR19972:SF4. PTHR19972:SF4. 1 hit.
Pfami PF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 5 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human calbindins: cDNA and gene cloning."
    Parmentier M.
    Adv. Exp. Med. Biol. 255:233-240(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the human brain calcium-binding protein calretinin and its expression in bacteria."
    Parmentier M., Lefort A.
    Eur. J. Biochem. 196:79-85(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue and Cerebellum.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiCALB2_HUMAN
AccessioniPrimary (citable) accession number: P22676
Secondary accession number(s): A8K4Y1, Q53HD2, Q96BK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3