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P22676

- CALB2_HUMAN

UniProt

P22676 - CALB2_HUMAN

Protein

Calretinin

Gene

CALB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Calretinin is a calcium-binding protein which is abundant in auditory neurons.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi29 – 40121CuratedAdd
    BLAST
    Calcium bindingi76 – 87122; possibly ancestralCuratedAdd
    BLAST
    Calcium bindingi120 – 131123CuratedAdd
    BLAST
    Calcium bindingi164 – 175124CuratedAdd
    BLAST
    Calcium bindingi208 – 219125CuratedAdd
    BLAST
    Calcium bindingi251 – 262126; possibly ancestralCuratedAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl

    GO - Biological processi

    1. cytosolic calcium ion homeostasis Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calretinin
    Short name:
    CR
    Alternative name(s):
    29 kDa calbindin
    Gene namesi
    Name:CALB2
    Synonyms:CAB29
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1435. CALB2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. gap junction Source: Ensembl
    3. nucleus Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26027.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271CalretininPRO_0000073479Add
    BLAST

    Proteomic databases

    MaxQBiP22676.
    PaxDbiP22676.
    PRIDEiP22676.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00027264.

    PTM databases

    PhosphoSiteiP22676.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    ArrayExpressiP22676.
    BgeeiP22676.
    CleanExiHS_CALB2.
    GenevestigatoriP22676.

    Organism-specific databases

    HPAiCAB000106.
    HPA007305.
    HPA007306.

    Interactioni

    Protein-protein interaction databases

    BioGridi107245. 1 interaction.
    STRINGi9606.ENSP00000307508.

    Structurei

    3D structure databases

    ProteinModelPortaliP22676.
    SMRiP22676. Positions 10-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini63 – 9836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini107 – 14236EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 18636EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 23036EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini235 – 27036EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the calbindin family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG299305.
    HOGENOMiHOG000231866.
    HOVERGENiHBG000855.
    InParanoidiP22676.
    OMAiSSTEFME.
    OrthoDBiEOG71G9VB.
    PhylomeDBiP22676.
    TreeFamiTF325083.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13405. EF-hand_6. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 5 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P22676-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK    50
    ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL 100
    CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP 150
    KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF 200
    NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL 250
    AEAGKLYRKD LEIVLCSEPP M 271
    Length:271
    Mass (Da):31,540
    Last modified:June 27, 2006 - v2
    Checksum:i98116AD706079DB9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101A → T in AAH15484. (PubMed:15489334)Curated
    Sequence conflicti235 – 2351M → I in CAA39991. (PubMed:2001709)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56667 mRNA. Translation: CAA39991.1.
    X56668 Genomic DNA. Translation: CAA39992.1.
    AK291096 mRNA. Translation: BAF83785.1.
    AK222495 mRNA. Translation: BAD96215.1.
    AK222648 mRNA. Translation: BAD96368.1.
    BC015484 mRNA. Translation: AAH15484.1.
    CCDSiCCDS10899.1.
    PIRiS14109. A60253.
    RefSeqiNP_001731.2. NM_001740.4.
    NP_009019.1. NM_007088.3.
    UniGeneiHs.106857.

    Genome annotation databases

    EnsembliENST00000302628; ENSP00000307508; ENSG00000172137.
    GeneIDi794.
    KEGGihsa:794.
    UCSCiuc002faa.4. human.

    Polymorphism databases

    DMDMi109940061.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Calbindin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56667 mRNA. Translation: CAA39991.1 .
    X56668 Genomic DNA. Translation: CAA39992.1 .
    AK291096 mRNA. Translation: BAF83785.1 .
    AK222495 mRNA. Translation: BAD96215.1 .
    AK222648 mRNA. Translation: BAD96368.1 .
    BC015484 mRNA. Translation: AAH15484.1 .
    CCDSi CCDS10899.1.
    PIRi S14109. A60253.
    RefSeqi NP_001731.2. NM_001740.4.
    NP_009019.1. NM_007088.3.
    UniGenei Hs.106857.

    3D structure databases

    ProteinModelPortali P22676.
    SMRi P22676. Positions 10-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107245. 1 interaction.
    STRINGi 9606.ENSP00000307508.

    PTM databases

    PhosphoSitei P22676.

    Polymorphism databases

    DMDMi 109940061.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00027264.

    Proteomic databases

    MaxQBi P22676.
    PaxDbi P22676.
    PRIDEi P22676.

    Protocols and materials databases

    DNASUi 794.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302628 ; ENSP00000307508 ; ENSG00000172137 .
    GeneIDi 794.
    KEGGi hsa:794.
    UCSCi uc002faa.4. human.

    Organism-specific databases

    CTDi 794.
    GeneCardsi GC16P071392.
    HGNCi HGNC:1435. CALB2.
    HPAi CAB000106.
    HPA007305.
    HPA007306.
    MIMi 114051. gene.
    neXtProti NX_P22676.
    PharmGKBi PA26027.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299305.
    HOGENOMi HOG000231866.
    HOVERGENi HBG000855.
    InParanoidi P22676.
    OMAi SSTEFME.
    OrthoDBi EOG71G9VB.
    PhylomeDBi P22676.
    TreeFami TF325083.

    Miscellaneous databases

    GeneWikii Calretinin.
    GenomeRNAii 794.
    NextBioi 3222.
    PROi P22676.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P22676.
    Bgeei P22676.
    CleanExi HS_CALB2.
    Genevestigatori P22676.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13405. EF-hand_6. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 5 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human calbindins: cDNA and gene cloning."
      Parmentier M.
      Adv. Exp. Med. Biol. 255:233-240(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of the human brain calcium-binding protein calretinin and its expression in bacteria."
      Parmentier M., Lefort A.
      Eur. J. Biochem. 196:79-85(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue and Cerebellum.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiCALB2_HUMAN
    AccessioniPrimary (citable) accession number: P22676
    Secondary accession number(s): A8K4Y1, Q53HD2, Q96BK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3