Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calretinin

Gene

CALB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Calretinin is a calcium-binding protein which is abundant in auditory neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi29 – 40121CuratedAdd
BLAST
Calcium bindingi76 – 87122; possibly ancestralCuratedAdd
BLAST
Calcium bindingi120 – 131123CuratedAdd
BLAST
Calcium bindingi164 – 175124CuratedAdd
BLAST
Calcium bindingi208 – 219125CuratedAdd
BLAST
Calcium bindingi251 – 262126; possibly ancestralCuratedAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calretinin
Short name:
CR
Alternative name(s):
29 kDa calbindin
Gene namesi
Name:CALB2
Synonyms:CAB29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1435. CALB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26027.

Polymorphism and mutation databases

BioMutaiCALB2.
DMDMi109940061.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271CalretininPRO_0000073479Add
BLAST

Proteomic databases

MaxQBiP22676.
PaxDbiP22676.
PRIDEiP22676.

2D gel databases

REPRODUCTION-2DPAGEIPI00027264.

PTM databases

PhosphoSiteiP22676.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiP22676.
CleanExiHS_CALB2.
ExpressionAtlasiP22676. baseline and differential.
GenevestigatoriP22676.

Organism-specific databases

HPAiCAB000106.
HPA007305.
HPA007306.

Interactioni

Protein-protein interaction databases

BioGridi107245. 5 interactions.
STRINGi9606.ENSP00000307508.

Structurei

3D structure databases

ProteinModelPortaliP22676.
SMRiP22676. Positions 10-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 5136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 9836EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini107 – 14236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 18636EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 23036EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini235 – 27036EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calbindin family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299305.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP22676.
OMAiFLDIWKH.
OrthoDBiEOG71G9VB.
PhylomeDBiP22676.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK
60 70 80 90 100
ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL
110 120 130 140 150
CFRQHVGSSA EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP
160 170 180 190 200
KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF
210 220 230 240 250
NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL
260 270
AEAGKLYRKD LEIVLCSEPP M
Length:271
Mass (Da):31,540
Last modified:June 27, 2006 - v2
Checksum:i98116AD706079DB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101A → T in AAH15484 (PubMed:15489334).Curated
Sequence conflicti235 – 2351M → I in CAA39991 (PubMed:2001709).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56667 mRNA. Translation: CAA39991.1.
X56668 Genomic DNA. Translation: CAA39992.1.
AK291096 mRNA. Translation: BAF83785.1.
AK222495 mRNA. Translation: BAD96215.1.
AK222648 mRNA. Translation: BAD96368.1.
BC015484 mRNA. Translation: AAH15484.1.
CCDSiCCDS10899.1.
PIRiS14109. A60253.
RefSeqiNP_001731.2. NM_001740.4.
NP_009019.1. NM_007088.3.
UniGeneiHs.106857.

Genome annotation databases

EnsembliENST00000302628; ENSP00000307508; ENSG00000172137.
GeneIDi794.
KEGGihsa:794.
UCSCiuc002faa.4. human.

Cross-referencesi

Web resourcesi

Wikipedia

Calbindin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56667 mRNA. Translation: CAA39991.1.
X56668 Genomic DNA. Translation: CAA39992.1.
AK291096 mRNA. Translation: BAF83785.1.
AK222495 mRNA. Translation: BAD96215.1.
AK222648 mRNA. Translation: BAD96368.1.
BC015484 mRNA. Translation: AAH15484.1.
CCDSiCCDS10899.1.
PIRiS14109. A60253.
RefSeqiNP_001731.2. NM_001740.4.
NP_009019.1. NM_007088.3.
UniGeneiHs.106857.

3D structure databases

ProteinModelPortaliP22676.
SMRiP22676. Positions 10-267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107245. 5 interactions.
STRINGi9606.ENSP00000307508.

PTM databases

PhosphoSiteiP22676.

Polymorphism and mutation databases

BioMutaiCALB2.
DMDMi109940061.

2D gel databases

REPRODUCTION-2DPAGEIPI00027264.

Proteomic databases

MaxQBiP22676.
PaxDbiP22676.
PRIDEiP22676.

Protocols and materials databases

DNASUi794.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302628; ENSP00000307508; ENSG00000172137.
GeneIDi794.
KEGGihsa:794.
UCSCiuc002faa.4. human.

Organism-specific databases

CTDi794.
GeneCardsiGC16P071392.
HGNCiHGNC:1435. CALB2.
HPAiCAB000106.
HPA007305.
HPA007306.
MIMi114051. gene.
neXtProtiNX_P22676.
PharmGKBiPA26027.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG299305.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP22676.
OMAiFLDIWKH.
OrthoDBiEOG71G9VB.
PhylomeDBiP22676.
TreeFamiTF325083.

Miscellaneous databases

GeneWikiiCalretinin.
GenomeRNAii794.
NextBioi3222.
PROiP22676.
SOURCEiSearch...

Gene expression databases

BgeeiP22676.
CleanExiHS_CALB2.
ExpressionAtlasiP22676. baseline and differential.
GenevestigatoriP22676.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR029646. CALB2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF4. PTHR19972:SF4. 1 hit.
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human calbindins: cDNA and gene cloning."
    Parmentier M.
    Adv. Exp. Med. Biol. 255:233-240(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the human brain calcium-binding protein calretinin and its expression in bacteria."
    Parmentier M., Lefort A.
    Eur. J. Biochem. 196:79-85(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue and Cerebellum.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiCALB2_HUMAN
AccessioniPrimary (citable) accession number: P22676
Secondary accession number(s): A8K4Y1, Q53HD2, Q96BK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 27, 2006
Last modified: April 29, 2015
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.