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Protein

Cyclin-O

Gene

CCNO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.2 Publications

Caution

Was originally thought to have uracil-DNA glycosylase (UDG) activity and wrongly named UNG2 and UDG2 (PubMed:2001396). It was later shown that it is a member of the cyclin family (PubMed:8419333). UNG2 corresponds to the isoform 2 of UNG gene.2 Publications

GO - Molecular functioni

  • uracil DNA N-glycosylase activity Source: HGNC

GO - Biological processi

  • base-excision repair Source: HGNC
  • cell division Source: UniProtKB-KW
  • cilium assembly Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB
  • multi-ciliated epithelial cell differentiation Source: UniProtKB
  • response to drug Source: Ensembl

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Cilium biogenesis/degradation

Enzyme and pathway databases

BRENDAi3.2.2.27 2681
SignaLinkiP22674

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-O
Gene namesi
Name:CCNO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000152669.8
HGNCiHGNC:18576 CCNO
MIMi607752 gene
neXtProtiNX_P22674

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Ciliary dyskinesia, primary, 29 (CILD29)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639).1 Publication
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition.
See also OMIM:615872
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077581213L → P in CILD29; decreases formation of basal bodies in multiciliated cells. 1 PublicationCorresponds to variant dbSNP:rs775051461EnsemblClinVar.1
Natural variantiVAR_071197239H → R in CILD29. 1 PublicationCorresponds to variant dbSNP:rs797045150EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Disease mutation, Primary ciliary dyskinesia

Organism-specific databases

DisGeNETi10309
MalaCardsiCCNO
MIMi615872 phenotype
OpenTargetsiENSG00000152669
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA38350

Polymorphism and mutation databases

BioMutaiCCNO
DMDMi118572733

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761751 – 350Cyclin-OAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP22674
PaxDbiP22674
PeptideAtlasiP22674
PRIDEiP22674

PTM databases

iPTMnetiP22674
PhosphoSitePlusiP22674

Expressioni

Tissue specificityi

Present in respiratory cells (at protein level).1 Publication

Developmental stagei

Maximum levels during G1 phase. Levels decrease through S and G2 phases.1 Publication

Gene expression databases

BgeeiENSG00000152669
CleanExiHS_CCNO
GenevisibleiP22674 HS

Organism-specific databases

HPAiHPA050090

Interactioni

Protein-protein interaction databases

BioGridi115595, 7 interactors
DIPiDIP-24234N
IntActiP22674, 6 interactors
MINTiP22674
STRINGi9606.ENSP00000282572

Structurei

3D structure databases

ProteinModelPortaliP22674
SMRiP22674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG0653 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
HOGENOMiHOG000060283
HOVERGENiHBG062171
InParanoidiP22674
KOiK10861
OMAiLDLQTFR
OrthoDBiEOG091G0J8R
PhylomeDBiP22674
TreeFamiTF332057

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR028864 Ccno
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF14 PTHR10177:SF14, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P22674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP
60 70 80 90 100
LPGDSGICDL FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD
110 120 130 140 150
YGQSCYAFRK AQESHFHPRE ALARQPQVTA ESRCKLLSWL IPVHRQFGLS
160 170 180 190 200
FESLCLTVNT LDRFLTTTPV AADCFQLLGV TSLLIACKQV EVHPPRVKQL
210 220 230 240 250
LALCCGAFSR QQLCNLECIV LHKLHFTLGA PTISFFLEHF THARVEAGQA
260 270 280 290 300
EASEALEAQA LARGVAELSL ADYAFTSYSP SLLAICCLAL ADRMLRVSRP
310 320 330 340 350
VDLRLGDHPE AALEDCMGKL QLLVAINSTS LTHMLPVQIC EKCSLPPSSK
Length:350
Mass (Da):38,096
Last modified:November 28, 2006 - v2
Checksum:iAF1C1D1C34334BED
GO
Isoform 2 (identifier: P22674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: TAE → RCW
     132-350: Missing.

Show »
Length:131
Mass (Da):14,297
Checksum:i75705330B7735297
GO

Sequence cautioni

The sequence AAB05817 differs from that shown. Sequencing errors.Curated
The sequence CAA36728 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246E → G in BAB15351 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029081161L → M. Corresponds to variant dbSNP:rs13169396Ensembl.1
Natural variantiVAR_077581213L → P in CILD29; decreases formation of basal bodies in multiciliated cells. 1 PublicationCorresponds to variant dbSNP:rs775051461EnsemblClinVar.1
Natural variantiVAR_071197239H → R in CILD29. 1 PublicationCorresponds to variant dbSNP:rs797045150EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021655129 – 131TAE → RCW in isoform 2. 2 Publications3
Alternative sequenceiVSP_021656132 – 350Missing in isoform 2. 2 PublicationsAdd BLAST219

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52486 mRNA Translation: CAA36728.1 Sequence problems.
M87499 Genomic DNA Translation: AAB05817.1 Sequence problems.
AK026075 mRNA Translation: BAB15351.1
AK290030 mRNA Translation: BAF82719.1
AC026704 Genomic DNA No translation available.
CH471123 Genomic DNA Translation: EAW54913.1
BC004877 mRNA Translation: AAH04877.1
CCDSiCCDS34157.1 [P22674-1]
PIRiS14266
RefSeqiNP_066970.3, NM_021147.4 [P22674-1]
UniGeneiHs.3041

Genome annotation databases

EnsembliENST00000282572; ENSP00000282572; ENSG00000152669 [P22674-1]
ENST00000501463; ENSP00000422485; ENSG00000152669 [P22674-2]
GeneIDi10309
KEGGihsa:10309
UCSCiuc003jpv.4 human [P22674-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCNO_HUMAN
AccessioniPrimary (citable) accession number: P22674
Secondary accession number(s): A8K1W5
, Q0P6J2, Q9H6B0, Q9UMD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 28, 2006
Last modified: March 28, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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