Reviewed, UniProtKB/Swiss-Prot P22674 (CCNO_HUMAN)

Names and origin

Protein names

Recommended name:
    Cyclin-O
    EC=3.2.2.-
Alternative name(s):
    Uracil-DNA glycosylase 2
      Short name=UDG2
    Cyclin-like uracil-DNA glycosylase

Gene names

Name:	CCNO
Synonyms:	UDG2, UNG2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Excises uracil residues from DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Sequence similarities	Belongs to the cyclin family.
Sequence caution	The sequence AAB05817.1 differs from that shown. Reason: Miscellaneous discrepancy. Sequencing errors. The sequence CAA36728.1 differs from that shown. Reason: Miscellaneous discrepancy. Sequencing errors.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Glycosidase Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	depyrimidination Inferred from Experiment. Source: Reactome
Cellular component	nucleoplasm Inferred from direct assay. Source: HGNC
Molecular function	uracil DNA N-glycosylase activity Inferred from direct assay. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P22674-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P22674-2)

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: TAE → RCW
     132-350: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Cyclin-O		PRO_0000176175
Amino acid modifications
	Modified residue	81	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	129 – 131	3	TAE → RCW in isoform 2.		VSP_021655
	Alternative sequence	132 – 350	219	Missing in isoform 2.		VSP_021656
	Natural variant	161	1	L → M: dbSNP rs13169396.		VAR_029081
Experimental info
	Sequence conflict	246	1	E → G in BAB15351. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: AF1C1D1C34334BED	FASTA	350	38,096
	10 20 30 40 50 60 MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP LPGDSGICDL 70 80 90 100 110 120 FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD YGQSCYAFRK AQESHFHPRE 130 140 150 160 170 180 ALARQPQVTA ESRCKLLSWL IPVHRQFGLS FESLCLTVNT LDRFLTTTPV AADCFQLLGV 190 200 210 220 230 240 TSLLIACKQV EVHPPRVKQL LALCCGAFSR QQLCNLECIV LHKLHFTLGA PTISFFLEHF 250 260 270 280 290 300 THARVEAGQA EASEALEAQA LARGVAELSL ADYAFTSYSP SLLAICCLAL ADRMLRVSRP 310 320 330 340 350 VDLRLGDHPE AALEDCMGKL QLLVAINSTS LTHMLPVQIC EKCSLPPSSK
	Isoform 2. Checksum: 75705330B7735297	FASTA	131	14,297
	10 20 30 40 50 60 MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP LPGDSGICDL 70 80 90 100 110 120 FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD YGQSCYAFRK AQESHFHPRE 130 ALARQPQVRC W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase." Muller S.J., Caradonna S. Biochim. Biophys. Acta 1088:197-207(1991) [PubMed: 2001396] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: T-cell.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney epithelium.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Pancreas.
[5]	"The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues." Hirst R., Gosden R., Miller D. Gene 375:95-102(2006) [PubMed: 16697536] [Abstract] Cited for: IDENTIFICATION.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X52486 mRNA. Translation: CAA36728.1. Sequence problems. M87499 Genomic DNA. Translation: AAB05817.1. Sequence problems. AK026075 mRNA. Translation: BAB15351.1. AC026704 Genomic DNA. No translation available. BC004877 mRNA. Translation: AAH04877.1.
IPI	IPI00186099. IPI00807451.
PIR	S14266.
RefSeq	NP_066970.3.
UniGene	Hs.3041
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:24234N.
Proteomic databases
PRIDE	P22674.
Genome annotation databases
Ensembl	ENSG00000152669. Homo sapiens. [Contig view]
GeneID	10309.
KEGG	hsa:10309.
NMPDR	fig|9606.3.peg.25248.
Organism-specific databases
GeneCards	GC05M054564.
H-InvDB	HIX0022318.
HGNC	HGNC:18576. CCNO.
MIM	607752. gene.
PharmGKB	PA38350.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P22674.
OMA	P22674. LDLQTFR.
Enzyme and pathway databases
Reactome	REACT_216. DNA Repair.
Gene expression databases
ArrayExpress	P22674.
Bgee	P22674.
CleanEx	HS_CCNO.
GermOnline	ENSG00000152669. Homo sapiens.
Family and domain databases
InterPro	IPR006670. Cyclin. IPR014400. Cyclin_A_B_D_E. IPR004367. Cyclin_C. IPR006671. Cyclin_N. IPR013763. Cyclin_related. [Graphical view]
Gene3D	G3DSA:1.10.472.10. Cyclin_related. 1 hit.
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMART	SM00385. CYCLIN. 2 hits. [Graphical view]
PROSITE	PS00292. CYCLINS. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	39071.
SOURCE	Search...

Entry information

Entry name

CCNO_HUMAN

Accession

Primary (citable) accession number: P22674
Secondary accession number(s): Q0P6J2, Q9H6B0, Q9UMD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	November 28, 2006
Last modified:	June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)