P22674 (CCNO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-O

Gene names

Name:

CCNO

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Developmental stage	Maximum levels during G1 phase. Levels decrease through S and G2 phases. Ref.6
Sequence similarities	Belongs to the cyclin family.
Caution	Was originally thought to have uracil-DNA glycosylase (UDG) activity and wrongly named UNG2 and UDG2 (Ref.1). It was later shown that it is a member of the cyclin family (Ref.6). UNG2 corresponds to the isoform 2 of UNG gene.
Sequence caution	The sequence AAB05817.1 differs from that shown. Reason: Sequencing errors. The sequence CAA36728.1 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Cyclin
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from direct assay Ref.6. Source: UniProtKB cell division Inferred from direct assay Ref.6. Source: UniProtKB depyrimidination Traceable author statement. Source: Reactome regulation of cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: InterPro
Cellular component	nucleoplasm Inferred from direct assay. Source: HGNC
Molecular function	protein kinase binding Inferred from electronic annotation. Source: InterPro uracil DNA N-glycosylase activity Inferred from direct assay. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P22674-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P22674-2)

The sequence of this isoform differs from the canonical sequence as follows:
     129-131: TAE → RCW
     132-350: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Cyclin-O		PRO_0000176175
Amino acid modifications
	Modified residue	3	1	Phosphothreonine Ref.10
	Modified residue	7	1	Phosphothreonine Ref.10
	Modified residue	8	1	Phosphoserine Ref.9 Ref.10
	Modified residue	11	1	Phosphoserine Ref.9 Ref.10
	Modified residue	81	1	Phosphoserine Ref.8 Ref.10
Natural variations
	Alternative sequence	129 – 131	3	TAE → RCW in isoform 2.		VSP_021655
	Alternative sequence	132 – 350	219	Missing in isoform 2.		VSP_021656
	Natural variant	161	1	L → M. Corresponds to variant rs13169396 [ dbSNP | Ensembl ].		VAR_029081
Experimental info
	Sequence conflict	246	1	E → G in BAB15351. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: AF1C1D1C34334BED	FASTA	350	38,096
	10 20 30 40 50 60 MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP LPGDSGICDL 70 80 90 100 110 120 FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD YGQSCYAFRK AQESHFHPRE 130 140 150 160 170 180 ALARQPQVTA ESRCKLLSWL IPVHRQFGLS FESLCLTVNT LDRFLTTTPV AADCFQLLGV 190 200 210 220 230 240 TSLLIACKQV EVHPPRVKQL LALCCGAFSR QQLCNLECIV LHKLHFTLGA PTISFFLEHF 250 260 270 280 290 300 THARVEAGQA EASEALEAQA LARGVAELSL ADYAFTSYSP SLLAICCLAL ADRMLRVSRP 310 320 330 340 350 VDLRLGDHPE AALEDCMGKL QLLVAINSTS LTHMLPVQIC EKCSLPPSSK
	Isoform 2 [UniParc]. Checksum: 75705330B7735297	FASTA	131	14,297
	10 20 30 40 50 60 MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP LPGDSGICDL 70 80 90 100 110 120 FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD YGQSCYAFRK AQESHFHPRE 130 ALARQPQVRC W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase." Muller S.J., Caradonna S. Biochim. Biophys. Acta 1088:197-207(1991) [PubMed: 2001396] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: T-cell.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Hippocampus and Kidney epithelium.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Pancreas.
[6]	"Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase." Muller S.J., Caradonna S. J. Biol. Chem. 268:1310-1319(1993) [PubMed: 8419333] [Abstract] Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.
[7]	"The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues." Hirst R., Gosden R., Miller D. Gene 375:95-102(2006) [PubMed: 16697536] [Abstract] Cited for: IDENTIFICATION.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8 AND SER-11, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3; THR-7; SER-8; SER-11 AND SER-81, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52486 mRNA. Translation: CAA36728.1. Sequence problems. M87499 Genomic DNA. Translation: AAB05817.1. Sequence problems. AK026075 mRNA. Translation: BAB15351.1. AK290030 mRNA. Translation: BAF82719.1. AC026704 Genomic DNA. No translation available. CH471123 Genomic DNA. Translation: EAW54913.1. BC004877 mRNA. Translation: AAH04877.1.
IPI	IPI00186099. IPI00807451.
PIR	S14266.
RefSeq	NP_066970.3. NM_021147.3.
UniGene	Hs.3041.
3D structure databases
ProteinModelPortal	P22674.
SMR	P22674. Positions 96-325.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-24234N.
IntAct	P22674. 3 interactions.
STRING	P22674.
PTM databases
PhosphoSite	P22674.
Polymorphism databases
DMDM	118572733.
Proteomic databases
PRIDE	P22674.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282572; ENSP00000282572; ENSG00000152669.
GeneID	10309.
KEGG	hsa:10309.
NMPDR	fig|9606.3.peg.25248.
UCSC	uc003jpw.1. human.
Organism-specific databases
CTD	10309.
GeneCards	GC05M054526.
H-InvDB	HIX0200729.
HGNC	HGNC:18576. CCNO.
MIM	607752. gene.
neXtProt	NX_P22674.
PharmGKB	PA162381969. PA38350.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09522.
GeneTree	ENSGT00560000076692.
HOGENOM	HBG713444.
HOVERGEN	HBG062171.
InParanoid	P22674.
OMA	KARESHF.
OrthoDB	EOG4V1718.
PhylomeDB	P22674.
Enzyme and pathway databases
Reactome	REACT_216. DNA Repair.
Gene expression databases
ArrayExpress	P22674.
Bgee	P22674.
CleanEx	HS_CCNO.
Genevestigator	P22674.
GermOnline	ENSG00000152669. Homo sapiens.
Family and domain databases
InterPro	IPR013763. Cyclin-like. IPR014400. Cyclin_A/B/D/E. IPR004367. Cyclin_C. IPR006671. Cyclin_N. [Graphical view]
Gene3D	G3DSA:1.10.472.10. Cyclin_related. 2 hits.
KO	K10861.
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. [Graphical view]
PIRSF	PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMART	SM00385. CYCLIN. 2 hits. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits.
PROSITE	PS00292. CYCLINS. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	39071.
SOURCE	Search...

Entry information

Entry name

CCNO_HUMAN

Accession

Primary (citable) accession number: P22674
Secondary accession number(s): A8K1W5 , Q0P6J2, Q9H6B0, Q9UMD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.