Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P22672

- VP2_ROTS1

UniProt

P22672 - VP2_ROTS1

Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain SA11-Both G3-P5B[2]-I2-R2-C5-M5-A5-N2-T5-E2-H5) (RV-A) (Simian Agent 11 (strain Both))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inner capsid protein VP2
    OrganismiRotavirus A (strain SA11-Both G3-P5B[2]-I2-R2-C5-M5-A5-N2-T5-E2-H5) (RV-A) (Simian Agent 11 (strain Both))
    Taxonomic identifieri37137 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
    Virus hostiMacaca mulatta (Rhesus macaque) [TaxID: 9544]
    ProteomesiUP000007180: Genome

    Subcellular locationi

    Virion Curated
    Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

    GO - Cellular componenti

    1. viral inner capsid Source: UniProtKB-KW
    2. viral nucleocapsid Source: InterPro

    Keywords - Cellular componenti

    Capsid protein, Inner capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 881881Inner capsid protein VP2PRO_0000149535Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer Potential. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.By similarityCurated

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9494Interaction with VP1 and VP3By similarityAdd
    BLAST
    Regioni395 – 41521HydrophobicBy similarityAdd
    BLAST
    Regioni423 – 44321HydrophobicBy similarityAdd
    BLAST
    Regioni537 – 55822Leucine-zipper 1Sequence AnalysisAdd
    BLAST
    Regioni666 – 68722Leucine-zipper 2Sequence AnalysisAdd
    BLAST

    Domaini

    The N-terminus is involved in VP1 binding.By similarity

    Sequence similaritiesi

    Belongs to the rotavirus VP2 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    InterProiIPR007779. Rotavirus_VP2.
    [Graphical view]
    PfamiPF05087. Rota_VP2. 1 hit.
    [Graphical view]
    ProDomiPD008866. Rota_VP2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P22672-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYRKRGARR ETNLKQDERM QEKEDSKNIN NDSPKSQLSE KVLSKKEEII    50
    TDNQEEVKIS DEVKKSNKEE SKQLLEVLKT KEEHQKEVQY EILQKTIPTF 100
    EPKESILKKL EDIKPEQAKK QTKLFRIFEP KQLPIYRANG ERELRNRWYW 150
    KLKRDTLPDG DYDVREYFLN LYDQVLMEMP DYLLLKDMAV ENKNSRDAGK 200
    VVDSETAAIC DAIFQDEEPK AVRRFIAEMR QRVQADRNVV NYPSILHPID 250
    HAFNEYFLQH QLVEPLNNVY IFNYIPERIR NDVNYILNMD RNLPSTARYI 300
    RPNLLQDRLN LHDNFESLWD TITTSNYILA RSVVPDLKEL VSTEAQIQKM 350
    SQDLQLEALT IQSETQFLTG INSQAANDCF KTLIAAMLSQ RTMSLDFVTT 400
    NYMSLISGMW LLTVIPNDMF IRESLVACQL AIINTIVYPA FGMQRMHYRN 450
    GDPQTPFQIA EQQIQNFQVA NWLHFVNYNQ FRQVVIDGVL NQVLNDNIRN 500
    GHVVNQLMEA LMQLSRQQFP TMPVDYKRSI QRGIFLLSNR LGQLVDLTRL 550
    LSYINETLMA CITMNMQHVQ TLTTEKLQLT SVTSLCMLIG NATVIPSPQT 600
    LFHYYNVNVN FHSNYNERIN DAVAIITAAN RLNLYQKKMK SIVEDFLKRL 650
    QIFDVARVPD DQMYRLRDRL RLLPVEIRRL DIFNLIAMNM EQIERASDKI 700
    AQGVIIAYRD MQLERDEMYG YVNIARNLDG FQQINLEELM RSGDYAQITN 750
    MLLNNQPVAL VGALPFITDS SVISLIAKLD ATVFAQIVKL RKVDTLKPIL 800
    YKINSDSNDF YLVANYDWIP TSTTKVYKQV PQQFDFRASM HMLTSNLTFT 850
    VYSDLLAFVS ADTVEPINAV AFDNMRIMNE L 881
    Length:881
    Mass (Da):102,697
    Last modified:August 1, 1991 - v1
    Checksum:i984AB341AD2F0B75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16831 Genomic RNA. Translation: CAA34733.1.
    PIRiB35321. P2XRSR.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16831 Genomic RNA. Translation: CAA34733.1 .
    PIRi B35321. P2XRSR.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR007779. Rotavirus_VP2.
    [Graphical view ]
    Pfami PF05087. Rota_VP2. 1 hit.
    [Graphical view ]
    ProDomi PD008866. Rota_VP2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genomic sequence of the simian rotavirus SA11: nucleotide sequences of segments 1, 2, and 3."
      Mitchell D.B., Both G.W.
      Virology 177:324-331(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVP2_ROTS1
    AccessioniPrimary (citable) accession number: P22672
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3