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P22672

- VP2_ROTS1

UniProt

P22672 - VP2_ROTS1

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Protein

Inner capsid protein VP2

Gene
N/A
Organism
Rotavirus A (strain SA11-Both G3-P5B[2]-I2-R2-C5-M5-A5-N2-T5-E2-H5) (RV-A) (Simian Agent 11 (strain Both))
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Inner capsid protein that self assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP2 is required for the replicase activity of VP1 polymerase. It probably plays a role in the coordination of packaging and genome replication by controlling the initiation of minus-strand synthesis. Binding to the polymerase VP1 presumably activates the autoinhibited VP1-RNA complex which will start the synthesis of the complementary minus-strand By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2
OrganismiRotavirus A (strain SA11-Both G3-P5B[2]-I2-R2-C5-M5-A5-N2-T5-E2-H5) (RV-A) (Simian Agent 11 (strain Both))
Taxonomic identifieri37137 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiMacaca mulatta (Rhesus macaque) [TaxID: 9544]
ProteomesiUP000007180: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Inner capsid protein. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

GO - Cellular componenti

  1. viral inner capsid Source: UniProtKB-KW
  2. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Inner capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 881881Inner capsid protein VP2PRO_0000149535Add
BLAST

Interactioni

Subunit structurei

Dimer Reviewed prediction. Interacts with VP1; this interaction presumably activates VP1. Interacts with VP3. Interacts with VP6. Interacts with NSP5 By similarity.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9494Interaction with VP1 and VP3 By similarityAdd
BLAST
Regioni395 – 41521Hydrophobic By similarityAdd
BLAST
Regioni423 – 44321Hydrophobic By similarityAdd
BLAST
Regioni537 – 55822Leucine-zipper 1 Reviewed predictionAdd
BLAST
Regioni666 – 68722Leucine-zipper 2 Reviewed predictionAdd
BLAST

Domaini

The N-terminus is involved in VP1 binding By similarity.

Sequence similaritiesi

Belongs to the rotavirus VP2 family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR007779. Rotavirus_VP2.
[Graphical view]
PfamiPF05087. Rota_VP2. 1 hit.
[Graphical view]
ProDomiPD008866. Rota_VP2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P22672-1 [UniParc]FASTAAdd to Basket

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MAYRKRGARR ETNLKQDERM QEKEDSKNIN NDSPKSQLSE KVLSKKEEII    50
TDNQEEVKIS DEVKKSNKEE SKQLLEVLKT KEEHQKEVQY EILQKTIPTF 100
EPKESILKKL EDIKPEQAKK QTKLFRIFEP KQLPIYRANG ERELRNRWYW 150
KLKRDTLPDG DYDVREYFLN LYDQVLMEMP DYLLLKDMAV ENKNSRDAGK 200
VVDSETAAIC DAIFQDEEPK AVRRFIAEMR QRVQADRNVV NYPSILHPID 250
HAFNEYFLQH QLVEPLNNVY IFNYIPERIR NDVNYILNMD RNLPSTARYI 300
RPNLLQDRLN LHDNFESLWD TITTSNYILA RSVVPDLKEL VSTEAQIQKM 350
SQDLQLEALT IQSETQFLTG INSQAANDCF KTLIAAMLSQ RTMSLDFVTT 400
NYMSLISGMW LLTVIPNDMF IRESLVACQL AIINTIVYPA FGMQRMHYRN 450
GDPQTPFQIA EQQIQNFQVA NWLHFVNYNQ FRQVVIDGVL NQVLNDNIRN 500
GHVVNQLMEA LMQLSRQQFP TMPVDYKRSI QRGIFLLSNR LGQLVDLTRL 550
LSYINETLMA CITMNMQHVQ TLTTEKLQLT SVTSLCMLIG NATVIPSPQT 600
LFHYYNVNVN FHSNYNERIN DAVAIITAAN RLNLYQKKMK SIVEDFLKRL 650
QIFDVARVPD DQMYRLRDRL RLLPVEIRRL DIFNLIAMNM EQIERASDKI 700
AQGVIIAYRD MQLERDEMYG YVNIARNLDG FQQINLEELM RSGDYAQITN 750
MLLNNQPVAL VGALPFITDS SVISLIAKLD ATVFAQIVKL RKVDTLKPIL 800
YKINSDSNDF YLVANYDWIP TSTTKVYKQV PQQFDFRASM HMLTSNLTFT 850
VYSDLLAFVS ADTVEPINAV AFDNMRIMNE L 881
Length:881
Mass (Da):102,697
Last modified:August 1, 1991 - v1
Checksum:i984AB341AD2F0B75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16831 Genomic RNA. Translation: CAA34733.1.
PIRiB35321. P2XRSR.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16831 Genomic RNA. Translation: CAA34733.1 .
PIRi B35321. P2XRSR.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR007779. Rotavirus_VP2.
[Graphical view ]
Pfami PF05087. Rota_VP2. 1 hit.
[Graphical view ]
ProDomi PD008866. Rota_VP2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genomic sequence of the simian rotavirus SA11: nucleotide sequences of segments 1, 2, and 3."
    Mitchell D.B., Both G.W.
    Virology 177:324-331(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiVP2_ROTS1
AccessioniPrimary (citable) accession number: P22672
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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