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Protein

MHC class II regulatory factor RFX1

Gene

RFX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi438 – 513RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

  • immune response Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP22670
SIGNORiP22670

Names & Taxonomyi

Protein namesi
Recommended name:
MHC class II regulatory factor RFX1
Alternative name(s):
Enhancer factor C
Short name:
EF-C
Regulatory factor X 1
Short name:
RFX
Transcription factor RFX1
Gene namesi
Name:RFX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000132005.8
HGNCiHGNC:9982 RFX1
MIMi600006 gene
neXtProtiNX_P22670

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5989
OpenTargetsiENSG00000132005
PharmGKBiPA34352

Polymorphism and mutation databases

BioMutaiRFX1
DMDMi288558824

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002152861 – 979MHC class II regulatory factor RFX1Add BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP22670
MaxQBiP22670
PaxDbiP22670
PeptideAtlasiP22670
PRIDEiP22670

PTM databases

iPTMnetiP22670
PhosphoSitePlusiP22670
SwissPalmiP22670

Expressioni

Gene expression databases

BgeeiENSG00000132005
CleanExiHS_RFX1
ExpressionAtlasiP22670 baseline and differential
GenevisibleiP22670 HS

Organism-specific databases

HPAiHPA048722

Interactioni

Subunit structurei

Homodimer; binds DNA as a homodimer (PubMed:10706293). Heterodimer; heterodimerizes with RFX2 and RFX3 (PubMed:10330134).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11192128 interactors.
IntActiP22670 15 interactors.
MINTiP22670
STRINGi9606.ENSP00000254325

Structurei

Secondary structure

1979
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi439 – 445Combined sources7
Beta strandi446 – 455Combined sources10
Helixi456 – 469Combined sources14
Helixi477 – 487Combined sources11
Beta strandi492 – 498Combined sources7
Beta strandi503 – 511Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DP7X-ray1.50P438-513[»]
ProteinModelPortaliP22670
SMRiP22670
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22670

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni744 – 979Necessary for dimerizationAdd BLAST236

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi381 – 411Gly-richAdd BLAST31
Compositional biasi920 – 936Asp/Glu-rich (acidic)Add BLAST17

Sequence similaritiesi

Belongs to the RFX family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3712 Eukaryota
ENOG410XSHE LUCA
GeneTreeiENSGT00550000074532
HOGENOMiHOG000294091
HOVERGENiHBG002753
InParanoidiP22670
KOiK09173
OMAiHVAQEVQ
OrthoDBiEOG091G0EID
PhylomeDBiP22670
TreeFamiTF321340

Family and domain databases

Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR003150 DNA-bd_RFX
IPR007668 RFX1_trans_act
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF04589 RFX1_trans_act, 1 hit
PF02257 RFX_DNA_binding, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS51526 RFX_DBD, 1 hit

Sequencei

Sequence statusi: Complete.

P22670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQAYTELQ AAPPPSQPPQ APPQAQPQPP PPPPPAAPQP PQPPTAAATP
60 70 80 90 100
QPQYVTELQS PQPQAQPPGG QKQYVTELPA VPAPSQPTGA PTPSPAPQQY
110 120 130 140 150
IVVTVSEGAM RASETVSEAS PGSTASQTGV PTQVVQQVQG TQQRLLVQTS
160 170 180 190 200
VQAKPGHVSP LQLTNIQVPQ QALPTQRLVV QSAAPGSKGG QVSLTVHGTQ
210 220 230 240 250
QVHSPPEQSP VQANSSSSKT AGAPTGTVPQ QLQVHGVQQS VPVTQERSVV
260 270 280 290 300
QATPQAPKPG PVQPLTVQGL QPVHVAQEVQ QLQQVPVPHV YSSQVQYVEG
310 320 330 340 350
GDASYTASAI RSSTYSYPET PLYTQTASTS YYEAAGTATQ VSTPATSQAV
360 370 380 390 400
ASSGSMPMYV SGSQVVASST STGAGASNSS GGGGSGGGGG GGGGGGGGGS
410 420 430 440 450
GSTGGGGSGA GTYVIQGGYM LGSASQSYSH TTRASPATVQ WLLDNYETAE
460 470 480 490 500
GVSLPRSTLY CHYLLHCQEQ KLEPVNAASF GKLIRSVFMG LRTRRLGTRG
510 520 530 540 550
NSKYHYYGLR IKASSPLLRL MEDQQHMAMR GQPFSQKQRL KPIQKMEGMT
560 570 580 590 600
NGVAVGQQPS TGLSDISAQV QQYQQFLDAS RSLPDFTELD LQGKVLPEGV
610 620 630 640 650
GPGDIKAFQV LYREHCEAIV DVMVNLQFTL VETLWKTFWR YNLSQPSEAP
660 670 680 690 700
PLAVHDEAEK RLPKAILVLL SKFEPVLQWT KHCDNVLYQG LVEILIPDVL
710 720 730 740 750
RPIPSALTQA IRNFAKSLES WLTHAMVNIP EEMLRVKVAA AGAFAQTLRR
760 770 780 790 800
YTSLNHLAQA ARAVLQNTAQ INQMLSDLNR VDFANVQEQA SWVCRCEDRV
810 820 830 840 850
VQRLEQDFKV TLQQQNSLEQ WAAWLDGVVS QVLKPYQGSA GFPKAAKLFL
860 870 880 890 900
LKWSFYSSMV IRDLTLRSAA SFGSFHLIRL LYDEYMYYLI EHRVAQAKGE
910 920 930 940 950
TPIAVMGEFA NLATSLNPLD PDKDEEEEEE EESEDELPQD ISLAAGGESP
960 970
ALGPETLEPP AKLARTDARG LFVQALPSS
Length:979
Mass (Da):104,758
Last modified:February 9, 2010 - v2
Checksum:i4FD8EA9C4AB1A411
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059781370T → A2 PublicationsCorresponds to variant dbSNP:rs2305780Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58964 mRNA Translation: CAA41730.1
AC020916 Genomic DNA No translation available.
AC022098 Genomic DNA No translation available.
BC049826 mRNA Translation: AAH49826.1
CCDSiCCDS12301.1
PIRiA35913
RefSeqiNP_002909.4, NM_002918.4
UniGeneiHs.655215

Genome annotation databases

EnsembliENST00000254325; ENSP00000254325; ENSG00000132005
GeneIDi5989
KEGGihsa:5989
UCSCiuc002mxv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRFX1_HUMAN
AccessioniPrimary (citable) accession number: P22670
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 9, 2010
Last modified: March 28, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome