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P22669

- GUN_ASPAC

UniProt

P22669 - GUN_ASPAC

Protein

Endoglucanase-1

Gene
N/A
Organism
Aspergillus aculeatus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH12. Glycoside Hydrolase Family 12.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase-1 (EC:3.2.1.4)
    Alternative name(s):
    Cellulase
    Endo-1,4-beta-glucanase
    Endoglucanase I
    FI-CMCase
    OrganismiAspergillus aculeatus
    Taxonomic identifieri5053 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 237221Endoglucanase-1PRO_0000008018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Pyrrolidone carboxylic acid1 Publication

    Keywords - PTMi

    Pyrrolidone carboxylic acid

    Expressioni

    Inductioni

    By cellulosic materials and hemicelluloses.

    Structurei

    3D structure databases

    ProteinModelPortaliP22669.
    SMRiP22669. Positions 21-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.60.120.180. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013319. Glyco_hydro_11/12.
    IPR002594. Glyco_hydro_12.
    [Graphical view]
    PfamiPF01670. Glyco_hydro_12. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22669-1 [UniParc]FASTAAdd to Basket

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    MKAFHLLAAL AGAAVAQQAQ LCDQYATYTG GVYTINNNLW GKDAGSGSQC    50
    TTVNSASSAG TSWSTKWNWS GGENSVKSYA NSGLTFNKKL VSQISQIPTT 100
    ARWSYDNTGI RADVAYDLFT AADINHVTWS GDYELMIWLA RYGGVQPIGS 150
    QIATATVDGQ TWELWYGANG SQKTYSFVAP TPITSFQGDV NDFFKYLTQN 200
    HGFPASSQYL ITLQFGTEPF TGGPATLSVS NWSASVQ 237
    Length:237
    Mass (Da):25,560
    Last modified:August 1, 1991 - v1
    Checksum:i8F173571A8AE6931
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00546 Genomic DNA. Translation: BAA00435.1.
    X52525 mRNA. Translation: CAA36757.1.
    PIRiS12610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00546 Genomic DNA. Translation: BAA00435.1 .
    X52525 mRNA. Translation: CAA36757.1 .
    PIRi S12610.

    3D structure databases

    ProteinModelPortali P22669.
    SMRi P22669. Positions 21-236.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH12. Glycoside Hydrolase Family 12.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.180. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013319. Glyco_hydro_11/12.
    IPR002594. Glyco_hydro_12.
    [Graphical view ]
    Pfami PF01670. Glyco_hydro_12. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequence of a gene coding for Aspergillus aculeatus cellulase (FI-CMCase)."
      Ooi T., Shinmyo A., Okada H., Murao S., Kawaguchi T., Arai M.
      Nucleic Acids Res. 18:5884-5884(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: F-50.
    2. "Cloning and sequence analysis of a cDNA for cellulase (FI-CMCase) from Aspergillus aculeatus."
      Ooi T., Shinmyo A., Okada H., Hara S., Ikenaka T., Murao S., Arai M.
      Curr. Genet. 18:217-222(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: F-50.

    Entry informationi

    Entry nameiGUN_ASPAC
    AccessioniPrimary (citable) accession number: P22669
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Will also hydrolyze 1,4-linkages in beta-D-glucans also containing 1,3-linkages.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3