Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P22649

- KITH_BHV2H

UniProt

P22649 - KITH_BHV2H

Protein

Thymidine kinase

Gene

TK

Organism
Bovine herpesvirus 2 (strain BHM-1) (BoHV-2) (Bovine mammillitis virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (27 May 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361Proton acceptorSequence Analysis
    Binding sitei54 – 541SubstrateBy similarity
    Binding sitei78 – 781SubstrateBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei169 – 1691ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 188ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiBovine herpesvirus 2 (strain BHM-1) (BoHV-2) (Bovine mammillitis virus)
    Taxonomic identifieri10297 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Thymidine kinasePRO_0000175063Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP22649.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P22649-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRLLRVYVD GPHGLGKTTA ASALASERGD AIYLPEPMSY WSGAGEDDLV    50
    ARVYTAQHRM DRGEIDAREA AGVVLGAQLT MSTPYVALNG LIAPHIGEEP 100
    SPGNATPPDL ILIFDRHPIA SLLCYPLARY LTRCLPIESV LSLIALIPPT 150
    PPGTNLILGT APAEDHLSRL VARGRPGELP DARMLRAIRY VYALLANTVK 200
    YLQSGGSWRA DLGSEPPRLP LAPPEIGDPN NPGGHNTLLA LIHGAGATRG 250
    CAAMTSWTLD LLADRLRSMN MFTVDYSAPP EACVAQMRNL LPSMQCTVTP 300
    KPESHRAVAD AALAFMREMS NCK 323
    Length:323
    Mass (Da):34,661
    Last modified:May 27, 2002 - v2
    Checksum:i5AB03D3F17EF1199
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00537 Genomic DNA. Translation: BAA00425.2.
    PIRiJT0532. KIBEB2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00537 Genomic DNA. Translation: BAA00425.2 .
    PIRi JT0532. KIBEB2.

    3D structure databases

    ProteinModelPortali P22649.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Location and characterization of the bovine herpesvirus type 2 thymidine kinase gene."
      Sheppard M., May J.T.
      J. Gen. Virol. 70:3067-3071(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Sheppard M., May J.T.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO C-TERMINUS.

    Entry informationi

    Entry nameiKITH_BHV2H
    AccessioniPrimary (citable) accession number: P22649
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: May 27, 2002
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3