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P22649 (KITH_BHV2H) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismBovine herpesvirus 2 (strain BHM-1) (BoHV-2) (Bovine mammillitis virus)
Taxonomic identifier10297 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostBos taurus (Bovine) [TaxID: 9913]

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Thymidine kinase
PRO_0000175063

Regions

Nucleotide binding11 – 188ATP By similarity

Sites

Active site361Proton acceptor Potential
Binding site541Substrate By similarity
Binding site781Substrate By similarity
Binding site1251Substrate By similarity
Binding site1691ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P22649 [UniParc].

Last modified May 27, 2002. Version 2.
Checksum: 5AB03D3F17EF1199

FASTA32334,661
        10         20         30         40         50         60 
MSRLLRVYVD GPHGLGKTTA ASALASERGD AIYLPEPMSY WSGAGEDDLV ARVYTAQHRM 

        70         80         90        100        110        120 
DRGEIDAREA AGVVLGAQLT MSTPYVALNG LIAPHIGEEP SPGNATPPDL ILIFDRHPIA 

       130        140        150        160        170        180 
SLLCYPLARY LTRCLPIESV LSLIALIPPT PPGTNLILGT APAEDHLSRL VARGRPGELP 

       190        200        210        220        230        240 
DARMLRAIRY VYALLANTVK YLQSGGSWRA DLGSEPPRLP LAPPEIGDPN NPGGHNTLLA 

       250        260        270        280        290        300 
LIHGAGATRG CAAMTSWTLD LLADRLRSMN MFTVDYSAPP EACVAQMRNL LPSMQCTVTP 

       310        320 
KPESHRAVAD AALAFMREMS NCK 

« Hide

References

[1]"Location and characterization of the bovine herpesvirus type 2 thymidine kinase gene."
Sheppard M., May J.T.
J. Gen. Virol. 70:3067-3071(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Sheppard M., May J.T.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO C-TERMINUS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00537 Genomic DNA. Translation: BAA00425.2.
PIRKIBEB2. JT0532.

3D structure databases

ProteinModelPortalP22649.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_BHV2H
AccessionPrimary (citable) accession number: P22649
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 27, 2002
Last modified: April 16, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families