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P22646

- CD3E_MOUSE

UniProt

P22646 - CD3E_MOUSE

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Protein

T-cell surface glycoprotein CD3 epsilon chain

Gene
Cd3e
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The CD3 complex mediates signal transduction.

GO - Molecular functioni

  1. protein binding Source: MGI
  2. signal transducer activity Source: MGI
  3. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic signaling pathway Source: MGI
  2. cell surface receptor signaling pathway Source: MGI
  3. lymphocyte activation Source: MGI
  4. negative regulation of smoothened signaling pathway Source: MGI
  5. negative thymic T cell selection Source: MGI
  6. positive regulation of alpha-beta T cell proliferation Source: MGI
  7. positive regulation of calcium-mediated signaling Source: MGI
  8. positive regulation of interferon-gamma production Source: MGI
  9. positive regulation of interleukin-2 biosynthetic process Source: MGI
  10. positive regulation of interleukin-4 production Source: MGI
  11. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  12. positive regulation of T cell activation Source: MGI
  13. positive regulation of T cell anergy Source: MGI
  14. positive regulation of T cell proliferation Source: MGI
  15. response to nutrient Source: Ensembl
  16. T cell costimulation Source: MGI
  17. T cell receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 epsilon chain
Alternative name(s):
T-cell surface antigen T3/Leu-4 epsilon chain
CD_antigen: CD3e
Gene namesi
Name:Cd3e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88332. Cd3e.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 10886Extracellular Reviewed predictionAdd
BLAST
Transmembranei109 – 13426Helical; Reviewed predictionAdd
BLAST
Topological domaini135 – 18955Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. alpha-beta T cell receptor complex Source: MGI
  2. cell-cell junction Source: MGI
  3. external side of plasma membrane Source: MGI
  4. immunological synapse Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 189168T-cell surface glycoprotein CD3 epsilon chainPRO_0000014609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 83
Modified residuei170 – 1701Phosphotyrosine By similarity
Modified residuei181 – 1811Phosphotyrosine By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP22646.
PRIDEiP22646.

PTM databases

PhosphoSiteiP22646.

Expressioni

Gene expression databases

ArrayExpressiP22646.
BgeeiP22646.
CleanExiMM_CD3E.
GenevestigatoriP22646.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Protein-protein interaction databases

BioGridi198596. 6 interactions.
IntActiP22646. 1 interaction.
MINTiMINT-7895702.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 345
Beta strandi37 – 415
Beta strandi51 – 544
Beta strandi57 – 593
Beta strandi65 – 717
Turni74 – 763
Beta strandi79 – 846
Beta strandi94 – 963
Turni135 – 1373
Helixi144 – 1463
Helixi168 – 1703
Helixi179 – 1824
Helixi183 – 1853
Turni186 – 1883

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JBJNMR-A22-100[»]
1XMWNMR-A22-100[»]
2K4FNMR-A134-189[»]
3R08X-ray4.10E22-100[»]
ProteinModelPortaliP22646.
SMRiP22646. Positions 22-100, 134-189.

Miscellaneous databases

EvolutionaryTraceiP22646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9977Ig-likeAdd
BLAST
Domaini160 – 18728ITAMAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG78872.
GeneTreeiENSGT00510000048592.
HOGENOMiHOG000290664.
HOVERGENiHBG102121.
InParanoidiP22646.
KOiK06451.
OMAiDIEWIST.
OrthoDBiEOG7N0C6H.
PhylomeDBiP22646.
TreeFamiTF335892.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PfamiPF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22646-1 [UniParc]FASTAAdd to Basket

« Hide

MRWNTFWGIL CLSLLAVGTC QDDAENIEYK VSISGTSVEL TCPLDSDENL    50
KWEKNGQELP QKHDKHLVLQ DFSEVEDSGY YVCYTPASNK NTYLYLKARV 100
CEYCVEVDLT AVAIIIIVDI CITLGLLMVI YYWSKNRKAK AKPVTRGTGA 150
GSRPRGQNKE RPPPVPNPDY EPIRKGQRDL YSGLNQRAV 189
Length:189
Mass (Da):21,393
Last modified:February 1, 1996 - v2
Checksum:i5CE92F784FA13B96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02990 mRNA. Translation: AAA40296.1.
M23376
, M23370, M23371, M23372, M23373, M23374, M23375 Genomic DNA. Translation: AAA72720.1.
CCDSiCCDS23125.1.
PIRiA31348.
RefSeqiNP_031674.1. NM_007648.4.
XP_006510029.1. XM_006509966.1.
UniGeneiMm.210361.

Genome annotation databases

EnsembliENSMUST00000102832; ENSMUSP00000099896; ENSMUSG00000032093.
GeneIDi12501.
KEGGimmu:12501.
UCSCiuc009pez.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02990 mRNA. Translation: AAA40296.1 .
M23376
, M23370 , M23371 , M23372 , M23373 , M23374 , M23375 Genomic DNA. Translation: AAA72720.1 .
CCDSi CCDS23125.1.
PIRi A31348.
RefSeqi NP_031674.1. NM_007648.4.
XP_006510029.1. XM_006509966.1.
UniGenei Mm.210361.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JBJ NMR - A 22-100 [» ]
1XMW NMR - A 22-100 [» ]
2K4F NMR - A 134-189 [» ]
3R08 X-ray 4.10 E 22-100 [» ]
ProteinModelPortali P22646.
SMRi P22646. Positions 22-100, 134-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198596. 6 interactions.
IntActi P22646. 1 interaction.
MINTi MINT-7895702.

PTM databases

PhosphoSitei P22646.

Proteomic databases

PaxDbi P22646.
PRIDEi P22646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102832 ; ENSMUSP00000099896 ; ENSMUSG00000032093 .
GeneIDi 12501.
KEGGi mmu:12501.
UCSCi uc009pez.1. mouse.

Organism-specific databases

CTDi 916.
MGIi MGI:88332. Cd3e.

Phylogenomic databases

eggNOGi NOG78872.
GeneTreei ENSGT00510000048592.
HOGENOMi HOG000290664.
HOVERGENi HBG102121.
InParanoidi P22646.
KOi K06451.
OMAi DIEWIST.
OrthoDBi EOG7N0C6H.
PhylomeDBi P22646.
TreeFami TF335892.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_215414. Translocation of ZAP-70 to Immunological synapse.
REACT_216080. Phosphorylation of CD3 and TCR zeta chains.
REACT_225145. Downstream TCR signaling.
REACT_225768. Generation of second messenger molecules.

Miscellaneous databases

EvolutionaryTracei P22646.
NextBioi 281450.
PROi P22646.
SOURCEi Search...

Gene expression databases

ArrayExpressi P22646.
Bgeei P22646.
CleanExi MM_CD3E.
Genevestigatori P22646.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR015484. CD3_esu/gsu/dsu.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view ]
PANTHERi PTHR10570. PTHR10570. 1 hit.
Pfami PF02189. ITAM. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 1 hit.
SM00077. ITAM. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS51055. ITAM_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family."
    Gold D.P., Clevers H., Alarcon B., Dunlap S., Novotny J., Williams A.F., Terhorst C.
    Proc. Natl. Acad. Sci. U.S.A. 84:7649-7653(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer."
    Sun Z.J., Kim K.S., Wagner G., Reinherz E.L.
    Cell 105:913-923(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 22-100.

Entry informationi

Entry nameiCD3E_MOUSE
AccessioniPrimary (citable) accession number: P22646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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