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P22635

- PCYA_SPHPI

UniProt

P22635 - PCYA_SPHPI

Protein

Protocatechuate 4,5-dioxygenase alpha chain

Gene

ligA

Organism
Sphingomonas paucimobilis (Pseudomonas paucimobilis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Responsible for the aromatic ring fission of protocatechuate.

    Catalytic activityi

    Protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde.

    Cofactori

    Fe2+ ion.

    GO - Molecular functioni

    1. protocatechuate 4,5-dioxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-15116.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocatechuate 4,5-dioxygenase alpha chain (EC:1.13.11.8)
    Alternative name(s):
    4,5-PCD
    Gene namesi
    Name:ligA
    OrganismiSphingomonas paucimobilis (Pseudomonas paucimobilis)
    Taxonomic identifieri13689 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeSphingomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Protocatechuate 4,5-dioxygenase alpha chainPRO_0000085100Add
    BLAST

    Interactioni

    Subunit structurei

    Composed of two subunits (alpha and beta) in a 1:1 ratio.

    Protein-protein interaction databases

    IntActiP22635. 1 interaction.

    Structurei

    Secondary structure

    1
    139
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 156
    Helixi16 – 194
    Helixi28 – 336
    Helixi35 – 439
    Helixi47 – 559
    Helixi57 – 626
    Turni63 – 653
    Helixi68 – 769
    Helixi79 – 846
    Helixi89 – 9810
    Helixi103 – 1097
    Turni110 – 1123
    Helixi115 – 1239
    Turni135 – 1373

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B4UX-ray2.20A/C1-139[»]
    1BOUX-ray2.20A/C1-139[»]
    ProteinModelPortaliP22635.
    SMRiP22635. Positions 8-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22635.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.700.10. 1 hit.
    InterProiIPR014159. PCA_ligA.
    IPR011986. Xdiol_dOase_LigA.
    [Graphical view]
    PfamiPF07746. LigA. 1 hit.
    [Graphical view]
    SUPFAMiSSF48076. SSF48076. 1 hit.
    TIGRFAMsiTIGR02792. PCA_ligA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P22635-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEKKERIDV HAYLAEFDDI PGTRVFTAQR ARKGYNLNQF AMSLMKAENR    50
    ERFKADESAY LDEWNLTPAA KAAVLARDYN AMIDEGGNVY FLSKLFSTDG 100
    KSFQFAAGSM TGMTQEEYAQ MMIDGGRSPA GVRSIKGGY 139
    Length:139
    Mass (Da):15,549
    Last modified:August 1, 1991 - v1
    Checksum:iE6CFEF0499A3FD26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34835 Unassigned DNA. Translation: AAA17727.1.
    PIRiA35271.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34835 Unassigned DNA. Translation: AAA17727.1 .
    PIRi A35271.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B4U X-ray 2.20 A/C 1-139 [» ]
    1BOU X-ray 2.20 A/C 1-139 [» ]
    ProteinModelPortali P22635.
    SMRi P22635. Positions 8-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P22635. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-15116.

    Miscellaneous databases

    EvolutionaryTracei P22635.

    Family and domain databases

    Gene3Di 1.10.700.10. 1 hit.
    InterProi IPR014159. PCA_ligA.
    IPR011986. Xdiol_dOase_LigA.
    [Graphical view ]
    Pfami PF07746. LigA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48076. SSF48076. 1 hit.
    TIGRFAMsi TIGR02792. PCA_ligA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the protocatechuate 4,5-dioxygenase genes of Pseudomonas paucimobilis."
      Noda Y., Nishikawa S., Shiozuka K., Kadokura H., Nakajima H., Yoda K., Katayama Y., Morohoshi N., Haraguchi T., Yamasaki M.
      J. Bacteriol. 172:2704-2709(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-34.
      Strain: SYK-6.

    Entry informationi

    Entry nameiPCYA_SPHPI
    AccessioniPrimary (citable) accession number: P22635
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: December 11, 2013
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3