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P22629

- SAV_STRAV

UniProt

P22629 - SAV_STRAV

Protein

Streptavidin

Gene
N/A
Organism
Streptomyces avidinii
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671Biotin
    Binding sitei78 – 781Biotin
    Binding sitei116 – 1161Biotin
    Binding sitei132 – 1321Biotin
    Binding sitei144 – 1441Biotin

    Keywords - Ligandi

    Biotin

    Enzyme and pathway databases

    SABIO-RKP22629.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Streptavidin
    OrganismiStreptomyces avidinii
    Taxonomic identifieri1895 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 183159StreptavidinPRO_0000002729Add
    BLAST

    Proteomic databases

    PRIDEiP22629.

    Interactioni

    Subunit structurei

    Homotetramer.

    Structurei

    Secondary structure

    1
    183
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni39 – 413
    Beta strandi43 – 475
    Beta strandi48 – 503
    Beta strandi52 – 576
    Beta strandi61 – 688
    Beta strandi70 – 734
    Helixi74 – 763
    Beta strandi78 – 847
    Beta strandi90 – 923
    Beta strandi95 – 10410
    Beta strandi109 – 12113
    Beta strandi123 – 1253
    Beta strandi127 – 13610
    Helixi140 – 1456
    Beta strandi147 – 15610
    Helixi161 – 1699
    Beta strandi172 – 1765
    Helixi178 – 1803

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DF8X-ray1.51A/B37-163[»]
    1HQQX-ray1.70A/B/C/D36-163[»]
    1HXLX-ray1.80A/B36-163[»]
    1HXZX-ray1.80A/B36-163[»]
    1HY2X-ray2.00A/B/C/D36-163[»]
    1I9HX-ray2.40A/B25-163[»]
    1KFFX-ray1.90A/B/C/D38-163[»]
    1KL3X-ray1.70A/B/C/D38-163[»]
    1KL4X-ray1.70A/B/C/D38-163[»]
    1KL5X-ray1.80A/B/C/D38-163[»]
    1LCVX-ray2.30A/B39-159[»]
    1LCWX-ray2.20A/B39-159[»]
    1LCZX-ray1.95A/B25-159[»]
    1LUQX-ray0.96A/B37-163[»]
    1MEPX-ray1.65A/B/C/D37-163[»]
    1MK5X-ray1.40A/B37-163[»]
    1MM9X-ray1.66A37-163[»]
    1MOYX-ray1.55A37-163[»]
    1N43X-ray1.89A/B/C/D37-163[»]
    1N4JX-ray2.18A37-163[»]
    1N7YX-ray1.96A/B/C/D37-163[»]
    1N9MX-ray1.60A/B/C/D37-163[»]
    1N9YX-ray1.53A/B/C/D37-163[»]
    1NBXX-ray1.70A/B/C/D37-163[»]
    1NC9X-ray1.80A/B/C/D37-163[»]
    1NDJX-ray1.81A/B/C/D37-163[»]
    1NQMX-ray1.70A/B/C/D24-159[»]
    1PTSX-ray2.00A/B37-157[»]
    1RSTX-ray1.70B38-163[»]
    1RSUX-ray1.70B38-163[»]
    1RXHX-ray2.90A/B37-163[»]
    1RXJX-ray1.14A/B/C/D39-159[»]
    1RXKX-ray1.70A/B38-159[»]
    1SLDX-ray2.50B25-159[»]
    1SLEX-ray2.00B/D25-159[»]
    1SLFX-ray1.76B/D25-159[»]
    1SLGX-ray1.76B/D25-159[»]
    1SREX-ray1.78A/B37-157[»]
    1SRFX-ray2.00A/B37-157[»]
    1SRGX-ray1.80A/B37-157[»]
    1SRHX-ray2.20A/B37-157[»]
    1SRIX-ray1.65A/B37-157[»]
    1SRJX-ray1.80A/B37-157[»]
    1STPX-ray2.60A25-183[»]
    1STRX-ray1.80B/D37-159[»]
    1STSX-ray1.95B/D37-159[»]
    1SWAX-ray1.90A/B/C/D37-163[»]
    1SWBX-ray1.85A/B/C/D37-163[»]
    1SWCX-ray1.80A/B/C/D37-163[»]
    1SWDX-ray1.90A/B/C/D37-163[»]
    1SWEX-ray2.06A/B/C/D37-163[»]
    1SWFX-ray2.00A/B/C/D75-163[»]
    1SWGX-ray1.80A/B/C/D75-178[»]
    1SWHX-ray1.70A/B/C/D37-163[»]
    1SWJX-ray2.00A/B/C/D37-163[»]
    1SWKX-ray2.00A/B/C/D37-163[»]
    1SWLX-ray1.80A/B/C/D37-163[»]
    1SWNX-ray2.20A/B/C/D37-163[»]
    1SWOX-ray1.95A/B/C/D37-163[»]
    1SWPX-ray2.00A/B/C/D37-163[»]
    1SWQX-ray1.90A/B/C/D37-163[»]
    1SWRX-ray1.90A/B/C/D37-163[»]
    1SWSX-ray2.00A/B/C/D37-163[»]
    1SWTX-ray2.00A/B37-163[»]
    1SWUX-ray1.14A/B/C/D37-163[»]
    1VWAX-ray1.85B/D37-159[»]
    1VWBX-ray1.82B37-159[»]
    1VWCX-ray1.86B37-159[»]
    1VWDX-ray1.87B37-159[»]
    1VWEX-ray1.50B37-159[»]
    1VWFX-ray1.92B37-159[»]
    1VWGX-ray1.46B37-159[»]
    1VWHX-ray1.48B37-159[»]
    1VWIX-ray1.50B/D37-159[»]
    1VWJX-ray1.45B/D37-159[»]
    1VWKX-ray1.45B/D37-159[»]
    1VWLX-ray1.45B/D37-159[»]
    1VWMX-ray1.60B37-159[»]
    1VWNX-ray1.85B37-159[»]
    1VWOX-ray1.65B37-159[»]
    1VWPX-ray1.75B37-159[»]
    1VWQX-ray1.70B37-159[»]
    1VWRX-ray1.50B37-159[»]
    2BC3X-ray1.54A/B38-183[»]
    2F01X-ray0.85A/B37-163[»]
    2G5LX-ray1.15A/B37-163[»]
    2GH7X-ray1.00A/B37-163[»]
    2IZAX-ray1.46A37-157[»]
    2IZBX-ray1.20A37-158[»]
    2IZCX-ray1.40B/D37-159[»]
    2IZDX-ray1.60B/D37-159[»]
    2IZEX-ray1.57B/D37-159[»]
    2IZFX-ray1.58B/D37-159[»]
    2IZGX-ray1.36B/D37-159[»]
    2IZHX-ray1.36B/D37-159[»]
    2IZIX-ray1.50A37-159[»]
    2IZJX-ray1.30A37-159[»]
    2IZKX-ray1.30A37-159[»]
    2IZLX-ray1.48B/D37-159[»]
    2QCBX-ray1.65A38-183[»]
    2RTAX-ray1.39A25-159[»]
    2RTBX-ray1.50B/D25-159[»]
    2RTCX-ray1.50B/D25-159[»]
    2RTDX-ray1.65B/D25-159[»]
    2RTEX-ray1.50B/D25-159[»]
    2RTFX-ray1.47B/D25-159[»]
    2RTGX-ray1.39B/D25-159[»]
    2RTHX-ray1.56B/D25-159[»]
    2RTIX-ray1.40B/D25-159[»]
    2RTJX-ray1.40A25-159[»]
    2RTKX-ray1.82A25-159[»]
    2RTLX-ray1.41A25-159[»]
    2RTMX-ray1.30A25-159[»]
    2RTNX-ray1.80B/D25-159[»]
    2RTOX-ray1.58B/D25-159[»]
    2RTPX-ray1.50B/D25-159[»]
    2RTQX-ray1.39B/D25-159[»]
    2RTRX-ray1.62B/D25-159[»]
    2WPUX-ray1.92A38-183[»]
    2Y3EX-ray1.45A/B37-163[»]
    2Y3FX-ray1.49A37-163[»]
    3MG5X-ray1.30A/B/C/D37-163[»]
    3PK2X-ray1.90A38-183[»]
    3RDMX-ray1.60A37-164[»]
    3RDOX-ray1.40A37-164[»]
    3RDQX-ray1.60A37-164[»]
    3RDSX-ray1.50A37-164[»]
    3RDUX-ray1.50A37-164[»]
    3RDXX-ray2.10A/B37-164[»]
    3RE5X-ray1.95A37-164[»]
    3RE6X-ray1.82A37-164[»]
    3RY1X-ray1.03A/B/C/D37-163[»]
    3RY2X-ray0.95A/B37-163[»]
    3T6FX-ray1.22A/B37-163[»]
    3T6LX-ray1.30A37-163[»]
    4BX5X-ray1.43A/C37-72[»]
    B/D37-163[»]
    4BX6X-ray1.60A/B/C/D37-163[»]
    4BX7X-ray2.26A/B37-163[»]
    4DNEX-ray1.88A/B1-183[»]
    4EKVX-ray2.00A25-183[»]
    4GD9X-ray1.50A/B/C/D37-163[»]
    4GDAX-ray1.00A/B37-163[»]
    4GJSX-ray1.85A/B38-183[»]
    4GJVX-ray2.40A38-183[»]
    4IRWX-ray1.40A36-163[»]
    4JO6X-ray1.75A/B/C/D25-183[»]
    ProteinModelPortaliP22629.
    SMRiP22629. Positions 38-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP22629.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 159123Avidin-likePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi83 – 853Cell attachment site; atypical

    Sequence similaritiesi

    Belongs to the avidin/streptavidin family.Curated
    Contains 1 avidin-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.40.128.30. 1 hit.
    InterProiIPR005469. Avidin.
    IPR017889. Avidin-like_CS.
    IPR005468. Avidin/str.
    [Graphical view]
    PfamiPF01382. Avidin. 1 hit.
    [Graphical view]
    PRINTSiPR00709. AVIDIN.
    SUPFAMiSSF50876. SSF50876. 1 hit.
    PROSITEiPS00577. AVIDIN_1. 1 hit.
    PS51326. AVIDIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P22629-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKIVVAAIA VSLTTVSITA SASADPSKDS KAQVSAAEAG ITGTWYNQLG    50
    STFIVTAGAD GALTGTYESA VGNAESRYVL TGRYDSAPAT DGSGTALGWT 100
    VAWKNNYRNA HSATTWSGQY VGGAEARINT QWLLTSGTTE ANAWKSTLVG 150
    HDTFTKVKPS AASIDAAKKA GVNNGNPLDA VQQ 183
    Length:183
    Mass (Da):18,834
    Last modified:August 1, 1991 - v1
    Checksum:i4652D8AE018468F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03591 Genomic DNA. Translation: CAA27265.1.
    PIRiA23513.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03591 Genomic DNA. Translation: CAA27265.1 .
    PIRi A23513.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DF8 X-ray 1.51 A/B 37-163 [» ]
    1HQQ X-ray 1.70 A/B/C/D 36-163 [» ]
    1HXL X-ray 1.80 A/B 36-163 [» ]
    1HXZ X-ray 1.80 A/B 36-163 [» ]
    1HY2 X-ray 2.00 A/B/C/D 36-163 [» ]
    1I9H X-ray 2.40 A/B 25-163 [» ]
    1KFF X-ray 1.90 A/B/C/D 38-163 [» ]
    1KL3 X-ray 1.70 A/B/C/D 38-163 [» ]
    1KL4 X-ray 1.70 A/B/C/D 38-163 [» ]
    1KL5 X-ray 1.80 A/B/C/D 38-163 [» ]
    1LCV X-ray 2.30 A/B 39-159 [» ]
    1LCW X-ray 2.20 A/B 39-159 [» ]
    1LCZ X-ray 1.95 A/B 25-159 [» ]
    1LUQ X-ray 0.96 A/B 37-163 [» ]
    1MEP X-ray 1.65 A/B/C/D 37-163 [» ]
    1MK5 X-ray 1.40 A/B 37-163 [» ]
    1MM9 X-ray 1.66 A 37-163 [» ]
    1MOY X-ray 1.55 A 37-163 [» ]
    1N43 X-ray 1.89 A/B/C/D 37-163 [» ]
    1N4J X-ray 2.18 A 37-163 [» ]
    1N7Y X-ray 1.96 A/B/C/D 37-163 [» ]
    1N9M X-ray 1.60 A/B/C/D 37-163 [» ]
    1N9Y X-ray 1.53 A/B/C/D 37-163 [» ]
    1NBX X-ray 1.70 A/B/C/D 37-163 [» ]
    1NC9 X-ray 1.80 A/B/C/D 37-163 [» ]
    1NDJ X-ray 1.81 A/B/C/D 37-163 [» ]
    1NQM X-ray 1.70 A/B/C/D 24-159 [» ]
    1PTS X-ray 2.00 A/B 37-157 [» ]
    1RST X-ray 1.70 B 38-163 [» ]
    1RSU X-ray 1.70 B 38-163 [» ]
    1RXH X-ray 2.90 A/B 37-163 [» ]
    1RXJ X-ray 1.14 A/B/C/D 39-159 [» ]
    1RXK X-ray 1.70 A/B 38-159 [» ]
    1SLD X-ray 2.50 B 25-159 [» ]
    1SLE X-ray 2.00 B/D 25-159 [» ]
    1SLF X-ray 1.76 B/D 25-159 [» ]
    1SLG X-ray 1.76 B/D 25-159 [» ]
    1SRE X-ray 1.78 A/B 37-157 [» ]
    1SRF X-ray 2.00 A/B 37-157 [» ]
    1SRG X-ray 1.80 A/B 37-157 [» ]
    1SRH X-ray 2.20 A/B 37-157 [» ]
    1SRI X-ray 1.65 A/B 37-157 [» ]
    1SRJ X-ray 1.80 A/B 37-157 [» ]
    1STP X-ray 2.60 A 25-183 [» ]
    1STR X-ray 1.80 B/D 37-159 [» ]
    1STS X-ray 1.95 B/D 37-159 [» ]
    1SWA X-ray 1.90 A/B/C/D 37-163 [» ]
    1SWB X-ray 1.85 A/B/C/D 37-163 [» ]
    1SWC X-ray 1.80 A/B/C/D 37-163 [» ]
    1SWD X-ray 1.90 A/B/C/D 37-163 [» ]
    1SWE X-ray 2.06 A/B/C/D 37-163 [» ]
    1SWF X-ray 2.00 A/B/C/D 75-163 [» ]
    1SWG X-ray 1.80 A/B/C/D 75-178 [» ]
    1SWH X-ray 1.70 A/B/C/D 37-163 [» ]
    1SWJ X-ray 2.00 A/B/C/D 37-163 [» ]
    1SWK X-ray 2.00 A/B/C/D 37-163 [» ]
    1SWL X-ray 1.80 A/B/C/D 37-163 [» ]
    1SWN X-ray 2.20 A/B/C/D 37-163 [» ]
    1SWO X-ray 1.95 A/B/C/D 37-163 [» ]
    1SWP X-ray 2.00 A/B/C/D 37-163 [» ]
    1SWQ X-ray 1.90 A/B/C/D 37-163 [» ]
    1SWR X-ray 1.90 A/B/C/D 37-163 [» ]
    1SWS X-ray 2.00 A/B/C/D 37-163 [» ]
    1SWT X-ray 2.00 A/B 37-163 [» ]
    1SWU X-ray 1.14 A/B/C/D 37-163 [» ]
    1VWA X-ray 1.85 B/D 37-159 [» ]
    1VWB X-ray 1.82 B 37-159 [» ]
    1VWC X-ray 1.86 B 37-159 [» ]
    1VWD X-ray 1.87 B 37-159 [» ]
    1VWE X-ray 1.50 B 37-159 [» ]
    1VWF X-ray 1.92 B 37-159 [» ]
    1VWG X-ray 1.46 B 37-159 [» ]
    1VWH X-ray 1.48 B 37-159 [» ]
    1VWI X-ray 1.50 B/D 37-159 [» ]
    1VWJ X-ray 1.45 B/D 37-159 [» ]
    1VWK X-ray 1.45 B/D 37-159 [» ]
    1VWL X-ray 1.45 B/D 37-159 [» ]
    1VWM X-ray 1.60 B 37-159 [» ]
    1VWN X-ray 1.85 B 37-159 [» ]
    1VWO X-ray 1.65 B 37-159 [» ]
    1VWP X-ray 1.75 B 37-159 [» ]
    1VWQ X-ray 1.70 B 37-159 [» ]
    1VWR X-ray 1.50 B 37-159 [» ]
    2BC3 X-ray 1.54 A/B 38-183 [» ]
    2F01 X-ray 0.85 A/B 37-163 [» ]
    2G5L X-ray 1.15 A/B 37-163 [» ]
    2GH7 X-ray 1.00 A/B 37-163 [» ]
    2IZA X-ray 1.46 A 37-157 [» ]
    2IZB X-ray 1.20 A 37-158 [» ]
    2IZC X-ray 1.40 B/D 37-159 [» ]
    2IZD X-ray 1.60 B/D 37-159 [» ]
    2IZE X-ray 1.57 B/D 37-159 [» ]
    2IZF X-ray 1.58 B/D 37-159 [» ]
    2IZG X-ray 1.36 B/D 37-159 [» ]
    2IZH X-ray 1.36 B/D 37-159 [» ]
    2IZI X-ray 1.50 A 37-159 [» ]
    2IZJ X-ray 1.30 A 37-159 [» ]
    2IZK X-ray 1.30 A 37-159 [» ]
    2IZL X-ray 1.48 B/D 37-159 [» ]
    2QCB X-ray 1.65 A 38-183 [» ]
    2RTA X-ray 1.39 A 25-159 [» ]
    2RTB X-ray 1.50 B/D 25-159 [» ]
    2RTC X-ray 1.50 B/D 25-159 [» ]
    2RTD X-ray 1.65 B/D 25-159 [» ]
    2RTE X-ray 1.50 B/D 25-159 [» ]
    2RTF X-ray 1.47 B/D 25-159 [» ]
    2RTG X-ray 1.39 B/D 25-159 [» ]
    2RTH X-ray 1.56 B/D 25-159 [» ]
    2RTI X-ray 1.40 B/D 25-159 [» ]
    2RTJ X-ray 1.40 A 25-159 [» ]
    2RTK X-ray 1.82 A 25-159 [» ]
    2RTL X-ray 1.41 A 25-159 [» ]
    2RTM X-ray 1.30 A 25-159 [» ]
    2RTN X-ray 1.80 B/D 25-159 [» ]
    2RTO X-ray 1.58 B/D 25-159 [» ]
    2RTP X-ray 1.50 B/D 25-159 [» ]
    2RTQ X-ray 1.39 B/D 25-159 [» ]
    2RTR X-ray 1.62 B/D 25-159 [» ]
    2WPU X-ray 1.92 A 38-183 [» ]
    2Y3E X-ray 1.45 A/B 37-163 [» ]
    2Y3F X-ray 1.49 A 37-163 [» ]
    3MG5 X-ray 1.30 A/B/C/D 37-163 [» ]
    3PK2 X-ray 1.90 A 38-183 [» ]
    3RDM X-ray 1.60 A 37-164 [» ]
    3RDO X-ray 1.40 A 37-164 [» ]
    3RDQ X-ray 1.60 A 37-164 [» ]
    3RDS X-ray 1.50 A 37-164 [» ]
    3RDU X-ray 1.50 A 37-164 [» ]
    3RDX X-ray 2.10 A/B 37-164 [» ]
    3RE5 X-ray 1.95 A 37-164 [» ]
    3RE6 X-ray 1.82 A 37-164 [» ]
    3RY1 X-ray 1.03 A/B/C/D 37-163 [» ]
    3RY2 X-ray 0.95 A/B 37-163 [» ]
    3T6F X-ray 1.22 A/B 37-163 [» ]
    3T6L X-ray 1.30 A 37-163 [» ]
    4BX5 X-ray 1.43 A/C 37-72 [» ]
    B/D 37-163 [» ]
    4BX6 X-ray 1.60 A/B/C/D 37-163 [» ]
    4BX7 X-ray 2.26 A/B 37-163 [» ]
    4DNE X-ray 1.88 A/B 1-183 [» ]
    4EKV X-ray 2.00 A 25-183 [» ]
    4GD9 X-ray 1.50 A/B/C/D 37-163 [» ]
    4GDA X-ray 1.00 A/B 37-163 [» ]
    4GJS X-ray 1.85 A/B 38-183 [» ]
    4GJV X-ray 2.40 A 38-183 [» ]
    4IRW X-ray 1.40 A 36-163 [» ]
    4JO6 X-ray 1.75 A/B/C/D 25-183 [» ]
    ProteinModelPortali P22629.
    SMRi P22629. Positions 38-159.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1075026.

    Proteomic databases

    PRIDEi P22629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P22629.

    Miscellaneous databases

    EvolutionaryTracei P22629.

    Family and domain databases

    Gene3Di 2.40.128.30. 1 hit.
    InterProi IPR005469. Avidin.
    IPR017889. Avidin-like_CS.
    IPR005468. Avidin/str.
    [Graphical view ]
    Pfami PF01382. Avidin. 1 hit.
    [Graphical view ]
    PRINTSi PR00709. AVIDIN.
    SUPFAMi SSF50876. SSF50876. 1 hit.
    PROSITEi PS00577. AVIDIN_1. 1 hit.
    PS51326. AVIDIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequence of the streptavidin gene."
      Argarana C.E., Kuntz I.D., Birken S., Axel R., Cantor C.R.
      Nucleic Acids Res. 14:1871-1882(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-64.
    2. "Studies on the biotin-binding site of streptavidin. Tryptophan residues involved in the active site."
      Gitlin G., Bayer E.A., Wilchek M.
      Biochem. J. 256:279-282(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: IMPORTANCE OF TRP IN BIOTIN-BINDING.
    3. "Studies on the biotin-binding sites of avidin and streptavidin. Tyrosine residues are involved in the binding site."
      Gitlin G., Bayer E.A., Wilchek M.
      Biochem. J. 269:527-530(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: IMPORTANCE OF TYR IN BIOTIN-BINDING.
    4. "Streptavidin contains an RYD sequence which mimics the RGD receptor domain of fibronectin."
      Alon R., Bayer E.A., Wilchek M.
      Biochem. Biophys. Res. Commun. 170:1236-1241(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: CELL-BINDING.
    5. "Structural origins of high-affinity biotin binding to streptavidin."
      Weber P.C., Ohlendorf D.H., Wendoloski J.J., Salemme F.R.
      Science 243:85-88(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 37-157.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 40-157.
    7. "In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0."
      Katz B.A., Cass R.T.
      J. Biol. Chem. 272:13220-13228(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 37-157.
    8. "Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH."
      Katz B.A.
      J. Mol. Biol. 274:776-800(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 37-157.
    9. "Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex."
      Freitag S., le Trong I., Chilkoti A., Klumb L.A., Stayton P.S., Stenkamp R.E.
      J. Mol. Biol. 279:211-221(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 37-157 OF MUTANTS.

    Entry informationi

    Entry nameiSAV_STRAV
    AccessioniPrimary (citable) accession number: P22629
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3