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P22629

- SAV_STRAV

UniProt

P22629 - SAV_STRAV

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Protein

Streptavidin

Gene
N/A
Organism
Streptomyces avidinii
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671Biotin
Binding sitei78 – 781Biotin
Binding sitei116 – 1161Biotin
Binding sitei132 – 1321Biotin
Binding sitei144 – 1441Biotin

Keywords - Ligandi

Biotin

Enzyme and pathway databases

SABIO-RKP22629.

Names & Taxonomyi

Protein namesi
Recommended name:
Streptavidin
OrganismiStreptomyces avidinii
Taxonomic identifieri1895 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 183159StreptavidinPRO_0000002729Add
BLAST

Proteomic databases

PRIDEiP22629.

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1
183
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni39 – 413
Beta strandi43 – 475
Beta strandi48 – 503
Beta strandi52 – 576
Beta strandi61 – 688
Beta strandi70 – 734
Helixi74 – 763
Beta strandi78 – 847
Beta strandi90 – 923
Beta strandi95 – 10410
Beta strandi109 – 12113
Beta strandi123 – 1253
Beta strandi127 – 13610
Helixi140 – 1456
Beta strandi147 – 15610
Helixi161 – 1699
Beta strandi172 – 1765
Helixi178 – 1803

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DF8X-ray1.51A/B37-163[»]
1HQQX-ray1.70A/B/C/D36-163[»]
1HXLX-ray1.80A/B36-163[»]
1HXZX-ray1.80A/B36-163[»]
1HY2X-ray2.00A/B/C/D36-163[»]
1I9HX-ray2.40A/B25-163[»]
1KFFX-ray1.90A/B/C/D38-163[»]
1KL3X-ray1.70A/B/C/D38-163[»]
1KL4X-ray1.70A/B/C/D38-163[»]
1KL5X-ray1.80A/B/C/D38-163[»]
1LCVX-ray2.30A/B39-159[»]
1LCWX-ray2.20A/B39-159[»]
1LCZX-ray1.95A/B25-159[»]
1LUQX-ray0.96A/B37-163[»]
1MEPX-ray1.65A/B/C/D37-163[»]
1MK5X-ray1.40A/B37-163[»]
1MM9X-ray1.66A37-163[»]
1MOYX-ray1.55A37-163[»]
1N43X-ray1.89A/B/C/D37-163[»]
1N4JX-ray2.18A37-163[»]
1N7YX-ray1.96A/B/C/D37-163[»]
1N9MX-ray1.60A/B/C/D37-163[»]
1N9YX-ray1.53A/B/C/D37-163[»]
1NBXX-ray1.70A/B/C/D37-163[»]
1NC9X-ray1.80A/B/C/D37-163[»]
1NDJX-ray1.81A/B/C/D37-163[»]
1NQMX-ray1.70A/B/C/D24-159[»]
1PTSX-ray2.00A/B37-157[»]
1RSTX-ray1.70B38-163[»]
1RSUX-ray1.70B38-163[»]
1RXHX-ray2.90A/B37-163[»]
1RXJX-ray1.14A/B/C/D39-159[»]
1RXKX-ray1.70A/B38-159[»]
1SLDX-ray2.50B25-159[»]
1SLEX-ray2.00B/D25-159[»]
1SLFX-ray1.76B/D25-159[»]
1SLGX-ray1.76B/D25-159[»]
1SREX-ray1.78A/B37-157[»]
1SRFX-ray2.00A/B37-157[»]
1SRGX-ray1.80A/B37-157[»]
1SRHX-ray2.20A/B37-157[»]
1SRIX-ray1.65A/B37-157[»]
1SRJX-ray1.80A/B37-157[»]
1STPX-ray2.60A25-183[»]
1STRX-ray1.80B/D37-159[»]
1STSX-ray1.95B/D37-159[»]
1SWAX-ray1.90A/B/C/D37-163[»]
1SWBX-ray1.85A/B/C/D37-163[»]
1SWCX-ray1.80A/B/C/D37-163[»]
1SWDX-ray1.90A/B/C/D37-163[»]
1SWEX-ray2.06A/B/C/D37-163[»]
1SWFX-ray2.00A/B/C/D75-163[»]
1SWGX-ray1.80A/B/C/D75-178[»]
1SWHX-ray1.70A/B/C/D37-163[»]
1SWJX-ray2.00A/B/C/D37-163[»]
1SWKX-ray2.00A/B/C/D37-163[»]
1SWLX-ray1.80A/B/C/D37-163[»]
1SWNX-ray2.20A/B/C/D37-163[»]
1SWOX-ray1.95A/B/C/D37-163[»]
1SWPX-ray2.00A/B/C/D37-163[»]
1SWQX-ray1.90A/B/C/D37-163[»]
1SWRX-ray1.90A/B/C/D37-163[»]
1SWSX-ray2.00A/B/C/D37-163[»]
1SWTX-ray2.00A/B37-163[»]
1SWUX-ray1.14A/B/C/D37-163[»]
1VWAX-ray1.85B/D37-159[»]
1VWBX-ray1.82B37-159[»]
1VWCX-ray1.86B37-159[»]
1VWDX-ray1.87B37-159[»]
1VWEX-ray1.50B37-159[»]
1VWFX-ray1.92B37-159[»]
1VWGX-ray1.46B37-159[»]
1VWHX-ray1.48B37-159[»]
1VWIX-ray1.50B/D37-159[»]
1VWJX-ray1.45B/D37-159[»]
1VWKX-ray1.45B/D37-159[»]
1VWLX-ray1.45B/D37-159[»]
1VWMX-ray1.60B37-159[»]
1VWNX-ray1.85B37-159[»]
1VWOX-ray1.65B37-159[»]
1VWPX-ray1.75B37-159[»]
1VWQX-ray1.70B37-159[»]
1VWRX-ray1.50B37-159[»]
2BC3X-ray1.54A/B38-183[»]
2F01X-ray0.85A/B37-163[»]
2G5LX-ray1.15A/B37-163[»]
2GH7X-ray1.00A/B37-163[»]
2IZAX-ray1.46A37-157[»]
2IZBX-ray1.20A37-158[»]
2IZCX-ray1.40B/D37-159[»]
2IZDX-ray1.60B/D37-159[»]
2IZEX-ray1.57B/D37-159[»]
2IZFX-ray1.58B/D37-159[»]
2IZGX-ray1.36B/D37-159[»]
2IZHX-ray1.36B/D37-159[»]
2IZIX-ray1.50A37-159[»]
2IZJX-ray1.30A37-159[»]
2IZKX-ray1.30A37-159[»]
2IZLX-ray1.48B/D37-159[»]
2QCBX-ray1.65A38-183[»]
2RTAX-ray1.39A25-159[»]
2RTBX-ray1.50B/D25-159[»]
2RTCX-ray1.50B/D25-159[»]
2RTDX-ray1.65B/D25-159[»]
2RTEX-ray1.50B/D25-159[»]
2RTFX-ray1.47B/D25-159[»]
2RTGX-ray1.39B/D25-159[»]
2RTHX-ray1.56B/D25-159[»]
2RTIX-ray1.40B/D25-159[»]
2RTJX-ray1.40A25-159[»]
2RTKX-ray1.82A25-159[»]
2RTLX-ray1.41A25-159[»]
2RTMX-ray1.30A25-159[»]
2RTNX-ray1.80B/D25-159[»]
2RTOX-ray1.58B/D25-159[»]
2RTPX-ray1.50B/D25-159[»]
2RTQX-ray1.39B/D25-159[»]
2RTRX-ray1.62B/D25-159[»]
2WPUX-ray1.92A38-183[»]
2Y3EX-ray1.45A/B37-163[»]
2Y3FX-ray1.49A37-163[»]
3MG5X-ray1.30A/B/C/D37-163[»]
3PK2X-ray1.90A38-183[»]
3RDMX-ray1.60A37-164[»]
3RDOX-ray1.40A37-164[»]
3RDQX-ray1.60A37-164[»]
3RDSX-ray1.50A37-164[»]
3RDUX-ray1.50A37-164[»]
3RDXX-ray2.10A/B37-164[»]
3RE5X-ray1.95A37-164[»]
3RE6X-ray1.82A37-164[»]
3RY1X-ray1.03A/B/C/D37-163[»]
3RY2X-ray0.95A/B37-163[»]
3T6FX-ray1.22A/B37-163[»]
3T6LX-ray1.30A37-163[»]
4BX5X-ray1.43A/C37-72[»]
B/D37-163[»]
4BX6X-ray1.60A/B/C/D37-163[»]
4BX7X-ray2.26A/B37-163[»]
4CPEX-ray1.06A/B37-163[»]
4CPFX-ray1.14A/B37-163[»]
4CPHX-ray1.64A/B/C/D37-163[»]
4CPIX-ray1.54A/B/C/D37-163[»]
4DNEX-ray1.88A/B1-183[»]
4EKVX-ray2.00A25-183[»]
4GD9X-ray1.50A/B/C/D37-163[»]
4GDAX-ray1.00A/B37-163[»]
4GJSX-ray1.85A/B38-183[»]
4GJVX-ray2.40A38-183[»]
4IRWX-ray1.40A36-163[»]
4JO6X-ray1.75A/B/C/D25-183[»]
ProteinModelPortaliP22629.
SMRiP22629. Positions 38-159.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22629.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 159123Avidin-likePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi83 – 853Cell attachment site; atypical

Sequence similaritiesi

Belongs to the avidin/streptavidin family.Curated
Contains 1 avidin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.128.30. 1 hit.
InterProiIPR005469. Avidin.
IPR017889. Avidin-like_CS.
IPR005468. Avidin/str.
[Graphical view]
PfamiPF01382. Avidin. 1 hit.
[Graphical view]
PRINTSiPR00709. AVIDIN.
SUPFAMiSSF50876. SSF50876. 1 hit.
PROSITEiPS00577. AVIDIN_1. 1 hit.
PS51326. AVIDIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22629 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKIVVAAIA VSLTTVSITA SASADPSKDS KAQVSAAEAG ITGTWYNQLG
60 70 80 90 100
STFIVTAGAD GALTGTYESA VGNAESRYVL TGRYDSAPAT DGSGTALGWT
110 120 130 140 150
VAWKNNYRNA HSATTWSGQY VGGAEARINT QWLLTSGTTE ANAWKSTLVG
160 170 180
HDTFTKVKPS AASIDAAKKA GVNNGNPLDA VQQ
Length:183
Mass (Da):18,834
Last modified:August 1, 1991 - v1
Checksum:i4652D8AE018468F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03591 Genomic DNA. Translation: CAA27265.1.
PIRiA23513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03591 Genomic DNA. Translation: CAA27265.1 .
PIRi A23513.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DF8 X-ray 1.51 A/B 37-163 [» ]
1HQQ X-ray 1.70 A/B/C/D 36-163 [» ]
1HXL X-ray 1.80 A/B 36-163 [» ]
1HXZ X-ray 1.80 A/B 36-163 [» ]
1HY2 X-ray 2.00 A/B/C/D 36-163 [» ]
1I9H X-ray 2.40 A/B 25-163 [» ]
1KFF X-ray 1.90 A/B/C/D 38-163 [» ]
1KL3 X-ray 1.70 A/B/C/D 38-163 [» ]
1KL4 X-ray 1.70 A/B/C/D 38-163 [» ]
1KL5 X-ray 1.80 A/B/C/D 38-163 [» ]
1LCV X-ray 2.30 A/B 39-159 [» ]
1LCW X-ray 2.20 A/B 39-159 [» ]
1LCZ X-ray 1.95 A/B 25-159 [» ]
1LUQ X-ray 0.96 A/B 37-163 [» ]
1MEP X-ray 1.65 A/B/C/D 37-163 [» ]
1MK5 X-ray 1.40 A/B 37-163 [» ]
1MM9 X-ray 1.66 A 37-163 [» ]
1MOY X-ray 1.55 A 37-163 [» ]
1N43 X-ray 1.89 A/B/C/D 37-163 [» ]
1N4J X-ray 2.18 A 37-163 [» ]
1N7Y X-ray 1.96 A/B/C/D 37-163 [» ]
1N9M X-ray 1.60 A/B/C/D 37-163 [» ]
1N9Y X-ray 1.53 A/B/C/D 37-163 [» ]
1NBX X-ray 1.70 A/B/C/D 37-163 [» ]
1NC9 X-ray 1.80 A/B/C/D 37-163 [» ]
1NDJ X-ray 1.81 A/B/C/D 37-163 [» ]
1NQM X-ray 1.70 A/B/C/D 24-159 [» ]
1PTS X-ray 2.00 A/B 37-157 [» ]
1RST X-ray 1.70 B 38-163 [» ]
1RSU X-ray 1.70 B 38-163 [» ]
1RXH X-ray 2.90 A/B 37-163 [» ]
1RXJ X-ray 1.14 A/B/C/D 39-159 [» ]
1RXK X-ray 1.70 A/B 38-159 [» ]
1SLD X-ray 2.50 B 25-159 [» ]
1SLE X-ray 2.00 B/D 25-159 [» ]
1SLF X-ray 1.76 B/D 25-159 [» ]
1SLG X-ray 1.76 B/D 25-159 [» ]
1SRE X-ray 1.78 A/B 37-157 [» ]
1SRF X-ray 2.00 A/B 37-157 [» ]
1SRG X-ray 1.80 A/B 37-157 [» ]
1SRH X-ray 2.20 A/B 37-157 [» ]
1SRI X-ray 1.65 A/B 37-157 [» ]
1SRJ X-ray 1.80 A/B 37-157 [» ]
1STP X-ray 2.60 A 25-183 [» ]
1STR X-ray 1.80 B/D 37-159 [» ]
1STS X-ray 1.95 B/D 37-159 [» ]
1SWA X-ray 1.90 A/B/C/D 37-163 [» ]
1SWB X-ray 1.85 A/B/C/D 37-163 [» ]
1SWC X-ray 1.80 A/B/C/D 37-163 [» ]
1SWD X-ray 1.90 A/B/C/D 37-163 [» ]
1SWE X-ray 2.06 A/B/C/D 37-163 [» ]
1SWF X-ray 2.00 A/B/C/D 75-163 [» ]
1SWG X-ray 1.80 A/B/C/D 75-178 [» ]
1SWH X-ray 1.70 A/B/C/D 37-163 [» ]
1SWJ X-ray 2.00 A/B/C/D 37-163 [» ]
1SWK X-ray 2.00 A/B/C/D 37-163 [» ]
1SWL X-ray 1.80 A/B/C/D 37-163 [» ]
1SWN X-ray 2.20 A/B/C/D 37-163 [» ]
1SWO X-ray 1.95 A/B/C/D 37-163 [» ]
1SWP X-ray 2.00 A/B/C/D 37-163 [» ]
1SWQ X-ray 1.90 A/B/C/D 37-163 [» ]
1SWR X-ray 1.90 A/B/C/D 37-163 [» ]
1SWS X-ray 2.00 A/B/C/D 37-163 [» ]
1SWT X-ray 2.00 A/B 37-163 [» ]
1SWU X-ray 1.14 A/B/C/D 37-163 [» ]
1VWA X-ray 1.85 B/D 37-159 [» ]
1VWB X-ray 1.82 B 37-159 [» ]
1VWC X-ray 1.86 B 37-159 [» ]
1VWD X-ray 1.87 B 37-159 [» ]
1VWE X-ray 1.50 B 37-159 [» ]
1VWF X-ray 1.92 B 37-159 [» ]
1VWG X-ray 1.46 B 37-159 [» ]
1VWH X-ray 1.48 B 37-159 [» ]
1VWI X-ray 1.50 B/D 37-159 [» ]
1VWJ X-ray 1.45 B/D 37-159 [» ]
1VWK X-ray 1.45 B/D 37-159 [» ]
1VWL X-ray 1.45 B/D 37-159 [» ]
1VWM X-ray 1.60 B 37-159 [» ]
1VWN X-ray 1.85 B 37-159 [» ]
1VWO X-ray 1.65 B 37-159 [» ]
1VWP X-ray 1.75 B 37-159 [» ]
1VWQ X-ray 1.70 B 37-159 [» ]
1VWR X-ray 1.50 B 37-159 [» ]
2BC3 X-ray 1.54 A/B 38-183 [» ]
2F01 X-ray 0.85 A/B 37-163 [» ]
2G5L X-ray 1.15 A/B 37-163 [» ]
2GH7 X-ray 1.00 A/B 37-163 [» ]
2IZA X-ray 1.46 A 37-157 [» ]
2IZB X-ray 1.20 A 37-158 [» ]
2IZC X-ray 1.40 B/D 37-159 [» ]
2IZD X-ray 1.60 B/D 37-159 [» ]
2IZE X-ray 1.57 B/D 37-159 [» ]
2IZF X-ray 1.58 B/D 37-159 [» ]
2IZG X-ray 1.36 B/D 37-159 [» ]
2IZH X-ray 1.36 B/D 37-159 [» ]
2IZI X-ray 1.50 A 37-159 [» ]
2IZJ X-ray 1.30 A 37-159 [» ]
2IZK X-ray 1.30 A 37-159 [» ]
2IZL X-ray 1.48 B/D 37-159 [» ]
2QCB X-ray 1.65 A 38-183 [» ]
2RTA X-ray 1.39 A 25-159 [» ]
2RTB X-ray 1.50 B/D 25-159 [» ]
2RTC X-ray 1.50 B/D 25-159 [» ]
2RTD X-ray 1.65 B/D 25-159 [» ]
2RTE X-ray 1.50 B/D 25-159 [» ]
2RTF X-ray 1.47 B/D 25-159 [» ]
2RTG X-ray 1.39 B/D 25-159 [» ]
2RTH X-ray 1.56 B/D 25-159 [» ]
2RTI X-ray 1.40 B/D 25-159 [» ]
2RTJ X-ray 1.40 A 25-159 [» ]
2RTK X-ray 1.82 A 25-159 [» ]
2RTL X-ray 1.41 A 25-159 [» ]
2RTM X-ray 1.30 A 25-159 [» ]
2RTN X-ray 1.80 B/D 25-159 [» ]
2RTO X-ray 1.58 B/D 25-159 [» ]
2RTP X-ray 1.50 B/D 25-159 [» ]
2RTQ X-ray 1.39 B/D 25-159 [» ]
2RTR X-ray 1.62 B/D 25-159 [» ]
2WPU X-ray 1.92 A 38-183 [» ]
2Y3E X-ray 1.45 A/B 37-163 [» ]
2Y3F X-ray 1.49 A 37-163 [» ]
3MG5 X-ray 1.30 A/B/C/D 37-163 [» ]
3PK2 X-ray 1.90 A 38-183 [» ]
3RDM X-ray 1.60 A 37-164 [» ]
3RDO X-ray 1.40 A 37-164 [» ]
3RDQ X-ray 1.60 A 37-164 [» ]
3RDS X-ray 1.50 A 37-164 [» ]
3RDU X-ray 1.50 A 37-164 [» ]
3RDX X-ray 2.10 A/B 37-164 [» ]
3RE5 X-ray 1.95 A 37-164 [» ]
3RE6 X-ray 1.82 A 37-164 [» ]
3RY1 X-ray 1.03 A/B/C/D 37-163 [» ]
3RY2 X-ray 0.95 A/B 37-163 [» ]
3T6F X-ray 1.22 A/B 37-163 [» ]
3T6L X-ray 1.30 A 37-163 [» ]
4BX5 X-ray 1.43 A/C 37-72 [» ]
B/D 37-163 [» ]
4BX6 X-ray 1.60 A/B/C/D 37-163 [» ]
4BX7 X-ray 2.26 A/B 37-163 [» ]
4CPE X-ray 1.06 A/B 37-163 [» ]
4CPF X-ray 1.14 A/B 37-163 [» ]
4CPH X-ray 1.64 A/B/C/D 37-163 [» ]
4CPI X-ray 1.54 A/B/C/D 37-163 [» ]
4DNE X-ray 1.88 A/B 1-183 [» ]
4EKV X-ray 2.00 A 25-183 [» ]
4GD9 X-ray 1.50 A/B/C/D 37-163 [» ]
4GDA X-ray 1.00 A/B 37-163 [» ]
4GJS X-ray 1.85 A/B 38-183 [» ]
4GJV X-ray 2.40 A 38-183 [» ]
4IRW X-ray 1.40 A 36-163 [» ]
4JO6 X-ray 1.75 A/B/C/D 25-183 [» ]
ProteinModelPortali P22629.
SMRi P22629. Positions 38-159.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1075026.

Proteomic databases

PRIDEi P22629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P22629.

Miscellaneous databases

EvolutionaryTracei P22629.

Family and domain databases

Gene3Di 2.40.128.30. 1 hit.
InterProi IPR005469. Avidin.
IPR017889. Avidin-like_CS.
IPR005468. Avidin/str.
[Graphical view ]
Pfami PF01382. Avidin. 1 hit.
[Graphical view ]
PRINTSi PR00709. AVIDIN.
SUPFAMi SSF50876. SSF50876. 1 hit.
PROSITEi PS00577. AVIDIN_1. 1 hit.
PS51326. AVIDIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and nucleotide sequence of the streptavidin gene."
    Argarana C.E., Kuntz I.D., Birken S., Axel R., Cantor C.R.
    Nucleic Acids Res. 14:1871-1882(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-64.
  2. "Studies on the biotin-binding site of streptavidin. Tryptophan residues involved in the active site."
    Gitlin G., Bayer E.A., Wilchek M.
    Biochem. J. 256:279-282(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMPORTANCE OF TRP IN BIOTIN-BINDING.
  3. "Studies on the biotin-binding sites of avidin and streptavidin. Tyrosine residues are involved in the binding site."
    Gitlin G., Bayer E.A., Wilchek M.
    Biochem. J. 269:527-530(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: IMPORTANCE OF TYR IN BIOTIN-BINDING.
  4. "Streptavidin contains an RYD sequence which mimics the RGD receptor domain of fibronectin."
    Alon R., Bayer E.A., Wilchek M.
    Biochem. Biophys. Res. Commun. 170:1236-1241(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: CELL-BINDING.
  5. "Structural origins of high-affinity biotin binding to streptavidin."
    Weber P.C., Ohlendorf D.H., Wendoloski J.J., Salemme F.R.
    Science 243:85-88(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 37-157.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 40-157.
  7. "In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0."
    Katz B.A., Cass R.T.
    J. Biol. Chem. 272:13220-13228(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 37-157.
  8. "Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH."
    Katz B.A.
    J. Mol. Biol. 274:776-800(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 37-157.
  9. "Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex."
    Freitag S., le Trong I., Chilkoti A., Klumb L.A., Stayton P.S., Stenkamp R.E.
    J. Mol. Biol. 279:211-221(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 37-157 OF MUTANTS.

Entry informationi

Entry nameiSAV_STRAV
AccessioniPrimary (citable) accession number: P22629
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3