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P22624

- MAP2_METFE

UniProt

P22624 - MAP2_METFE

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Protein

Methionine aminopeptidase

Gene

map

Organism
Methanothermus fervidus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity).By similarity

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601SubstrateBy similarity
Metal bindingi80 – 801Divalent metal cation 1By similarity
Metal bindingi91 – 911Divalent metal cation 1By similarity
Metal bindingi91 – 911Divalent metal cation 2; catalyticBy similarity
Metal bindingi164 – 1641Divalent metal cation 2; catalytic; via tele nitrogenBy similarity
Binding sitei172 – 1721SubstrateBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metalloexopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase (EC:3.4.11.18)
Short name:
MAP
Short name:
MetAP
Alternative name(s):
Peptidase M
Gene namesi
Name:map
OrganismiMethanothermus fervidus
Taxonomic identifieri2180 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›188›188Methionine aminopeptidasePRO_0000148974Add
BLAST

Proteomic databases

PRIDEiP22624.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP22624.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.90.230.10. 1 hit.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P22624-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKFKKAGKI ASKVRKKAIK AVKGEMKILD LAEFIENEIE KMGAKPAFPC
60 70 80 90 100
NISVNEITAH YSPPCNDDRK ILPGDLVKID IGVHVDGFIG DTATTVLVEG
110 120 130 140 150
YEDLKNYNDE LAEKNKKMIE AAESALENAI NTIRDGVEIG KIGEVIENTI
160 170 180
NKFGFKPISN LTGHTIDRWV LHSGLSIPNV KGQNSHKL
Length:188
Mass (Da):20,713
Last modified:August 1, 1991 - v1
Checksum:i73057519CA497F62
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei188 – 1881

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26978 Genomic DNA. Translation: AAA72775.1.
PIRiPS0039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26978 Genomic DNA. Translation: AAA72775.1 .
PIRi PS0039.

3D structure databases

ProteinModelPortali P22624.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P22624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.90.230.10. 1 hit.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes encoding 5S rRNA and tRNAs in the extremely thermophilic archaebacterium Methanothermus fervidus."
    Haas E.S., Daniels C.J., Reeve J.N.
    Gene 77:253-263(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: SIMILARITY.

Entry informationi

Entry nameiMAP2_METFE
AccessioniPrimary (citable) accession number: P22624
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3