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P22624

- MAP2_METFE

UniProt

P22624 - MAP2_METFE

Protein

Methionine aminopeptidase

Gene

map

Organism
Methanothermus fervidus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Aug 1991)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.By similarity

    Catalytic activityi

    Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    Cofactori

    Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601SubstrateBy similarity
    Metal bindingi80 – 801Divalent metal cation 1By similarity
    Metal bindingi91 – 911Divalent metal cation 1By similarity
    Metal bindingi91 – 911Divalent metal cation 2; catalyticBy similarity
    Metal bindingi164 – 1641Divalent metal cation 2; catalytic; via tele nitrogenBy similarity
    Binding sitei172 – 1721SubstrateBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. metalloexopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Metal-binding

    Protein family/group databases

    MEROPSiM24.035.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine aminopeptidase (EC:3.4.11.18)
    Short name:
    MAP
    Short name:
    MetAP
    Alternative name(s):
    Peptidase M
    Gene namesi
    Name:map
    OrganismiMethanothermus fervidus
    Taxonomic identifieri2180 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›188›188Methionine aminopeptidasePRO_0000148974Add
    BLAST

    Proteomic databases

    PRIDEiP22624.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP22624.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.90.230.10. 1 hit.
    InterProiIPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR018349. Pept_M24A_MAP2_BS.
    [Graphical view]
    PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
    PfamiPF00557. Peptidase_M24. 1 hit.
    [Graphical view]
    PRINTSiPR00599. MAPEPTIDASE.
    SUPFAMiSSF55920. SSF55920. 1 hit.
    PROSITEiPS01202. MAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P22624-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKFKKAGKI ASKVRKKAIK AVKGEMKILD LAEFIENEIE KMGAKPAFPC    50
    NISVNEITAH YSPPCNDDRK ILPGDLVKID IGVHVDGFIG DTATTVLVEG 100
    YEDLKNYNDE LAEKNKKMIE AAESALENAI NTIRDGVEIG KIGEVIENTI 150
    NKFGFKPISN LTGHTIDRWV LHSGLSIPNV KGQNSHKL 188
    Length:188
    Mass (Da):20,713
    Last modified:August 1, 1991 - v1
    Checksum:i73057519CA497F62
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei188 – 1881

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26978 Genomic DNA. Translation: AAA72775.1.
    PIRiPS0039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26978 Genomic DNA. Translation: AAA72775.1 .
    PIRi PS0039.

    3D structure databases

    ProteinModelPortali P22624.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M24.035.

    Proteomic databases

    PRIDEi P22624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.90.230.10. 1 hit.
    InterProi IPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR018349. Pept_M24A_MAP2_BS.
    [Graphical view ]
    PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
    Pfami PF00557. Peptidase_M24. 1 hit.
    [Graphical view ]
    PRINTSi PR00599. MAPEPTIDASE.
    SUPFAMi SSF55920. SSF55920. 1 hit.
    PROSITEi PS01202. MAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes encoding 5S rRNA and tRNAs in the extremely thermophilic archaebacterium Methanothermus fervidus."
      Haas E.S., Daniels C.J., Reeve J.N.
      Gene 77:253-263(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: SIMILARITY.

    Entry informationi

    Entry nameiMAP2_METFE
    AccessioniPrimary (citable) accession number: P22624
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3