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Protein

Spermatid nuclear transition protein 1

Gene

TNP1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
Protein T
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:TNP1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componentsi: Chromosome 2, Unplaced

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Loaded onto the nucleosomes of condensing spermatids.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001914212 – 55Spermatid nuclear transition protein 11 PublicationAdd BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine1 Publication1
Modified residuei36Phosphoserine1 Publication1
Modified residuei37Phosphoserine1 Publication1
Modified residuei40Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP22613.

Expressioni

Tissue specificityi

Testis.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000000539.
OMAiKRCDDAN.

Family and domain databases

InterProiView protein in InterPro
IPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiView protein in Pfam
PF02079. TP1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292. TP1. 1 hit.
PROSITEiView protein in PROSITE
PS00541. TP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKSQ GTRRGKNRTP HKGVKRGCSK RKYRKSSLKS RKRCDDANRN

FRSHL
Length:55
Mass (Da):6,475
Last modified:June 7, 2017 - v2
Checksum:i728408304DCA8479
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti28C → G1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01055949 Genomic DNA. No translation available.
PIRiS16075. BGSH.
RefSeqiXP_004004966.1. XM_004004917.3.

Genome annotation databases

EnsembliENSOART00000021156; ENSOARP00000020868; ENSOARG00000019426.
GeneIDi101108026.
KEGGioas:101108026.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMGL01055949 Genomic DNA. No translation available.
PIRiS16075. BGSH.
RefSeqiXP_004004966.1. XM_004004917.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP22613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000021156; ENSOARP00000020868; ENSOARG00000019426.
GeneIDi101108026.
KEGGioas:101108026.

Organism-specific databases

CTDi7141.

Phylogenomic databases

GeneTreeiENSGT00390000000539.
OMAiKRCDDAN.

Family and domain databases

InterProiView protein in InterPro
IPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiView protein in Pfam
PF02079. TP1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292. TP1. 1 hit.
PROSITEiView protein in PROSITE
PS00541. TP1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTP1_SHEEP
AccessioniPrimary (citable) accession number: P22613
Secondary accession number(s): W5QDS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 7, 2017
Last modified: June 7, 2017
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.