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Protein

Spermatid nuclear transition protein 1

Gene

TNP1

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
Protein T
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:TNP1
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001914211 – 54Spermatid nuclear transition protein 1Add BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8Phosphoserine1 Publication1
Modified residuei35Phosphoserine1 Publication1
Modified residuei36Phosphoserine1 Publication1
Modified residuei39Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP22613.

Expressioni

Tissue specificityi

Testis.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OMAiKRCDDAN.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
STSRKLKSQG TRRGKNRTPH KGVKRGCSKR KYRKSSLKSR KRCDDANRNF

RSHL
Length:54
Mass (Da):6,344
Last modified:August 1, 1991 - v1
Checksum:i82C945304DCAFD24
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti27C → G.1 Publication1

Sequence databases

PIRiS16075. BGSH.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

PIRiS16075. BGSH.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP22613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

CTDi7141.

Phylogenomic databases

OMAiKRCDDAN.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTP1_SHEEP
AccessioniPrimary (citable) accession number: P22613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.