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Protein

Alpha-1-antitrypsin 1-2

Gene

Serpina1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei377 – 3782Reactive bondBy similarity

GO - Molecular functioni

  • glycoprotein binding Source: MGI
  • identical protein binding Source: MGI
  • protease binding Source: MGI
  • serine-type endopeptidase inhibitor activity Source: MGI

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • in utero embryonic development Source: MGI
  • protein N-linked glycosylation Source: MGI
  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.

Protein family/group databases

MEROPSiI04.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antitrypsin 1-2
Short name:
AAT
Alternative name(s):
Alpha-1 protease inhibitor 2
Alpha-1-antiproteinase
Serine protease inhibitor 1-2
Serine protease inhibitor A1b
Short name:
Serpin A1b
Gene namesi
Name:Serpina1b
Synonyms:Aat2, Dom2, Spi1-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:891970. Serpina1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 413389Alpha-1-antitrypsin 1-2PRO_0000032389Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)1 Publication
Glycosylationi265 – 2651N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP22599.
PaxDbiP22599.
PeptideAtlasiP22599.
PRIDEiP22599.

PTM databases

iPTMnetiP22599.
PhosphoSiteiP22599.

Expressioni

Gene expression databases

BgeeiENSMUSG00000071178.
ExpressionAtlasiP22599. baseline and differential.
GenevisibleiP22599. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203428. 1 interaction.
IntActiP22599. 2 interactions.
MINTiMINT-1855477.
STRINGi10090.ENSMUSP00000093101.

Structurei

3D structure databases

ProteinModelPortaliP22599.
SMRiP22599. Positions 42-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 38720RCLAdd
BLAST

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP22599.
KOiK03984.
OMAiNITEMSE.
OrthoDBiEOG091G0ION.
PhylomeDBiP22599.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSISWGLL LLAGLCCMVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD
60 70 80 90 100
FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF
110 120 130 140 150
NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE
160 170 180 190 200
EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIVEA VKELDQDTVF
210 220 230 240 250
ALANYILFKG KWKKPFDPEN TEEAEFHVDK STTVKVPMMM LSGMLDVHHC
260 270 280 290 300
SILSSWVLLM DYAGNASAVF LLPEDGKMQH LEQTLNKELI SKILLNRRRR
310 320 330 340 350
LVQIHIPRLS ISGDYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSK
360 370 380 390 400
AVHKAVLTID ETGTEAAAAT VFEAVPMSMP PILRFDHPFL FIIFEEHTQS
410
PIFVGKVVDP THK
Length:413
Mass (Da):45,975
Last modified:June 21, 2005 - v2
Checksum:i92BD12B6D4768D7B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181M → L (PubMed:2303252).Curated
Sequence conflicti18 – 181M → L (PubMed:12408969).Curated
Sequence conflicti18 – 181M → L in AAH22109 (PubMed:15489334).Curated
Sequence conflicti18 – 181M → L in AAH25445 (PubMed:15489334).Curated
Sequence conflicti18 – 181M → L in AAH49255 (PubMed:15489334).Curated
Sequence conflicti203 – 2031A → G in AAA37132 (PubMed:2303252).Curated
Sequence conflicti240 – 2401M → T (PubMed:2303252).Curated
Sequence conflicti240 – 2401M → T (PubMed:12408969).Curated
Sequence conflicti240 – 2401M → T in AAH22109 (PubMed:15489334).Curated
Sequence conflicti240 – 2401M → T in AAH25445 (PubMed:15489334).Curated
Sequence conflicti240 – 2401M → T in AAH49255 (PubMed:15489334).Curated
Sequence conflicti252 – 2521I → T (PubMed:2303252).Curated
Sequence conflicti252 – 2521I → T (PubMed:12408969).Curated
Sequence conflicti252 – 2521I → T in AAH22109 (PubMed:15489334).Curated
Sequence conflicti252 – 2521I → T in AAH25445 (PubMed:15489334).Curated
Sequence conflicti252 – 2521I → T in AAH49255 (PubMed:15489334).Curated
Sequence conflicti263 – 2631A → V in AAM47489 (PubMed:12408969).Curated
Sequence conflicti263 – 2631A → V in AAH22109 (PubMed:15489334).Curated
Sequence conflicti263 – 2631A → V in AAH25445 (PubMed:15489334).Curated
Sequence conflicti263 – 2631A → V in AAH49255 (PubMed:15489334).Curated
Sequence conflicti286 – 2861N → S in AAM47489 (PubMed:12408969).Curated
Sequence conflicti286 – 2861N → S in AAH22109 (PubMed:15489334).Curated
Sequence conflicti286 – 2861N → S in AAH25445 (PubMed:15489334).Curated
Sequence conflicti286 – 2861N → S in AAH49255 (PubMed:15489334).Curated
Sequence conflicti298 – 2981R → H in AAM47489 (PubMed:12408969).Curated
Sequence conflicti298 – 2981R → H in AAH22109 (PubMed:15489334).Curated
Sequence conflicti298 – 2981R → H in AAH25445 (PubMed:15489334).Curated
Sequence conflicti298 – 2981R → H in AAH49255 (PubMed:15489334).Curated
Sequence conflicti314 – 3141D → E in AAA37132 (PubMed:2303252).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25529 mRNA. Translation: AAA37132.1.
AF481949 Genomic DNA. Translation: AAM47489.1.
BC022109 mRNA. Translation: AAH22109.1.
BC025445 mRNA. Translation: AAH25445.1.
BC049255 mRNA. Translation: AAH49255.2.
M75716 mRNA. Translation: AAC28865.1.
CCDSiCCDS26138.1.
PIRiI49452.
I49471.
RefSeqiNP_033270.3. NM_009244.4.
UniGeneiMm.439692.
Mm.439693.
Mm.439695.

Genome annotation databases

EnsembliENSMUST00000095450; ENSMUSP00000093101; ENSMUSG00000071178.
ENSMUST00000164454; ENSMUSP00000127266; ENSMUSG00000071178.
ENSMUST00000186166; ENSMUSP00000139941; ENSMUSG00000071178.
GeneIDi20701.
KEGGimmu:20701.
UCSCiuc007owe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25529 mRNA. Translation: AAA37132.1.
AF481949 Genomic DNA. Translation: AAM47489.1.
BC022109 mRNA. Translation: AAH22109.1.
BC025445 mRNA. Translation: AAH25445.1.
BC049255 mRNA. Translation: AAH49255.2.
M75716 mRNA. Translation: AAC28865.1.
CCDSiCCDS26138.1.
PIRiI49452.
I49471.
RefSeqiNP_033270.3. NM_009244.4.
UniGeneiMm.439692.
Mm.439693.
Mm.439695.

3D structure databases

ProteinModelPortaliP22599.
SMRiP22599. Positions 42-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203428. 1 interaction.
IntActiP22599. 2 interactions.
MINTiMINT-1855477.
STRINGi10090.ENSMUSP00000093101.

Protein family/group databases

MEROPSiI04.001.

PTM databases

iPTMnetiP22599.
PhosphoSiteiP22599.

Proteomic databases

MaxQBiP22599.
PaxDbiP22599.
PeptideAtlasiP22599.
PRIDEiP22599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095450; ENSMUSP00000093101; ENSMUSG00000071178.
ENSMUST00000164454; ENSMUSP00000127266; ENSMUSG00000071178.
ENSMUST00000186166; ENSMUSP00000139941; ENSMUSG00000071178.
GeneIDi20701.
KEGGimmu:20701.
UCSCiuc007owe.1. mouse.

Organism-specific databases

CTDi20701.
MGIiMGI:891970. Serpina1b.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiP22599.
KOiK03984.
OMAiNITEMSE.
OrthoDBiEOG091G0ION.
PhylomeDBiP22599.
TreeFamiTF343201.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.

Miscellaneous databases

PROiP22599.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071178.
ExpressionAtlasiP22599. baseline and differential.
GenevisibleiP22599. MM.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1AT2_MOUSE
AccessioniPrimary (citable) accession number: P22599
Secondary accession number(s): Q61283, Q80ZH5, Q8VC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: June 21, 2005
Last modified: September 7, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.