P22596 (GC_EHV4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycoprotein C
Short name=gC

Alternative name(s):
Glycoprotein 13

Gene names

Name:	GC
Synonyms:	GP13

Organism

Equine herpesvirus 4 (strain 1942) (EHV-4) (Equine rhinopneumonitis virus)

Taxonomic identifier

10333 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Equid herpesvirus 4

Virus host

Equus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Plays also a role in host immune evasion by inhibiting the host complement cascade activation. Ref.2
Subunit structure	Interacts with host complement component C3; this interaction inhibits host immune response by disregulating complement cascade. Ref.2
Subcellular location	Virion membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the herpesviridae glycoprotein C family. Contains 1 Ig-like (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Inhibition of host complement factors by virus Viral attachment to host cell Viral immunoevasion Virus entry into host cell
Cellular component	Membrane Virion
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological_process	suppression by virus of host complement activation Inferred from electronic annotation. Source: UniProtKB-KW viral attachment to host cell Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32
	Chain	33 – 485	453	Glycoprotein C		PRO_0000038204
Regions
	Topological domain	33 – 444	412	Virion surface Potential
	Transmembrane	445 – 468	24	Helical
	Topological domain	469 – 485	17	Cytoplasmic Potential
	Domain	237 – 330	94	Ig-like
Amino acid modifications
	Glycosylation	60	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	61	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	66	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	67	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	72	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	108	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	116	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	147	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	220	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	225	1	N-linked (GlcNAc...); by host Potential
	Glycosylation	286	1	N-linked (GlcNAc...); by host Potential
	Disulfide bond	92 ↔ 109		By similarity
	Disulfide bond	256 ↔ 318		By similarity
	Disulfide bond	357 ↔ 416		By similarity
	Disulfide bond	361 ↔ 390		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P22596 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 599AC10EB9C2598E	FASTA	485	52,509
	10 20 30 40 50 60 MGLVNIMRFI TFAYIICGGF ILTRTSGTSA SASPATPTTN TGEGTSSPVT PTYTTSTDSN 70 80 90 100 110 120 NSTATNNSTD VNGTEATPTP SHPHSHENTI TCTNSLISVP YYTSVTINCS TTVSVNHSEY 130 140 150 160 170 180 RLEIHLNQRT PFSDTPPGDQ ENYVNHNATK DQTLLLFSTA HSSAKSRRVG QLGVIPDRLP 190 200 210 220 230 240 KRQLFNLPAH TNGGTNFPLN IKSIDWRTAG VYVWYLFAKN GSLINSTSVT VLTYNAPLMD 250 260 270 280 290 300 LSVHPSLKGE NHRAVCVVAS YFPHNSVKLR WYKNAKEVDF TKYVTNASSV WVDGLITRIS 310 320 330 340 350 360 TVSIPADPDE EYPPSLRCSI EWYRDEVSFS RMAKAGTPSV FVAPTVSVNV EDGAAVCTAE 370 380 390 400 410 420 CVPSNGVFVS WVVNDHLPGV PSQDVTTGVC SSHPGLVNMR SSRPLSEENG EREYNCIIEG 430 440 450 460 470 480 YPDGLPMFSD SVVYDASPIV EDMPVLTGII AVTCGAAALA LVVLITAVCF YCSKPSQVPY KKADF

References

[1]	"The nucleotide sequence of the equine herpesvirus 4 gC gene homologue." Nicolson L., Onions D.E. Virology 179:378-387(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Glycoprotein C of equine herpesvirus 4 plays a role in viral binding to cell surface heparan sulfate." Azab W., Tsujimura K., Maeda K., Kobayashi K., Mohamed Y.M., Kato K., Matsumura T., Akashi H. Virus Res. 151:1-9(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH HOST C3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M58031 Genomic DNA. Translation: AAA46083.1.
PIR	B45343.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR001038. GA_GC. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF02124. Marek_A. 1 hit. [Graphical view]
PRINTS	PR00668. GLYCPROTEINC.
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GC_EHV4

Accession

Primary (citable) accession number: P22596

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program