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Protein

Movement and silencing protein TGBp1

Gene

ORF2

Organism
Potato virus X (strain CP) (PVX)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).By similarity

Miscellaneous

TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-cell propagation. TGBp1 is the main movement protein that physically cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would facilitate TGBp1 function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement and silencing protein TGBp1
Alternative name(s):
25 kDa protein
Silencing suppressor P25
Triple gene block 1 protein
Short name:
TGBp1
Gene namesi
ORF Names:ORF2
OrganismiPotato virus X (strain CP) (PVX)
Taxonomic identifieri12184 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaePotexvirus
Virus hostiBrassica campestris (Field mustard) [TaxID: 3711]
Solanum tuberosum (Potato) [TaxID: 4113]
Proteomesi
  • UP000008615 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002225711 – 226Movement and silencing protein TGBp1Add BLAST226

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with capsid protein. Interacts with host AGO1; this interaction targets the host protein for degradation, thereby suppressing the antiviral RNA silencing (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 138(+)RNA virus helicase ATP-bindingAdd BLAST138
Domaini139 – 226(+)RNA virus helicase C-terminalAdd BLAST88

Sequence similaritiesi

Belongs to the Tymovirales TGBp1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000NV.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
PfamiView protein in Pfam
PF01443. Viral_helicase1. 1 hit.
PROSITEiView protein in PROSITE
PS51657. PSRV_HELICASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P22592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDILIISLKS LGYSRTARPL DSSPLVVHAV AGAGKSTALR KLLARHSTFT
60 70 80 90 100
VHTLGVPDKI SIRTRGIQKP GPIPEGNFAI LDEYTLDATT REAYQALFAD
110 120 130 140 150
PYQAPELSLE PHFYLETSFR TPTKAAALIA SCGFDFETNS QEEGHLEITG
160 170 180 190 200
IFKGPLLGKV IAIDSEAETT LSRHGVEFVK PCQVTGLEFP VVTIVSAAPI
210 220
EEIGQSTLFY NAITRSKGLT YVRAGA
Length:226
Mass (Da):24,420
Last modified:August 1, 1991 - v1
Checksum:i664CD0903C1DAEFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31541 Genomic RNA. Translation: AAA47179.1.
X55802 Genomic RNA. Translation: CAA39325.1.
PIRiS14006.

Similar proteinsi

Entry informationi

Entry nameiTGB1_PVXCP
AccessioniPrimary (citable) accession number: P22592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 25, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families