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P22573 (DYR_SHV2C) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Viral dihydrofolate reductase

Short name=vDHFR
EC=1.5.1.3
Gene names
Name:DHFR
Synonyms:2
OrganismSaimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifier10384 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Viral dihydrofolate reductase
PRO_0000186381

Regions

Domain4 – 184181DHFR
Nucleotide binding16 – 227NADP By similarity
Nucleotide binding54 – 563NADP By similarity
Nucleotide binding76 – 783NADP By similarity
Nucleotide binding116 – 1238NADP By similarity
Region31 – 366Substrate binding By similarity

Sites

Binding site101NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site701Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P22573 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 932BBB2EA200033C

FASTA21324,577
        10         20         30         40         50         60 
MVLLLNCIVA VDQNMGIGKK GHLPWPLLIN DFKYFQRMTT SSVKNKQNLV IMGKNTWFSI 

        70         80         90        100        110        120 
PEKNRPLKDR INLVLSKKLK EIPHGAHFLA RSLNDALKLI EQPELVNKVD RVWIIGGSSV 

       130        140        150        160        170        180 
YKDAMNYSSH LKLFVTRIMQ SFETDTFFPE IDLKNYKLLI EYPGVPSNTQ EEKGIKYKFE 

       190        200        210 
VYEKIVNTFL FKSHAGLTCS VKPKEASYDF ELS 

« Hide

References

[1]"The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype."
Biesinger B., Trimble J.J., Desrosiers R.C., Fleckenstein B.
Virology 176:505-514(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55264 Genomic DNA. Translation: AAA72932.1.

3D structure databases

ProteinModelPortalP22573.
SMRP22573. Positions 5-184.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00077; UER00158.

Family and domain databases

Gene3D3.40.430.10. 1 hit.
InterProIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSPR00070. DHFR.
SUPFAMSSF53597. SSF53597. 1 hit.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDYR_SHV2C
AccessionPrimary (citable) accession number: P22573
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 16, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways