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Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6H

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166119Add
BLAST

Interactioni

Subunit structurei

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018123.

Structurei

3D structure databases

ProteinModelPortaliP22571.
SMRiP22571. Positions 11-83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
BLAST

Domaini

The C-terminal region is important in conferring inhibition.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG44345.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP22571.
KOiK13760.
OMAiNDIPLME.
OrthoDBiEOG7SN8FW.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P22571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI
60 70 80
PGMEGLGTDI TVICPWEAFS HLELHELAQF GII
Length:83
Mass (Da):9,102
Last modified:August 1, 1991 - v1
Checksum:i755D0639015327DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05578 mRNA. Translation: AAA30689.1.
RefSeqiNP_776847.1. NM_174422.2.
UniGeneiBt.445.

Genome annotation databases

EnsembliENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635.
GeneIDi281978.
KEGGibta:281978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05578 mRNA. Translation: AAA30689.1.
RefSeqiNP_776847.1. NM_174422.2.
UniGeneiBt.445.

3D structure databases

ProteinModelPortaliP22571.
SMRiP22571. Positions 11-83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018123.

Chemistry

ChEMBLiCHEMBL2096979.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635.
GeneIDi281978.
KEGGibta:281978.

Organism-specific databases

CTDi5149.

Phylogenomic databases

eggNOGiNOG44345.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP22571.
KOiK13760.
OMAiNDIPLME.
OrthoDBiEOG7SN8FW.
TreeFamiTF333297.

Miscellaneous databases

NextBioi20805849.
PROiP22571.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A phosphodiesterase inhibitor specific to a subset of bovine retinal cones."
    Hamilton S.E., Hurley J.B.
    J. Biol. Chem. 265:11259-11264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCNCG_BOVIN
AccessioniPrimary (citable) accession number: P22571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 29, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.