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Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6H

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processSensory transduction, Vision
LigandcGMP

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2096979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001661191 – 83Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaAdd BLAST83

Proteomic databases

PaxDbiP22571.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013635.

Interactioni

Subunit structurei

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018123.

Chemistry databases

BindingDBiP22571.

Structurei

3D structure databases

ProteinModelPortaliP22571.
SMRiP22571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 41Arg/Lys-rich (basic)Add BLAST22

Domaini

The C-terminal region is important in conferring inhibition.

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP22571.
KOiK13760.
OMAiNDIPLME.
OrthoDBiEOG091G14J5.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiView protein in InterPro
IPR006952. PDE6_gamma.
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiView protein in Pfam
PF04868. PDE6_gamma. 1 hit.
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P22571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI
60 70 80
PGMEGLGTDI TVICPWEAFS HLELHELAQF GII
Length:83
Mass (Da):9,102
Last modified:August 1, 1991 - v1
Checksum:i755D0639015327DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05578 mRNA. Translation: AAA30689.1.
RefSeqiNP_776847.1. NM_174422.2.
UniGeneiBt.445.

Genome annotation databases

EnsembliENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635.
GeneIDi281978.
KEGGibta:281978.

Similar proteinsi

Entry informationi

Entry nameiCNCG_BOVIN
AccessioniPrimary (citable) accession number: P22571
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: August 30, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families