P22571 (CNCG_BOVIN) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 70.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma Short name=GMP-PDE gamma EC=3.1.4.35 | ||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||
| Taxonomic identifier | 9913 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 83 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. |
| Catalytic activity | Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. |
| Subunit structure | Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). |
| Domain | The C-terminal region is important in conferring inhibition. |
| Sequence similarities | Belongs to the rod/cone cGMP-PDE gamma subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Sensory transduction Vision |
| Ligand | cGMP |
| Molecular function | Hydrolase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | visual perception Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3',5'-cyclic-GMP phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
References
| [1] | "A phosphodiesterase inhibitor specific to a subset of bovine retinal cones." Hamilton S.E., Hurley J.B. J. Biol. Chem. 265:11259-11264(1990) [PubMed: 2162841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | J05578 mRNA. Translation: AAA30689.1. |
| IPI | IPI00706689. |
| RefSeq | NP_776847.1. NM_174422.2. |
| UniGene | Bt.445. |
3D structure databases | |
| ProteinModelPortal | P22571. |
| SMR | P22571. Positions 11-83. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P22571. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635. |
| GeneID | 281978. |
| KEGG | bta:281978. |
Organism-specific databases | |
| CTD | 5149. |
Phylogenomic databases | |
| eggNOG | maNOG20695. |
| GeneTree | ENSGT00390000013260. |
| HOVERGEN | HBG000447. |
| InParanoid | P22571. |
| OMA | TSNQGPT. |
| OrthoDB | EOG43210Q. |
| PhylomeDB | P22571. |
Family and domain databases | |
| InterPro | IPR006952. PDE6_gamma. [Graphical view] |
| KO | K13760. |
| PANTHER | PTHR12122. PDE6_gamma. 1 hit. |
| Pfam | PF04868. PDE6_gamma. 1 hit. [Graphical view] |
| PIRSF | PIRSF000969. 35-cGMP_Pdiase_g. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | CNCG_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P22571 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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