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P22571 (CNCG_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Short name=GMP-PDE gamma
EC=3.1.4.35
Gene names
Name:PDE6H
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length83 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Subunit structure

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Domain

The C-terminal region is important in conferring inhibition.

Sequence similarities

Belongs to the rod/cone cGMP-PDE gamma subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
PRO_0000166119

Regions

Compositional bias20 – 4122Arg/Lys-rich (basic)

Sequences

Sequence LengthMass (Da)Tools
P22571 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 755D0639015327DA

FASTA839,102
        10         20         30         40         50         60 
MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI 

        70         80 
TVICPWEAFS HLELHELAQF GII 

« Hide

References

[1]"A phosphodiesterase inhibitor specific to a subset of bovine retinal cones."
Hamilton S.E., Hurley J.B.
J. Biol. Chem. 265:11259-11264(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05578 mRNA. Translation: AAA30689.1.
RefSeqNP_776847.1. NM_174422.2.
UniGeneBt.445.

3D structure databases

ProteinModelPortalP22571.
SMRP22571. Positions 11-83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000018123.

Chemistry

BindingDBP22571.
ChEMBLCHEMBL2096979.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635.
GeneID281978.
KEGGbta:281978.

Organism-specific databases

CTD5149.

Phylogenomic databases

eggNOGNOG44345.
GeneTreeENSGT00390000013260.
HOGENOMHOG000261673.
HOVERGENHBG000447.
InParanoidP22571.
KOK13760.
OMATSNQGPT.
OrthoDBEOG7SN8FW.
TreeFamTF333297.

Family and domain databases

Gene3D4.10.1120.10. 1 hit.
InterProIPR006952. PDE6_gamma.
[Graphical view]
PANTHERPTHR12122. PTHR12122. 1 hit.
PfamPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetSearch...

Other

NextBio20805849.

Entry information

Entry nameCNCG_BOVIN
AccessionPrimary (citable) accession number: P22571
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families