Reviewed, UniProtKB/Swiss-Prot P22571 (CNCG_BOVIN)

Names and origin

Protein names

Recommended name:
    Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
      Short name=GMP-PDE gamma
    EC=3.1.4.17

Gene names

Name:

PDE6H

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	83 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).
Domain	The C-terminal region is important in conferring inhibition.
Sequence similarities	Belongs to the rod/cone cGMP-PDE gamma subunit family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Ligand	cGMP
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 83	83	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		PRO_0000166119
Regions
	Compositional bias	20 – 41	22	Arg/Lys-rich (basic)

Sequences

	Sequence		Length	Mass (Da)
	P22571-1 [UniParc]. Last modified August 1, 1991. Version 1. Checksum: 755D0639015327DA	FASTA	83	9,102
	10 20 30 40 50 60 MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI PGMEGLGTDI 70 80 TVICPWEAFS HLELHELAQF GII

References

[1]	"A phosphodiesterase inhibitor specific to a subset of bovine retinal cones." Hamilton S.E., Hurley J.B. J. Biol. Chem. 265:11259-11264(1990) [PubMed: 2162841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	J05578 mRNA. Translation: AAA30689.1.
IPI	IPI00706689.
RefSeq	NP_776847.1.
UniGene	Bt.445
3D structure databases
SMR	P22571. Positions 11-82, 46-83.
ModBase	Search...
Protein-protein interaction databases
STRING	P22571.
Genome annotation databases
Ensembl	ENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635; Bos taurus. [Genome view]
GeneID	281978.
KEGG	bta:281978.
Organism-specific databases
CTD	281978.
Phylogenomic databases
eggNOG	maNOG20695.
HOVERGEN	P22571.
InParanoid	P22571.
OMA	MSDNTAL.
OrthoDB	EOG9KSS52.
PhylomeDB	P22571.
Enzyme and pathway databases
BRENDA	3.1.4.17. 251.
Family and domain databases
InterPro	IPR006952. PDE6_gamma. [Graphical view]
PANTHER	PTHR12122. PDE6_gamma. 1 hit.
Pfam	PF04868. PDE6_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CNCG_BOVIN

Accession

Primary (citable) accession number: P22571

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	August 1, 1991
Last modified:	January 19, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)