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P22571

- CNCG_BOVIN

UniProt

P22571 - CNCG_BOVIN

Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6H

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:PDE6H
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 5

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166119Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000018123.

    Structurei

    3D structure databases

    ProteinModelPortaliP22571.
    SMRiP22571. Positions 11-83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
    BLAST

    Domaini

    The C-terminal region is important in conferring inhibition.

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44345.
    GeneTreeiENSGT00390000013260.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    InParanoidiP22571.
    KOiK13760.
    OMAiTSNQGPT.
    OrthoDBiEOG7SN8FW.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P22571-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI   50
    PGMEGLGTDI TVICPWEAFS HLELHELAQF GII 83
    Length:83
    Mass (Da):9,102
    Last modified:August 1, 1991 - v1
    Checksum:i755D0639015327DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05578 mRNA. Translation: AAA30689.1.
    RefSeqiNP_776847.1. NM_174422.2.
    UniGeneiBt.445.

    Genome annotation databases

    EnsembliENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635.
    GeneIDi281978.
    KEGGibta:281978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05578 mRNA. Translation: AAA30689.1 .
    RefSeqi NP_776847.1. NM_174422.2.
    UniGenei Bt.445.

    3D structure databases

    ProteinModelPortali P22571.
    SMRi P22571. Positions 11-83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000018123.

    Chemistry

    BindingDBi P22571.
    ChEMBLi CHEMBL2096979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000018123 ; ENSBTAP00000018123 ; ENSBTAG00000013635 .
    GeneIDi 281978.
    KEGGi bta:281978.

    Organism-specific databases

    CTDi 5149.

    Phylogenomic databases

    eggNOGi NOG44345.
    GeneTreei ENSGT00390000013260.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    InParanoidi P22571.
    KOi K13760.
    OMAi TSNQGPT.
    OrthoDBi EOG7SN8FW.
    TreeFami TF333297.

    Miscellaneous databases

    NextBioi 20805849.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A phosphodiesterase inhibitor specific to a subset of bovine retinal cones."
      Hamilton S.E., Hurley J.B.
      J. Biol. Chem. 265:11259-11264(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCNCG_BOVIN
    AccessioniPrimary (citable) accession number: P22571
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1991
    Last sequence update: August 1, 1991
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3