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P22571

- CNCG_BOVIN

UniProt

P22571 - CNCG_BOVIN

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Protein

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6H

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cGMP binding Source: InterPro

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  4. response to stimulus Source: UniProtKB-KW
  5. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166119Add
BLAST

Interactioni

Subunit structurei

Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018123.

Structurei

3D structure databases

ProteinModelPortaliP22571.
SMRiP22571. Positions 11-83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 4122Arg/Lys-rich (basic)Add
BLAST

Domaini

The C-terminal region is important in conferring inhibition.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG44345.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP22571.
KOiK13760.
OMAiTSNQGPT.
OrthoDBiEOG7SN8FW.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P22571-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDNTVLAPP TSNQGPTTPR KGPPKFKQRQ TRQFKSKPPK KGVKGFGDDI
60 70 80
PGMEGLGTDI TVICPWEAFS HLELHELAQF GII
Length:83
Mass (Da):9,102
Last modified:August 1, 1991 - v1
Checksum:i755D0639015327DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05578 mRNA. Translation: AAA30689.1.
RefSeqiNP_776847.1. NM_174422.2.
UniGeneiBt.445.

Genome annotation databases

EnsembliENSBTAT00000018123; ENSBTAP00000018123; ENSBTAG00000013635.
GeneIDi281978.
KEGGibta:281978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05578 mRNA. Translation: AAA30689.1 .
RefSeqi NP_776847.1. NM_174422.2.
UniGenei Bt.445.

3D structure databases

ProteinModelPortali P22571.
SMRi P22571. Positions 11-83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000018123.

Chemistry

ChEMBLi CHEMBL2096979.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000018123 ; ENSBTAP00000018123 ; ENSBTAG00000013635 .
GeneIDi 281978.
KEGGi bta:281978.

Organism-specific databases

CTDi 5149.

Phylogenomic databases

eggNOGi NOG44345.
GeneTreei ENSGT00390000013260.
HOGENOMi HOG000261673.
HOVERGENi HBG000447.
InParanoidi P22571.
KOi K13760.
OMAi TSNQGPT.
OrthoDBi EOG7SN8FW.
TreeFami TF333297.

Miscellaneous databases

NextBioi 20805849.

Family and domain databases

Gene3Di 4.10.1120.10. 1 hit.
InterProi IPR006952. PDE6_gamma.
[Graphical view ]
PANTHERi PTHR12122. PTHR12122. 1 hit.
Pfami PF04868. PDE6_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A phosphodiesterase inhibitor specific to a subset of bovine retinal cones."
    Hamilton S.E., Hurley J.B.
    J. Biol. Chem. 265:11259-11264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCNCG_BOVIN
AccessioniPrimary (citable) accession number: P22571
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3