##gff-version 3
P22543	UniProtKB	Chain	1	875	.	.	.	ID=PRO_0000088818;Note=Phosphatidylinositol 3-kinase VPS34	
P22543	UniProtKB	Domain	14	188	.	.	.	Note=C2 PI3K-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00880	
P22543	UniProtKB	Domain	293	526	.	.	.	Note=PIK helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00878	
P22543	UniProtKB	Domain	593	859	.	.	.	Note=PI3K/PI4K catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269	
P22543	UniProtKB	Region	599	605	.	.	.	Note=G-loop;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269	
P22543	UniProtKB	Region	728	736	.	.	.	Note=Catalytic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269	
P22543	UniProtKB	Region	747	768	.	.	.	Note=Activation loop;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00269	
P22543	UniProtKB	Mutagenesis	731	731	.	.	.	Note=Loss of kinase activity and no vacuolar carboxypeptidase Y (PCR1) sorting to the vacuole. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8385367;Dbxref=PMID:8385367	
P22543	UniProtKB	Mutagenesis	736	736	.	.	.	Note=Loss of kinase activity and no vacuolar carboxypeptidase Y (PCR1) sorting to the vacuole. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8385367;Dbxref=PMID:8385367	
P22543	UniProtKB	Mutagenesis	749	749	.	.	.	Note=Loss of kinase activity and no vacuolar carboxypeptidase Y (PCR1) sorting to the vacuole. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8385367;Dbxref=PMID:8385367