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Protein

Heat-stable enterotoxin II

Gene

stiI

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.

GO - Molecular functioni

Keywordsi

Molecular functionEnterotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Heat-stable enterotoxin II
Short name:
STII
Alternative name(s):
Enterotoxin B
ST-B
Gene namesi
Name:stiI
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000003513224 – 71Heat-stable enterotoxin IIAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 71
Disulfide bondi44 ↔ 59

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 45Combined sources13
Beta strandi48 – 55Combined sources8
Turni58 – 62Combined sources5
Helixi63 – 66Combined sources4
Turni67 – 69Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EHSNMR-A24-71[»]
ProteinModelPortaliP22542.
SMRiP22542.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP22542.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.10.10. 1 hit.
InterProiView protein in InterPro
IPR015160. STb_secrete.
IPR036479. STb_sf.
PfamiView protein in Pfam
PF09075. STb_secrete. 1 hit.
SUPFAMiSSF57007. SSF57007. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKNIAFLLA SMFVFSIATN AYASTQSNKK DLCEHYRQIA KESCKKGFLG
60 70
VRDGTAGACF GAQIMVAAKG C
Length:71
Mass (Da):7,642
Last modified:August 1, 1991 - v1
Checksum:iD7D1B6EDF5347DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35729 Genomic DNA. Translation: AAA23989.1.
M35586 Genomic DNA. Translation: AAA24655.1.
PIRiA33065.
RefSeqiWP_000739296.1. NZ_NXMG01000115.1.

Similar proteinsi

Entry informationi

Entry nameiHSTI_ECOLX
AccessioniPrimary (citable) accession number: P22542
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: January 31, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references