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P22541 (GUNA_BUTFI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endoglucanase A

EC=3.2.1.4
Alternative name(s):
Cellulase A
Endo-1,4-beta-glucanase A
Short name=EgA
Gene names
Name:celA
OrganismButyrivibrio fibrisolvens
Taxonomic identifier831 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sequence similarities

Belongs to the glycosyl hydrolase 5 (cellulase A) family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncellulase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Ref.1
Chain35 – 429395Endoglucanase A
PRO_0000007842

Sites

Active site2491Proton donor By similarity
Active site3341Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P22541 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 7144A574505E2EAE

FASTA42948,859
        10         20         30         40         50         60 
MVSKKQKFLT VILVIVLAIV IVGGVFGISF VKGRVTFPWQ LQNSEAKTEQ VKEPAKEEPK 

        70         80         90        100        110        120 
LVIKEKKQDE SAKKEQELKK AKEEAEAAVE KETEKTEEEP VDNLLNDMKL KYYGKLAVEG 

       130        140        150        160        170        180 
SHLVDADGHE VLLMGVSTHG INWYPEYASA ETIKSLRDTW GINVIRLAMY TSDYNGYCVA 

       190        200        210        220        230        240 
GKENQEKLKD IIDDAVEAAT DNDMYVIIDW HTLNDADPNE YKADAIQFFG EMVRKYKDNE 

       250        260        270        280        290        300 
NVIYEICNEP NGDTTWNDVR RYANEVIPVI RNVDAIILVG TPKWATDLDS VLDKPLDFDN 

       310        320        330        340        350        360 
IMYTYHFYAG THHKAERNAL RDALDEGLPV FISEYGLVDA DGDGNLNEKE ADYWYDMIRK 

       370        380        390        400        410        420 
EYGVSSCMWN LSNKDEGSAM INADCDKLSD FTEEDLSESA MWLIDQISQL KHSDLEQGVD 


WITPENNNR 

« Hide

References

[1]"Cloning and sequencing of the celA gene encoding endoglucanase A of Butyrivibrio fibrisolvens strain A46."
Hazlewood G.P., Davidson K., Laurie J.I., Romaniec M.P.M., Gilbert H.J.
J. Gen. Microbiol. 136:2089-2097(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 35-50.
Strain: A46.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37031 Genomic DNA. Translation: AAA20893.1.
PIRS29044.

3D structure databases

ProteinModelPortalP22541.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUNA_BUTFI
AccessionPrimary (citable) accession number: P22541
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries