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P22541

- GUNA_BUTFI

UniProt

P22541 - GUNA_BUTFI

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Protein

Endoglucanase A

Gene
celA
Organism
Butyrivibrio fibrisolvens
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei249 – 2491Proton donor By similarity
Active sitei334 – 3341Nucleophile By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase A (EC:3.2.1.4)
Alternative name(s):
Cellulase A
Endo-1,4-beta-glucanase A
Short name:
EgA
Gene namesi
Name:celA
OrganismiButyrivibrio fibrisolvens
Taxonomic identifieri831 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeButyrivibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 34341 PublicationAdd
BLAST
Chaini35 – 429395Endoglucanase APRO_0000007842Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP22541.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P22541-1 [UniParc]FASTAAdd to Basket

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MVSKKQKFLT VILVIVLAIV IVGGVFGISF VKGRVTFPWQ LQNSEAKTEQ    50
VKEPAKEEPK LVIKEKKQDE SAKKEQELKK AKEEAEAAVE KETEKTEEEP 100
VDNLLNDMKL KYYGKLAVEG SHLVDADGHE VLLMGVSTHG INWYPEYASA 150
ETIKSLRDTW GINVIRLAMY TSDYNGYCVA GKENQEKLKD IIDDAVEAAT 200
DNDMYVIIDW HTLNDADPNE YKADAIQFFG EMVRKYKDNE NVIYEICNEP 250
NGDTTWNDVR RYANEVIPVI RNVDAIILVG TPKWATDLDS VLDKPLDFDN 300
IMYTYHFYAG THHKAERNAL RDALDEGLPV FISEYGLVDA DGDGNLNEKE 350
ADYWYDMIRK EYGVSSCMWN LSNKDEGSAM INADCDKLSD FTEEDLSESA 400
MWLIDQISQL KHSDLEQGVD WITPENNNR 429
Length:429
Mass (Da):48,859
Last modified:August 1, 1991 - v1
Checksum:i7144A574505E2EAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37031 Genomic DNA. Translation: AAA20893.1.
PIRiS29044.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37031 Genomic DNA. Translation: AAA20893.1 .
PIRi S29044.

3D structure databases

ProteinModelPortali P22541.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the celA gene encoding endoglucanase A of Butyrivibrio fibrisolvens strain A46."
    Hazlewood G.P., Davidson K., Laurie J.I., Romaniec M.P.M., Gilbert H.J.
    J. Gen. Microbiol. 136:2089-2097(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 35-50.
    Strain: A46.

Entry informationi

Entry nameiGUNA_BUTFI
AccessioniPrimary (citable) accession number: P22541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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