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Protein

Small proline-rich protein 2D

Gene

SPRR2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: GO_Central
  • peptide cross-linking Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2D
Short name:
SPR-2D
Alternative name(s):
Small proline-rich protein II
Short name:
SPR-II
Gene namesi
Name:SPRR2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11264. SPRR2D.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: GO_Central
  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36093.

Polymorphism and mutation databases

BioMutaiSPRR2D.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Small proline-rich protein 2DPRO_0000150010Add
BLAST

Proteomic databases

PaxDbiP22532.
PRIDEiP22532.

PTM databases

iPTMnetiP22532.

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiP22532.
CleanExiHS_SPRR2D.
GenevisibleiP22532. HS.

Interactioni

Protein-protein interaction databases

BioGridi112581. 5 interactions.
IntActiP22532. 4 interactions.
MINTiMINT-8247553.
STRINGi9606.ENSP00000353542.

Structurei

3D structure databases

ProteinModelPortaliP22532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati30 – 3892
Repeati39 – 4793

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 47273 X 9 AA tandem repeats of P-K-C-P-[EQ]-P-C-P-[PS]Add
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCEW. Eukaryota.
ENOG4110P1H. LUCA.
GeneTreeiENSGT00840000130291.
HOVERGENiHBG095432.
OMAiCTEKCTP.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPSPK CPQPCPPQQC
60 70
QQKYPPVTPS PPCQPKCPPK SK
Length:72
Mass (Da):7,905
Last modified:March 15, 2004 - v2
Checksum:i87B4502DD773D448
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221K → N in AAA36640 (PubMed:3133554).Curated
Sequence conflicti32 – 321C → S in AAA36640 (PubMed:3133554).Curated
Sequence conflicti38 – 392SP → PS in AAA36640 (PubMed:3133554).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201T → A.1 Publication
Corresponds to variant rs1846857 [ dbSNP | Ensembl ].
VAR_053049

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21302 mRNA. Translation: AAA36640.1.
AF333954 Genomic DNA. Translation: AAK70941.1.
AK291317 mRNA. Translation: BAF84006.1.
AL356867 Genomic DNA. Translation: CAI19806.1.
CH471121 Genomic DNA. Translation: EAW53348.1.
CH471121 Genomic DNA. Translation: EAW53349.1.
CH471121 Genomic DNA. Translation: EAW53350.1.
BC120938 mRNA. Translation: AAI20939.1.
CCDSiCCDS30864.1.
RefSeqiNP_008876.3. NM_006945.4.
UniGeneiHs.505327.

Genome annotation databases

EnsembliENST00000360379; ENSP00000353542; ENSG00000163216.
ENST00000368756; ENSP00000357745; ENSG00000163216.
ENST00000368757; ENSP00000357746; ENSG00000163216.
ENST00000368758; ENSP00000357747; ENSG00000163216.
GeneIDi6703.
KEGGihsa:6703.
UCSCiuc001fbb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21302 mRNA. Translation: AAA36640.1.
AF333954 Genomic DNA. Translation: AAK70941.1.
AK291317 mRNA. Translation: BAF84006.1.
AL356867 Genomic DNA. Translation: CAI19806.1.
CH471121 Genomic DNA. Translation: EAW53348.1.
CH471121 Genomic DNA. Translation: EAW53349.1.
CH471121 Genomic DNA. Translation: EAW53350.1.
BC120938 mRNA. Translation: AAI20939.1.
CCDSiCCDS30864.1.
RefSeqiNP_008876.3. NM_006945.4.
UniGeneiHs.505327.

3D structure databases

ProteinModelPortaliP22532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112581. 5 interactions.
IntActiP22532. 4 interactions.
MINTiMINT-8247553.
STRINGi9606.ENSP00000353542.

PTM databases

iPTMnetiP22532.

Polymorphism and mutation databases

BioMutaiSPRR2D.

Proteomic databases

PaxDbiP22532.
PRIDEiP22532.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360379; ENSP00000353542; ENSG00000163216.
ENST00000368756; ENSP00000357745; ENSG00000163216.
ENST00000368757; ENSP00000357746; ENSG00000163216.
ENST00000368758; ENSP00000357747; ENSG00000163216.
GeneIDi6703.
KEGGihsa:6703.
UCSCiuc001fbb.2. human.

Organism-specific databases

CTDi6703.
GeneCardsiSPRR2D.
HGNCiHGNC:11264. SPRR2D.
neXtProtiNX_P22532.
PharmGKBiPA36093.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCEW. Eukaryota.
ENOG4110P1H. LUCA.
GeneTreeiENSGT00840000130291.
HOVERGENiHBG095432.
OMAiCTEKCTP.

Miscellaneous databases

GenomeRNAii6703.
PROiP22532.

Gene expression databases

BgeeiP22532.
CleanExiHS_SPRR2D.
GenevisibleiP22532. HS.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes."
    Kartasova T., van de Putte P.
    Mol. Cell. Biol. 8:2195-2203(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Keratinocyte.
  2. "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function."
    Cabral A., Voskamp P., Cleton-Jansen A.-M., South A., Nizetic D., Backendorf C.
    J. Biol. Chem. 276:19231-19237(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-20.
    Tissue: Tongue.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSPR2D_HUMAN
AccessioniPrimary (citable) accession number: P22532
Secondary accession number(s): A4QN03
, A8K5K2, D3DV33, Q5T523, Q96RM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 15, 2004
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.