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Protein

Small proline-rich protein 2E

Gene

SPRR2E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: GO_Central
  • peptide cross-linking Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2E
Short name:
SPR-2E
Alternative name(s):
Small proline-rich protein II
Short name:
SPR-II
Gene namesi
Name:SPRR2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11265. SPRR2E.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: GO_Central
  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36094.

Polymorphism and mutation databases

BioMutaiSPRR2E.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Small proline-rich protein 2EPRO_0000150011Add
BLAST

Proteomic databases

PaxDbiP22531.
PRIDEiP22531.

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

CleanExiHS_SPRR2E.

Interactioni

Protein-protein interaction databases

BioGridi112582. 8 interactions.
IntActiP22531. 8 interactions.
STRINGi9606.ENSP00000357739.

Structurei

3D structure databases

DisProtiDP00130.
ProteinModelPortaliP22531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati30 – 3892
Repeati39 – 4793

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 47273 X 9 AA tandem repeats of P-K-C-P-[EQ]-P-C-P-PAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCBD. Eukaryota.
ENOG4110P50. LUCA.
GeneTreeiENSGT00840000130291.
OMAiQQEQCKQ.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P22531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC
60 70
QQKCPPVTPS PPCQPKCPPK SK
Length:72
Mass (Da):7,855
Last modified:March 15, 2004 - v2
Checksum:i87B4420A98A3D448
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451C → S in AAA36639 (PubMed:3133554).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20030 mRNA. Translation: AAA36639.1.
AF333955 Genomic DNA. Translation: AAK70942.1.
AL139417 Genomic DNA. Translation: CAI21953.1.
CCDSiCCDS30866.1.
PIRiB27725.
RefSeqiNP_001019380.2. NM_001024209.3.
UniGeneiHs.568518.

Genome annotation databases

EnsembliENST00000368750; ENSP00000357739; ENSG00000203785.
ENST00000368751; ENSP00000357740; ENSG00000203785.
GeneIDi6704.
KEGGihsa:6704.
UCSCiuc001fbh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20030 mRNA. Translation: AAA36639.1.
AF333955 Genomic DNA. Translation: AAK70942.1.
AL139417 Genomic DNA. Translation: CAI21953.1.
CCDSiCCDS30866.1.
PIRiB27725.
RefSeqiNP_001019380.2. NM_001024209.3.
UniGeneiHs.568518.

3D structure databases

DisProtiDP00130.
ProteinModelPortaliP22531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112582. 8 interactions.
IntActiP22531. 8 interactions.
STRINGi9606.ENSP00000357739.

Polymorphism and mutation databases

BioMutaiSPRR2E.

Proteomic databases

PaxDbiP22531.
PRIDEiP22531.

Protocols and materials databases

DNASUi6704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368750; ENSP00000357739; ENSG00000203785.
ENST00000368751; ENSP00000357740; ENSG00000203785.
GeneIDi6704.
KEGGihsa:6704.
UCSCiuc001fbh.3. human.

Organism-specific databases

CTDi6704.
GeneCardsiSPRR2E.
H-InvDBHIX0028770.
HIX0028927.
HGNCiHGNC:11265. SPRR2E.
neXtProtiNX_P22531.
PharmGKBiPA36094.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCBD. Eukaryota.
ENOG4110P50. LUCA.
GeneTreeiENSGT00840000130291.
OMAiQQEQCKQ.

Miscellaneous databases

GenomeRNAii6704.
PROiP22531.

Gene expression databases

CleanExiHS_SPRR2E.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes."
    Kartasova T., van de Putte P.
    Mol. Cell. Biol. 8:2195-2203(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Keratinocyte.
  2. "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function."
    Cabral A., Voskamp P., Cleton-Jansen A.-M., South A., Nizetic D., Backendorf C.
    J. Biol. Chem. 276:19231-19237(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSPR2E_HUMAN
AccessioniPrimary (citable) accession number: P22531
Secondary accession number(s): Q5T9T4, Q96RM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: March 15, 2004
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.